Gene Card
Best human hits
MTHFD1; MTHFD2; MTHFD2L
Unique Gene ID
Cirobu.g00003679
Gene Model ID
KH2012:KH.C14.259
Location
KhC14:2424318..2426191
Transcript Models and Sequences
KH2012:KH.C14.259.v1.A.ND1-1
KH2012:KH.C14.259.v1.A.nonSL2-1
KH2012:KH.C14.259.v1.A.nonSL3-1
KH2012:KH.C14.259.v1.A.nonSL4-1
KH2012:KH.C14.259.v1.A.nonSL5-1
KH2012:KH.C14.259.v1.A.nonSL6-1
KH2012:KH.C14.259.v1.A.nonSL7-1
KH2012:KH.C14.259.v1.A.nonSL8-1
KH2012:KH.C14.259.v1.A.nonSL9-1
External database links
2 results
| Database | Gene ID |
|---|---|
| ENSEMBL | ENSCING00000014490 |
| NCBI Reference Sequence | XM_002123977.3 |
Gateway full ORF
2 results
cien48290
Plate: VES77_L20
cien200247
Plate: VES101_H10
Gene collection 1 (N. Satoh)
2 results
cieg007d06
Plate: R1CiGC16d13
cieg054g24
Plate: R1CiGC24o11
n/a
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Click here to see the tree inference method
InterPro
7 results
| IPR Term | Analysis | Definition |
|---|---|---|
| THF_DH/CycHdrlase_CS | ProSitePatterns | Tetrahydrofolate dehydrogenase/cyclohydrolase, conserved site |
| THF_DH/CycHdrlase_NAD-bd_dom | Pfam | Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain |
| THF_DH/CycHdrlase_cat_dom | Pfam | Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain |
| THF_DH/CycHdrlase | Hamap | Tetrahydrofolate dehydrogenase/cyclohydrolase |
| THF_DH/CycHdrlase | PRINTS | Tetrahydrofolate dehydrogenase/cyclohydrolase |
| NAD(P)-bd_dom_sf | SUPERFAMILY | NAD(P)-binding domain superfamily |
| THF_DH/CycHdrlase | PANTHER | Tetrahydrofolate dehydrogenase/cyclohydrolase |
GOSlim
22 results
| GO Term | Annotation Origin | Type |
|---|---|---|
| nucleotide binding | Blast | molecular function |
| magnesium ion binding | Orthology | molecular function |
| catalytic activity | Orthology | molecular function |
| protein binding | Blast | molecular function |
| ATP binding | Blast | molecular function |
| extracellular space | Orthology | cellular component |
| cytoplasm | Blast | cellular component |
| mitochondrion | Orthology | cellular component |
| mitochondrial inner membrane | Orthology | cellular component |
| mitochondrial matrix | Orthology | cellular component |
| cytosol | Blast | cellular component |
| metabolic process | Orthology | biological process |
| membrane | Orthology | cellular component |
| hydrolase activity | Orthology | molecular function |
| ligase activity | Blast | molecular function |
| oxidation-reduction process | Orthology | biological process |
| extracellular exosome | Blast | cellular component |
| phosphate-containing compound metabolic process | Orthology | biological process |
| cellular metabolic process | Orthology | biological process |
| cellular biosynthetic process | Orthology | biological process |
| cellular aromatic compound metabolic process | Orthology | biological process |
| anion binding | Orthology | molecular function |
GO (Orthology)
22 results
| GO Term | SpeciesCe = Caenorhabditis elegans Dr = Danio rerio Dm = Drosophila melanogaster Gg = Gallus gallus Hs = Homo sapiens Mm = Mus musculus Sc = Saccharomyces cerevisiae |
Type |
|---|---|---|
| magnesium ion binding | Hs | molecular function |
| catalytic activity | Hs | molecular function |
| methenyltetrahydrofolate cyclohydrolase activity | Hs | molecular function |
| methylenetetrahydrofolate dehydrogenase (NAD+) activity | Hs | molecular function |
| methylenetetrahydrofolate dehydrogenase (NADP+) activity | Hs | molecular function |
| extracellular space | Hs | cellular component |
| mitochondrion | Hs | cellular component |
| mitochondrial inner membrane | Hs | cellular component |
| mitochondrial matrix | Hs | cellular component |
| purine nucleotide biosynthetic process | Hs | biological process |
| one-carbon metabolic process | Hs | biological process |
| metabolic process | Hs | biological process |
| cellular amino acid biosynthetic process | Hs | biological process |
| methionine biosynthetic process | Hs | biological process |
| membrane | Hs | cellular component |
| oxidoreductase activity | Hs | molecular function |
| hydrolase activity | Hs | molecular function |
| tetrahydrofolate interconversion | Hs | biological process |
| phosphate ion binding | Hs | molecular function |
| tetrahydrofolate metabolic process | Hs | biological process |
| folic acid metabolic process | Hs | biological process |
| oxidation-reduction process | Hs | biological process |
GO (Blast)
22 results
| GO Term | SpeciesCe = Caenorhabditis elegans Dr = Danio rerio Dm = Drosophila melanogaster Gg = Gallus gallus Hs = Homo sapiens Mm = Mus musculus Sc = Saccharomyces cerevisiae |
Type | Score | E-value |
|---|---|---|---|---|
| nucleotide binding | Hs | molecular function | 187 | 4.52e-53 |
| magnesium ion binding | Hs | molecular function | 416 | 3.33e-146 |
| catalytic activity | Hs | molecular function | 428 | 5.07e-151 |
| formate-tetrahydrofolate ligase activity | Hs | molecular function | 187 | 4.52e-53 |
| methenyltetrahydrofolate cyclohydrolase activity | Hs | molecular function | 428 | 5.07e-151 |
| methylenetetrahydrofolate dehydrogenase [NAD(P)+] activity | Hs | molecular function | 187 | 4.52e-53 |
| methylenetetrahydrofolate dehydrogenase (NAD+) activity | Hs | molecular function | 428 | 5.07e-151 |
| methylenetetrahydrofolate dehydrogenase (NADP+) activity | Hs | molecular function | 428 | 5.07e-151 |
| protein binding | Hs | molecular function | 187 | 4.52e-53 |
| ATP binding | Hs | molecular function | 187 | 4.52e-53 |
| extracellular space | Hs | cellular component | 416 | 3.33e-146 |
| cytoplasm | Hs | cellular component | 187 | 4.52e-53 |
| mitochondrion | Hs | cellular component | 428 | 5.07e-151 |
| mitochondrial inner membrane | Hs | cellular component | 428 | 5.07e-151 |
| mitochondrial matrix | Hs | cellular component | 428 | 5.07e-151 |
| cytosol | Hs | cellular component | 187 | 4.52e-53 |
| membrane | Hs | cellular component | 428 | 5.07e-151 |
| oxidoreductase activity | Hs | molecular function | 428 | 5.07e-151 |
| hydrolase activity | Hs | molecular function | 428 | 5.07e-151 |
| ligase activity | Hs | molecular function | 187 | 4.52e-53 |
| phosphate ion binding | Hs | molecular function | 416 | 3.33e-146 |
| extracellular exosome | Hs | cellular component | 187 | 4.52e-53 |
GO (InterProScan)
3 results
| GO Term | Analysis | Type | e-value |
|---|---|---|---|
| catalytic activity | ProSitePatterns | molecular function | |
| methylenetetrahydrofolate dehydrogenase (NADP+) activity | PANTHER | molecular function | 4.7E-148 |
| oxidation-reduction process | PANTHER | biological process | 4.7E-148 |
