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Gene Card

Best human hits

LRP5; LRP6

Species

C. robusta formely Ciona int. type A

Unique Gene ID

Cirobu.g00011548

Gene Model ID

KH2012:KH.L154.1

Location

KhL154:337861..372434

Transcript Models and Sequences

  KH2012:KH.L154.1.v1.R.ND1-1
KH2012:KH.L154.1.v2.R.SL2-1
KH2012:KH.L154.1.v3.A.SL2-1

External Database Gene Card

External database links

5 results

Database Gene ID
ENSEMBL ENSCING00000015578
ENSEMBL ENSCING00000022060
ENSEMBL ENSCING00000022269
ENSEMBL ENSCING00000023147
ENSEMBL ENSCING00000024564
Collections

Gateway full ORF

2 results

cien126871

Plate: VES90_D04

cien173806

Plate: VES97_D04

Gene collection 1 (N. Satoh)

3 results

citb011i10

Plate: R1CiGC30c12

cieg035b09

Plate: R1CiGC21m17

ciad037o02

Plate: R1CiGC04o17

WashU Genome Browser

Click here to view results in the tunicate WashU Browser

Genomicus Synteny Browser

Genomicus browser link

Regulatory Regions

Regulatory Regions

No result

n/a

Gene Phylogeny

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Gene Annotations

InterPro

12 results

IPR Term Analysis Definition
LDLR_classB_rpt ProSiteProfiles LDLR class B repeat
EGF-like_dom SMART EGF-like domain
LDL_receptor-like_sf SUPERFAMILY LDL receptor-like superfamily
6-blade_b-propeller_TolB-like Gene3D Six-bladed beta-propeller, TolB-like
LDrepeatLR_classA_rpt SMART Low-density lipoprotein (LDL) receptor class A repeat
LDrepeatLR_classA_rpt Pfam Low-density lipoprotein (LDL) receptor class A repeat
LDrepeatLR_classA_rpt ProSiteProfiles Low-density lipoprotein (LDL) receptor class A repeat
LDrepeatLR_classA_rpt CDD Low-density lipoprotein (LDL) receptor class A repeat
LDLR_classB_rpt SMART LDLR class B repeat
LDrepeatLR_classA_rpt PRINTS Low-density lipoprotein (LDL) receptor class A repeat
LDLR_classB_rpt Pfam LDLR class B repeat
LDLR_class-A_CS ProSitePatterns Low-density lipoprotein (LDL) receptor class A, conserved site

GOSlim

76 results

GO Term Annotation Origin Type
vasculature development Orthology biological process
receptor binding Orthology molecular function
protein binding Orthology molecular function
extracellular region Orthology cellular component
mitochondrion Orthology cellular component
early endosome Orthology cellular component
endoplasmic reticulum Orthology cellular component
Golgi apparatus Orthology cellular component
plasma membrane Orthology cellular component
regulation of transcription, DNA-templated Orthology biological process
chemical synaptic transmission Orthology biological process
multicellular organism development Orthology biological process
positive regulation of cell proliferation Orthology biological process
cell surface Orthology cellular component
membrane Orthology cellular component
integral component of membrane Orthology cellular component
cytoplasmic vesicle Orthology cellular component
identical protein binding Orthology molecular function
protein homodimerization activity Orthology molecular function
regulation of apoptotic process Orthology biological process
neuronal cell body Orthology cellular component
membrane raft Orthology cellular component
synapse Orthology cellular component
positive regulation of transcription, DNA-templated Orthology biological process
positive regulation of transcription from RNA polymerase II promoter Orthology biological process
regulation of canonical Wnt signaling pathway Orthology biological process
negative regulation of canonical Wnt signaling pathway Orthology biological process
positive regulation of canonical Wnt signaling pathway Orthology biological process
anatomical structure formation involved in morphogenesis Orthology biological process
nervous system development Orthology biological process
protein phosphorylation Orthology biological process
cell development Orthology biological process
heart development Orthology biological process
anatomical structure morphogenesis Orthology biological process
membrane organization Orthology biological process
organelle organization Orthology biological process
macromolecular complex binding Orthology molecular function
plasma membrane region Orthology cellular component
regulation of catalytic activity Orthology biological process
protein kinase activity Orthology molecular function
cellular process Orthology biological process
cell Orthology cellular component
animal organ development Orthology biological process
cell differentiation Orthology biological process
cell surface receptor signaling pathway Orthology biological process
cell-cell signaling Orthology biological process
kinase activity Orthology molecular function
enzyme regulator activity Orthology molecular function
transmembrane transport Orthology biological process
brain development Orthology biological process
whole membrane Orthology cellular component
intracellular organelle part Orthology cellular component
bounding membrane of organelle Orthology cellular component
developmental process Orthology biological process
cell migration Orthology biological process
transmembrane signaling receptor activity Orthology molecular function
macromolecular complex Orthology cellular component
response to organic substance Orthology biological process
cell cycle Orthology biological process
transcription factor activity, sequence-specific DNA binding Orthology molecular function
anatomical structure development Orthology biological process
head development Orthology biological process
cellular response to organic substance Orthology biological process
protein transport Orthology biological process
regulation of signaling Orthology biological process
blood vessel morphogenesis Orthology biological process
neuron differentiation Orthology biological process
protein serine/threonine kinase activity Orthology molecular function
signaling receptor activity Orthology molecular function
protein localization to membrane Orthology biological process
organic substance transport Orthology biological process
intracellular transport Orthology biological process
cell adhesion Orthology biological process
apoptotic process Orthology biological process
plasma membrane part Orthology cellular component
positive regulation of Wnt signaling pathway Orthology biological process

GO (Orthology)

99 results

GO Term SpeciesCe = Caenorhabditis elegans
Dr = Danio rerio
Dm = Drosophila melanogaster
Gg = Gallus gallus
Hs = Homo sapiens
Mm = Mus musculus
Sc = Saccharomyces cerevisiae		 Type
gastrulation with mouth forming second Hs biological process
neural tube closure Hs biological process
negative regulation of protein phosphorylation Hs biological process
vasculature development Hs biological process
osteoblast development Hs biological process
pericardium morphogenesis Hs biological process
low-density lipoprotein receptor activity Hs molecular function
receptor binding Hs molecular function
frizzled binding Hs molecular function
protein binding Hs molecular function
extracellular region Hs cellular component
mitochondrion Hs cellular component
early endosome Hs cellular component
endoplasmic reticulum Hs cellular component
Golgi apparatus Hs cellular component
plasma membrane Hs cellular component
caveola Hs cellular component
glucose catabolic process Hs biological process
regulation of transcription, DNA-templated Hs biological process
negative regulation of protein kinase activity Hs biological process
endocytosis Hs biological process
positive regulation of cytosolic calcium ion concentration Hs biological process
chemical synaptic transmission Hs biological process
multicellular organism development Hs biological process
cholesterol metabolic process Hs biological process
regulation of blood pressure Hs biological process
positive regulation of cell proliferation Hs biological process
response to radiation Hs biological process
embryonic pattern specification Hs biological process
anterior/posterior pattern specification Hs biological process
cell surface Hs cellular component
neural crest formation Hs biological process
neural crest cell differentiation Hs biological process
membrane Hs cellular component
integral component of membrane Hs cellular component
Wnt signaling pathway Hs biological process
Wnt-protein binding Hs molecular function
kinase inhibitor activity Hs molecular function
toxin transporter activity Hs molecular function
cerebellum morphogenesis Hs biological process
thalamus development Hs biological process
cerebral cortex development Hs biological process
midbrain-hindbrain boundary development Hs biological process
cytoplasmic vesicle Hs cellular component
early endosome membrane Hs cellular component
apolipoprotein binding Hs molecular function
somatic stem cell population maintenance Hs biological process
limb morphogenesis Hs biological process
cell migration involved in gastrulation Hs biological process
cholesterol homeostasis Hs biological process
identical protein binding Hs molecular function
protein homodimerization activity Hs molecular function
Wnt-activated receptor activity Hs molecular function
regulation of apoptotic process Hs biological process
neuronal cell body Hs cellular component
receptor complex Hs cellular component
response to peptide hormone Hs biological process
Wnt signaling pathway involved in dorsal/ventral axis specification Hs biological process
membrane raft Hs cellular component
synapse Hs cellular component
positive regulation of fat cell differentiation Hs biological process
negative regulation of osteoblast differentiation Hs biological process
positive regulation of cell cycle Hs biological process
positive regulation of mitotic nuclear division Hs biological process
positive regulation of transcription, DNA-templated Hs biological process
positive regulation of transcription from RNA polymerase II promoter Hs biological process
bone remodeling Hs biological process
regulation of bone remodeling Hs biological process
positive regulation of sequence-specific DNA binding transcription factor activity Hs biological process
palate development Hs biological process
convergent extension Hs biological process
anatomical structure regression Hs biological process
retina morphogenesis in camera-type eye Hs biological process
embryonic retina morphogenesis in camera-type eye Hs biological process
canonical Wnt signaling pathway Hs biological process
face morphogenesis Hs biological process
bone development Hs biological process
bone morphogenesis Hs biological process
adipose tissue development Hs biological process
regulation of canonical Wnt signaling pathway Hs biological process
regulation of insulin secretion involved in cellular response to glucose stimulus Hs biological process
retinal blood vessel morphogenesis Hs biological process
dopaminergic neuron differentiation Hs biological process
negative regulation of protein serine/threonine kinase activity Hs biological process
coreceptor activity involved in Wnt signaling pathway Hs molecular function
protein localization to plasma membrane Hs biological process
primitive streak formation Hs biological process
negative regulation of canonical Wnt signaling pathway Hs biological process
receptor-mediated endocytosis involved in cholesterol transport Hs biological process
Wnt signaling pathway involved in somitogenesis Hs biological process
axis elongation involved in somitogenesis Hs biological process
positive regulation of canonical Wnt signaling pathway Hs biological process
cell-cell adhesion Hs biological process
toxin transport Hs biological process
apoptotic process involved in blood vessel morphogenesis Hs biological process
coreceptor activity involved in canonical Wnt signaling pathway Hs molecular function
Wnt-Frizzled-LRP5/6 complex Hs cellular component
Wnt signalosome Hs cellular component
positive regulation of Wnt signaling pathway involved in dorsal/ventral axis specification Hs biological process

GO (Blast)

31 results

GO Term SpeciesCe = Caenorhabditis elegans
Dr = Danio rerio
Dm = Drosophila melanogaster
Gg = Gallus gallus
Hs = Homo sapiens
Mm = Mus musculus
Sc = Saccharomyces cerevisiae		 Type Score E-value
low-density lipoprotein receptor activity Hs molecular function 1332 0.0
receptor binding Hs molecular function 1332 0.0
frizzled binding Hs molecular function 1332 0.0
protein binding Hs molecular function 1332 0.0
extracellular region Hs cellular component 1332 0.0
mitochondrion Hs cellular component 1257 0.0
early endosome Hs cellular component 1332 0.0
endoplasmic reticulum Hs cellular component 1332 0.0
Golgi apparatus Hs cellular component 1332 0.0
plasma membrane Hs cellular component 1332 0.0
caveola Hs cellular component 1332 0.0
cell surface Hs cellular component 1332 0.0
membrane Hs cellular component 1332 0.0
integral component of membrane Hs cellular component 1332 0.0
Wnt-protein binding Hs molecular function 1332 0.0
kinase inhibitor activity Hs molecular function 1332 0.0
toxin transporter activity Hs molecular function 1332 0.0
cytoplasmic vesicle Hs cellular component 1332 0.0
early endosome membrane Hs cellular component 1332 0.0
apolipoprotein binding Hs molecular function 1332 0.0
identical protein binding Hs molecular function 1332 0.0
protein homodimerization activity Hs molecular function 1332 0.0
Wnt-activated receptor activity Hs molecular function 1332 0.0
neuronal cell body Hs cellular component 1332 0.0
receptor complex Hs cellular component 1332 0.0
membrane raft Hs cellular component 1332 0.0
synapse Hs cellular component 1332 0.0
coreceptor activity involved in Wnt signaling pathway Hs molecular function 1332 0.0
coreceptor activity involved in canonical Wnt signaling pathway Hs molecular function 1332 0.0
Wnt-Frizzled-LRP5/6 complex Hs cellular component 1332 0.0
Wnt signalosome Hs cellular component 1332 0.0

GO (InterProScan)

1 result

GO Term Analysis Type e-value
protein binding SMART molecular function 2.4E-14

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