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GENE CARD

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Gene Card

Best human hits

DHH; IHH; SHH

Species

C. robusta formely Ciona int. type A

Unique Gene ID

Cirobu.g00008984

Gene Model ID

KH2012:KH.C8.359

Location

KhC8:1633951..1643097

Transcript Models and Sequences

  KH2012:KH.C8.359.v1.A.SL2-1
KH2012:KH.C8.359.v1.R.ND1-1

External Database Gene Card

External database links

2 results

Database Gene ID
ENSEMBL ENSCING00000006761
NCBI Reference Sequence NM_001032462.1
Collections

Gateway full ORF

1 result

cien229348

Plate: VES105_E14

Gene collection 1 (N. Satoh)

1 result

ciad016g22

Plate: R1CiGC02p01

WashU Genome Browser

Click here to view results in the tunicate WashU Browser

Genomicus Synteny Browser

Genomicus browser link

Regulatory Regions

Regulatory Regions

No result

n/a

Gene Phylogeny

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Gene Annotations

InterPro

10 results

IPR Term Analysis Definition
Hedgehog_signalling_dom Pfam Hedgehog, N-terminal signalling domain
Hint_dom_N SMART Hint domain N-terminal
Intein_N ProSiteProfiles Intein N-terminal splicing region
Hint_dom_sf SUPERFAMILY Hint domain superfamily
Hedgehog_sig/DD-Pept_Zn-bd_sf SUPERFAMILY Hedgehog signalling/DD-peptidase zinc-binding domain superfamily
Hedgehog PRINTS Hedgehog protein
Hedgehog_sig/DD-Pept_Zn-bd_sf Gene3D Hedgehog signalling/DD-peptidase zinc-binding domain superfamily
Hint_dom Pfam Hedgehog protein, Hint domain
Intein_N TIGRFAM Intein N-terminal splicing region
Hint_dom_C SMART Hint domain C-terminal

GOSlim

84 results

GO Term Annotation Origin Type
negative regulation of transcription from RNA polymerase II promoter Orthology biological process
angiogenesis Orthology biological process
vasculature development Orthology biological process
calcium ion binding Orthology molecular function
protein binding Orthology molecular function
extracellular region Orthology cellular component
extracellular space Orthology cellular component
endoplasmic reticulum lumen Orthology cellular component
cytosol Orthology cellular component
plasma membrane Orthology cellular component
regulation of transcription, DNA-templated Orthology biological process
proteolysis Orthology biological process
cell-cell signaling Orthology biological process
multicellular organism development Orthology biological process
axon guidance Orthology biological process
central nervous system development Orthology biological process
heart development Orthology biological process
blood coagulation Orthology biological process
peptidase activity Orthology molecular function
zinc ion binding Orthology molecular function
cell proliferation Orthology biological process
positive regulation of cell proliferation Orthology biological process
cell surface Orthology cellular component
regulation of gene expression Orthology biological process
positive regulation of gene expression Orthology biological process
negative regulation of gene expression Orthology biological process
membrane Orthology cellular component
hydrolase activity Orthology molecular function
cell differentiation Orthology biological process
positive regulation of Wnt signaling pathway Orthology biological process
negative regulation of Wnt signaling pathway Orthology biological process
regulation of cell proliferation Orthology biological process
negative regulation of apoptotic process Orthology biological process
membrane raft Orthology cellular component
positive regulation of transcription, DNA-templated Orthology biological process
positive regulation of transcription from RNA polymerase II promoter Orthology biological process
metal ion binding Orthology molecular function
cell development Orthology biological process
anatomical structure formation involved in morphogenesis Orthology biological process
neuron development Orthology biological process
anatomical structure development Orthology biological process
negative regulation of canonical Wnt signaling pathway Orthology biological process
system development Orthology biological process
blood vessel morphogenesis Orthology biological process
anatomical structure morphogenesis Orthology biological process
animal organ development Orthology biological process
cell migration Orthology biological process
generation of neurons Orthology biological process
cell division Orthology biological process
immune system process Orthology biological process
cell morphogenesis involved in differentiation Orthology biological process
receptor binding Orthology molecular function
carbohydrate derivative binding Orthology molecular function
protein metabolic process Orthology biological process
membrane organization Orthology biological process
organelle organization Orthology biological process
cell surface receptor signaling pathway Orthology biological process
transcription factor activity, sequence-specific DNA binding Orthology molecular function
intracellular signal transduction Orthology biological process
spermatogenesis Orthology biological process
cellular metabolic process Orthology biological process
regulation of molecular function Orthology biological process
regulation of signal transduction Orthology biological process
signaling receptor activity Orthology molecular function
neurogenesis Orthology biological process
molecular function regulator Orthology molecular function
gene expression Orthology biological process
neuron differentiation Orthology biological process
brain development Orthology biological process
cellular process Orthology biological process
reproductive process Orthology biological process
response to lipid Orthology biological process
protein localization to organelle Orthology biological process
developmental process Orthology biological process
intracellular protein transport Orthology biological process
establishment of protein localization to organelle Orthology biological process
nervous system development Orthology biological process
response to stimulus Orthology biological process
positive regulation of signal transduction Orthology biological process
head development Orthology biological process
blood vessel development Orthology biological process
cell adhesion Orthology biological process
signal transduction Orthology biological process
apoptotic process Orthology biological process

GO (Orthology)

162 results

GO Term SpeciesCe = Caenorhabditis elegans
Dr = Danio rerio
Dm = Drosophila melanogaster
Gg = Gallus gallus
Hs = Homo sapiens
Mm = Mus musculus
Sc = Saccharomyces cerevisiae		 Type
negative regulation of transcription from RNA polymerase II promoter Hs biological process
skeletal system development Hs biological process
ossification Hs biological process
angiogenesis Hs biological process
branching involved in blood vessel morphogenesis Hs biological process
vasculogenesis Hs biological process
osteoblast differentiation Hs biological process
branching involved in ureteric bud morphogenesis Hs biological process
cell fate specification Hs biological process
neural crest cell migration Hs biological process
morphogenesis of a branching structure Hs biological process
kidney development Hs biological process
vasculature development Hs biological process
heart looping Hs biological process
positive regulation of neuroblast proliferation Hs biological process
osteoblast development Hs biological process
lymphoid progenitor cell differentiation Hs biological process
determination of left/right asymmetry in lateral mesoderm Hs biological process
epithelial cell morphogenesis Hs biological process
retinal pigment epithelium development Hs biological process
patched binding Hs molecular function
calcium ion binding Hs molecular function
protein binding Hs molecular function
glycosaminoglycan binding Hs molecular function
extracellular region Hs cellular component
proteinaceous extracellular matrix Hs cellular component
extracellular space Hs cellular component
endoplasmic reticulum lumen Hs cellular component
cytosol Hs cellular component
plasma membrane Hs cellular component
proteoglycan metabolic process Hs biological process
regulation of transcription, DNA-templated Hs biological process
proteolysis Hs biological process
endocytosis Hs biological process
smoothened signaling pathway Hs biological process
positive regulation of hh target transcription factor activity Hs biological process
cell-cell signaling Hs biological process
multicellular organism development Hs biological process
spermatid development Hs biological process
determination of left/right symmetry Hs biological process
pattern specification process Hs biological process
ectoderm development Hs biological process
neuroblast proliferation Hs biological process
axon guidance Hs biological process
central nervous system development Hs biological process
ventral midline development Hs biological process
hindgut morphogenesis Hs biological process
heart development Hs biological process
blood coagulation Hs biological process
androgen metabolic process Hs biological process
peptidase activity Hs molecular function
zinc ion binding Hs molecular function
cell proliferation Hs biological process
positive regulation of cell proliferation Hs biological process
response to mechanical stimulus Hs biological process
embryonic pattern specification Hs biological process
polarity specification of anterior/posterior axis Hs biological process
anterior/posterior pattern specification Hs biological process
dorsal/ventral pattern formation Hs biological process
cell surface Hs cellular component
regulation of gene expression Hs biological process
regulation of receptor activity Hs biological process
positive regulation of gene expression Hs biological process
negative regulation of gene expression Hs biological process
oligodendrocyte development Hs biological process
striated muscle tissue development Hs biological process
morphogen activity Hs molecular function
membrane Hs cellular component
intein-mediated protein splicing Hs biological process
hydrolase activity Hs molecular function
spinal cord dorsal/ventral patterning Hs biological process
spinal cord motor neuron differentiation Hs biological process
thalamus development Hs biological process
forebrain regionalization Hs biological process
establishment of cell polarity Hs biological process
cell differentiation Hs biological process
regulation of proteolysis Hs biological process
positive regulation of Wnt signaling pathway Hs biological process
negative regulation of Wnt signaling pathway Hs biological process
male sex determination Hs biological process
lung development Hs biological process
embryonic limb morphogenesis Hs biological process
negative regulation of cell migration Hs biological process
male genitalia development Hs biological process
thyroid gland development Hs biological process
forebrain development Hs biological process
midbrain development Hs biological process
hindbrain development Hs biological process
pancreas development Hs biological process
response to estradiol Hs biological process
negative regulation of proteasomal ubiquitin-dependent protein catabolic process Hs biological process
T cell differentiation in thymus Hs biological process
negative regulation of transcription elongation from RNA polymerase II promoter Hs biological process
protein localization to nucleus Hs biological process
embryonic hindlimb morphogenesis Hs biological process
multicellular organism growth Hs biological process
chondrocyte proliferation Hs biological process
regulation of growth Hs biological process
regulation of cell proliferation Hs biological process
negative regulation of protein catabolic process Hs biological process
positive regulation of protein import into nucleus Hs biological process
odontogenesis Hs biological process
myelination Hs biological process
camera-type eye development Hs biological process
negative regulation of apoptotic process Hs biological process
laminin-1 binding Hs molecular function
skin development Hs biological process
response to estrogen Hs biological process
intermediate filament organization Hs biological process
membrane raft Hs cellular component
cell fate commitment Hs biological process
myoblast differentiation Hs biological process
bone resorption Hs biological process
negative regulation of cell differentiation Hs biological process
positive regulation of cell differentiation Hs biological process
positive regulation of smoothened signaling pathway Hs biological process
positive regulation of transcription, DNA-templated Hs biological process
positive regulation of transcription from RNA polymerase II promoter Hs biological process
metal ion binding Hs molecular function
cell development Hs biological process
thymus development Hs biological process
digestive tract morphogenesis Hs biological process
embryonic digestive tract morphogenesis Hs biological process
embryonic organ development Hs biological process
developmental growth Hs biological process
embryonic camera-type eye morphogenesis Hs biological process
embryonic morphogenesis Hs biological process
embryonic foregut morphogenesis Hs biological process
anatomical structure formation involved in morphogenesis Hs biological process
neuron fate commitment Hs biological process
neuron development Hs biological process
embryonic skeletal system development Hs biological process
oligodendrocyte differentiation Hs biological process
positive regulation of oligodendrocyte differentiation Hs biological process
smooth muscle tissue development Hs biological process
branching morphogenesis of an epithelial tube Hs biological process
inner ear development Hs biological process
anatomical structure development Hs biological process
formation of anatomical boundary Hs biological process
stem cell development Hs biological process
positive regulation of epithelial cell proliferation Hs biological process
striated muscle cell differentiation Hs biological process
positive regulation of striated muscle cell differentiation Hs biological process
cartilage development Hs biological process
positive regulation of cell division Hs biological process
palate development Hs biological process
canonical Wnt signaling pathway Hs biological process
limb development Hs biological process
limb bud formation Hs biological process
head morphogenesis Hs biological process
trachea development Hs biological process
trachea morphogenesis Hs biological process
salivary gland cavitation Hs biological process
artery development Hs biological process
somite development Hs biological process
dopaminergic neuron differentiation Hs biological process
renal system development Hs biological process
embryonic skeletal joint development Hs biological process
negative regulation of canonical Wnt signaling pathway Hs biological process
epithelial cell-cell adhesion Hs biological process
apoptotic signaling pathway Hs biological process
regulation of protein localization to nucleus Hs biological process

GO (Blast)

19 results

GO Term SpeciesCe = Caenorhabditis elegans
Dr = Danio rerio
Dm = Drosophila melanogaster
Gg = Gallus gallus
Hs = Homo sapiens
Mm = Mus musculus
Sc = Saccharomyces cerevisiae		 Type Score E-value
patched binding Hs molecular function 285 1.91e-90
calcium ion binding Hs molecular function 285 1.91e-90
protein binding Hs molecular function 285 1.91e-90
glycosaminoglycan binding Hs molecular function 285 1.91e-90
extracellular region Hs cellular component 285 1.91e-90
proteinaceous extracellular matrix Hs cellular component 285 1.91e-90
extracellular space Hs cellular component 285 1.91e-90
endoplasmic reticulum lumen Hs cellular component 285 1.91e-90
cytosol Hs cellular component 285 1.91e-90
plasma membrane Hs cellular component 285 1.91e-90
peptidase activity Hs molecular function 285 1.91e-90
zinc ion binding Hs molecular function 285 1.91e-90
cell surface Hs cellular component 285 1.91e-90
morphogen activity Hs molecular function 285 1.91e-90
membrane Hs cellular component 285 1.91e-90
hydrolase activity Hs molecular function 285 1.91e-90
laminin-1 binding Hs molecular function 285 1.91e-90
membrane raft Hs cellular component 285 1.91e-90
metal ion binding Hs molecular function 285 1.91e-90

GO (InterProScan)

5 results

GO Term Analysis Type e-value
proteolysis Pfam biological process 4.8E-75
cell-cell signaling Pfam biological process 1.1E-71
multicellular organism development PRINTS biological process 1.3E-39
peptidase activity Pfam molecular function 4.8E-75
intein-mediated protein splicing TIGRFAM biological process 6.0E-6

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