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Gene Card

Best human hits

SMAD2; SMAD3; SMAD5

Species

C. robusta formely Ciona int. type A

Unique Gene ID

Cirobu.g00002798

Gene Model ID

KH2012:KH.C12.26

Location

KhC12:156293..163445

Transcript Models and Sequences

  KH2012:KH.C12.26.v1.A.SL1-1
KH2012:KH.C12.26.v1.A.SL2-1

External Database Gene Card

External database links

2 results

Database Gene ID
ENSEMBL ENSCING00000006188
NCBI Reference Sequence XM_002119122.3
Collections

Gateway full ORF

2 results

cima889094

Plate: VES70_I11

cien118768

Plate: VES88_M21

Gene collection 1 (N. Satoh)

1 result

cieg050i11

Plate: R1CiGC23n07

WashU Genome Browser

Click here to view results in the tunicate WashU Browser

Genomicus Synteny Browser

Genomicus browser link

Regulatory Regions

Regulatory Regions

No result

n/a

Gene Phylogeny

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Gene Annotations

InterPro

11 results

IPR Term Analysis Definition
SMAD_MH1_sf Gene3D SMAD MH1 domain superfamily
SMAD_dom_Dwarfin-type Pfam SMAD domain, Dwarfin-type
SMAD_FHA_dom_sf SUPERFAMILY SMAD/FHA domain superfamily
MAD_homology1_Dwarfin-type Pfam MAD homology 1, Dwarfin-type
SMAD-like_dom_sf Gene3D SMAD-like domain superfamily
Dwarfin PANTHER Dwarfin
MAD_homology_MH1 ProSiteProfiles MAD homology, MH1
SMAD_dom_Dwarfin-type ProSiteProfiles SMAD domain, Dwarfin-type
SMAD_dom_Dwarfin-type SMART SMAD domain, Dwarfin-type
MAD_homology1_Dwarfin-type SMART MAD homology 1, Dwarfin-type
SMAD_MH1_sf SUPERFAMILY SMAD MH1 domain superfamily

GOSlim

95 results

GO Term Annotation Origin Type
negative regulation of transcription from RNA polymerase II promoter Orthology biological process
RNA polymerase II regulatory region sequence-specific DNA binding Orthology molecular function
RNA polymerase II core promoter proximal region sequence-specific DNA binding Orthology molecular function
RNA polymerase II transcription factor activity, sequence-specific DNA binding Orthology molecular function
core promoter proximal region sequence-specific DNA binding Orthology molecular function
transcription factor activity, transcription factor binding Orthology molecular function
response to hypoxia Orthology biological process
DNA binding Orthology molecular function
chromatin binding Orthology molecular function
double-stranded DNA binding Orthology molecular function
transcription factor activity, sequence-specific DNA binding Orthology molecular function
protein binding Orthology molecular function
intracellular Orthology cellular component
nucleus Orthology cellular component
nucleoplasm Orthology cellular component
cytoplasm Orthology cellular component
cytosol Orthology cellular component
plasma membrane Orthology cellular component
transcription, DNA-templated Orthology biological process
regulation of transcription, DNA-templated Orthology biological process
regulation of transcription from RNA polymerase II promoter Orthology biological process
transcription from RNA polymerase II promoter Orthology biological process
protein phosphorylation Orthology biological process
immune response Orthology biological process
signal transduction Orthology biological process
heart development Orthology biological process
transcription factor binding Orthology molecular function
zinc ion binding Orthology molecular function
negative regulation of cell proliferation Orthology biological process
positive regulation of gene expression Orthology biological process
negative regulation of gene expression Orthology biological process
membrane Orthology cellular component
integral component of membrane Orthology cellular component
enzyme binding Orthology molecular function
protein kinase binding Orthology molecular function
ubiquitin protein ligase binding Orthology molecular function
macromolecular complex Orthology cellular component
intracellular signal transduction Orthology biological process
wound healing Orthology biological process
identical protein binding Orthology molecular function
protein homodimerization activity Orthology molecular function
negative regulation of apoptotic process Orthology biological process
sequence-specific DNA binding Orthology molecular function
transcription regulatory region DNA binding Orthology molecular function
negative regulation of transcription, DNA-templated Orthology biological process
positive regulation of transcription, DNA-templated Orthology biological process
positive regulation of transcription from RNA polymerase II promoter Orthology biological process
metal ion binding Orthology molecular function
protein heterodimerization activity Orthology molecular function
intracellular non-membrane-bounded organelle Orthology cellular component
nuclear lumen Orthology cellular component
system development Orthology biological process
cell differentiation Orthology biological process
animal organ development Orthology biological process
anatomical structure formation involved in morphogenesis Orthology biological process
multicellular organism development Orthology biological process
anatomical structure morphogenesis Orthology biological process
cell development Orthology biological process
receptor binding Orthology molecular function
macromolecular complex binding Orthology molecular function
organelle inner membrane Orthology cellular component
nuclear membrane Orthology cellular component
intracellular part Orthology cellular component
endopeptidase activity Orthology molecular function
positive regulation of hydrolase activity Orthology biological process
positive regulation of apoptotic process Orthology biological process
cell surface receptor signaling pathway Orthology biological process
cellular response to organic substance Orthology biological process
anatomical structure development Orthology biological process
response to organic substance Orthology biological process
peptidase activity, acting on L-amino acid peptides Orthology molecular function
regulation of signal transduction Orthology biological process
regulation of gene expression Orthology biological process
cell-cell signaling Orthology biological process
protein transport Orthology biological process
cellular component organization Orthology biological process
cell migration Orthology biological process
negative regulation of signal transduction Orthology biological process
positive regulation of signal transduction Orthology biological process
molecular transducer activity Orthology molecular function
RNA processing Orthology biological process
nuclear part Orthology cellular component
developmental process Orthology biological process
cellular process Orthology biological process
immune system process Orthology biological process
protein metabolic process Orthology biological process
regulation of cell proliferation Orthology biological process
defense response Orthology biological process
chemotaxis Orthology biological process
cell Orthology cellular component
organelle organization Orthology biological process
cell adhesion Orthology biological process
RNA binding Orthology molecular function
apoptotic process Orthology biological process
extracellular matrix organization Orthology biological process

GO (Orthology)

145 results

GO Term SpeciesCe = Caenorhabditis elegans
Dr = Danio rerio
Dm = Drosophila melanogaster
Gg = Gallus gallus
Hs = Homo sapiens
Mm = Mus musculus
Sc = Saccharomyces cerevisiae		 Type
negative regulation of transcription from RNA polymerase II promoter Hs biological process
nuclear chromatin Hs cellular component
RNA polymerase II regulatory region sequence-specific DNA binding Hs molecular function
RNA polymerase II core promoter proximal region sequence-specific DNA binding Hs molecular function
RNA polymerase II transcription factor activity, sequence-specific DNA binding Hs molecular function
transcription factor activity, RNA polymerase II core promoter sequence-specific Hs molecular function
core promoter proximal region sequence-specific DNA binding Hs molecular function
transcription factor activity, transcription factor binding Hs molecular function
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding Hs molecular function
RNA polymerase II activating transcription factor binding Hs molecular function
skeletal system development Hs biological process
osteoblast differentiation Hs biological process
ureteric bud development Hs biological process
response to hypoxia Hs biological process
endoderm formation Hs biological process
mesoderm formation Hs biological process
somitogenesis Hs biological process
liver development Hs biological process
heart looping Hs biological process
osteoblast development Hs biological process
DNA binding Hs molecular function
chromatin binding Hs molecular function
double-stranded DNA binding Hs molecular function
transcription factor activity, sequence-specific DNA binding Hs molecular function
transforming growth factor beta receptor binding Hs molecular function
protein binding Hs molecular function
collagen binding Hs molecular function
intracellular Hs cellular component
nucleus Hs cellular component
nuclear inner membrane Hs cellular component
nucleoplasm Hs cellular component
transcription factor complex Hs cellular component
cytoplasm Hs cellular component
cytosol Hs cellular component
plasma membrane Hs cellular component
transcription, DNA-templated Hs biological process
regulation of transcription, DNA-templated Hs biological process
regulation of transcription from RNA polymerase II promoter Hs biological process
transcription from RNA polymerase II promoter Hs biological process
protein phosphorylation Hs biological process
activation of cysteine-type endopeptidase activity involved in apoptotic process Hs biological process
immune response Hs biological process
cell cycle arrest Hs biological process
transforming growth factor beta receptor signaling pathway Hs biological process
gastrulation Hs biological process
pattern specification process Hs biological process
endoderm development Hs biological process
heart development Hs biological process
beta-catenin binding Hs molecular function
transcription factor binding Hs molecular function
zinc ion binding Hs molecular function
negative regulation of cell proliferation Hs biological process
response to glucose Hs biological process
post-embryonic development Hs biological process
embryonic pattern specification Hs biological process
anterior/posterior pattern specification Hs biological process
positive regulation of gene expression Hs biological process
negative regulation of gene expression Hs biological process
positive regulation of epithelial to mesenchymal transition Hs biological process
membrane Hs cellular component
integral component of membrane Hs cellular component
regulation of striated muscle tissue development Hs biological process
protein deubiquitination Hs biological process
regulation of transforming growth factor beta receptor signaling pathway Hs biological process
DEAD/H-box RNA helicase binding Hs molecular function
enzyme binding Hs molecular function
protein kinase binding Hs molecular function
phosphatase binding Hs molecular function
signal transduction involved in regulation of gene expression Hs biological process
insulin secretion Hs biological process
negative regulation of cell growth Hs biological process
lung development Hs biological process
positive regulation of cell migration Hs biological process
positive regulation of bone mineralization Hs biological process
negative regulation of transforming growth factor beta receptor signaling pathway Hs biological process
positive regulation of BMP signaling pathway Hs biological process
transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity Hs molecular function
thyroid gland development Hs biological process
pancreas development Hs biological process
primary miRNA processing Hs biological process
chromatin DNA binding Hs molecular function
ubiquitin protein ligase binding Hs molecular function
mineralocorticoid receptor binding Hs molecular function
positive regulation of chondrocyte differentiation Hs biological process
activin responsive factor complex Hs cellular component
activin receptor signaling pathway Hs biological process
macromolecular complex Hs cellular component
activating transcription factor binding Hs molecular function
negative regulation of osteoblast proliferation Hs biological process
type I transforming growth factor beta receptor binding Hs molecular function
somatic stem cell population maintenance Hs biological process
glucocorticoid receptor binding Hs molecular function
organ growth Hs biological process
enhancer binding Hs molecular function
intracellular signal transduction Hs biological process
nodal signaling pathway Hs biological process
wound healing Hs biological process
T cell activation Hs biological process
negative regulation of protein catabolic process Hs biological process
identical protein binding Hs molecular function
protein homodimerization activity Hs molecular function
positive regulation of transcription factor import into nucleus Hs biological process
negative regulation of apoptotic process Hs biological process
ubiquitin binding Hs molecular function
receptor complex Hs cellular component
bHLH transcription factor binding Hs molecular function
sequence-specific DNA binding Hs molecular function
transcription regulatory region DNA binding Hs molecular function
cell fate commitment Hs biological process
cell-cell junction organization Hs biological process
positive regulation of nitric oxide biosynthetic process Hs biological process
negative regulation of osteoblast differentiation Hs biological process
negative regulation of transcription, DNA-templated Hs biological process
positive regulation of transcription, DNA-templated Hs biological process
negative regulation of mitotic cell cycle Hs biological process
positive regulation of transcription from RNA polymerase II promoter Hs biological process
SMAD binding Hs molecular function
metal ion binding Hs molecular function
protein heterodimerization activity Hs molecular function
developmental growth Hs biological process
embryonic foregut morphogenesis Hs biological process
embryonic cranial skeleton morphogenesis Hs biological process
regulation of epithelial cell proliferation Hs biological process
negative regulation of inflammatory response Hs biological process
regulation of immune response Hs biological process
protein stabilization Hs biological process
positive regulation of positive chemotaxis Hs biological process
negative regulation of cytosolic calcium ion concentration Hs biological process
positive regulation of stress fiber assembly Hs biological process
positive regulation of focal adhesion assembly Hs biological process
palate development Hs biological process
canonical Wnt signaling pathway Hs biological process
transdifferentiation Hs biological process
SMAD protein signal transduction Hs biological process
lens fiber cell differentiation Hs biological process
co-SMAD binding Hs molecular function
I-SMAD binding Hs molecular function
R-SMAD binding Hs molecular function
primary miRNA binding Hs molecular function
SMAD protein complex Hs cellular component
SMAD2-SMAD3 protein complex Hs cellular component
cellular response to transforming growth factor beta stimulus Hs biological process
extrinsic apoptotic signaling pathway Hs biological process
disordered domain specific binding Hs molecular function
positive regulation of extracellular matrix assembly Hs biological process

GO (Blast)

61 results

GO Term SpeciesCe = Caenorhabditis elegans
Dr = Danio rerio
Dm = Drosophila melanogaster
Gg = Gallus gallus
Hs = Homo sapiens
Mm = Mus musculus
Sc = Saccharomyces cerevisiae		 Type Score E-value
nuclear chromatin Hs cellular component 639 0.0
RNA polymerase II regulatory region sequence-specific DNA binding Hs molecular function 639 0.0
RNA polymerase II core promoter proximal region sequence-specific DNA binding Hs molecular function 639 0.0
RNA polymerase II transcription factor activity, sequence-specific DNA binding Hs molecular function 639 0.0
transcription factor activity, RNA polymerase II core promoter sequence-specific Hs molecular function 639 0.0
core promoter proximal region sequence-specific DNA binding Hs molecular function 639 0.0
transcription factor activity, transcription factor binding Hs molecular function 639 0.0
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding Hs molecular function 615 0.0
RNA polymerase II activating transcription factor binding Hs molecular function 639 0.0
DNA binding Hs molecular function 639 0.0
chromatin binding Hs molecular function 639 0.0
double-stranded DNA binding Hs molecular function 639 0.0
transcription factor activity, sequence-specific DNA binding Hs molecular function 639 0.0
signal transducer activity, downstream of receptor Hs molecular function 513 0.0
transforming growth factor beta receptor binding Hs molecular function 639 0.0
protein binding Hs molecular function 639 0.0
collagen binding Hs molecular function 639 0.0
intracellular Hs cellular component 639 0.0
nucleus Hs cellular component 639 0.0
nuclear inner membrane Hs cellular component 639 0.0
nucleoplasm Hs cellular component 639 0.0
transcription factor complex Hs cellular component 639 0.0
cytoplasm Hs cellular component 639 0.0
cytosol Hs cellular component 639 0.0
plasma membrane Hs cellular component 639 0.0
beta-catenin binding Hs molecular function 639 0.0
transcription factor binding Hs molecular function 639 0.0
zinc ion binding Hs molecular function 639 0.0
membrane Hs cellular component 615 0.0
integral component of membrane Hs cellular component 615 0.0
DEAD/H-box RNA helicase binding Hs molecular function 639 0.0
enzyme binding Hs molecular function 639 0.0
protein kinase binding Hs molecular function 639 0.0
phosphatase binding Hs molecular function 639 0.0
transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity Hs molecular function 639 0.0
chromatin DNA binding Hs molecular function 639 0.0
ubiquitin protein ligase binding Hs molecular function 639 0.0
mineralocorticoid receptor binding Hs molecular function 639 0.0
activin responsive factor complex Hs cellular component 615 0.0
macromolecular complex Hs cellular component 615 0.0
activating transcription factor binding Hs molecular function 615 0.0
type I transforming growth factor beta receptor binding Hs molecular function 615 0.0
glucocorticoid receptor binding Hs molecular function 639 0.0
enhancer binding Hs molecular function 639 0.0
identical protein binding Hs molecular function 639 0.0
protein homodimerization activity Hs molecular function 639 0.0
ubiquitin binding Hs molecular function 639 0.0
receptor complex Hs cellular component 639 0.0
bHLH transcription factor binding Hs molecular function 639 0.0
sequence-specific DNA binding Hs molecular function 639 0.0
transcription regulatory region DNA binding Hs molecular function 639 0.0
SMAD binding Hs molecular function 639 0.0
metal ion binding Hs molecular function 639 0.0
protein heterodimerization activity Hs molecular function 639 0.0
co-SMAD binding Hs molecular function 639 0.0
I-SMAD binding Hs molecular function 615 0.0
R-SMAD binding Hs molecular function 639 0.0
primary miRNA binding Hs molecular function 639 0.0
SMAD protein complex Hs cellular component 639 0.0
SMAD2-SMAD3 protein complex Hs cellular component 639 0.0
disordered domain specific binding Hs molecular function 615 0.0

GO (InterProScan)

6 results

GO Term Analysis Type e-value
transcription factor activity, sequence-specific DNA binding ProSiteProfiles molecular function 35.44
protein binding SUPERFAMILY molecular function 2.73E-92
intracellular PANTHER cellular component 8.0E-230
transcription factor complex ProSiteProfiles cellular component 35.44
regulation of transcription, DNA-templated PANTHER biological process 8.0E-230
transforming growth factor beta receptor signaling pathway Gene3D biological process 1.0E-63

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