Gene Card
Best human hits
KMT2A; SETD1A; SETD1B
Unique Gene ID
Cirobu.g00006948
Gene Model ID
KH2012:KH.C4.91
Location
KhC4:440457..457120
Transcript Models and Sequences
cien107675
Plate: VES87_B03
cien145911
Plate: VES93_M01
n/a
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You can Press 'Ctrl' Key + Left Mouse Click on nodes to do a multiple selection.

IPR Term | Analysis | Definition |
---|---|---|
RBD_domain_sf | SUPERFAMILY | RNA-binding domain superfamily |
SET_dom | ProSiteProfiles | SET domain |
RRM_dom | Pfam | RNA recognition motif domain |
Post-SET_dom | SMART | Post-SET domain |
SETD1B | PANTHER | Histone-lysine N-methyltransferase SETD1B |
COMPASS_Set1_N-SET | SMART | COMPASS complex Set1 subunit, N-SET domain |
Post-SET_dom | ProSiteProfiles | Post-SET domain |
Nucleotide-bd_a/b_plait_sf | Gene3D | Nucleotide-binding alpha-beta plait domain superfamily |
RRM_dom | ProSiteProfiles | RNA recognition motif domain |
COMPASS_Set1_N-SET | Pfam | COMPASS complex Set1 subunit, N-SET domain |
SET_dom | SMART | SET domain |
RRM_dom | SMART | RNA recognition motif domain |
SET_dom | Pfam | SET domain |
SETD1-like | PANTHER | Histone-lysine N-methyltransferase SETD1-like |
GO Term | Annotation Origin | Type |
---|---|---|
RNA polymerase II transcription factor activity, sequence-specific DNA binding | Orthology | molecular function |
nucleic acid binding | Blast | molecular function |
DNA binding | Orthology | molecular function |
chromatin binding | Blast | molecular function |
transcription factor activity, sequence-specific DNA binding | Blast | molecular function |
RNA binding | Orthology | molecular function |
protein binding | Orthology | molecular function |
nucleus | Orthology | cellular component |
nucleoplasm | Orthology | cellular component |
cytosol | Blast | cellular component |
transcription, DNA-templated | Orthology | biological process |
regulation of transcription, DNA-templated | Orthology | biological process |
transcription factor binding | Blast | molecular function |
zinc ion binding | Blast | molecular function |
nuclear speck | Blast | cellular component |
transferase activity | Orthology | molecular function |
identical protein binding | Blast | molecular function |
protein homodimerization activity | Blast | molecular function |
transcription regulatory region DNA binding | Orthology | molecular function |
positive regulation of transcription from RNA polymerase II promoter | Orthology | biological process |
metal ion binding | Orthology | molecular function |
positive regulation of cell proliferation | Orthology | biological process |
organelle organization | Orthology | biological process |
metabolic process | Orthology | biological process |
cellular protein modification process | Orthology | biological process |
nucleoplasm part | Orthology | cellular component |
macromolecular complex | Orthology | cellular component |
cell development | Orthology | biological process |
gamete generation | Orthology | biological process |
negative regulation of transcription, DNA-templated | Orthology | biological process |
response to stimulus | Orthology | biological process |
intracellular non-membrane-bounded organelle | Blast | cellular component |
nuclear lumen | Blast | cellular component |
transcription regulatory region sequence-specific DNA binding | Blast | molecular function |
sequence-specific double-stranded DNA binding | Blast | molecular function |
sequence-specific DNA binding | Blast | molecular function |
GO Term | SpeciesCe = Caenorhabditis elegans Dr = Danio rerio Dm = Drosophila melanogaster Gg = Gallus gallus Hs = Homo sapiens Mm = Mus musculus Sc = Saccharomyces cerevisiae |
Type |
---|---|---|
RNA polymerase II transcription factor activity, sequence-specific DNA binding | Hs | molecular function |
DNA binding | Hs | molecular function |
RNA binding | Hs | molecular function |
protein binding | Hs | molecular function |
nucleus | Hs | cellular component |
nucleoplasm | Hs | cellular component |
chromatin organization | Hs | biological process |
transcription, DNA-templated | Hs | biological process |
regulation of transcription, DNA-templated | Hs | biological process |
methyltransferase activity | Hs | molecular function |
transferase activity | Hs | molecular function |
histone-lysine N-methyltransferase activity | Hs | molecular function |
methylation | Hs | biological process |
histone lysine methylation | Hs | biological process |
histone methyltransferase complex | Hs | cellular component |
histone methyltransferase activity (H3-K4 specific) | Hs | molecular function |
transcription regulatory region DNA binding | Hs | molecular function |
positive regulation of transcription from RNA polymerase II promoter | Hs | biological process |
metal ion binding | Hs | molecular function |
histone H3-K4 methylation | Hs | biological process |
oocyte growth | Hs | biological process |
chromatin silencing | Hs | biological process |
positive regulation of cell proliferation | Hs | biological process |
transferase activity, transferring acyl groups | Hs | molecular function |
response to estrogen | Hs | biological process |
MLL3/4 complex | Hs | cellular component |
oogenesis | Hs | biological process |
GO Term | SpeciesCe = Caenorhabditis elegans Dr = Danio rerio Dm = Drosophila melanogaster Gg = Gallus gallus Hs = Homo sapiens Mm = Mus musculus Sc = Saccharomyces cerevisiae |
Type | Score | E-value |
---|---|---|---|---|
nuclear chromatin | Hs | cellular component | 309 | 5.72e-85 |
RNA polymerase II transcription factor activity, sequence-specific DNA binding | Hs | molecular function | 169 | 1.22e-41 |
core promoter sequence-specific DNA binding | Hs | molecular function | 169 | 1.22e-41 |
nucleic acid binding | Hs | molecular function | 315 | 1.31e-86 |
DNA binding | Hs | molecular function | 169 | 1.22e-41 |
AT DNA binding | Hs | molecular function | 169 | 1.22e-41 |
chromatin binding | Hs | molecular function | 169 | 1.22e-41 |
transcription factor activity, sequence-specific DNA binding | Hs | molecular function | 169 | 1.22e-41 |
RNA binding | Hs | molecular function | 315 | 1.31e-86 |
protein binding | Hs | molecular function | 315 | 1.31e-86 |
nucleus | Hs | cellular component | 315 | 1.31e-86 |
nucleoplasm | Hs | cellular component | 315 | 1.31e-86 |
chromosome | Hs | cellular component | 315 | 1.31e-86 |
cytosol | Hs | cellular component | 315 | 1.31e-86 |
beta-catenin binding | Hs | molecular function | 309 | 5.72e-85 |
transcription factor binding | Hs | molecular function | 309 | 5.72e-85 |
methyltransferase activity | Hs | molecular function | 315 | 1.31e-86 |
zinc ion binding | Hs | molecular function | 169 | 1.22e-41 |
nuclear speck | Hs | cellular component | 315 | 1.31e-86 |
transferase activity | Hs | molecular function | 315 | 1.31e-86 |
histone-lysine N-methyltransferase activity | Hs | molecular function | 315 | 1.31e-86 |
histone methyltransferase complex | Hs | cellular component | 315 | 1.31e-86 |
histone methyltransferase activity (H3-K4 specific) | Hs | molecular function | 315 | 1.31e-86 |
identical protein binding | Hs | molecular function | 169 | 1.22e-41 |
protein homodimerization activity | Hs | molecular function | 169 | 1.22e-41 |
transcription regulatory region DNA binding | Hs | molecular function | 169 | 1.22e-41 |
unmethylated CpG binding | Hs | molecular function | 169 | 1.22e-41 |
metal ion binding | Hs | molecular function | 169 | 1.22e-41 |
Set1C/COMPASS complex | Hs | cellular component | 315 | 1.31e-86 |
lysine-acetylated histone binding | Hs | molecular function | 169 | 1.22e-41 |
MLL1 complex | Hs | cellular component | 169 | 1.22e-41 |
GO Term | Analysis | Type | e-value |
---|---|---|---|
nucleic acid binding | SUPERFAMILY | molecular function | 3.66E-15 |
protein binding | SMART | molecular function | 3.2E-33 |
histone-lysine N-methyltransferase activity | PANTHER | molecular function | 5.7E-160 |
histone methyltransferase activity (H3-K4 specific) | PANTHER | molecular function | 7.7E-106 |
Set1C/COMPASS complex | PANTHER | cellular component | 5.7E-160 |
histone H3-K4 methylation | PANTHER | biological process | 5.7E-160 |