Aniseed - Gene card

Gene Card

Best human hits

AC008695.1; RAPGEF2; RAPGEF6

Species

C. robusta formely Ciona int. type A

Unique Gene ID

Cirobu.g00007616

Gene Model ID

KH2012:KH.C6.101

Location

KhC6:747685..796030

Transcript Models and Sequences

KH2012:KH.C6.101.v1.A.SL1-1
KH2012:KH.C6.101.v2.A.SL3-1
KH2012:KH.C6.101.v2.A.SL4-1
KH2012:KH.C6.101.v2.A.SL5-1
KH2012:KH.C6.101.v2.R.ND2-1

External Database Gene Card

External database links

5 results

Database	Gene ID
ENSEMBL	ENSCING00000007786
ENSEMBL	ENSCING00000020441
ENSEMBL	ENSCING00000022779
ENSEMBL	ENSCING00000023141
NCBI Reference Sequence	XM_009860570.2

Collections

Gene collection 1 (N. Satoh)

4 results

cicl104o15

Plate: R1CiGC39h18

WashU Genome Browser

Click here to view results in the tunicate WashU Browser

Genomicus Synteny Browser

Regulatory Regions

No result

n/a

Gene Phylogeny

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Gene Annotations

InterPro

19 results

IPR Term	Analysis	Definition
PDZ	SMART	PDZ domain
RmlC-like_jellyroll	Gene3D	RmlC-like jelly roll fold
Ras_G-nucl-exch_fac_CS	ProSitePatterns	Ras guanine-nucleotide exchange factor, conserved site
Ras-like_Gua-exchang_fac_N	SMART	Ras-like guanine nucleotide exchange factor, N-terminal
cNMP-bd-like	SUPERFAMILY	Cyclic nucleotide-binding-like
cNMP-bd_dom	CDD	Cyclic nucleotide-binding domain
Ras-like_Gua-exchang_fac_N	ProSiteProfiles	Ras-like guanine nucleotide exchange factor, N-terminal
RapGEF2	PANTHER	Rap guanine nucleotide exchange factor 2
Ras-like_Gua-exchang_fac_N	CDD	Ras-like guanine nucleotide exchange factor, N-terminal
RASGEF_cat_dom	SMART	Ras guanine-nucleotide exchange factors catalytic domain
PDZ	Pfam	PDZ domain
PDZ_sf	SUPERFAMILY	PDZ superfamily
Ras_GEF_dom_sf	SUPERFAMILY	Ras guanine nucleotide exchange factor domain superfamily
RASGEF_cat_dom	Pfam	Ras guanine-nucleotide exchange factors catalytic domain
PDZ	ProSiteProfiles	PDZ domain
RASGEF_cat_dom	ProSiteProfiles	Ras guanine-nucleotide exchange factors catalytic domain
Ras-like_Gua-exchang_fac_N	Pfam	Ras-like guanine nucleotide exchange factor, N-terminal
cNMP-bd_dom	ProSiteProfiles	Cyclic nucleotide-binding domain
cNMP-bd_dom	SMART	Cyclic nucleotide-binding domain

GOSlim

60 results

GO Term	Annotation Origin	Type
blood vessel development	Orthology	biological process
signal transducer activity	Orthology	molecular function
GTPase activator activity	Orthology	molecular function
calcium ion binding	Orthology	molecular function
protein binding	Orthology	molecular function
intracellular	Orthology	cellular component
cytoplasm	Orthology	cellular component
endosome	Orthology	cellular component
centrosome	Orthology	cellular component
cytosol	Orthology	cellular component
plasma membrane	Orthology	cellular component
integral component of plasma membrane	Orthology	cellular component
signal transduction	Orthology	biological process
G-protein coupled receptor signaling pathway	Orthology	biological process
small GTPase mediated signal transduction	Orthology	biological process
multicellular organism development	Orthology	biological process
nervous system development	Orthology	biological process
negative regulation of cell proliferation	Orthology	biological process
membrane	Orthology	cellular component
apical plasma membrane	Orthology	cellular component
cell junction	Orthology	cellular component
cell differentiation	Orthology	biological process
neuron projection development	Orthology	biological process
macromolecular complex	Orthology	cellular component
intracellular signal transduction	Orthology	biological process
regulation of cell proliferation	Orthology	biological process
neuron projection	Orthology	cellular component
neuronal cell body	Orthology	cellular component
regulation of GTPase activity	Orthology	biological process
positive regulation of GTPase activity	Orthology	biological process
synapse	Orthology	cellular component
perinuclear region of cytoplasm	Orthology	cellular component
regulation of molecular function	Orthology	biological process
protein phosphorylation	Orthology	biological process
cell migration	Orthology	biological process
generation of neurons	Orthology	biological process
enzyme binding	Orthology	molecular function
molecular function regulator	Orthology	molecular function
binding	Orthology	molecular function
brain development	Orthology	biological process
neuron development	Orthology	biological process
cell projection assembly	Orthology	biological process
cytoplasmic vesicle	Orthology	cellular component
anion binding	Orthology	molecular function
adenyl ribonucleotide binding	Orthology	molecular function
receptor binding	Orthology	molecular function
cell surface receptor signaling pathway	Orthology	biological process
cellular response to organic substance	Orthology	biological process
positive regulation of signal transduction	Orthology	biological process
positive regulation of catalytic activity	Orthology	biological process
protein kinase activity	Orthology	molecular function
chemical synaptic transmission	Orthology	biological process
regulation of signaling	Orthology	biological process
cell morphogenesis involved in neuron differentiation	Orthology	biological process
neuron projection morphogenesis	Orthology	biological process
cell development	Orthology	biological process
regulation of catalytic activity	Orthology	biological process
regulation of signal transduction	Orthology	biological process
protein localization to membrane	Orthology	biological process
positive regulation of apoptotic process	Orthology	biological process

GO (Orthology)

74 results

GO Term	SpeciesCe = Caenorhabditis elegans Dr = Danio rerio Dm = Drosophila melanogaster Gg = Gallus gallus Hs = Homo sapiens Mm = Mus musculus Sc = Saccharomyces cerevisiae	Type
MAPK cascade	Hs	biological process
blood vessel development	Hs	biological process
neuron migration	Hs	biological process
signal transducer activity	Hs	molecular function
guanyl-nucleotide exchange factor activity	Hs	molecular function
Ras guanyl-nucleotide exchange factor activity	Hs	molecular function
GTPase activator activity	Hs	molecular function
calcium ion binding	Hs	molecular function
protein binding	Hs	molecular function
intracellular	Hs	cellular component
cytoplasm	Hs	cellular component
endosome	Hs	cellular component
late endosome	Hs	cellular component
centrosome	Hs	cellular component
cytosol	Hs	cellular component
plasma membrane	Hs	cellular component
integral component of plasma membrane	Hs	cellular component
cell-cell junction	Hs	cellular component
bicellular tight junction	Hs	cellular component
signal transduction	Hs	biological process
G-protein coupled receptor signaling pathway	Hs	biological process
neuropeptide signaling pathway	Hs	biological process
small GTPase mediated signal transduction	Hs	biological process
Ras protein signal transduction	Hs	biological process
multicellular organism development	Hs	biological process
nervous system development	Hs	biological process
negative regulation of cell proliferation	Hs	biological process
positive regulation of neuron projection development	Hs	biological process
membrane	Hs	cellular component
apical plasma membrane	Hs	cellular component
Ras GTPase binding	Hs	molecular function
Rap guanyl-nucleotide exchange factor activity	Hs	molecular function
cAMP-mediated signaling	Hs	biological process
diacylglycerol binding	Hs	molecular function
ventricular system development	Hs	biological process
forebrain neuron development	Hs	biological process
microvillus assembly	Hs	biological process
cell junction	Hs	cellular component
endocytic vesicle	Hs	cellular component
cell differentiation	Hs	biological process
PDZ domain binding	Hs	molecular function
cAMP binding	Hs	molecular function
GTP-dependent protein binding	Hs	molecular function
neuron projection development	Hs	biological process
beta-1 adrenergic receptor binding	Hs	molecular function
positive regulation of protein binding	Hs	biological process
Rap protein signal transduction	Hs	biological process
macromolecular complex	Hs	cellular component
intracellular signal transduction	Hs	biological process
nerve growth factor signaling pathway	Hs	biological process
regulation of cell proliferation	Hs	biological process
neuron projection	Hs	cellular component
neuronal cell body	Hs	cellular component
regulation of GTPase activity	Hs	biological process
positive regulation of GTPase activity	Hs	biological process
positive regulation of cAMP-mediated signaling	Hs	biological process
synapse	Hs	cellular component
positive regulation of protein kinase activity	Hs	biological process
negative regulation of melanin biosynthetic process	Hs	biological process
regulation of synaptic plasticity	Hs	biological process
perinuclear region of cytoplasm	Hs	cellular component
WW domain binding	Hs	molecular function
negative regulation of dendrite morphogenesis	Hs	biological process
establishment of endothelial barrier	Hs	biological process
regulation of molecular function	Hs	biological process
phosphatidic acid binding	Hs	molecular function
positive regulation of ERK1 and ERK2 cascade	Hs	biological process
cellular response to cGMP	Hs	biological process
adenylate cyclase-activating adrenergic receptor signaling pathway	Hs	biological process
protein localization to plasma membrane	Hs	biological process
establishment of endothelial intestinal barrier	Hs	biological process
regulation of cell junction assembly	Hs	biological process
positive regulation of dendritic cell apoptotic process	Hs	biological process
positive regulation of neuron migration	Hs	biological process

GO (Blast)

34 results

GO Term	SpeciesCe = Caenorhabditis elegans Dr = Danio rerio Dm = Drosophila melanogaster Gg = Gallus gallus Hs = Homo sapiens Mm = Mus musculus Sc = Saccharomyces cerevisiae	Type	Score	E-value
signal transducer activity	Hs	molecular function	413	4.58e-119
guanyl-nucleotide exchange factor activity	Hs	molecular function	413	4.58e-119
Ras guanyl-nucleotide exchange factor activity	Hs	molecular function	413	4.58e-119
GTPase activator activity	Hs	molecular function	413	4.58e-119
calcium ion binding	Hs	molecular function	413	4.58e-119
protein binding	Hs	molecular function	413	4.58e-119
intracellular	Hs	cellular component	166	4.51e-41
cytoplasm	Hs	cellular component	413	4.58e-119
endosome	Hs	cellular component	413	4.58e-119
late endosome	Hs	cellular component	413	4.58e-119
centrosome	Hs	cellular component	172	1.01e-42
cytosol	Hs	cellular component	413	4.58e-119
plasma membrane	Hs	cellular component	413	4.58e-119
integral component of plasma membrane	Hs	cellular component	413	4.58e-119
cell-cell junction	Hs	cellular component	413	4.58e-119
bicellular tight junction	Hs	cellular component	413	4.58e-119
membrane	Hs	cellular component	413	4.58e-119
apical plasma membrane	Hs	cellular component	413	4.58e-119
Ras GTPase binding	Hs	molecular function	166	4.51e-41
Rap guanyl-nucleotide exchange factor activity	Hs	molecular function	413	4.58e-119
diacylglycerol binding	Hs	molecular function	413	4.58e-119
cell junction	Hs	cellular component	413	4.58e-119
endocytic vesicle	Hs	cellular component	413	4.58e-119
PDZ domain binding	Hs	molecular function	413	4.58e-119
cAMP binding	Hs	molecular function	413	4.58e-119
GTP-dependent protein binding	Hs	molecular function	166	4.51e-41
beta-1 adrenergic receptor binding	Hs	molecular function	413	4.58e-119
macromolecular complex	Hs	cellular component	413	4.58e-119
neuron projection	Hs	cellular component	413	4.58e-119
neuronal cell body	Hs	cellular component	413	4.58e-119
synapse	Hs	cellular component	413	4.58e-119
perinuclear region of cytoplasm	Hs	cellular component	413	4.58e-119
WW domain binding	Hs	molecular function	413	4.58e-119
phosphatidic acid binding	Hs	molecular function	413	4.58e-119

GO (InterProScan)

7 results

GO Term	Analysis	Type	e-value
guanyl-nucleotide exchange factor activity	Pfam	molecular function	9.6E-16
GTPase activator activity	PANTHER	molecular function	4.4E-230
protein binding	SUPERFAMILY	molecular function	4.13E-16
small GTPase mediated signal transduction	Pfam	biological process	9.6E-16
Rap guanyl-nucleotide exchange factor activity	PANTHER	molecular function	4.4E-230
regulation of cell proliferation	PANTHER	biological process	4.4E-230
positive regulation of GTPase activity	PANTHER	biological process	4.4E-230