Gene Card
Best human hits
FBXW11; FBXW7; TRAF7
Unique Gene ID
Cirobu.g00000085
Gene Model ID
KH2012:KH.C1.1074
Location
KhC1:6665505..6674552
Transcript Models and Sequences
cien117089
Plate: VES88_C15
cien127462
Plate: VES90_M05
cieg025c06
Plate: R1CiGC19f09
n/a
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You can Press 'Ctrl' Key + Left Mouse Click on nodes to do a multiple selection.

IPR Term | Analysis | Definition |
---|---|---|
WD40_repeat | ProSiteProfiles | WD40 repeat |
Znf-RING_LisH | Pfam | RING-type zinc-finger, LisH dimerisation motif |
WD40_repeat_CS | ProSitePatterns | WD40 repeat, conserved site |
WD40_repeat_dom | ProSiteProfiles | WD40-repeat-containing domain |
Znf_RING/FYVE/PHD | Gene3D | Zinc finger, RING/FYVE/PHD-type |
WD40_repeat_dom_sf | SUPERFAMILY | WD40-repeat-containing domain superfamily |
Znf_RING | SMART | Zinc finger, RING-type |
Znf_TRAF | ProSiteProfiles | Zinc finger, TRAF-type |
WD40/YVTN_repeat-like_dom_sf | Gene3D | WD40/YVTN repeat-like-containing domain superfamily |
WD40_repeat | SMART | WD40 repeat |
WD40_repeat | Pfam | WD40 repeat |
TRAF-like | SUPERFAMILY | TRAF-like |
Znf_RING | ProSiteProfiles | Zinc finger, RING-type |
G-protein_beta_WD-40_rep | PRINTS | G-protein beta WD-40 repeat |
GO Term | Annotation Origin | Type |
---|---|---|
ubiquitin-protein transferase activity | Orthology | molecular function |
protein binding | Orthology | molecular function |
nucleus | Blast | cellular component |
nucleoplasm | Blast | cellular component |
nucleolus | Blast | cellular component |
cytoplasm | Blast | cellular component |
centrosome | Blast | cellular component |
cytosol | Blast | cellular component |
plasma membrane | Orthology | cellular component |
transcription, DNA-templated | Orthology | biological process |
regulation of transcription, DNA-templated | Orthology | biological process |
apoptotic process | Orthology | biological process |
zinc ion binding | Orthology | molecular function |
protein ubiquitination | Orthology | biological process |
transferase activity | Orthology | molecular function |
cytoplasmic vesicle | Orthology | cellular component |
ubiquitin protein ligase binding | Blast | molecular function |
identical protein binding | Blast | molecular function |
intracellular membrane-bounded organelle | Orthology | cellular component |
metal ion binding | Orthology | molecular function |
protein dimerization activity | Blast | molecular function |
intracellular part | Orthology | cellular component |
macromolecular complex | Orthology | cellular component |
positive regulation of catalytic activity | Orthology | biological process |
intracellular signal transduction | Orthology | biological process |
protein serine/threonine kinase activity | Orthology | molecular function |
positive regulation of signal transduction | Orthology | biological process |
protein phosphorylation | Orthology | biological process |
positive regulation of apoptotic process | Orthology | biological process |
enzyme regulator activity | Blast | molecular function |
GO Term | SpeciesCe = Caenorhabditis elegans Dr = Danio rerio Dm = Drosophila melanogaster Gg = Gallus gallus Hs = Homo sapiens Mm = Mus musculus Sc = Saccharomyces cerevisiae |
Type |
---|---|---|
ubiquitin ligase complex | Hs | cellular component |
activation of MAPKKK activity | Hs | biological process |
ubiquitin-protein transferase activity | Hs | molecular function |
protein binding | Hs | molecular function |
plasma membrane | Hs | cellular component |
transcription, DNA-templated | Hs | biological process |
regulation of transcription, DNA-templated | Hs | biological process |
apoptotic process | Hs | biological process |
zinc ion binding | Hs | molecular function |
protein ubiquitination | Hs | biological process |
transferase activity | Hs | molecular function |
cytoplasmic vesicle | Hs | cellular component |
intracellular membrane-bounded organelle | Hs | cellular component |
positive regulation of MAPK cascade | Hs | biological process |
metal ion binding | Hs | molecular function |
positive regulation of apoptotic signaling pathway | Hs | biological process |
GO Term | SpeciesCe = Caenorhabditis elegans Dr = Danio rerio Dm = Drosophila melanogaster Gg = Gallus gallus Hs = Homo sapiens Mm = Mus musculus Sc = Saccharomyces cerevisiae |
Type | Score | E-value |
---|---|---|---|---|
ubiquitin ligase complex | Hs | cellular component | 807 | 0.0 |
ubiquitin-protein transferase activity | Hs | molecular function | 807 | 0.0 |
protein binding | Hs | molecular function | 807 | 0.0 |
nucleus | Hs | cellular component | 124 | 1.89e-29 |
nucleoplasm | Hs | cellular component | 124 | 1.89e-29 |
nucleolus | Hs | cellular component | 124 | 1.89e-29 |
cytoplasm | Hs | cellular component | 124 | 1.89e-29 |
centrosome | Hs | cellular component | 115 | 7.90e-27 |
cytosol | Hs | cellular component | 124 | 1.89e-29 |
plasma membrane | Hs | cellular component | 807 | 0.0 |
zinc ion binding | Hs | molecular function | 807 | 0.0 |
transferase activity | Hs | molecular function | 807 | 0.0 |
SCF ubiquitin ligase complex | Hs | cellular component | 124 | 1.89e-29 |
cyclin binding | Hs | molecular function | 124 | 1.89e-29 |
protein binding, bridging | Hs | molecular function | 124 | 1.89e-29 |
cytoplasmic vesicle | Hs | cellular component | 807 | 0.0 |
ubiquitin protein ligase binding | Hs | molecular function | 124 | 1.89e-29 |
identical protein binding | Hs | molecular function | 124 | 1.89e-29 |
intracellular membrane-bounded organelle | Hs | cellular component | 807 | 0.0 |
metal ion binding | Hs | molecular function | 807 | 0.0 |
protein dimerization activity | Hs | molecular function | 115 | 7.90e-27 |
phosphothreonine residue binding | Hs | molecular function | 124 | 1.89e-29 |
ubiquitin protein ligase activity | Hs | molecular function | 115 | 7.90e-27 |
ubiquitin-protein transferase activator activity | Hs | molecular function | 124 | 1.89e-29 |
Parkin-FBXW7-Cul1 ubiquitin ligase complex | Hs | cellular component | 124 | 1.89e-29 |
GO Term | Analysis | Type | e-value |
---|---|---|---|
protein binding | SUPERFAMILY | molecular function | 5.25E-66 |
zinc ion binding | ProSiteProfiles | molecular function | 10.131 |