Aniseed - Gene card

Gene Card

Best human hits

FZD5; FZD7; SMO

Species

C. robusta formely Ciona int. type A

Unique Gene ID

Cirobu.g00012563

Gene Model ID

KH2012:KH.L41.13

Location

KhL41:105799..112760

Transcript Models and Sequences

KH2012:KH.L41.13.v1.B.nonSL3-1
KH2012:KH.L41.13.v1.B.nonSL4-1
KH2012:KH.L41.13.v1.B.nonSL5-1
KH2012:KH.L41.13.v1.B.nonSL6-1
KH2012:KH.L41.13.v1.B.nonSL7-1
KH2012:KH.L41.13.v1.B.SL1-1
KH2012:KH.L41.13.v2.R.ND2-2

External Database Gene Card

External database links

2 results

Database	Gene ID
ENSEMBL	ENSCING00000001387
ENSEMBL	ENSCING00000018008

Collections

Gateway full ORF

2 results

Gene collection 1 (N. Satoh)

1 result

cits048p23

Plate: R1CiGC35h24

WashU Genome Browser

Click here to view results in the tunicate WashU Browser

Genomicus Synteny Browser

Regulatory Regions

No result

n/a

Gene Phylogeny

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Gene Annotations

InterPro

11 results

IPR Term	Analysis	Definition
Frizzled_dom_sf	Gene3D	Frizzled cysteine-rich domain superfamily
Frizzled/Smoothened_TM	PRINTS	Frizzled/Smoothened, transmembrane domain
Frizzled_dom_sf	SUPERFAMILY	Frizzled cysteine-rich domain superfamily
SMO	PANTHER	Smoothened
Frizzled_dom	ProSiteProfiles	Frizzled domain
Frizzled_dom	Pfam	Frizzled domain
Frizzled/Smoothened_TM	Pfam	Frizzled/Smoothened, transmembrane domain
Frizzled_dom	SMART	Frizzled domain
Frizzled/Smoothened_TM	SMART	Frizzled/Smoothened, transmembrane domain
Frizzled/SFRP	PANTHER	Frizzled/secreted frizzled-related protein
GPCR_2-like	ProSiteProfiles	GPCR, family 2-like

GOSlim

76 results

GO Term	Annotation Origin	Type
negative regulation of transcription from RNA polymerase II promoter	Orthology	biological process
Golgi membrane	Blast	cellular component
signal transducer activity	Orthology	molecular function
transmembrane signaling receptor activity	Orthology	molecular function
G-protein coupled receptor activity	Orthology	molecular function
protein binding	Orthology	molecular function
cytoplasm	Orthology	cellular component
endosome	Blast	cellular component
early endosome	Blast	cellular component
Golgi apparatus	Orthology	cellular component
plasma membrane	Orthology	cellular component
integral component of plasma membrane	Blast	cellular component
signal transduction	Orthology	biological process
cell surface receptor signaling pathway	Orthology	biological process
G-protein coupled receptor signaling pathway	Orthology	biological process
multicellular organism development	Orthology	biological process
central nervous system development	Orthology	biological process
positive regulation of cell proliferation	Orthology	biological process
cell surface	Blast	cellular component
regulation of gene expression	Orthology	biological process
positive regulation of gene expression	Orthology	biological process
negative regulation of gene expression	Orthology	biological process
membrane	Orthology	cellular component
integral component of membrane	Orthology	cellular component
protein kinase binding	Blast	molecular function
cell junction	Blast	cellular component
neuron differentiation	Orthology	biological process
axon	Blast	cellular component
ubiquitin protein ligase binding	Blast	molecular function
cell projection	Orthology	cellular component
negative regulation of apoptotic process	Orthology	biological process
intracellular membrane-bounded organelle	Orthology	cellular component
synapse	Blast	cellular component
negative regulation of transcription, DNA-templated	Orthology	biological process
positive regulation of transcription, DNA-templated	Orthology	biological process
positive regulation of transcription from RNA polymerase II promoter	Orthology	biological process
cell development	Orthology	biological process
perinuclear region of cytoplasm	Blast	cellular component
extracellular exosome	Orthology	cellular component
blood vessel morphogenesis	Orthology	biological process
cell differentiation	Orthology	biological process
cell migration	Orthology	biological process
animal organ development	Orthology	biological process
heart development	Orthology	biological process
anatomical structure morphogenesis	Orthology	biological process
generation of neurons	Orthology	biological process
cell division	Orthology	biological process
receptor binding	Orthology	molecular function
membrane raft	Orthology	cellular component
plasma membrane region	Orthology	cellular component
organelle	Orthology	cellular component
macromolecular complex	Orthology	cellular component
transcription factor activity, sequence-specific DNA binding	Orthology	molecular function
intracellular signal transduction	Orthology	biological process
system development	Orthology	biological process
binding	Orthology	molecular function
brain development	Orthology	biological process
intracellular organelle part	Orthology	cellular component
whole membrane	Orthology	cellular component
cytoplasmic vesicle	Orthology	cellular component
bounding membrane of organelle	Orthology	cellular component
protein localization to organelle	Orthology	biological process
developmental process	Orthology	biological process
intracellular protein transport	Orthology	biological process
establishment of protein localization to organelle	Orthology	biological process
regulation of molecular function	Orthology	biological process
DNA binding	Orthology	molecular function
positive regulation of signal transduction	Orthology	biological process
defense response	Orthology	biological process
neurogenesis	Orthology	biological process
cell projection membrane	Orthology	cellular component
organelle part	Orthology	cellular component
cell projection part	Orthology	cellular component
anion binding	Blast	molecular function
cell-cell signaling	Blast	biological process
neuronal cell body	Blast	cellular component

GO (Orthology)

79 results

GO Term	SpeciesCe = Caenorhabditis elegans Dr = Danio rerio Dm = Drosophila melanogaster Gg = Gallus gallus Hs = Homo sapiens Mm = Mus musculus Sc = Saccharomyces cerevisiae	Type
negative regulation of transcription from RNA polymerase II promoter	Hs	biological process
ossification	Hs	biological process
vasculogenesis	Hs	biological process
osteoblast differentiation	Hs	biological process
cell fate specification	Hs	biological process
neural crest cell migration	Hs	biological process
heart looping	Hs	biological process
positive regulation of neuroblast proliferation	Hs	biological process
heart morphogenesis	Hs	biological process
determination of left/right asymmetry in lateral mesoderm	Hs	biological process
type B pancreatic cell development	Hs	biological process
signal transducer activity	Hs	molecular function
transmembrane signaling receptor activity	Hs	molecular function
G-protein coupled receptor activity	Hs	molecular function
patched binding	Hs	molecular function
protein binding	Hs	molecular function
cytoplasm	Hs	cellular component
Golgi apparatus	Hs	cellular component
plasma membrane	Hs	cellular component
caveola	Hs	cellular component
cilium	Hs	cellular component
signal transduction	Hs	biological process
cell surface receptor signaling pathway	Hs	biological process
G-protein coupled receptor signaling pathway	Hs	biological process
smoothened signaling pathway	Hs	biological process
positive regulation of hh target transcription factor activity	Hs	biological process
multicellular organism development	Hs	biological process
determination of left/right symmetry	Hs	biological process
pattern specification process	Hs	biological process
central nervous system development	Hs	biological process
midgut development	Hs	biological process
drug binding	Hs	molecular function
positive regulation of cell proliferation	Hs	biological process
anterior/posterior pattern specification	Hs	biological process
dorsal/ventral pattern formation	Hs	biological process
regulation of gene expression	Hs	biological process
positive regulation of gene expression	Hs	biological process
negative regulation of gene expression	Hs	biological process
membrane	Hs	cellular component
integral component of membrane	Hs	cellular component
Wnt-protein binding	Hs	molecular function
thalamus development	Hs	biological process
smoothened signaling pathway involved in ventral spinal cord patterning	Hs	biological process
central nervous system neuron differentiation	Hs	biological process
cerebral cortex development	Hs	biological process
endocytic vesicle membrane	Hs	cellular component
protein localization to nucleus	Hs	biological process
multicellular organism growth	Hs	biological process
positive regulation of multicellular organism growth	Hs	biological process
positive regulation of protein import into nucleus	Hs	biological process
cell projection	Hs	cellular component
negative regulation of apoptotic process	Hs	biological process
intracellular membrane-bounded organelle	Hs	cellular component
negative regulation of DNA binding	Hs	biological process
positive regulation of smoothened signaling pathway	Hs	biological process
negative regulation of transcription, DNA-templated	Hs	biological process
positive regulation of transcription, DNA-templated	Hs	biological process
positive regulation of transcription from RNA polymerase II promoter	Hs	biological process
positive regulation of organ growth	Hs	biological process
astrocyte activation	Hs	biological process
cell development	Hs	biological process
digestive tract development	Hs	biological process
embryonic organ development	Hs	biological process
developmental growth	Hs	biological process
skeletal muscle fiber development	Hs	biological process
forebrain morphogenesis	Hs	biological process
homeostasis of number of cells within a tissue	Hs	biological process
positive regulation of epithelial cell proliferation	Hs	biological process
protein stabilization	Hs	biological process
myoblast migration	Hs	biological process
ciliary membrane	Hs	cellular component
somite development	Hs	biological process
pancreas morphogenesis	Hs	biological process
extracellular exosome	Hs	cellular component
left/right axis specification	Hs	biological process
renal system development	Hs	biological process
positive regulation of branching involved in ureteric bud morphogenesis	Hs	biological process
ciliary tip	Hs	cellular component
regulation of heart morphogenesis	Hs	biological process

GO (Blast)

45 results

GO Term	SpeciesCe = Caenorhabditis elegans Dr = Danio rerio Dm = Drosophila melanogaster Gg = Gallus gallus Hs = Homo sapiens Mm = Mus musculus Sc = Saccharomyces cerevisiae	Type	Score	E-value
Golgi membrane	Hs	cellular component	145	1.57e-37
amyloid-beta binding	Hs	molecular function	145	1.57e-37
signal transducer activity	Hs	molecular function	481	2.26e-163
transmembrane signaling receptor activity	Hs	molecular function	481	2.26e-163
G-protein coupled receptor activity	Hs	molecular function	481	2.26e-163
frizzled binding	Hs	molecular function	147	3.50e-38
patched binding	Hs	molecular function	481	2.26e-163
protein binding	Hs	molecular function	481	2.26e-163
phosphatidylinositol-4,5-bisphosphate binding	Hs	molecular function	147	3.50e-38
cytoplasm	Hs	cellular component	481	2.26e-163
endosome	Hs	cellular component	147	3.50e-38
early endosome	Hs	cellular component	145	1.57e-37
Golgi apparatus	Hs	cellular component	481	2.26e-163
plasma membrane	Hs	cellular component	481	2.26e-163
integral component of plasma membrane	Hs	cellular component	145	1.57e-37
caveola	Hs	cellular component	481	2.26e-163
bicellular tight junction	Hs	cellular component	145	1.57e-37
cilium	Hs	cellular component	481	2.26e-163
drug binding	Hs	molecular function	481	2.26e-163
lipid binding	Hs	molecular function	145	1.57e-37
cell surface	Hs	cellular component	145	1.57e-37
endosome membrane	Hs	cellular component	147	3.50e-38
membrane	Hs	cellular component	481	2.26e-163
integral component of membrane	Hs	cellular component	481	2.26e-163
Wnt-protein binding	Hs	molecular function	481	2.26e-163
protein kinase binding	Hs	molecular function	145	1.57e-37
cell junction	Hs	cellular component	145	1.57e-37
PDZ domain binding	Hs	molecular function	147	3.50e-38
axon	Hs	cellular component	145	1.57e-37
dendrite	Hs	cellular component	145	1.57e-37
endocytic vesicle membrane	Hs	cellular component	481	2.26e-163
clathrin-coated endocytic vesicle membrane	Hs	cellular component	145	1.57e-37
ubiquitin protein ligase binding	Hs	molecular function	145	1.57e-37
early endosome membrane	Hs	cellular component	145	1.57e-37
Wnt-activated receptor activity	Hs	molecular function	147	3.50e-38
cell projection	Hs	cellular component	481	2.26e-163
perikaryon	Hs	cellular component	145	1.57e-37
intracellular membrane-bounded organelle	Hs	cellular component	481	2.26e-163
synapse	Hs	cellular component	145	1.57e-37
perinuclear region of cytoplasm	Hs	cellular component	145	1.57e-37
recycling endosome membrane	Hs	cellular component	147	3.50e-38
ciliary membrane	Hs	cellular component	481	2.26e-163
extracellular exosome	Hs	cellular component	481	2.26e-163
ciliary tip	Hs	cellular component	481	2.26e-163
amyloid-beta complex	Hs	cellular component	145	1.57e-37

GO (InterProScan)

6 results

GO Term	Analysis	Type	e-value
transmembrane signaling receptor activity	ProSiteProfiles	molecular function	25.406
protein binding	Gene3D	molecular function	3.3E-37
cell surface receptor signaling pathway	SMART	biological process	1.2E-92
smoothened signaling pathway	PANTHER	biological process	1.2E-215
membrane	SMART	cellular component	1.2E-92
integral component of membrane	ProSiteProfiles	cellular component	25.406