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Gene Card

Best human hits

NEDD4L; SMURF1; SMURF2

Species

B.leachii

Unique Gene ID

Boleac.g00007700

Gene Model ID

Boleac.CG.SB_v3.S324.g07700

Location

S324:10266..18552

Transcript Models and Sequences

  Boleac.CG.SB_v3.S324.g07700.01.t

External Database Gene Card

External database links

No result

Collections
WashU Genome Browser

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Genomicus Synteny Browser

Genomicus browser link

Regulatory Regions

Regulatory Regions

No result

n/a

Gene Phylogeny

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Gene Annotations

InterPro

16 results

IPR Term Analysis Definition
Hect_E3_ubiquitin_ligase SUPERFAMILY HECT, E3 ligase catalytic domain
C2_domain_sf Gene3D C2 domain superfamily
E3_ub_ligase_SMURF1 PIRSF E3 ubiquitin-protein ligase, SMURF1 type
HECT_dom Pfam HECT domain
WW_dom ProSiteProfiles WW domain
C2_dom ProSiteProfiles C2 domain
HECT_dom SMART HECT domain
HECT_dom ProSiteProfiles HECT domain
C2_dom Pfam C2 domain
WW_dom Pfam WW domain
C2_dom SMART C2 domain
WW_dom CDD WW domain
HECT_dom CDD HECT domain
WW_dom SMART WW domain
WW_dom ProSitePatterns WW domain
WW_dom_sf SUPERFAMILY WW domain superfamily

GOSlim

No result

GO Term Annotation Origin Type

GO (Orthology)

49 results

GO Term SpeciesCe = Caenorhabditis elegans
Dr = Danio rerio
Dm = Drosophila melanogaster
Gg = Gallus gallus
Hs = Homo sapiens
Mm = Mus musculus
Sc = Saccharomyces cerevisiae		 Type
negative regulation of transcription from RNA polymerase II promoter Hs biological process
ubiquitin ligase complex Hs cellular component
protein polyubiquitination Hs biological process
ubiquitin-protein transferase activity Hs molecular function
transforming growth factor beta receptor binding Hs molecular function
protein binding Hs molecular function
phospholipid binding Hs molecular function
nucleus Hs cellular component
nucleoplasm Hs cellular component
cytoplasm Hs cellular component
mitochondrion Hs cellular component
cytosol Hs cellular component
plasma membrane Hs cellular component
ubiquitin-dependent protein catabolic process Hs biological process
protein export from nucleus Hs biological process
transforming growth factor beta receptor signaling pathway Hs biological process
ectoderm development Hs biological process
membrane Hs cellular component
protein ubiquitination Hs biological process
protein deubiquitination Hs biological process
nuclear speck Hs cellular component
transferase activity Hs molecular function
regulation of transforming growth factor beta receptor signaling pathway Hs biological process
cell differentiation Hs biological process
negative regulation of ossification Hs biological process
axon Hs cellular component
BMP signaling pathway Hs biological process
negative regulation of transforming growth factor beta receptor signaling pathway Hs biological process
negative regulation of BMP signaling pathway Hs biological process
ubiquitin-dependent SMAD protein catabolic process Hs biological process
receptor catabolic process Hs biological process
protein localization to cell surface Hs biological process
identical protein binding Hs molecular function
neuronal cell body Hs cellular component
proteasome-mediated ubiquitin-dependent protein catabolic process Hs biological process
membrane raft Hs cellular component
negative regulation of transcription, DNA-templated Hs biological process
SMAD binding Hs molecular function
activin binding Hs molecular function
Wnt signaling pathway, planar cell polarity pathway Hs biological process
ubiquitin protein ligase activity Hs molecular function
extracellular exosome Hs cellular component
I-SMAD binding Hs molecular function
R-SMAD binding Hs molecular function
protein localization to plasma membrane Hs biological process
positive regulation of canonical Wnt signaling pathway Hs biological process
positive regulation of trophoblast cell migration Hs biological process
positive regulation of dendrite extension Hs biological process
positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process Hs biological process

GO (Blast)

33 results

GO Term SpeciesCe = Caenorhabditis elegans
Dr = Danio rerio
Dm = Drosophila melanogaster
Gg = Gallus gallus
Hs = Homo sapiens
Mm = Mus musculus
Sc = Saccharomyces cerevisiae		 Type Score E-value
ubiquitin ligase complex Hs cellular component 850 0.0
ubiquitin-protein transferase activity Hs molecular function 850 0.0
transforming growth factor beta receptor binding Hs molecular function 850 0.0
protein binding Hs molecular function 850 0.0
phospholipid binding Hs molecular function 811 0.0
intracellular Hs cellular component 414 3.27e-131
nucleus Hs cellular component 850 0.0
nucleoplasm Hs cellular component 850 0.0
cytoplasm Hs cellular component 850 0.0
mitochondrion Hs cellular component 811 0.0
endosome Hs cellular component 414 3.27e-131
multivesicular body Hs cellular component 414 3.27e-131
Golgi apparatus Hs cellular component 414 3.27e-131
cytosol Hs cellular component 850 0.0
plasma membrane Hs cellular component 850 0.0
potassium channel regulator activity Hs molecular function 414 3.27e-131
membrane Hs cellular component 850 0.0
nuclear speck Hs cellular component 850 0.0
transferase activity Hs molecular function 850 0.0
sodium channel regulator activity Hs molecular function 414 3.27e-131
potassium channel inhibitor activity Hs molecular function 414 3.27e-131
sodium channel inhibitor activity Hs molecular function 414 3.27e-131
axon Hs cellular component 811 0.0
identical protein binding Hs molecular function 850 0.0
neuronal cell body Hs cellular component 811 0.0
ion channel binding Hs molecular function 414 3.27e-131
membrane raft Hs cellular component 850 0.0
SMAD binding Hs molecular function 850 0.0
activin binding Hs molecular function 811 0.0
ubiquitin protein ligase activity Hs molecular function 850 0.0
extracellular exosome Hs cellular component 811 0.0
I-SMAD binding Hs molecular function 811 0.0
R-SMAD binding Hs molecular function 811 0.0

GO (InterProScan)

4 results

GO Term Analysis Type e-value
ubiquitin-protein transferase activity CDD molecular function 1.30887E-140
protein binding SUPERFAMILY molecular function 2.64E-13
ubiquitin-dependent protein catabolic process PIRSF biological process 1.6E-144
ubiquitin protein ligase activity PIRSF molecular function 1.6E-144

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