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GENE CARD

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Gene Card

Best human hits

NPC1; PTCH1; PTCH2

Species

C. robusta formely Ciona int. type A

Unique Gene ID

Cirobu.g00007559

Gene Model ID

KH2012:KH.C5.651

Location

KhC5:4237415..4265899

Transcript Models and Sequences

  KH2012:KH.C5.651.v1.A.ND1-1

External Database Gene Card

External database links

3 results

Database Gene ID
ENSEMBL ENSCING00000018399
NCBI Reference Sequence XM_009860380.2
NCBI Reference Sequence XM_018812051.1
Collections

Gene collection 1 (N. Satoh)

2 results

ciad016e02

Plate: R1CiGC02n09

cilv006p17

Plate: R1CiGC25d11

WashU Genome Browser

Click here to view results in the tunicate WashU Browser

Genomicus Synteny Browser

Genomicus browser link

Regulatory Regions

Regulatory Regions

No result

n/a

Gene Phylogeny

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Gene Annotations

InterPro

3 results

IPR Term Analysis Definition
Ptc/Disp Pfam Protein patched/dispatched
SSD ProSiteProfiles Sterol-sensing domain
TM_rcpt_patched TIGRFAM Transmembrane receptor, patched

GOSlim

73 results

GO Term Annotation Origin Type
negative regulation of transcription from RNA polymerase II promoter Orthology biological process
transmembrane signaling receptor activity Orthology molecular function
protein binding Orthology molecular function
extracellular region Blast cellular component
nucleus Orthology cellular component
nuclear envelope Blast cellular component
lysosome Blast cellular component
lysosomal membrane Blast cellular component
endosome Blast cellular component
endoplasmic reticulum Blast cellular component
Golgi apparatus Orthology cellular component
plasma membrane Orthology cellular component
integral component of plasma membrane Blast cellular component
signal transduction Orthology biological process
brain development Orthology biological process
negative regulation of cell proliferation Orthology biological process
membrane Orthology cellular component
integral component of membrane Orthology cellular component
midbody Orthology cellular component
vesicle Blast cellular component
regulation of cell proliferation Orthology biological process
intracellular membrane-bounded organelle Orthology cellular component
macromolecular complex binding Orthology molecular function
membrane raft Orthology cellular component
negative regulation of transcription, DNA-templated Orthology biological process
positive regulation of transcription, DNA-templated Orthology biological process
perinuclear region of cytoplasm Orthology cellular component
extracellular exosome Blast cellular component
anatomical structure morphogenesis Orthology biological process
animal organ development Orthology biological process
cell differentiation Orthology biological process
anatomical structure formation involved in morphogenesis Orthology biological process
nervous system development Orthology biological process
heart development Orthology biological process
receptor binding Orthology molecular function
plasma membrane region Orthology cellular component
organelle Orthology cellular component
cell projection Orthology cellular component
macromolecular complex Orthology cellular component
cell surface receptor signaling pathway Orthology biological process
multicellular organism development Orthology biological process
anion binding Orthology molecular function
carbohydrate derivative binding Orthology molecular function
anatomical structure development Orthology biological process
regulation of signal transduction Orthology biological process
postsynapse Orthology cellular component
neuron part Orthology cellular component
response to organic substance Orthology biological process
small molecule binding Orthology molecular function
organic cyclic compound binding Orthology molecular function
gene expression Orthology biological process
proteolysis Orthology biological process
neuron differentiation Orthology biological process
central nervous system development Orthology biological process
intracellular organelle part Orthology cellular component
whole membrane Orthology cellular component
cytoplasmic vesicle Orthology cellular component
bounding membrane of organelle Orthology cellular component
response to lipid Orthology biological process
protein localization Orthology biological process
developmental process Orthology biological process
regulation of molecular function Orthology biological process
transcription factor activity, sequence-specific DNA binding Orthology molecular function
axon Orthology cellular component
cell projection part Orthology cellular component
negative regulation of signal transduction Orthology biological process
cell division Orthology biological process
system development Orthology biological process
cell projection membrane Orthology cellular component
axon guidance Orthology biological process
protein localization to membrane Orthology biological process
binding Blast molecular function
organic substance transport Blast biological process

GO (Orthology)

71 results

GO Term SpeciesCe = Caenorhabditis elegans
Dr = Danio rerio
Dm = Drosophila melanogaster
Gg = Gallus gallus
Hs = Homo sapiens
Mm = Mus musculus
Sc = Saccharomyces cerevisiae		 Type
negative regulation of transcription from RNA polymerase II promoter Hs biological process
branching involved in ureteric bud morphogenesis Hs biological process
cell fate determination Hs biological process
neural tube formation Hs biological process
neural tube closure Hs biological process
heart morphogenesis Hs biological process
patched binding Hs molecular function
smoothened binding Hs molecular function
protein binding Hs molecular function
nucleus Hs cellular component
Golgi apparatus Hs cellular component
plasma membrane Hs cellular component
caveola Hs cellular component
cilium Hs cellular component
signal transduction Hs biological process
smoothened signaling pathway Hs biological process
regulation of mitotic cell cycle Hs biological process
pattern specification process Hs biological process
brain development Hs biological process
hedgehog receptor activity Hs molecular function
heparin binding Hs molecular function
negative regulation of cell proliferation Hs biological process
epidermis development Hs biological process
regulation of smoothened signaling pathway Hs biological process
response to mechanical stimulus Hs biological process
animal organ morphogenesis Hs biological process
dorsal/ventral pattern formation Hs biological process
epidermal cell fate specification Hs biological process
response to chlorate Hs biological process
postsynaptic density Hs cellular component
response to organic cyclic compound Hs biological process
cholesterol binding Hs molecular function
membrane Hs cellular component
integral component of membrane Hs cellular component
protein processing Hs biological process
spinal cord motor neuron differentiation Hs biological process
neural tube patterning Hs biological process
embryonic limb morphogenesis Hs biological process
cyclin binding Hs molecular function
midbody Hs cellular component
endocytic vesicle membrane Hs cellular component
response to estradiol Hs biological process
response to retinoic acid Hs biological process
regulation of protein localization Hs biological process
limb morphogenesis Hs biological process
regulation of growth Hs biological process
negative regulation of multicellular organism growth Hs biological process
regulation of cell proliferation Hs biological process
response to drug Hs biological process
glucose homeostasis Hs biological process
intracellular membrane-bounded organelle Hs cellular component
negative regulation of sequence-specific DNA binding transcription factor activity Hs biological process
skin development Hs biological process
dendritic growth cone Hs cellular component
axonal growth cone Hs cellular component
macromolecular complex binding Hs molecular function
negative regulation of osteoblast differentiation Hs biological process
negative regulation of smoothened signaling pathway Hs biological process
negative regulation of transcription, DNA-templated Hs biological process
positive regulation of transcription, DNA-templated Hs biological process
perinuclear region of cytoplasm Hs cellular component
embryonic organ development Hs biological process
negative regulation of epithelial cell proliferation Hs biological process
negative regulation of cell division Hs biological process
pharyngeal system development Hs biological process
ciliary membrane Hs cellular component
somite development Hs biological process
commissural neuron axon guidance Hs biological process
renal system development Hs biological process
protein localization to plasma membrane Hs biological process
hedgehog family protein binding Hs molecular function

GO (Blast)

40 results

GO Term SpeciesCe = Caenorhabditis elegans
Dr = Danio rerio
Dm = Drosophila melanogaster
Gg = Gallus gallus
Hs = Homo sapiens
Mm = Mus musculus
Sc = Saccharomyces cerevisiae		 Type Score E-value
virus receptor activity Hs molecular function 117 2.85e-26
receptor activity Hs molecular function 117 2.85e-26
transmembrane signaling receptor activity Hs molecular function 117 2.85e-26
patched binding Hs molecular function 531 6.17e-163
smoothened binding Hs molecular function 531 6.17e-163
lipid transporter activity Hs molecular function 117 2.85e-26
protein binding Hs molecular function 531 6.17e-163
extracellular region Hs cellular component 117 2.85e-26
nucleus Hs cellular component 531 6.17e-163
nuclear envelope Hs cellular component 117 2.85e-26
lysosome Hs cellular component 117 2.85e-26
lysosomal membrane Hs cellular component 117 2.85e-26
endosome Hs cellular component 117 2.85e-26
endoplasmic reticulum Hs cellular component 117 2.85e-26
Golgi apparatus Hs cellular component 531 6.17e-163
plasma membrane Hs cellular component 531 6.17e-163
integral component of plasma membrane Hs cellular component 117 2.85e-26
caveola Hs cellular component 531 6.17e-163
cilium Hs cellular component 531 6.17e-163
hedgehog receptor activity Hs molecular function 531 6.17e-163
heparin binding Hs molecular function 531 6.17e-163
postsynaptic density Hs cellular component 531 6.17e-163
sterol transporter activity Hs molecular function 117 2.85e-26
cholesterol binding Hs molecular function 531 6.17e-163
membrane Hs cellular component 531 6.17e-163
integral component of membrane Hs cellular component 531 6.17e-163
cyclin binding Hs molecular function 531 6.17e-163
midbody Hs cellular component 531 6.17e-163
endocytic vesicle membrane Hs cellular component 531 6.17e-163
late endosome membrane Hs cellular component 117 2.85e-26
vesicle Hs cellular component 117 2.85e-26
intracellular membrane-bounded organelle Hs cellular component 531 6.17e-163
dendritic growth cone Hs cellular component 531 6.17e-163
axonal growth cone Hs cellular component 531 6.17e-163
macromolecular complex binding Hs molecular function 531 6.17e-163
membrane raft Hs cellular component 117 2.85e-26
perinuclear region of cytoplasm Hs cellular component 531 6.17e-163
ciliary membrane Hs cellular component 531 6.17e-163
extracellular exosome Hs cellular component 117 2.85e-26
hedgehog family protein binding Hs molecular function 531 6.17e-163

GO (InterProScan)

2 results

GO Term Analysis Type e-value
hedgehog receptor activity TIGRFAM molecular function 0.0
integral component of membrane TIGRFAM cellular component 0.0

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