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GENE CARD

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Gene Card

Best human hits

LEF1; TCF7; TCF7L2

Species

C. robusta formely Ciona int. type A

Unique Gene ID

Cirobu.g00007886

Gene Model ID

KH2012:KH.C6.71

Location

KhC6:117207..142099

Transcript Models and Sequences

  KH2012:KH.C6.71.v1.A.ND2-1
KH2012:KH.C6.71.v2.A.nonSL10-1
KH2012:KH.C6.71.v2.A.nonSL1-1
KH2012:KH.C6.71.v2.A.nonSL11-1
KH2012:KH.C6.71.v2.A.nonSL12-1
KH2012:KH.C6.71.v2.A.nonSL4-1
KH2012:KH.C6.71.v2.A.nonSL5-1
KH2012:KH.C6.71.v2.A.nonSL6-1
KH2012:KH.C6.71.v2.A.nonSL7-1
KH2012:KH.C6.71.v2.A.nonSL8-1
KH2012:KH.C6.71.v2.A.nonSL9-1
KH2012:KH.C6.71.v2.A.SL3-1

External Database Gene Card

External database links

No result

Collections

Gateway full ORF

2 results

cien109274

Plate: VES87_E09

cien51442

Plate: VES78_P06

Gene collection 1 (N. Satoh)

3 results

cicl049a12

Plate: R1CiGC13p03

ciad081m17

Plate: R1CiGC08g07

cilv016j02

Plate: R1CiGC26k08

WashU Genome Browser

Click here to view results in the tunicate WashU Browser

Genomicus Synteny Browser

Genomicus browser link

Regulatory Regions

Regulatory Regions

No result

n/a

Gene Phylogeny

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Gene Annotations

InterPro

6 results

IPR Term Analysis Definition
HMG_box_dom_sf Gene3D High mobility group box domain superfamily
HMG_box_dom_sf SUPERFAMILY High mobility group box domain superfamily
HMG_box_dom SMART High mobility group box domain
HMG_box_dom Pfam High mobility group box domain
TCF/LEF PANTHER Transcription factor TCF/LEF
HMG_box_dom ProSiteProfiles High mobility group box domain

GOSlim

86 results

GO Term Annotation Origin Type
negative regulation of transcription from RNA polymerase II promoter Orthology biological process
RNA polymerase II regulatory region sequence-specific DNA binding Orthology molecular function
RNA polymerase II core promoter proximal region sequence-specific DNA binding Orthology molecular function
RNA polymerase II transcription factor activity, sequence-specific DNA binding Orthology molecular function
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding Orthology molecular function
blood vessel development Orthology biological process
vasculature development Orthology biological process
DNA binding Orthology molecular function
chromatin binding Orthology molecular function
transcription factor activity, sequence-specific DNA binding Orthology molecular function
protein binding Orthology molecular function
nucleus Orthology cellular component
nucleoplasm Orthology cellular component
cytoplasm Orthology cellular component
transcription, DNA-templated Orthology biological process
regulation of transcription, DNA-templated Orthology biological process
regulation of transcription from RNA polymerase II promoter Orthology biological process
transcription from RNA polymerase II promoter Orthology biological process
immune response Orthology biological process
transcription factor binding Orthology molecular function
cell proliferation Orthology biological process
positive regulation of cell proliferation Orthology biological process
positive regulation of gene expression Orthology biological process
nuclear body Orthology cellular component
protein kinase binding Orthology molecular function
regulation of Wnt signaling pathway Orthology biological process
regulation of cell proliferation Orthology biological process
negative regulation of apoptotic process Orthology biological process
sequence-specific DNA binding Orthology molecular function
transcription regulatory region DNA binding Orthology molecular function
negative regulation of transcription, DNA-templated Orthology biological process
positive regulation of transcription, DNA-templated Orthology biological process
positive regulation of transcription from RNA polymerase II promoter Orthology biological process
cell development Orthology biological process
negative regulation of canonical Wnt signaling pathway Orthology biological process
cytosol Orthology cellular component
intracellular non-membrane-bounded organelle Orthology cellular component
nuclear lumen Orthology cellular component
angiogenesis Orthology biological process
cell differentiation Orthology biological process
cell migration Orthology biological process
animal organ development Orthology biological process
anatomical structure formation involved in morphogenesis Orthology biological process
multicellular organism development Orthology biological process
intracellular part Orthology cellular component
macromolecular complex Orthology cellular component
cell surface receptor signaling pathway Orthology biological process
cell-cell signaling Orthology biological process
response to organic substance Orthology biological process
brain development Orthology biological process
generation of neurons Orthology biological process
cell division Orthology biological process
neuron differentiation Orthology biological process
nervous system development Orthology biological process
cell morphogenesis involved in differentiation Orthology biological process
cell adhesion Orthology biological process
immune system process Orthology biological process
signal transduction Orthology biological process
response to lipid Orthology biological process
signaling receptor activity Orthology molecular function
cellular response to organic substance Orthology biological process
cellular component organization Orthology biological process
anatomical structure morphogenesis Orthology biological process
receptor binding Orthology molecular function
reproductive process Orthology biological process
protein transport Orthology biological process
regulation of metabolic process Orthology biological process
DNA metabolic process Orthology biological process
cellular process Orthology biological process
enzyme binding Orthology molecular function
endopeptidase activity Orthology molecular function
enzyme regulator activity Orthology molecular function
regulation of molecular function Orthology biological process
organelle organization Orthology biological process
cellular protein modification process Orthology biological process
intracellular protein transport Orthology biological process
sensory perception Orthology biological process
intracellular signal transduction Orthology biological process
positive regulation of signal transduction Orthology biological process
anatomical structure development Orthology biological process
head development Orthology biological process
chemotaxis Orthology biological process
apoptotic process Orthology biological process
nuclear part Orthology cellular component
blood vessel morphogenesis Orthology biological process
negative regulation of signal transduction Orthology biological process

GO (Orthology)

124 results

GO Term SpeciesCe = Caenorhabditis elegans
Dr = Danio rerio
Dm = Drosophila melanogaster
Gg = Gallus gallus
Hs = Homo sapiens
Mm = Mus musculus
Sc = Saccharomyces cerevisiae		 Type
negative regulation of transcription from RNA polymerase II promoter Hs biological process
nuclear chromatin Hs cellular component
RNA polymerase II regulatory region sequence-specific DNA binding Hs molecular function
RNA polymerase II core promoter proximal region sequence-specific DNA binding Hs molecular function
RNA polymerase II transcription factor activity, sequence-specific DNA binding Hs molecular function
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding Hs molecular function
RNA polymerase II repressing transcription factor binding Hs molecular function
transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding Hs molecular function
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding Hs molecular function
blood vessel development Hs biological process
branching involved in blood vessel morphogenesis Hs biological process
osteoblast differentiation Hs biological process
neural crest cell migration Hs biological process
somitogenesis Hs biological process
epithelial to mesenchymal transition Hs biological process
vasculature development Hs biological process
sprouting angiogenesis Hs biological process
DNA binding Hs molecular function
chromatin binding Hs molecular function
transcription factor activity, sequence-specific DNA binding Hs molecular function
transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding Hs molecular function
protein binding Hs molecular function
nucleus Hs cellular component
nucleoplasm Hs cellular component
transcription factor complex Hs cellular component
nuclear euchromatin Hs cellular component
cytoplasm Hs cellular component
transcription, DNA-templated Hs biological process
regulation of transcription, DNA-templated Hs biological process
regulation of transcription from RNA polymerase II promoter Hs biological process
transcription from RNA polymerase II promoter Hs biological process
immune response Hs biological process
cell cycle arrest Hs biological process
Wnt signaling pathway, calcium modulating pathway Hs biological process
beta-catenin binding Hs molecular function
transcription factor binding Hs molecular function
cell proliferation Hs biological process
positive regulation of cell proliferation Hs biological process
DNA binding, bending Hs molecular function
response to glucose Hs biological process
positive regulation of gene expression Hs biological process
positive regulation of epithelial to mesenchymal transition Hs biological process
Wnt signaling pathway Hs biological process
regulation of striated muscle tissue development Hs biological process
nuclear body Hs cellular component
PML body Hs cellular component
protein kinase binding Hs molecular function
hypothalamus development Hs biological process
forebrain radial glial cell differentiation Hs biological process
forebrain neuroblast division Hs biological process
forebrain neuron differentiation Hs biological process
neural tube development Hs biological process
formation of radial glial scaffolds Hs biological process
regulation of cell-cell adhesion Hs biological process
regulation of Wnt signaling pathway Hs biological process
neutrophil differentiation Hs biological process
estrogen receptor activity Hs molecular function
positive regulation of cell growth Hs biological process
embryonic limb morphogenesis Hs biological process
estrogen receptor binding Hs molecular function
positive regulation of cell migration Hs biological process
BMP signaling pathway Hs biological process
embryonic genitalia morphogenesis Hs biological process
pancreas development Hs biological process
positive regulation of insulin secretion Hs biological process
positive regulation of protein binding Hs biological process
regulation of hormone metabolic process Hs biological process
negative regulation of interleukin-13 production Hs biological process
negative regulation of interleukin-4 production Hs biological process
negative regulation of interleukin-5 production Hs biological process
protein-DNA complex Hs cellular component
T cell receptor V(D)J recombination Hs biological process
nuclear hormone receptor binding Hs molecular function
enhancer binding Hs molecular function
B cell proliferation Hs biological process
regulation of cell proliferation Hs biological process
histone binding Hs molecular function
glucose homeostasis Hs biological process
histone deacetylase binding Hs molecular function
cysteine-type endopeptidase inhibitor activity involved in apoptotic process Hs molecular function
negative regulation of apoptotic process Hs biological process
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process Hs biological process
negative regulation of DNA binding Hs biological process
steroid hormone mediated signaling pathway Hs biological process
negative regulation of sequence-specific DNA binding transcription factor activity Hs biological process
sequence-specific DNA binding Hs molecular function
maintenance of DNA repeat elements Hs biological process
histone H3 acetylation Hs biological process
histone H4 acetylation Hs biological process
transcription regulatory region DNA binding Hs molecular function
gamma-catenin binding Hs molecular function
fat cell differentiation Hs biological process
negative regulation of striated muscle tissue development Hs biological process
negative regulation of transcription, DNA-templated Hs biological process
positive regulation of transcription, DNA-templated Hs biological process
positive regulation of transcription from RNA polymerase II promoter Hs biological process
alpha-beta T cell differentiation Hs biological process
positive regulation of protein export from nucleus Hs biological process
eye pigmentation Hs biological process
paraxial mesoderm formation Hs biological process
cell development Hs biological process
embryonic digestive tract morphogenesis Hs biological process
muscle fiber development Hs biological process
sensory perception of taste Hs biological process
positive regulation of protein kinase B signaling Hs biological process
palate development Hs biological process
anatomical structure regression Hs biological process
canonical Wnt signaling pathway Hs biological process
face morphogenesis Hs biological process
cell chemotaxis Hs biological process
apoptotic process involved in morphogenesis Hs biological process
trachea gland development Hs biological process
armadillo repeat domain binding Hs molecular function
beta-catenin-TCF7L2 complex Hs cellular component
C2H2 zinc finger domain binding Hs molecular function
positive regulation of cell proliferation in bone marrow Hs biological process
negative regulation of apoptotic process in bone marrow Hs biological process
odontoblast differentiation Hs biological process
negative regulation of canonical Wnt signaling pathway Hs biological process
apoptotic process involved in blood vessel morphogenesis Hs biological process
beta-catenin-TCF complex Hs cellular component
negative regulation of extrinsic apoptotic signaling pathway Hs biological process
cytosol Hs cellular component
chromatin organization Hs biological process

GO (Blast)

39 results

GO Term SpeciesCe = Caenorhabditis elegans
Dr = Danio rerio
Dm = Drosophila melanogaster
Gg = Gallus gallus
Hs = Homo sapiens
Mm = Mus musculus
Sc = Saccharomyces cerevisiae		 Type Score E-value
nuclear chromatin Hs cellular component 229 2.43e-66
RNA polymerase II regulatory region sequence-specific DNA binding Hs molecular function 188 1.98e-53
RNA polymerase II core promoter proximal region sequence-specific DNA binding Hs molecular function 229 2.43e-66
RNA polymerase II transcription factor activity, sequence-specific DNA binding Hs molecular function 229 2.43e-66
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding Hs molecular function 188 1.98e-53
RNA polymerase II repressing transcription factor binding Hs molecular function 229 2.43e-66
transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding Hs molecular function 222 5.37e-65
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding Hs molecular function 188 1.98e-53
DNA binding Hs molecular function 229 2.43e-66
chromatin binding Hs molecular function 188 1.98e-53
transcription factor activity, sequence-specific DNA binding Hs molecular function 229 2.43e-66
transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding Hs molecular function 188 1.98e-53
protein binding Hs molecular function 229 2.43e-66
nucleus Hs cellular component 229 2.43e-66
nucleoplasm Hs cellular component 229 2.43e-66
transcription factor complex Hs cellular component 222 5.37e-65
nuclear euchromatin Hs cellular component 222 5.37e-65
cytoplasm Hs cellular component 188 1.98e-53
beta-catenin binding Hs molecular function 229 2.43e-66
transcription factor binding Hs molecular function 229 2.43e-66
DNA binding, bending Hs molecular function 188 1.98e-53
nuclear body Hs cellular component 222 5.37e-65
PML body Hs cellular component 229 2.43e-66
protein kinase binding Hs molecular function 229 2.43e-66
estrogen receptor activity Hs molecular function 188 1.98e-53
estrogen receptor binding Hs molecular function 188 1.98e-53
protein-DNA complex Hs cellular component 229 2.43e-66
nuclear hormone receptor binding Hs molecular function 229 2.43e-66
enhancer binding Hs molecular function 188 1.98e-53
histone binding Hs molecular function 188 1.98e-53
histone deacetylase binding Hs molecular function 188 1.98e-53
cysteine-type endopeptidase inhibitor activity involved in apoptotic process Hs molecular function 188 1.98e-53
sequence-specific DNA binding Hs molecular function 229 2.43e-66
transcription regulatory region DNA binding Hs molecular function 229 2.43e-66
gamma-catenin binding Hs molecular function 229 2.43e-66
armadillo repeat domain binding Hs molecular function 229 2.43e-66
beta-catenin-TCF7L2 complex Hs cellular component 229 2.43e-66
C2H2 zinc finger domain binding Hs molecular function 188 1.98e-53
beta-catenin-TCF complex Hs cellular component 188 1.98e-53

GO (InterProScan)

1 result

GO Term Analysis Type e-value
Wnt signaling pathway PANTHER biological process 7.7E-118

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