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- Region 'REG00001595'
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Cis-regulatory Region
Name
REG.CirobuKH.C11:1684423-1684923_EboxMut|TnI
Short name
TnI -836/-335bp_EboxMut (Izzi 2013)
Region ID
REG00001595
Status
Curated
Origin
engineered region from C. robusta formely Ciona int. type A
Type of Activity
regulatory_region
(complex_region)
Author
Stephanie A Izzi (2023-04-13)
Annotator
Marion Gueroult-Bellone (2023-04-13)
Curator
Marion Gueroult-Bellone (2023-04-13)
The mutation of the E-box binding site significantly decreases the activity of the 500bp TnI enhancer : it is nearly inactive.
Modification of REG.CirobuKH.C11:1684423-1684923|TnI by substitution
CONS00001684: p.REG.CirobuKH.C11:1684423-1684923_EboxMut>LacZ
1,684,4231,684,923
| Motif Name | Binding Factor(s) | Sequence | Position in Region | Comment |
|---|
Aniseed Coordinates: [1,684,423 / 1,684,923] on scaffold KhC11
The 500bp Tnl enhancer, located upstream (-836/-335bp) of its TSS, carries a mutated E-box sequence (CAGCTG > acGCgt, lowercase in the text).
Show sequence
Length: 501
GTAGGTGCTTGTGACGTCATACTGacGCgtTTATCGCCTGAGCAGCAGTGTTCCCCGTGA
TTTTGTGCTTTGAATCAAATTTAAATATTACAAATATAAAAAATATATTCTGTTATACTT
AATCAAAGTAAAGTATTGGTATAAGCATATTTTCGTTAATTTAGTCCAAATCAACTATAG
TTTAAGCAGTTTCTAGACGTTTACATCAGTACGGCGGCAACACTCGTTCTATATTAAATC
CAGACAACCAGAACTTCTTCTTCGTTTAGTCCCTCGATGTTCTATTTAAGGGAGCTTACA
GCATCCATCCAACATCGGTAATCGAGAATCTGTTAACCTTGTTTAGTCACAGCGAAAGGT
TCATGCATTTAAGAACCCCTTGGTGAATTTAAAGAATTTTCTTGTAGAAAGGGACGCGTA
GTGGCGATAGTTACTATGGTTAACTATTAGCTTAGCTGAGTTTATCATGATTACTATTTT
TATTATTTAGATTTCTGAAGG
