Aniseed - Gene card

Gene Card

Best human hits

IGF1; INS

Species

C. robusta formely Ciona int. type A

Unique Gene ID

Cirobu.g00004500

Gene Model ID

KH2012:KH.C2.313

Location

KhC2:855362..857108

Transcript Models and Sequences

KH2012:KH.C2.313.v1.A.ND2-1
KH2012:KH.C2.313.v1.A.SL1-1

External Database Gene Card

External database links

2 results

Database	Gene ID
ENSEMBL	ENSCING00000020389
NCBI Reference Sequence	NM_001129873.1

Collections

Gateway full ORF

1 result

Gene collection 1 (N. Satoh)

1 result

ciad078g23

Plate: R1CiGC07b06

WashU Genome Browser

Click here to view results in the tunicate WashU Browser

Genomicus Synteny Browser

Regulatory Regions

No result

n/a

Gene Phylogeny

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Gene Annotations

InterPro

3 results

IPR Term	Analysis	Definition
Insulin-like_sf	SUPERFAMILY	Insulin-like superfamily
Insulin-like	SMART	Insulin-like
Insulin-like	Pfam	Insulin-like

GOSlim

72 results

GO Term	Annotation Origin	Type
Golgi membrane	Blast	cellular component
integrin binding	Orthology	molecular function
protein binding	Orthology	molecular function
extracellular region	Orthology	cellular component
extracellular space	Orthology	cellular component
endoplasmic reticulum lumen	Blast	cellular component
plasma membrane	Orthology	cellular component
DNA replication	Orthology	biological process
regulation of transcription, DNA-templated	Orthology	biological process
signal transduction	Orthology	biological process
cell proliferation	Orthology	biological process
positive regulation of cell proliferation	Orthology	biological process
regulation of gene expression	Orthology	biological process
positive regulation of gene expression	Orthology	biological process
identical protein binding	Blast	molecular function
negative regulation of apoptotic process	Orthology	biological process
positive regulation of transcription, DNA-templated	Orthology	biological process
positive regulation of transcription from RNA polymerase II promoter	Orthology	biological process
negative regulation of transcription from RNA polymerase II promoter	Orthology	biological process
multicellular organism development	Orthology	biological process
positive regulation of catalytic activity	Orthology	biological process
extracellular exosome	Orthology	cellular component
intracellular signal transduction	Orthology	biological process
protein serine/threonine kinase activity	Orthology	molecular function
positive regulation of signal transduction	Orthology	biological process
system development	Orthology	biological process
cellular process	Orthology	biological process
membrane organization	Orthology	biological process
organelle organization	Orthology	biological process
receptor binding	Orthology	molecular function
macromolecular complex binding	Orthology	molecular function
molecular function regulator	Orthology	molecular function
regulation of signal transduction	Orthology	biological process
signaling receptor activity	Orthology	molecular function
organic substance metabolic process	Orthology	biological process
small GTPase mediated signal transduction	Orthology	biological process
animal organ development	Orthology	biological process
cell surface receptor signaling pathway	Orthology	biological process
cellular response to organic substance	Orthology	biological process
response to stress	Orthology	biological process
regulation of molecular function	Orthology	biological process
macromolecular complex	Orthology	cellular component
protein metabolic process	Orthology	biological process
cell migration	Orthology	biological process
intracellular organelle part	Orthology	cellular component
cytoplasmic vesicle	Orthology	cellular component
endomembrane system	Orthology	cellular component
intracellular organelle lumen	Orthology	cellular component
plasma membrane part	Orthology	cellular component
developmental process	Orthology	biological process
protein phosphorylation	Orthology	biological process
DNA binding	Orthology	molecular function
anatomical structure development	Orthology	biological process
cell differentiation	Orthology	biological process
oxidation-reduction process	Orthology	biological process
organic substance transport	Orthology	biological process
transmembrane transport	Orthology	biological process
protein transport	Orthology	biological process
cell development	Orthology	biological process
gamete generation	Orthology	biological process
negative regulation of signal transduction	Orthology	biological process
nucleobase-containing compound metabolic process	Orthology	biological process
anatomical structure morphogenesis	Orthology	biological process
enzyme activator activity	Orthology	molecular function
protein kinase binding	Orthology	molecular function
cell division	Orthology	biological process
enzyme binding	Blast	molecular function
Golgi apparatus part	Blast	cellular component
endosome	Blast	cellular component
cytoplasmic part	Blast	cellular component
intracellular membrane-bounded organelle	Blast	cellular component
bounding membrane of organelle	Blast	cellular component

GO (Orthology)

80 results

GO Term	SpeciesCe = Caenorhabditis elegans Dr = Danio rerio Dm = Drosophila melanogaster Gg = Gallus gallus Hs = Homo sapiens Mm = Mus musculus Sc = Saccharomyces cerevisiae	Type
activation of MAPK activity	Hs	biological process
skeletal system development	Hs	biological process
cell activation	Hs	biological process
platelet degranulation	Hs	biological process
insulin receptor binding	Hs	molecular function
insulin-like growth factor receptor binding	Hs	molecular function
integrin binding	Hs	molecular function
hormone activity	Hs	molecular function
protein binding	Hs	molecular function
extracellular region	Hs	cellular component
extracellular space	Hs	cellular component
plasma membrane	Hs	cellular component
carbohydrate metabolic process	Hs	biological process
glucose metabolic process	Hs	biological process
DNA replication	Hs	biological process
regulation of transcription, DNA-templated	Hs	biological process
signal transduction	Hs	biological process
Ras protein signal transduction	Hs	biological process
muscle organ development	Hs	biological process
growth factor activity	Hs	molecular function
cell proliferation	Hs	biological process
positive regulation of cell proliferation	Hs	biological process
insulin receptor signaling pathway	Hs	biological process
response to heat	Hs	biological process
regulation of gene expression	Hs	biological process
regulation of receptor activity	Hs	biological process
positive regulation of gene expression	Hs	biological process
phosphatidylinositol 3-kinase signaling	Hs	biological process
positive regulation of phosphatidylinositol 3-kinase signaling	Hs	biological process
insulin-like growth factor binding protein complex	Hs	cellular component
proteoglycan biosynthetic process	Hs	biological process
positive regulation of cell migration	Hs	biological process
platelet alpha granule lumen	Hs	cellular component
positive regulation of protein import into nucleus, translocation	Hs	biological process
alphav-beta3 integrin-IGF-1-IGF1R complex	Hs	cellular component
regulation of multicellular organism growth	Hs	biological process
positive regulation of tyrosine phosphorylation of STAT protein	Hs	biological process
insulin-like growth factor ternary complex	Hs	cellular component
negative regulation of apoptotic process	Hs	biological process
positive regulation of DNA binding	Hs	biological process
positive regulation of MAPK cascade	Hs	biological process
protein kinase B signaling	Hs	biological process
positive regulation of insulin-like growth factor receptor signaling pathway	Hs	biological process
myoblast differentiation	Hs	biological process
positive regulation of osteoblast differentiation	Hs	biological process
positive regulation of glycogen biosynthetic process	Hs	biological process
positive regulation of DNA replication	Hs	biological process
positive regulation of mitotic nuclear division	Hs	biological process
positive regulation of transcription, DNA-templated	Hs	biological process
positive regulation of transcription from RNA polymerase II promoter	Hs	biological process
positive regulation of glucose import	Hs	biological process
positive regulation of Ras protein signal transduction	Hs	biological process
positive regulation of insulin receptor signaling pathway	Hs	biological process
insulin-like growth factor receptor signaling pathway	Hs	biological process
phosphatidylinositol-mediated signaling	Hs	biological process
positive regulation of epithelial cell proliferation	Hs	biological process
positive regulation of protein secretion	Hs	biological process
positive regulation of peptidyl-tyrosine phosphorylation	Hs	biological process
protein stabilization	Hs	biological process
myoblast proliferation	Hs	biological process
positive regulation of protein kinase B signaling	Hs	biological process
negative regulation of oocyte development	Hs	biological process
exocytic vesicle	Hs	cellular component
negative regulation of extrinsic apoptotic signaling pathway	Hs	biological process
negative regulation of transcription from RNA polymerase II promoter	Hs	biological process
ossification	Hs	biological process
osteoblast differentiation	Hs	biological process
positive regulation of protein phosphorylation	Hs	biological process
regulation of gene expression by genetic imprinting	Hs	biological process
multicellular organism development	Hs	biological process
animal organ morphogenesis	Hs	biological process
exocrine pancreas development	Hs	biological process
positive regulation of multicellular organism growth	Hs	biological process
positive regulation of catalytic activity	Hs	biological process
protein serine/threonine kinase activator activity	Hs	molecular function
receptor ligand activity	Hs	molecular function
striated muscle cell differentiation	Hs	biological process
positive regulation of cell division	Hs	biological process
extracellular exosome	Hs	cellular component
positive regulation of protein serine/threonine kinase activity	Hs	biological process

GO (Blast)

23 results

GO Term	SpeciesCe = Caenorhabditis elegans Dr = Danio rerio Dm = Drosophila melanogaster Gg = Gallus gallus Hs = Homo sapiens Mm = Mus musculus Sc = Saccharomyces cerevisiae	Type	Score	E-value
Golgi membrane	Hs	cellular component	35.0	0.002
protease binding	Hs	molecular function	35.0	0.002
insulin receptor binding	Hs	molecular function	35.8	0.003
insulin-like growth factor receptor binding	Hs	molecular function	35.8	0.003
integrin binding	Hs	molecular function	35.8	0.003
hormone activity	Hs	molecular function	35.8	0.003
protein binding	Hs	molecular function	35.8	0.003
extracellular region	Hs	cellular component	35.8	0.003
extracellular space	Hs	cellular component	35.8	0.003
endoplasmic reticulum lumen	Hs	cellular component	35.0	0.002
Golgi lumen	Hs	cellular component	35.0	0.002
plasma membrane	Hs	cellular component	35.8	0.003
growth factor activity	Hs	molecular function	35.8	0.003
insulin-like growth factor binding protein complex	Hs	cellular component	35.8	0.003
transport vesicle	Hs	cellular component	35.0	0.002
platelet alpha granule lumen	Hs	cellular component	35.8	0.003
endosome lumen	Hs	cellular component	35.0	0.002
endoplasmic reticulum-Golgi intermediate compartment membrane	Hs	cellular component	35.0	0.002
secretory granule lumen	Hs	cellular component	35.0	0.002
alphav-beta3 integrin-IGF-1-IGF1R complex	Hs	cellular component	35.8	0.003
insulin-like growth factor ternary complex	Hs	cellular component	35.8	0.003
identical protein binding	Hs	molecular function	35.0	0.002
exocytic vesicle	Hs	cellular component	35.8	0.003

GO (InterProScan)