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Gene Card

Best human hits

TOP1; TOP1MT

Species

C. robusta formely Ciona int. type A

Unique Gene ID

Cirobu.g00011034

Gene Model ID

KH2012:KH.L131.2

Location

KhL131:66354..71907

Transcript Models and Sequences

  KH2012:KH.L131.2.v1.A.ND1-1
KH2012:KH.L131.2.v2.A.SL2-1

External Database Gene Card

External database links

2 results

Database Gene ID
ENSEMBL ENSCING00000003086
NCBI Reference Sequence XM_018815235.1
Collections

Gateway full ORF

2 results

cima828767

Plate: VES61_O13

cima898427

Plate: VES72_L09

Gene collection 1 (N. Satoh)

2 results

cieg014l13

Plate: R1CiGC17l17

cieg022c02

Plate: R1CiGC18n12

WashU Genome Browser

Click here to view results in the tunicate WashU Browser

Genomicus Synteny Browser

Genomicus browser link

Regulatory Regions

Regulatory Regions

No result

n/a

Gene Phylogeny

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Gene Annotations

InterPro

14 results

IPR Term Analysis Definition
TopoI_cat_euk CDD DNA topoisomerase I, catalytic core, eukaryotic-type
TopoI_DNA-bd_euk Pfam DNA topoisomerase I, DNA binding, eukaryotic-type
TopoI PANTHER DNA topoisomerase I
DNA_brk_join_enz SUPERFAMILY DNA breaking-rejoining enzyme, catalytic core
DNA_topo_DNA_db_N_dom2 Gene3D DNA topoisomerase I, DNA binding, N-terminal domain 2
TopoI_AS ProSitePatterns DNA topoisomerase I, active site
TopoI_cat_euk Pfam DNA topoisomerase I, catalytic core, eukaryotic-type
TopoI_euk SMART DNA topoisomerase I, eukaryotic-type
TopoI_C_dom Pfam Topoisomerase I C-terminal domain
TopoI PRINTS DNA topoisomerase I
DNA_topo_DNA_db_N_dom1 Gene3D DNA topoisomerase I, DNA binding, N-terminal domain 1
TopoI_cat_a/b-sub_euk Gene3D DNA topoisomerase I, catalytic core, alpha/beta subdomain
TopoI_cat_a-hlx-sub_euk Gene3D DNA topoisomerase I, catalytic core, alpha-helical subdomain, eukaryotic-type
TopoI_DNA-bd_euk_N_sf SUPERFAMILY DNA topoisomerase I, DNA binding, eukaryotic-type, N-terminal domain superfamily

GOSlim

33 results

GO Term Annotation Origin Type
DNA binding Orthology molecular function
chromatin binding Orthology molecular function
double-stranded DNA binding Orthology molecular function
RNA binding Orthology molecular function
protein serine/threonine kinase activity Orthology molecular function
protein binding Orthology molecular function
ATP binding Orthology molecular function
nucleus Orthology cellular component
nucleoplasm Orthology cellular component
nucleolus Orthology cellular component
cytoplasm Orthology cellular component
mitochondrion Orthology cellular component
DNA replication Orthology biological process
programmed cell death Orthology biological process
phosphorylation Orthology biological process
intracellular non-membrane-bounded organelle Orthology cellular component
nuclear lumen Orthology cellular component
cytoplasmic part Orthology cellular component
macromolecular complex Orthology cellular component
transcription regulatory region sequence-specific DNA binding Orthology molecular function
catalytic activity Orthology molecular function
organelle organization Orthology biological process
DNA metabolic process Orthology biological process
cellular process Orthology biological process
intracellular part Orthology cellular component
protein modification by small protein conjugation Orthology biological process
protein phosphorylation Orthology biological process
nucleoplasm part Orthology cellular component
regulation of gene expression Orthology biological process
cell division Orthology biological process
multicellular organism development Orthology biological process
mitochondrial matrix Orthology cellular component
neuronal cell body Orthology cellular component

GO (Orthology)

42 results

GO Term SpeciesCe = Caenorhabditis elegans
Dr = Danio rerio
Dm = Drosophila melanogaster
Gg = Gallus gallus
Hs = Homo sapiens
Mm = Mus musculus
Sc = Saccharomyces cerevisiae		 Type
nuclear chromosome Hs cellular component
P-body Hs cellular component
core promoter sequence-specific DNA binding Hs molecular function
fibrillar center Hs cellular component
DNA binding Hs molecular function
chromatin binding Hs molecular function
double-stranded DNA binding Hs molecular function
single-stranded DNA binding Hs molecular function
RNA binding Hs molecular function
DNA topoisomerase activity Hs molecular function
DNA topoisomerase type I activity Hs molecular function
protein serine/threonine kinase activity Hs molecular function
protein binding Hs molecular function
ATP binding Hs molecular function
nucleus Hs cellular component
nucleoplasm Hs cellular component
chromosome Hs cellular component
nucleolus Hs cellular component
cytoplasm Hs cellular component
mitochondrion Hs cellular component
DNA replication Hs biological process
DNA topological change Hs biological process
chromatin remodeling Hs biological process
chromosome segregation Hs biological process
circadian rhythm Hs biological process
DNA topoisomerase complex (ATP-hydrolyzing) Hs cellular component
programmed cell death Hs biological process
viral process Hs biological process
phosphorylation Hs biological process
isomerase activity Hs molecular function
protein sumoylation Hs biological process
peptidyl-serine phosphorylation Hs biological process
protein domain specific binding Hs molecular function
replication fork protection complex Hs cellular component
circadian regulation of gene expression Hs biological process
protein-DNA complex Hs cellular component
embryonic cleavage Hs biological process
response to drug Hs biological process
mitochondrial nucleoid Hs cellular component
perikaryon Hs cellular component
rhythmic process Hs biological process
supercoiled DNA binding Hs molecular function

GO (Blast)

28 results

GO Term SpeciesCe = Caenorhabditis elegans
Dr = Danio rerio
Dm = Drosophila melanogaster
Gg = Gallus gallus
Hs = Homo sapiens
Mm = Mus musculus
Sc = Saccharomyces cerevisiae		 Type Score E-value
nuclear chromosome Hs cellular component 778 0.0
P-body Hs cellular component 778 0.0
core promoter sequence-specific DNA binding Hs molecular function 778 0.0
fibrillar center Hs cellular component 778 0.0
DNA binding Hs molecular function 778 0.0
chromatin binding Hs molecular function 778 0.0
double-stranded DNA binding Hs molecular function 778 0.0
single-stranded DNA binding Hs molecular function 778 0.0
RNA binding Hs molecular function 778 0.0
DNA topoisomerase activity Hs molecular function 778 0.0
DNA topoisomerase type I activity Hs molecular function 778 0.0
protein serine/threonine kinase activity Hs molecular function 778 0.0
protein binding Hs molecular function 778 0.0
ATP binding Hs molecular function 778 0.0
nucleus Hs cellular component 778 0.0
nucleoplasm Hs cellular component 778 0.0
chromosome Hs cellular component 778 0.0
nucleolus Hs cellular component 778 0.0
cytoplasm Hs cellular component 778 0.0
mitochondrion Hs cellular component 712 0.0
DNA topoisomerase complex (ATP-hydrolyzing) Hs cellular component 778 0.0
isomerase activity Hs molecular function 778 0.0
protein domain specific binding Hs molecular function 778 0.0
replication fork protection complex Hs cellular component 778 0.0
protein-DNA complex Hs cellular component 778 0.0
mitochondrial nucleoid Hs cellular component 712 0.0
perikaryon Hs cellular component 778 0.0
supercoiled DNA binding Hs molecular function 778 0.0

GO (InterProScan)

4 results

GO Term Analysis Type e-value
DNA binding PANTHER molecular function 8.3E-291
DNA topoisomerase type I activity PANTHER molecular function 8.3E-291
chromosome SMART cellular component 4.1E-241
DNA topological change PANTHER biological process 8.3E-291

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