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Gene Card

Best human hits

PIK3CA; PIK3CB; PIK3CD

Species

C. robusta formely Ciona int. type A

Unique Gene ID

Cirobu.g00000958

Gene Model ID

KH2012:KH.C1.695

Location

KhC1:3272704..3290553

Transcript Models and Sequences

  KH2012:KH.C1.695.v1.A.SL1-1
KH2012:KH.C1.695.v1.A.SL2-1

External Database Gene Card

External database links

1 result

Database Gene ID
ENSEMBL ENSCING00000005192
Collections

Gateway full ORF

2 results

cien111334

Plate: VES87_L19

cien186570

Plate: VES99_P01

Gene collection 1 (N. Satoh)

2 results

cilv016p10

Plate: R1CiGC26m16

cilv055l18

Plate: R1CiGC44i12

WashU Genome Browser

Click here to view results in the tunicate WashU Browser

Genomicus Synteny Browser

Genomicus browser link

Regulatory Regions

Regulatory Regions

No result

n/a

Gene Phylogeny

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Gene Annotations

InterPro

21 results

IPR Term Analysis Definition
PInositide-3_kin_accessory_dom ProSiteProfiles Phosphoinositide 3-kinase, accessory (PIK) domain
PI3K_C2_dom SMART Phosphatidylinositol 3-kinase, C2 domain
PI3K_C2_dom Pfam Phosphatidylinositol 3-kinase, C2 domain
PI3K_adapt-bd_dom ProSiteProfiles Phosphatidylinositol 3-kinase adaptor-binding (PI3K ABD) domain
ARM-type_fold SUPERFAMILY Armadillo-type fold
PI3/4_kinase_cat_sf Gene3D Phosphatidylinositol 3-/4-kinase, catalytic domain superfamily
PI3K_C2_dom ProSiteProfiles Phosphatidylinositol 3-kinase, C2 domain
PI_Kinase PANTHER Phosphatidylinositol kinase
PI3K_adapt-bd_dom SMART Phosphatidylinositol 3-kinase adaptor-binding (PI3K ABD) domain
C2_domain_sf Gene3D C2 domain superfamily
PI3/4_kinase_cat_dom ProSiteProfiles Phosphatidylinositol 3-/4-kinase, catalytic domain
PI3K_Ras-bd_dom Pfam Phosphatidylinositol 3-kinase Ras-binding (PI3K RBD) domain
PI3K_adapt-bd_dom Pfam Phosphatidylinositol 3-kinase adaptor-binding (PI3K ABD) domain
PI3/4_kinase_cat_dom SMART Phosphatidylinositol 3-/4-kinase, catalytic domain
PI3K_Vps34 PIRSF Phosphatidylinositol 3-kinase, Vps34 type
Ubiquitin-like_domsf SUPERFAMILY Ubiquitin-like domain superfamily
PInositide-3_kin_accessory_dom SMART Phosphoinositide 3-kinase, accessory (PIK) domain
Kinase-like_dom_sf SUPERFAMILY Protein kinase-like domain superfamily
PI3/4_kinase_CS ProSitePatterns Phosphatidylinositol 3/4-kinase, conserved site
PInositide-3_kin_accessory_dom Pfam Phosphoinositide 3-kinase, accessory (PIK) domain
PI3/4_kinase_cat_dom Pfam Phosphatidylinositol 3-/4-kinase, catalytic domain

GOSlim

56 results

GO Term Annotation Origin Type
nucleotide binding Orthology molecular function
angiogenesis Orthology biological process
immune system process Orthology biological process
protein serine/threonine kinase activity Orthology molecular function
binding Orthology molecular function
protein binding Orthology molecular function
ATP binding Orthology molecular function
intracellular Orthology cellular component
nucleus Orthology cellular component
nucleolus Orthology cellular component
cytoplasm Orthology cellular component
cytosol Orthology cellular component
plasma membrane Orthology cellular component
protein phosphorylation Orthology biological process
chemotaxis Orthology biological process
cell adhesion Orthology biological process
signal transduction Orthology biological process
G-protein coupled receptor signaling pathway Orthology biological process
axon guidance Orthology biological process
response to wounding Orthology biological process
positive regulation of gene expression Orthology biological process
kinase activity Orthology molecular function
phosphorylation Orthology biological process
cell migration Orthology biological process
transferase activity Orthology molecular function
cytokine-mediated signaling pathway Orthology biological process
lamellipodium Blast cellular component
cell differentiation Orthology biological process
midbody Orthology cellular component
innate immune response Orthology biological process
positive regulation of catalytic activity Orthology biological process
intracellular signal transduction Orthology biological process
positive regulation of signal transduction Orthology biological process
animal organ development Orthology biological process
cell proliferation Orthology biological process
immune response Orthology biological process
membrane part Orthology cellular component
macromolecular complex Orthology cellular component
cellular biosynthetic process Orthology biological process
phosphate-containing compound metabolic process Orthology biological process
cellular process Orthology biological process
cell Orthology cellular component
membrane organization Orthology biological process
organelle organization Orthology biological process
defense response Orthology biological process
cell surface receptor signaling pathway Orthology biological process
phosphotransferase activity, alcohol group as acceptor Orthology molecular function
blood coagulation Orthology biological process
organic substance metabolic process Orthology biological process
cell division Orthology biological process
multicellular organism development Orthology biological process
lysosome Orthology cellular component
wound healing Orthology biological process
enzyme activator activity Blast molecular function
protein kinase binding Blast molecular function
protein kinase activity Blast molecular function

GO (Orthology)

71 results

GO Term SpeciesCe = Caenorhabditis elegans
Dr = Danio rerio
Dm = Drosophila melanogaster
Gg = Gallus gallus
Hs = Homo sapiens
Mm = Mus musculus
Sc = Saccharomyces cerevisiae		 Type
nucleotide binding Hs molecular function
activation of MAPK activity Hs biological process
natural killer cell differentiation Hs biological process
cytokine production Hs biological process
endothelial cell proliferation Hs biological process
regulation of cell-matrix adhesion Hs biological process
adaptive immune response Hs biological process
immune system process Hs biological process
binding Hs molecular function
protein binding Hs molecular function
ATP binding Hs molecular function
intracellular Hs cellular component
nucleus Hs cellular component
nucleolus Hs cellular component
cytoplasm Hs cellular component
cytosol Hs cellular component
plasma membrane Hs cellular component
phosphatidylinositol 3-kinase complex Hs cellular component
protein phosphorylation Hs biological process
phosphatidylinositol biosynthetic process Hs biological process
cellular calcium ion homeostasis Hs biological process
endocytosis Hs biological process
autophagy Hs biological process
chemotaxis Hs biological process
inflammatory response Hs biological process
cell adhesion Hs biological process
homophilic cell adhesion via plasma membrane adhesion molecules Hs biological process
signal transduction Hs biological process
transmembrane receptor protein tyrosine kinase signaling pathway Hs biological process
G-protein coupled receptor signaling pathway Hs biological process
axon guidance Hs biological process
response to wounding Hs biological process
positive regulation of autophagy Hs biological process
positive regulation of gene expression Hs biological process
T cell chemotaxis Hs biological process
phosphatidylinositol 3-kinase signaling Hs biological process
kinase activity Hs molecular function
1-phosphatidylinositol-3-kinase activity Hs molecular function
phosphorylation Hs biological process
cell migration Hs biological process
transferase activity Hs molecular function
cytokine-mediated signaling pathway Hs biological process
cell differentiation Hs biological process
platelet activation Hs biological process
T cell differentiation Hs biological process
positive regulation of cell migration Hs biological process
midbody Hs cellular component
neutrophil chemotaxis Hs biological process
phosphatidylinositol 3-kinase activity Hs molecular function
1-phosphatidylinositol-4-phosphate 3-kinase activity Hs molecular function
B cell chemotaxis Hs biological process
phosphatidylinositol-3-phosphate biosynthetic process Hs biological process
Fc-epsilon receptor signaling pathway Hs biological process
embryonic cleavage Hs biological process
T cell activation Hs biological process
B cell activation Hs biological process
mast cell granule Hs cellular component
insulin receptor substrate binding Hs molecular function
innate immune response Hs biological process
phosphatidylinositol phosphorylation Hs biological process
phosphatidylinositol-4,5-bisphosphate 3-kinase activity Hs molecular function
vascular endothelial growth factor receptor signaling pathway Hs biological process
phosphatidylinositol-mediated signaling Hs biological process
T cell receptor signaling pathway Hs biological process
B cell receptor signaling pathway Hs biological process
leukocyte migration Hs biological process
positive regulation of protein kinase B signaling Hs biological process
angiogenesis involved in wound healing Hs biological process
cell chemotaxis Hs biological process
platelet aggregation Hs biological process
regulation of clathrin-dependent endocytosis Hs biological process

GO (Blast)

24 results

GO Term SpeciesCe = Caenorhabditis elegans
Dr = Danio rerio
Dm = Drosophila melanogaster
Gg = Gallus gallus
Hs = Homo sapiens
Mm = Mus musculus
Sc = Saccharomyces cerevisiae		 Type Score E-value
nucleotide binding Hs molecular function 823 0.0
protein serine/threonine kinase activity Hs molecular function 635 0.0
binding Hs molecular function 823 0.0
protein binding Hs molecular function 823 0.0
ATP binding Hs molecular function 823 0.0
intracellular Hs cellular component 823 0.0
nucleus Hs cellular component 823 0.0
nucleolus Hs cellular component 823 0.0
cytoplasm Hs cellular component 823 0.0
cytosol Hs cellular component 823 0.0
plasma membrane Hs cellular component 823 0.0
phosphatidylinositol 3-kinase complex Hs cellular component 823 0.0
phosphatidylinositol 3-kinase complex, class IA Hs cellular component 635 0.0
kinase activity Hs molecular function 823 0.0
1-phosphatidylinositol-3-kinase activity Hs molecular function 823 0.0
transferase activity Hs molecular function 823 0.0
lamellipodium Hs cellular component 635 0.0
protein kinase activator activity Hs molecular function 635 0.0
midbody Hs cellular component 823 0.0
phosphatidylinositol 3-kinase activity Hs molecular function 823 0.0
1-phosphatidylinositol-4-phosphate 3-kinase activity Hs molecular function 823 0.0
mast cell granule Hs cellular component 759 0.0
insulin receptor substrate binding Hs molecular function 823 0.0
phosphatidylinositol-4,5-bisphosphate 3-kinase activity Hs molecular function 823 0.0

GO (InterProScan)

5 results

GO Term Analysis Type e-value
binding SUPERFAMILY molecular function 4.32E-51
kinase activity Gene3D molecular function 1.2E-78
1-phosphatidylinositol-3-kinase activity PIRSF molecular function 1.5E-79
phosphatidylinositol phosphorylation PANTHER biological process 0.0
phosphatidylinositol-mediated signaling PANTHER biological process 0.0

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