Gene Card
Best human hits
FURIN; PCSK1; PCSK2
Unique Gene ID
Cirobu.g00010959
Gene Model ID
KH2012:KH.L128.2
Location
KhL128:212528..231064
Transcript Models and Sequences
cilv026a23
Plate: R1CiGC27a18
- Cirobu.REG.KH2012.L128:214285-215843|Furin,Nec1/2 REG00001365 [ regulatory_region (complex_region) ]
- Cirobu.REG.KH2012.L128:215034-215843|Furin,Nec1/2 REG00001366 [ no_output ]
- Cirobu.REG.KH2012.L128:214285-215033|Furin,Nec1/2 REG00001367 [ regulatory_region (enhancer) ]
- Cirobu.REG.KH2012.L128:214285-215033_Fox3Mut|Furin,Nec1/2 REG00001368 [ regulatory_region (enhancer) ]
- Cirobu.REG.KH2012.L128:214285-215033_Bra8Mut|Furin,Nec1/2 REG00001369 [ regulatory_region (enhancer) ]
- Cirobu.REG.KH2012.L128:214285-215033_Bra4Mut|Furin,Nec1/2 REG00001370 [ regulatory_region (enhancer) ]
- Cirobu.REG.KH2012.L128:214487-215033|Furin,Nec1/2 REG00001371 [ regulatory_region (enhancer) ]
- Cirobu.REG.KH2012.L128:214719-215033|Furin,Nec1/2 REG00001372 [ no_output ]
- Cirobu.REG.KH2012.L128:214487-215033_Bra4Mut1|Furin,Nec1/2 REG00001373 [ regulatory_region (enhancer) ]
- Cirobu.REG.KH2012.L128:214487-215033_Bra4Mut2|Furin,Nec1/2 REG00001374 [ regulatory_region (enhancer) ]
- Cirobu.REG.KH2012.L128:214487-215033_Bra4Mut3|Furin,Nec1/2 REG00001375 [ regulatory_region (enhancer) ]
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IPR Term | Analysis | Definition |
---|---|---|
Peptidase_S8/S53_dom_sf | Gene3D | Peptidase S8/S53 domain superfamily |
Kexin/furin | CDD | Kexin/furin catalytic domain |
Peptidase_S8/S53_dom | Pfam | Peptidase S8/S53 domain |
Peptidase_S8_His-AS | ProSitePatterns | Peptidase S8, subtilisin, His-active site |
Peptidase_S8_subtilisin-rel | PRINTS | Peptidase S8, subtilisin-related |
Peptidase_S8/S53_dom_sf | SUPERFAMILY | Peptidase S8/S53 domain superfamily |
Peptidase_S8_Ser-AS | ProSitePatterns | Peptidase S8, subtilisin, Ser-active site |
P_dom | Pfam | P domain |
Galactose-bd-like_sf | Gene3D | Galactose-binding-like domain superfamily |
S8_pro-domain | Pfam | Peptidase S8, pro-domain |
P_dom | ProSiteProfiles | P domain |
S8_pro-domain_sf | Gene3D | Peptidase S8, pro-domain superfamily |
Peptidase_S8_Asp-AS | ProSitePatterns | Peptidase S8, subtilisin, Asp-active site |
Galactose-bd-like_sf | SUPERFAMILY | Galactose-binding-like domain superfamily |
GO Term | Annotation Origin | Type |
---|---|---|
Golgi membrane | Blast | cellular component |
endopeptidase activity | Orthology | molecular function |
serine-type endopeptidase activity | Orthology | molecular function |
protein binding | Orthology | molecular function |
extracellular region | Orthology | cellular component |
extracellular space | Orthology | cellular component |
nucleus | Orthology | cellular component |
endosome | Blast | cellular component |
endoplasmic reticulum | Blast | cellular component |
Golgi apparatus | Blast | cellular component |
plasma membrane | Blast | cellular component |
proteolysis | Orthology | biological process |
nervous system development | Orthology | biological process |
peptidase activity | Orthology | molecular function |
serine-type peptidase activity | Orthology | molecular function |
cell surface | Blast | cellular component |
membrane | Orthology | cellular component |
integral component of membrane | Blast | cellular component |
hydrolase activity | Orthology | molecular function |
cytoplasmic vesicle | Orthology | cellular component |
identical protein binding | Blast | molecular function |
neuronal cell body | Orthology | cellular component |
intracellular membrane-bounded organelle | Orthology | cellular component |
membrane raft | Blast | cellular component |
metal ion binding | Blast | molecular function |
extracellular exosome | Blast | cellular component |
gene expression | Orthology | biological process |
peptide metabolic process | Orthology | biological process |
endomembrane system | Orthology | cellular component |
intracellular organelle part | Orthology | cellular component |
intracellular organelle lumen | Orthology | cellular component |
enzyme binding | Blast | molecular function |
enzyme regulator activity | Blast | molecular function |
Golgi apparatus part | Blast | cellular component |
whole membrane | Blast | cellular component |
bounding membrane of organelle | Blast | cellular component |
binding | Blast | molecular function |
GO Term | SpeciesCe = Caenorhabditis elegans Dr = Danio rerio Dm = Drosophila melanogaster Gg = Gallus gallus Hs = Homo sapiens Mm = Mus musculus Sc = Saccharomyces cerevisiae |
Type |
---|---|---|
endopeptidase activity | Hs | molecular function |
serine-type endopeptidase activity | Hs | molecular function |
protein binding | Hs | molecular function |
extracellular region | Hs | cellular component |
extracellular space | Hs | cellular component |
nucleus | Hs | cellular component |
proteolysis | Hs | biological process |
nervous system development | Hs | biological process |
peptidase activity | Hs | molecular function |
serine-type peptidase activity | Hs | molecular function |
membrane | Hs | cellular component |
protein processing | Hs | biological process |
peptide hormone processing | Hs | biological process |
protein autoprocessing | Hs | biological process |
hydrolase activity | Hs | molecular function |
insulin processing | Hs | biological process |
transport vesicle | Hs | cellular component |
secretory granule | Hs | cellular component |
dendrite | Hs | cellular component |
cytoplasmic vesicle | Hs | cellular component |
secretory granule lumen | Hs | cellular component |
neuronal cell body | Hs | cellular component |
perikaryon | Hs | cellular component |
intracellular membrane-bounded organelle | Hs | cellular component |
GO Term | SpeciesCe = Caenorhabditis elegans Dr = Danio rerio Dm = Drosophila melanogaster Gg = Gallus gallus Hs = Homo sapiens Mm = Mus musculus Sc = Saccharomyces cerevisiae |
Type | Score | E-value |
---|---|---|---|---|
Golgi membrane | Hs | cellular component | 513 | 4.11e-173 |
protease binding | Hs | molecular function | 513 | 4.11e-173 |
endopeptidase activity | Hs | molecular function | 826 | 0.0 |
serine-type endopeptidase activity | Hs | molecular function | 826 | 0.0 |
serine-type endopeptidase inhibitor activity | Hs | molecular function | 513 | 4.11e-173 |
protein binding | Hs | molecular function | 826 | 0.0 |
extracellular region | Hs | cellular component | 826 | 0.0 |
extracellular space | Hs | cellular component | 826 | 0.0 |
nucleus | Hs | cellular component | 826 | 0.0 |
endosome | Hs | cellular component | 513 | 4.11e-173 |
endoplasmic reticulum | Hs | cellular component | 513 | 4.11e-173 |
Golgi apparatus | Hs | cellular component | 513 | 4.11e-173 |
Golgi lumen | Hs | cellular component | 513 | 4.11e-173 |
trans-Golgi network | Hs | cellular component | 513 | 4.11e-173 |
plasma membrane | Hs | cellular component | 513 | 4.11e-173 |
peptidase activity | Hs | molecular function | 826 | 0.0 |
serine-type peptidase activity | Hs | molecular function | 826 | 0.0 |
cell surface | Hs | cellular component | 513 | 4.11e-173 |
endosome membrane | Hs | cellular component | 513 | 4.11e-173 |
membrane | Hs | cellular component | 826 | 0.0 |
integral component of membrane | Hs | cellular component | 513 | 4.11e-173 |
hydrolase activity | Hs | molecular function | 826 | 0.0 |
transport vesicle | Hs | cellular component | 826 | 0.0 |
trans-Golgi network transport vesicle | Hs | cellular component | 513 | 4.11e-173 |
secretory granule | Hs | cellular component | 826 | 0.0 |
dendrite | Hs | cellular component | 826 | 0.0 |
cytoplasmic vesicle | Hs | cellular component | 826 | 0.0 |
secretory granule lumen | Hs | cellular component | 826 | 0.0 |
peptide binding | Hs | molecular function | 513 | 4.11e-173 |
identical protein binding | Hs | molecular function | 481 | 3.50e-161 |
neuronal cell body | Hs | cellular component | 826 | 0.0 |
perikaryon | Hs | cellular component | 826 | 0.0 |
intracellular membrane-bounded organelle | Hs | cellular component | 826 | 0.0 |
membrane raft | Hs | cellular component | 513 | 4.11e-173 |
metal ion binding | Hs | molecular function | 513 | 4.11e-173 |
nerve growth factor binding | Hs | molecular function | 513 | 4.11e-173 |
extracellular exosome | Hs | cellular component | 513 | 4.11e-173 |
GO Term | Analysis | Type | e-value |
---|---|---|---|
serine-type endopeptidase activity | Gene3D | molecular function | 1.9E-87 |
proteolysis | Gene3D | biological process | 1.9E-87 |