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Gene Card

Best human hits

NOTCH1; NOTCH2; NOTCH3

Species

C. robusta formely Ciona int. type A

Unique Gene ID

Cirobu.g00009697

Gene Model ID

KH2012:KH.C9.176

Location

KhC9:4753038..4787101

Transcript Models and Sequences

  KH2012:KH.C9.176.v1.R.SL1-1
KH2012:KH.C9.176.v2.R.SL1-1
KH2012:KH.C9.176.v3.R.SL1-1
KH2012:KH.C9.176.v4.R.SL1-1
KH2012:KH.C9.176.v5.R.SL1-1
KH2012:KH.C9.176.v6.R.SL1-1
KH2012:KH.C9.176.v7.R.SL1-1
KH2012:KH.C9.176.v8.A.ND2-1

External Database Gene Card

External database links

1 result

Database Gene ID
NCBI Reference Sequence NM_001044360.1
Collections

Gateway full ORF

2 results

cima886613

Plate: VES69_D23

cien174142

Plate: VES97_P05

Gene collection 1 (N. Satoh)

2 results

citb038p24

Plate: R1CiGC32l15

cign051f12

Plate: R1CiGC42h17

WashU Genome Browser

Click here to view results in the tunicate WashU Browser

Genomicus Synteny Browser

Genomicus browser link

Regulatory Regions

Regulatory Regions

1 results

Gene Phylogeny

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Gene Annotations

InterPro

29 results

IPR Term Analysis Definition
Notch_dom SMART Notch domain
EGF-like_CS ProSitePatterns EGF-like, conserved site
EGF-like_dom ProSiteProfiles EGF-like domain
Notch_dom ProSiteProfiles Notch domain
EGF-type_Asp/Asn_hydroxyl_site ProSitePatterns EGF-type aspartate/asparagine hydroxylation site
Ankyrin_rpt ProSiteProfiles Ankyrin repeat
EGF-like_CS Pfam EGF-like, conserved site
Notch-like_dom_sf SUPERFAMILY Notch-like domain superfamily
Ankyrin_rpt SMART Ankyrin repeat
Growth_fac_rcpt_cys_sf SUPERFAMILY Growth factor receptor cysteine-rich domain superfamily
Ankyrin_rpt-contain_dom CDD Ankyrin repeat-containing domain
Notch_NOD_dom Pfam Notch, NOD domain
DUF3454_notch SMART Domain of unknown function DUF3454, notch
EGF-like_Ca-bd_dom Pfam EGF-like calcium-binding domain
EGF_Ca-bd_CS ProSitePatterns EGF-like calcium-binding, conserved site
Ankyrin_rpt-contain_dom ProSiteProfiles Ankyrin repeat-containing domain
Notch_dom PRINTS Notch domain
EGF-like_dom SMART EGF-like domain
Notch_dom Pfam Notch domain
Notch PIRSF Notch
Notch_NOD_dom SMART Notch, NOD domain
Ankyrin_rpt-contain_sf SUPERFAMILY Ankyrin repeat-containing domain superfamily
EGF-like_Ca-bd_dom SMART EGF-like calcium-binding domain
Ankyrin_rpt-contain_dom Pfam Ankyrin repeat-containing domain
Ankyrin_rpt-contain_sf Gene3D Ankyrin repeat-containing domain superfamily
EGF-like_dom Pfam EGF-like domain
DUF3454_notch Pfam Domain of unknown function DUF3454, notch
Notch_NODP_dom Pfam Notch, NODP domain
Notch_NODP_dom SMART Notch, NODP domain

GOSlim

93 results

GO Term Annotation Origin Type
negative regulation of transcription from RNA polymerase II promoter Orthology biological process
Golgi membrane Orthology cellular component
angiogenesis Orthology biological process
chromatin binding Orthology molecular function
transcription factor activity, sequence-specific DNA binding Orthology molecular function
transmembrane signaling receptor activity Orthology molecular function
calcium ion binding Orthology molecular function
protein binding Orthology molecular function
extracellular region Orthology cellular component
nucleus Orthology cellular component
nucleoplasm Orthology cellular component
cytoplasm Orthology cellular component
endoplasmic reticulum Orthology cellular component
endoplasmic reticulum membrane Orthology cellular component
Golgi apparatus Orthology cellular component
cytosol Orthology cellular component
plasma membrane Orthology cellular component
integral component of plasma membrane Orthology cellular component
adherens junction Orthology cellular component
transcription, DNA-templated Orthology biological process
regulation of transcription, DNA-templated Orthology biological process
regulation of transcription from RNA polymerase II promoter Orthology biological process
transcription initiation from RNA polymerase II promoter Orthology biological process
apoptotic process Orthology biological process
immune response Orthology biological process
Notch signaling pathway Orthology biological process
multicellular organism development Orthology biological process
spermatogenesis Orthology biological process
nervous system development Orthology biological process
axonogenesis Orthology biological process
brain development Orthology biological process
heart development Orthology biological process
positive regulation of cell proliferation Orthology biological process
negative regulation of cell proliferation Orthology biological process
cell surface Orthology cellular component
regulation of gene expression Orthology biological process
negative regulation of gene expression Orthology biological process
membrane Orthology cellular component
integral component of membrane Orthology cellular component
apical plasma membrane Orthology cellular component
enzyme binding Orthology molecular function
cell differentiation Orthology biological process
neuron differentiation Orthology biological process
cytoplasmic vesicle Orthology cellular component
response to lipopolysaccharide Orthology biological process
regulation of cell proliferation Orthology biological process
identical protein binding Orthology molecular function
positive regulation of apoptotic process Orthology biological process
negative regulation of apoptotic process Orthology biological process
sequence-specific DNA binding Orthology molecular function
negative regulation of transcription, DNA-templated Orthology biological process
positive regulation of transcription, DNA-templated Orthology biological process
positive regulation of transcription from RNA polymerase II promoter Orthology biological process
metal ion binding Orthology molecular function
protein heterodimerization activity Orthology molecular function
negative regulation of cell death Orthology biological process
cell periphery Orthology cellular component
negative regulation of canonical Wnt signaling pathway Orthology biological process
transcription regulatory region DNA binding Orthology molecular function
endomembrane system Orthology cellular component
animal organ development Orthology biological process
anatomical structure morphogenesis Orthology biological process
cell development Orthology biological process
generation of neurons Orthology biological process
cell division Orthology biological process
macromolecular complex Orthology cellular component
enzyme regulator activity Orthology molecular function
receptor binding Orthology molecular function
system development Orthology biological process
anatomical structure development Orthology biological process
regulation of signal transduction Orthology biological process
neurogenesis Orthology biological process
anatomical structure formation involved in morphogenesis Orthology biological process
cytoskeleton Orthology cellular component
developmental process Orthology biological process
immune system process Orthology biological process
cell migration Orthology biological process
cell surface receptor signaling pathway Orthology biological process
cellular response to organic substance Orthology biological process
positive regulation of signal transduction Orthology biological process
negative regulation of signal transduction Orthology biological process
signal transduction Orthology biological process
DNA binding Orthology molecular function
wound healing Orthology biological process
regulation of catalytic activity Orthology biological process
cell adhesion molecule binding Orthology molecular function
small GTPase mediated signal transduction Orthology biological process
central nervous system development Orthology biological process
blood vessel morphogenesis Orthology biological process
cell proliferation Orthology biological process
blood vessel development Orthology biological process
intracellular signal transduction Orthology biological process
protein phosphorylation Orthology biological process

GO (Orthology)

154 results

GO Term SpeciesCe = Caenorhabditis elegans
Dr = Danio rerio
Dm = Drosophila melanogaster
Gg = Gallus gallus
Hs = Homo sapiens
Mm = Mus musculus
Sc = Saccharomyces cerevisiae		 Type
negative regulation of transcription from RNA polymerase II promoter Hs biological process
Golgi membrane Hs cellular component
core promoter binding Hs molecular function
transcriptional activator activity, RNA polymerase II transcription factor binding Hs molecular function
angiogenesis Hs biological process
acrosomal vesicle Hs cellular component
cell fate specification Hs biological process
cell fate determination Hs biological process
epithelial to mesenchymal transition Hs biological process
liver development Hs biological process
heart looping Hs biological process
sprouting angiogenesis Hs biological process
positive regulation of neuroblast proliferation Hs biological process
MAML1-RBP-Jkappa- ICN1 complex Hs cellular component
endocardium development Hs biological process
endocardium morphogenesis Hs biological process
atrioventricular valve morphogenesis Hs biological process
endocardial cushion development Hs biological process
endocardial cushion morphogenesis Hs biological process
cardiac ventricle morphogenesis Hs biological process
cardiac atrium morphogenesis Hs biological process
ventricular trabecula myocardium morphogenesis Hs biological process
pericardium morphogenesis Hs biological process
chromatin binding Hs molecular function
transcription factor activity, sequence-specific DNA binding Hs molecular function
enzyme inhibitor activity Hs molecular function
receptor activity Hs molecular function
transmembrane signaling receptor activity Hs molecular function
Notch binding Hs molecular function
calcium ion binding Hs molecular function
protein binding Hs molecular function
extracellular region Hs cellular component
nucleus Hs cellular component
nucleoplasm Hs cellular component
cytoplasm Hs cellular component
endoplasmic reticulum Hs cellular component
endoplasmic reticulum membrane Hs cellular component
Golgi apparatus Hs cellular component
cytosol Hs cellular component
plasma membrane Hs cellular component
integral component of plasma membrane Hs cellular component
adherens junction Hs cellular component
transcription, DNA-templated Hs biological process
regulation of transcription, DNA-templated Hs biological process
regulation of transcription from RNA polymerase II promoter Hs biological process
transcription initiation from RNA polymerase II promoter Hs biological process
apoptotic process Hs biological process
immune response Hs biological process
humoral immune response Hs biological process
cell cycle arrest Hs biological process
Notch signaling pathway Hs biological process
positive regulation of transcription of Notch receptor target Hs biological process
multicellular organism development Hs biological process
spermatogenesis Hs biological process
determination of left/right symmetry Hs biological process
compartment pattern specification Hs biological process
nervous system development Hs biological process
axonogenesis Hs biological process
brain development Hs biological process
foregut morphogenesis Hs biological process
endoderm development Hs biological process
heart development Hs biological process
positive regulation of cell proliferation Hs biological process
negative regulation of cell proliferation Hs biological process
epidermis development Hs biological process
regulation of Notch signaling pathway Hs biological process
animal organ morphogenesis Hs biological process
cell surface Hs cellular component
glial cell differentiation Hs biological process
regulation of gene expression Hs biological process
negative regulation of gene expression Hs biological process
positive regulation of epithelial to mesenchymal transition Hs biological process
regulation of somitogenesis Hs biological process
actin cytoskeleton Hs cellular component
membrane Hs cellular component
integral component of membrane Hs cellular component
apical plasma membrane Hs cellular component
stem cell population maintenance Hs biological process
enzyme binding Hs molecular function
neural tube development Hs biological process
hemopoiesis Hs biological process
cell differentiation Hs biological process
neuron differentiation Hs biological process
keratinocyte differentiation Hs biological process
negative regulation of ossification Hs biological process
lung development Hs biological process
embryonic limb morphogenesis Hs biological process
regulation of cell migration Hs biological process
positive regulation of cell migration Hs biological process
positive regulation of BMP signaling pathway Hs biological process
negative regulation of BMP signaling pathway Hs biological process
intracellular receptor signaling pathway Hs biological process
forebrain development Hs biological process
animal organ regeneration Hs biological process
cytoplasmic vesicle Hs cellular component
chromatin DNA binding Hs molecular function
response to lipopolysaccharide Hs biological process
embryonic hindlimb morphogenesis Hs biological process
tube formation Hs biological process
skeletal muscle cell differentiation Hs biological process
cellular response to vascular endothelial growth factor stimulus Hs biological process
transcription factor activity, ligand-activated RNA polymerase II transcription factor binding Hs molecular function
regulation of cell proliferation Hs biological process
tissue regeneration Hs biological process
identical protein binding Hs molecular function
positive regulation of apoptotic process Hs biological process
negative regulation of apoptotic process Hs biological process
negative regulation of catalytic activity Hs biological process
receptor complex Hs cellular component
sequence-specific DNA binding Hs molecular function
cell fate commitment Hs biological process
cadherin binding Hs molecular function
negative regulation of cell differentiation Hs biological process
positive regulation of endothelial cell differentiation Hs biological process
negative regulation of neuron differentiation Hs biological process
negative regulation of osteoblast differentiation Hs biological process
negative regulation of Notch signaling pathway Hs biological process
positive regulation of Notch signaling pathway Hs biological process
negative regulation of transcription, DNA-templated Hs biological process
positive regulation of transcription, DNA-templated Hs biological process
positive regulation of transcription from RNA polymerase II promoter Hs biological process
negative regulation of growth rate Hs biological process
positive regulation of JAK-STAT cascade Hs biological process
negative regulation of photoreceptor cell differentiation Hs biological process
positive regulation of Ras protein signal transduction Hs biological process
bone remodeling Hs biological process
metal ion binding Hs molecular function
protein heterodimerization activity Hs molecular function
somatic stem cell division Hs biological process
neuron fate commitment Hs biological process
astrocyte differentiation Hs biological process
oligodendrocyte differentiation Hs biological process
branching morphogenesis of an epithelial tube Hs biological process
artery morphogenesis Hs biological process
venous blood vessel morphogenesis Hs biological process
regulation of epithelial cell proliferation Hs biological process
positive regulation of epithelial cell proliferation Hs biological process
regulation of neurogenesis Hs biological process
negative regulation of neurogenesis Hs biological process
regulation of developmental process Hs biological process
cardiac muscle tissue morphogenesis Hs biological process
cardiac muscle cell proliferation Hs biological process
negative regulation of glial cell proliferation Hs biological process
cilium assembly Hs biological process
negative regulation of cell death Hs biological process
arterial endothelial cell differentiation Hs biological process
endocardial cell differentiation Hs biological process
positive regulation of ERK1 and ERK2 cascade Hs biological process
left/right axis specification Hs biological process
cell periphery Hs cellular component
glomerular capillary formation Hs biological process
negative regulation of canonical Wnt signaling pathway Hs biological process
neuronal stem cell population maintenance Hs biological process
negative regulation of stem cell differentiation Hs biological process

GO (Blast)

40 results

GO Term SpeciesCe = Caenorhabditis elegans
Dr = Danio rerio
Dm = Drosophila melanogaster
Gg = Gallus gallus
Hs = Homo sapiens
Mm = Mus musculus
Sc = Saccharomyces cerevisiae		 Type Score E-value
Golgi membrane Hs cellular component 2011 0.0
core promoter binding Hs molecular function 1956 0.0
transcriptional activator activity, RNA polymerase II transcription factor binding Hs molecular function 1956 0.0
acrosomal vesicle Hs cellular component 1956 0.0
MAML1-RBP-Jkappa- ICN1 complex Hs cellular component 1956 0.0
chromatin binding Hs molecular function 1956 0.0
transcription factor activity, sequence-specific DNA binding Hs molecular function 1956 0.0
enzyme inhibitor activity Hs molecular function 1956 0.0
receptor activity Hs molecular function 2011 0.0
transmembrane signaling receptor activity Hs molecular function 1956 0.0
Notch binding Hs molecular function 1956 0.0
calcium ion binding Hs molecular function 2011 0.0
protein binding Hs molecular function 2011 0.0
extracellular region Hs cellular component 2011 0.0
nucleus Hs cellular component 2011 0.0
nucleoplasm Hs cellular component 2011 0.0
cytoplasm Hs cellular component 2011 0.0
endoplasmic reticulum Hs cellular component 1956 0.0
endoplasmic reticulum membrane Hs cellular component 2011 0.0
Golgi apparatus Hs cellular component 1956 0.0
cytosol Hs cellular component 1956 0.0
plasma membrane Hs cellular component 2011 0.0
integral component of plasma membrane Hs cellular component 2011 0.0
adherens junction Hs cellular component 1956 0.0
cell surface Hs cellular component 2011 0.0
actin cytoskeleton Hs cellular component 1409 0.0
membrane Hs cellular component 2011 0.0
integral component of membrane Hs cellular component 2011 0.0
apical plasma membrane Hs cellular component 1956 0.0
enzyme binding Hs molecular function 1956 0.0
cytoplasmic vesicle Hs cellular component 1956 0.0
chromatin DNA binding Hs molecular function 1956 0.0
transcription factor activity, ligand-activated RNA polymerase II transcription factor binding Hs molecular function 2011 0.0
identical protein binding Hs molecular function 1409 0.0
receptor complex Hs cellular component 2011 0.0
sequence-specific DNA binding Hs molecular function 1956 0.0
cadherin binding Hs molecular function 1409 0.0
metal ion binding Hs molecular function 1956 0.0
protein heterodimerization activity Hs molecular function 1956 0.0
cell periphery Hs cellular component 1956 0.0

GO (InterProScan)

7 results

GO Term Analysis Type e-value
calcium ion binding SMART molecular function 2.8E-13
protein binding SMART molecular function 4.3E-4
Notch signaling pathway PIRSF biological process 0.0
multicellular organism development SMART biological process 4.9E-21
integral component of membrane PIRSF cellular component 0.0
cell differentiation PIRSF biological process 0.0
regulation of developmental process PIRSF biological process 0.0

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