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Gene Card

Best human hits

ALOX12B; ALOX5

Species

C. robusta formely Ciona int. type A

Unique Gene ID

Cirobu.g00001869

Gene Model ID

KH2012:KH.C10.68

Location

KhC10:4290726..4296829

Transcript Models and Sequences

  KH2012:KH.C10.68.v1.A.ND1-1

External Database Gene Card

External database links

2 results

Database Gene ID
ENSEMBL ENSCING00000007740
NCBI Reference Sequence XM_002123777.4
Collections
WashU Genome Browser

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Genomicus Synteny Browser

Genomicus browser link

Regulatory Regions

Regulatory Regions

No result

n/a

Gene Phylogeny

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Gene Annotations

InterPro

12 results

IPR Term Analysis Definition
PLAT/LH2_dom ProSiteProfiles PLAT/LH2 domain
LipOase_CS ProSitePatterns Lipoxygenase, conserved site
LipOase_C_sf SUPERFAMILY Lipoxigenase, C-terminal domain superfamily
PLAT/LH2_dom Pfam PLAT/LH2 domain
LipOase_mml PRINTS Lipoxygenase, mammalian
Catalase_core_sf Gene3D Catalase core domain superfamily
LipOase_C ProSiteProfiles Lipoxygenase, C-terminal
PLAT/LH2_dom_sf SUPERFAMILY PLAT/LH2 domain superfamily
LipOase PANTHER Lipoxygenase
LipOase_C PRINTS Lipoxygenase, C-terminal
PLAT/LH2_dom SMART PLAT/LH2 domain
LipOase_C Pfam Lipoxygenase, C-terminal

GOSlim

58 results

GO Term Annotation Origin Type
catalytic activity Orthology molecular function
iron ion binding Orthology molecular function
protein binding Orthology molecular function
extracellular region Orthology cellular component
extracellular space Orthology cellular component
nucleus Orthology cellular component
nuclear envelope Orthology cellular component
nucleoplasm Orthology cellular component
cytoplasm Orthology cellular component
cytosol Orthology cellular component
positive regulation of gene expression Orthology biological process
membrane Orthology cellular component
cytokine-mediated signaling pathway Orthology biological process
nuclear membrane Orthology cellular component
metal ion binding Orthology molecular function
oxidation-reduction process Orthology biological process
heme binding InterProScan molecular function
calcium ion binding Orthology molecular function
intracellular Orthology cellular component
cytoskeleton Orthology cellular component
plasma membrane Orthology cellular component
apoptotic process Orthology biological process
negative regulation of cell proliferation Orthology biological process
hydrolase activity Orthology molecular function
wound healing Orthology biological process
extracellular exosome Orthology cellular component
intracellular organelle lumen Orthology cellular component
cellular protein modification process Orthology biological process
organic substance metabolic process Orthology biological process
cellular metabolic process Orthology biological process
defense response Orthology biological process
nuclear lumen Orthology cellular component
cellular biosynthetic process Orthology biological process
intracellular organelle part Orthology cellular component
cytoplasmic vesicle Orthology cellular component
endomembrane system Orthology cellular component
intracellular signal transduction Orthology biological process
positive regulation of signal transduction Orthology biological process
protein phosphorylation Orthology biological process
amide biosynthetic process Orthology biological process
animal organ development Orthology biological process
organic substance transport Orthology biological process
anion binding Orthology molecular function
intracellular non-membrane-bounded organelle Orthology cellular component
phosphate-containing compound metabolic process Orthology biological process
binding Orthology molecular function
cell adhesion Orthology biological process
sensory perception Orthology biological process
membrane part Orthology cellular component
cell migration Orthology biological process
organelle organization Orthology biological process
multicellular organism development Orthology biological process
cell differentiation Orthology biological process
intracellular part Orthology cellular component
plasma membrane part Orthology cellular component
cellular response to stress Orthology biological process
signal transduction Orthology biological process
cell cycle Orthology biological process

GO (Orthology)

80 results

GO Term SpeciesCe = Caenorhabditis elegans
Dr = Danio rerio
Dm = Drosophila melanogaster
Gg = Gallus gallus
Hs = Homo sapiens
Mm = Mus musculus
Sc = Saccharomyces cerevisiae		 Type
catalytic activity Hs molecular function
arachidonate 5-lipoxygenase activity Hs molecular function
arachidonate 12-lipoxygenase activity Hs molecular function
iron ion binding Hs molecular function
protein binding Hs molecular function
extracellular region Hs cellular component
extracellular space Hs cellular component
nucleus Hs cellular component
nuclear envelope Hs cellular component
nuclear envelope lumen Hs cellular component
nucleoplasm Hs cellular component
cytoplasm Hs cellular component
cytosol Hs cellular component
protein lipidation Hs biological process
lipid metabolic process Hs biological process
fatty acid metabolic process Hs biological process
sphingolipid metabolic process Hs biological process
leukotriene metabolic process Hs biological process
inflammatory response Hs biological process
positive regulation of gene expression Hs biological process
membrane Hs cellular component
nuclear matrix Hs cellular component
oxidoreductase activity Hs molecular function
oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen Hs molecular function
cytokine-mediated signaling pathway Hs biological process
arachidonic acid metabolic process Hs biological process
leukotriene biosynthetic process Hs biological process
nuclear membrane Hs cellular component
secretory granule lumen Hs cellular component
positive regulation of MAPK cascade Hs biological process
ceramide biosynthetic process Hs biological process
metal ion binding Hs molecular function
dioxygenase activity Hs molecular function
oxidation-reduction process Hs biological process
establishment of skin barrier Hs biological process
positive regulation of mucus secretion Hs biological process
ficolin-1-rich granule lumen Hs cellular component
linoleate 9S-lipoxygenase activity Hs molecular function
ossification Hs biological process
calcium ion binding Hs molecular function
phosphatidylinositol-4,5-bisphosphate binding Hs molecular function
intracellular Hs cellular component
lipid droplet Hs cellular component
cytoskeleton Hs cellular component
plasma membrane Hs cellular component
phosphatidylethanolamine biosynthetic process Hs biological process
apoptotic process Hs biological process
negative regulation of cell proliferation Hs biological process
lipid binding Hs molecular function
positive regulation of cell-substrate adhesion Hs biological process
linoleate 13S-lipoxygenase activity Hs molecular function
hydrolase activity Hs molecular function
lyase activity Hs molecular function
isomerase activity Hs molecular function
sensory perception of pain Hs biological process
fatty acid oxidation Hs biological process
extrinsic component of membrane Hs cellular component
bone mineralization Hs biological process
negative regulation of cell migration Hs biological process
positive regulation of actin filament polymerization Hs biological process
regulation of epithelial cell differentiation Hs biological process
extrinsic component of cytoplasmic side of plasma membrane Hs cellular component
positive regulation of heterotypic cell-cell adhesion Hs biological process
response to endoplasmic reticulum stress Hs biological process
peroxisome proliferator activated receptor signaling pathway Hs biological process
arachidonate 8(S)-lipoxygenase activity Hs molecular function
wound healing Hs biological process
sarcolemma Hs cellular component
superoxide anion generation Hs biological process
apoptotic cell clearance Hs biological process
fat cell differentiation Hs biological process
negative regulation of cell cycle Hs biological process
negative regulation of growth Hs biological process
hepoxilin-epoxide hydrolase activity Hs molecular function
arachidonate 15-lipoxygenase activity Hs molecular function
hepoxilin A3 synthase activity Hs molecular function
extracellular exosome Hs cellular component
positive regulation of ERK1 and ERK2 cascade Hs biological process
cellular response to calcium ion Hs biological process
eoxin A4 synthase activity Hs molecular function

GO (Blast)

23 results

GO Term SpeciesCe = Caenorhabditis elegans
Dr = Danio rerio
Dm = Drosophila melanogaster
Gg = Gallus gallus
Hs = Homo sapiens
Mm = Mus musculus
Sc = Saccharomyces cerevisiae		 Type Score E-value
catalytic activity Hs molecular function 360 1.45e-114
arachidonate 5-lipoxygenase activity Hs molecular function 458 1.47e-152
arachidonate 12-lipoxygenase activity Hs molecular function 360 1.45e-114
iron ion binding Hs molecular function 458 1.47e-152
protein binding Hs molecular function 458 1.47e-152
extracellular region Hs cellular component 458 1.47e-152
extracellular space Hs cellular component 458 1.47e-152
nucleus Hs cellular component 458 1.47e-152
nuclear envelope Hs cellular component 458 1.47e-152
nuclear envelope lumen Hs cellular component 458 1.47e-152
nucleoplasm Hs cellular component 458 1.47e-152
cytoplasm Hs cellular component 458 1.47e-152
cytosol Hs cellular component 458 1.47e-152
membrane Hs cellular component 458 1.47e-152
nuclear matrix Hs cellular component 458 1.47e-152
oxidoreductase activity Hs molecular function 458 1.47e-152
oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen Hs molecular function 458 1.47e-152
nuclear membrane Hs cellular component 458 1.47e-152
secretory granule lumen Hs cellular component 458 1.47e-152
metal ion binding Hs molecular function 458 1.47e-152
dioxygenase activity Hs molecular function 458 1.47e-152
ficolin-1-rich granule lumen Hs cellular component 458 1.47e-152
linoleate 9S-lipoxygenase activity Hs molecular function 360 1.45e-114

GO (InterProScan)

7 results

GO Term Analysis Type e-value
iron ion binding PRINTS molecular function 4.8E-9
protein binding SUPERFAMILY molecular function 2.06E-26
oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen PANTHER molecular function 8.6E-201
metal ion binding PANTHER molecular function 8.6E-201
oxidation-reduction process PANTHER biological process 8.6E-201
catalase activity Gene3D molecular function 6.5E-32
heme binding Gene3D molecular function 6.5E-32

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