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Gene Card

Best human hits

NKX2-3; NKX2-5; NKX2-6

Species

C. robusta formely Ciona int. type A

Unique Gene ID

Cirobu.g00009121

Gene Model ID

KH2012:KH.C8.482

Location

KhC8:4055579..4061421

Transcript Models and Sequences

  KH2012:KH.C8.482.v1.A.SL2-1
KH2012:KH.C8.482.v2.A.ND1-1
KH2012:KH.C8.482.v2.A.SL3-1

External Database Gene Card

External database links

2 results

Database Gene ID
ENSEMBL ENSCING00000007218
NCBI Reference Sequence NM_001078489.1
Collections

Gateway full ORF

1 result

cima856134

Plate: VES63_E22

Gene collection 1 (N. Satoh)

3 results

citb5h13

Plate: R1CiGC29k02

ciad071n08

Plate: R1CiGC07i11

citb060o03

Plate: R1CiGC46c17

WashU Genome Browser

Click here to view results in the tunicate WashU Browser

Genomicus Synteny Browser

Genomicus browser link

Regulatory Regions

Regulatory Regions

No result

n/a

Gene Phylogeny

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Gene Annotations

InterPro

8 results

IPR Term Analysis Definition
Homeobox_dom ProSiteProfiles Homeobox domain
Homeobox-like_sf SUPERFAMILY Homeobox-like domain superfamily
Homeobox_metazoa PRINTS Homeobox domain, metazoa
Homeobox_dom Pfam Homeobox domain
Homeobox_CS ProSitePatterns Homeobox, conserved site
Homeobox_dom CDD Homeobox domain
Homeobox_dom SMART Homeobox domain
NKX-2.5 PANTHER Homeobox protein NKX-2.5

GOSlim

53 results

GO Term Annotation Origin Type
negative regulation of transcription from RNA polymerase II promoter Orthology biological process
RNA polymerase II core promoter proximal region sequence-specific DNA binding Orthology molecular function
RNA polymerase II transcription factor activity, sequence-specific DNA binding Orthology molecular function
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding Orthology molecular function
DNA binding Orthology molecular function
chromatin binding Orthology molecular function
transcription factor activity, sequence-specific DNA binding Orthology molecular function
protein binding Orthology molecular function
nucleus Orthology cellular component
cytoplasm Orthology cellular component
transcription, DNA-templated Orthology biological process
regulation of transcription, DNA-templated Orthology biological process
regulation of transcription from RNA polymerase II promoter Orthology biological process
transcription from RNA polymerase II promoter Orthology biological process
immune response Orthology biological process
multicellular organism development Orthology biological process
heart development Orthology biological process
transcription factor binding Orthology molecular function
positive regulation of cell proliferation Orthology biological process
positive regulation of gene expression Orthology biological process
cell differentiation Orthology biological process
macromolecular complex Orthology cellular component
regulation of cell proliferation Orthology biological process
protein homodimerization activity Orthology molecular function
negative regulation of apoptotic process Orthology biological process
sequence-specific DNA binding Orthology molecular function
transcription regulatory region DNA binding Orthology molecular function
negative regulation of transcription, DNA-templated Orthology biological process
positive regulation of transcription, DNA-templated Orthology biological process
positive regulation of transcription from RNA polymerase II promoter Orthology biological process
protein heterodimerization activity Orthology molecular function
cardiovascular system development Orthology biological process
negative regulation of canonical Wnt signaling pathway Orthology biological process
blood vessel morphogenesis Orthology biological process
anatomical structure morphogenesis Orthology biological process
anatomical structure formation involved in morphogenesis Orthology biological process
animal organ development Orthology biological process
intracellular part Orthology cellular component
cellular metabolic process Orthology biological process
organic substance metabolic process Orthology biological process
brain development Orthology biological process
immune system process Orthology biological process
cell surface receptor signaling pathway Orthology biological process
cellular response to organic substance Orthology biological process
cell development Orthology biological process
neuron differentiation Orthology biological process
system development Orthology biological process
cell migration Orthology biological process
cell proliferation Orthology biological process
cell-cell signaling Orthology biological process
transcription initiation from RNA polymerase II promoter Orthology biological process
nuclear part Orthology cellular component
regulation of signaling Orthology biological process

GO (Orthology)

85 results

GO Term SpeciesCe = Caenorhabditis elegans
Dr = Danio rerio
Dm = Drosophila melanogaster
Gg = Gallus gallus
Hs = Homo sapiens
Mm = Mus musculus
Sc = Saccharomyces cerevisiae		 Type
negative regulation of transcription from RNA polymerase II promoter Hs biological process
RNA polymerase II core promoter proximal region sequence-specific DNA binding Hs molecular function
RNA polymerase II transcription factor activity, sequence-specific DNA binding Hs molecular function
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding Hs molecular function
RNA polymerase II transcription cofactor activity Hs molecular function
transcriptional activator activity, RNA polymerase II transcription factor binding Hs molecular function
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding Hs molecular function
vasculogenesis Hs biological process
heart looping Hs biological process
heart morphogenesis Hs biological process
outflow tract morphogenesis Hs biological process
cardiac conduction system development Hs biological process
cardiac ventricle morphogenesis Hs biological process
cardiac ventricle formation Hs biological process
ventricular trabecula myocardium morphogenesis Hs biological process
proepicardium development Hs biological process
DNA binding Hs molecular function
chromatin binding Hs molecular function
transcription factor activity, sequence-specific DNA binding Hs molecular function
transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding Hs molecular function
protein binding Hs molecular function
nucleus Hs cellular component
transcription factor complex Hs cellular component
cytoplasm Hs cellular component
transcription, DNA-templated Hs biological process
regulation of transcription, DNA-templated Hs biological process
regulation of transcription from RNA polymerase II promoter Hs biological process
transcription from RNA polymerase II promoter Hs biological process
triglyceride metabolic process Hs biological process
immune response Hs biological process
multicellular organism development Hs biological process
heart development Hs biological process
adult heart development Hs biological process
transcription factor binding Hs molecular function
positive regulation of cell proliferation Hs biological process
post-embryonic development Hs biological process
positive regulation of gene expression Hs biological process
negative regulation of cardiac muscle cell apoptotic process Hs biological process
positive regulation of transcription via serum response element binding Hs biological process
serum response element binding Hs molecular function
hypothalamus development Hs biological process
hemopoiesis Hs biological process
cell differentiation Hs biological process
B cell differentiation Hs biological process
macrophage differentiation Hs biological process
BMP signaling pathway Hs biological process
thyroid gland development Hs biological process
macromolecular complex Hs cellular component
protein-DNA complex Hs cellular component
embryonic heart tube development Hs biological process
regulation of cell proliferation Hs biological process
protein homodimerization activity Hs molecular function
negative regulation of apoptotic process Hs biological process
sequence-specific DNA binding Hs molecular function
transcription regulatory region DNA binding Hs molecular function
sarcomere organization Hs biological process
positive regulation of neuron differentiation Hs biological process
positive regulation of heart contraction Hs biological process
negative regulation of transcription, DNA-templated Hs biological process
positive regulation of transcription, DNA-templated Hs biological process
positive regulation of transcription from RNA polymerase II promoter Hs biological process
protein heterodimerization activity Hs molecular function
digestive tract development Hs biological process
post-embryonic digestive tract morphogenesis Hs biological process
cardiac muscle tissue development Hs biological process
leukocyte migration Hs biological process
ventricular cardiac myofibril assembly Hs biological process
cardiac muscle cell differentiation Hs biological process
cardiac muscle tissue morphogenesis Hs biological process
atrial cardiac muscle cell development Hs biological process
ventricular cardiac muscle cell development Hs biological process
regulation of cardiac muscle contraction Hs biological process
pharyngeal system development Hs biological process
cardiac muscle cell proliferation Hs biological process
regulation of cardiac muscle cell proliferation Hs biological process
heart contraction Hs biological process
cardiac muscle contraction Hs biological process
canonical Wnt signaling pathway Hs biological process
positive regulation of transcription initiation from RNA polymerase II promoter Hs biological process
heart trabecula formation Hs biological process
embryonic heart tube left/right pattern formation Hs biological process
cardiovascular system development Hs biological process
negative regulation of canonical Wnt signaling pathway Hs biological process
RNA polymerase II transcription factor complex Hs cellular component
regulation of cardiac conduction Hs biological process

GO (Blast)

23 results

GO Term SpeciesCe = Caenorhabditis elegans
Dr = Danio rerio
Dm = Drosophila melanogaster
Gg = Gallus gallus
Hs = Homo sapiens
Mm = Mus musculus
Sc = Saccharomyces cerevisiae		 Type Score E-value
RNA polymerase II core promoter proximal region sequence-specific DNA binding Hs molecular function 158 1.94e-43
RNA polymerase II transcription factor activity, sequence-specific DNA binding Hs molecular function 171 2.05e-48
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding Hs molecular function 158 1.94e-43
RNA polymerase II transcription cofactor activity Hs molecular function 158 1.94e-43
transcriptional activator activity, RNA polymerase II transcription factor binding Hs molecular function 158 1.94e-43
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding Hs molecular function 158 1.94e-43
DNA binding Hs molecular function 171 2.05e-48
chromatin binding Hs molecular function 158 1.94e-43
transcription factor activity, sequence-specific DNA binding Hs molecular function 171 2.05e-48
transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding Hs molecular function 158 1.94e-43
protein binding Hs molecular function 158 1.94e-43
nucleus Hs cellular component 171 2.05e-48
transcription factor complex Hs cellular component 158 1.94e-43
cytoplasm Hs cellular component 158 1.94e-43
transcription factor binding Hs molecular function 158 1.94e-43
serum response element binding Hs molecular function 158 1.94e-43
macromolecular complex Hs cellular component 158 1.94e-43
protein-DNA complex Hs cellular component 158 1.94e-43
protein homodimerization activity Hs molecular function 158 1.94e-43
sequence-specific DNA binding Hs molecular function 171 2.05e-48
transcription regulatory region DNA binding Hs molecular function 158 1.94e-43
protein heterodimerization activity Hs molecular function 158 1.94e-43
RNA polymerase II transcription factor complex Hs cellular component 158 1.94e-43

GO (InterProScan)

8 results

GO Term Analysis Type e-value
DNA binding SMART molecular function 3.0E-24
transcription factor activity, sequence-specific DNA binding PANTHER molecular function 7.0E-74
regulation of transcription, DNA-templated ProSitePatterns biological process
regulation of transcription from RNA polymerase II promoter PANTHER biological process 7.0E-74
heart development PANTHER biological process 7.0E-74
sequence-specific DNA binding ProSitePatterns molecular function
cardiac muscle contraction PANTHER biological process 7.0E-74
regulation of cardiac conduction PANTHER biological process 7.0E-74

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