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Gene Card

Best human hits

DNMT1; KDM2B; KMT2A

Species

C. robusta formely Ciona int. type A

Unique Gene ID

Cirobu.g00013248

Gene Model ID

KH2012:KH.L9.21

Location

KhL9:190324..195386

Transcript Models and Sequences

  KH2012:KH.L9.21.v1.R.SL1-1
KH2012:KH.L9.21.v2.B.SL1-1

External Database Gene Card

External database links

1 result

Database Gene ID
ENSEMBL ENSCING00000005243
Collections

Gene collection 1 (N. Satoh)

2 results

cieg024g10

Plate: R1CiGC19k16

cieg026i20

Plate: R1CiGC19f08

WashU Genome Browser

Click here to view results in the tunicate WashU Browser

Genomicus Synteny Browser

Genomicus browser link

Regulatory Regions

Regulatory Regions

No result

n/a

Gene Phylogeny

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Gene Annotations

InterPro

13 results

IPR Term Analysis Definition
Cytosine_MeTrfase1_RFD Pfam DNA (cytosine-5)-methyltransferase 1, replication foci domain
BAH_dom SMART Bromo adjacent homology (BAH) domain
Znf_CXXC ProSiteProfiles Zinc finger, CXXC-type
BAH_dom ProSiteProfiles Bromo adjacent homology (BAH) domain
BAH_dom Pfam Bromo adjacent homology (BAH) domain
Znf_CXXC Pfam Zinc finger, CXXC-type
C5_MeTfrase PRINTS C-5 cytosine methyltransferase
C5_MeTfrase Pfam C-5 cytosine methyltransferase
C5_DNA_meth_AS ProSitePatterns DNA methylase, C-5 cytosine-specific, active site
C5_MeTfrase ProSiteProfiles C-5 cytosine methyltransferase
DNMT1-like PIRSF DNA (cytosine-5)-methyltransferase 1-like
SAM-dependent_MTases SUPERFAMILY S-adenosyl-L-methionine-dependent methyltransferase
C5_meth_CS ProSitePatterns DNA methylase, C-5 cytosine-specific, conserved site

GOSlim

44 results

GO Term Annotation Origin Type
negative regulation of transcription from RNA polymerase II promoter Orthology biological process
RNA polymerase II core promoter proximal region sequence-specific DNA binding Blast molecular function
RNA polymerase II transcription factor activity, sequence-specific DNA binding Blast molecular function
DNA binding Orthology molecular function
chromatin binding Orthology molecular function
transcription factor activity, sequence-specific DNA binding Blast molecular function
RNA binding Orthology molecular function
protein binding Orthology molecular function
nucleus Orthology cellular component
nucleoplasm Orthology cellular component
nucleolus Blast cellular component
cytosol Blast cellular component
transcription, DNA-templated Orthology biological process
regulation of transcription, DNA-templated Orthology biological process
zinc ion binding Orthology molecular function
regulation of gene expression Orthology biological process
positive regulation of gene expression Orthology biological process
transferase activity Orthology molecular function
regulation of cell proliferation Orthology biological process
identical protein binding Blast molecular function
protein homodimerization activity Blast molecular function
transcription regulatory region DNA binding Blast molecular function
negative regulation of transcription, DNA-templated Orthology biological process
metal ion binding Orthology molecular function
oxidation-reduction process Blast biological process
intracellular organelle part Orthology cellular component
intracellular non-membrane-bounded organelle Orthology cellular component
DNA metabolic process Orthology biological process
organelle organization Orthology biological process
small GTPase mediated signal transduction Orthology biological process
metabolic process Orthology biological process
sequence-specific DNA binding Orthology molecular function
nucleotide binding Orthology molecular function
negative regulation of gene expression Orthology biological process
cellular process Orthology biological process
multicellular organism development Orthology biological process
cellular protein modification process Orthology biological process
cellular response to organic substance Orthology biological process
transcription regulatory region sequence-specific DNA binding Blast molecular function
sequence-specific double-stranded DNA binding Blast molecular function
catalytic activity Blast molecular function
nuclear part Blast cellular component
macromolecular complex Blast cellular component
nucleoplasm part Blast cellular component

GO (Orthology)

37 results

GO Term SpeciesCe = Caenorhabditis elegans
Dr = Danio rerio
Dm = Drosophila melanogaster
Gg = Gallus gallus
Hs = Homo sapiens
Mm = Mus musculus
Sc = Saccharomyces cerevisiae		 Type
negative regulation of transcription from RNA polymerase II promoter Hs biological process
heterochromatin Hs cellular component
DNA binding Hs molecular function
chromatin binding Hs molecular function
RNA binding Hs molecular function
DNA (cytosine-5-)-methyltransferase activity Hs molecular function
protein binding Hs molecular function
nucleus Hs cellular component
nucleoplasm Hs cellular component
replication fork Hs cellular component
pericentric heterochromatin Hs cellular component
DNA methylation Hs biological process
chromatin organization Hs biological process
transcription, DNA-templated Hs biological process
regulation of transcription, DNA-templated Hs biological process
Ras protein signal transduction Hs biological process
methyltransferase activity Hs molecular function
zinc ion binding Hs molecular function
methyl-CpG binding Hs molecular function
DNA-methyltransferase activity Hs molecular function
maintenance of DNA methylation Hs biological process
regulation of gene expression Hs biological process
positive regulation of gene expression Hs biological process
gene silencing Hs biological process
transferase activity Hs molecular function
methylation Hs biological process
DNA methylation on cytosine Hs biological process
regulation of cell proliferation Hs biological process
DNA methylation involved in embryo development Hs biological process
negative regulation of gene expression, epigenetic Hs biological process
negative regulation of transcription, DNA-templated Hs biological process
metal ion binding Hs molecular function
positive regulation of histone H3-K4 methylation Hs biological process
cellular response to amino acid stimulus Hs biological process
C-5 methylation of cytosine Hs biological process
positive regulation of methylation-dependent chromatin silencing Hs biological process
promoter-specific chromatin binding Hs molecular function

GO (Blast)

39 results

GO Term SpeciesCe = Caenorhabditis elegans
Dr = Danio rerio
Dm = Drosophila melanogaster
Gg = Gallus gallus
Hs = Homo sapiens
Mm = Mus musculus
Sc = Saccharomyces cerevisiae		 Type Score E-value
heterochromatin Hs cellular component 1405 0.0
RNA polymerase II core promoter proximal region sequence-specific DNA binding Hs molecular function 60.8 5.26e-09
RNA polymerase II transcription factor activity, sequence-specific DNA binding Hs molecular function 54.3 5.54e-07
core promoter sequence-specific DNA binding Hs molecular function 54.3 5.54e-07
DNA binding Hs molecular function 1405 0.0
AT DNA binding Hs molecular function 54.3 5.54e-07
chromatin binding Hs molecular function 1405 0.0
transcription factor activity, sequence-specific DNA binding Hs molecular function 54.3 5.54e-07
RNA binding Hs molecular function 1405 0.0
DNA (cytosine-5-)-methyltransferase activity Hs molecular function 1405 0.0
protein binding Hs molecular function 1405 0.0
nucleus Hs cellular component 1405 0.0
nucleoplasm Hs cellular component 1405 0.0
replication fork Hs cellular component 1405 0.0
pericentric heterochromatin Hs cellular component 1405 0.0
nucleolus Hs cellular component 60.8 5.26e-09
cytosol Hs cellular component 54.3 5.54e-07
methyltransferase activity Hs molecular function 1405 0.0
zinc ion binding Hs molecular function 1405 0.0
methyl-CpG binding Hs molecular function 1405 0.0
DNA-methyltransferase activity Hs molecular function 1405 0.0
oxidoreductase activity Hs molecular function 60.8 5.26e-09
transferase activity Hs molecular function 1405 0.0
histone-lysine N-methyltransferase activity Hs molecular function 54.3 5.54e-07
rRNA binding Hs molecular function 60.8 5.26e-09
PcG protein complex Hs cellular component 60.8 5.26e-09
histone demethylase activity Hs molecular function 60.8 5.26e-09
histone methyltransferase complex Hs cellular component 54.3 5.54e-07
histone methyltransferase activity (H3-K4 specific) Hs molecular function 54.3 5.54e-07
identical protein binding Hs molecular function 54.3 5.54e-07
protein homodimerization activity Hs molecular function 54.3 5.54e-07
transcription regulatory region DNA binding Hs molecular function 54.3 5.54e-07
unmethylated CpG binding Hs molecular function 54.3 5.54e-07
metal ion binding Hs molecular function 1405 0.0
dioxygenase activity Hs molecular function 60.8 5.26e-09
histone demethylase activity (H3-K36 specific) Hs molecular function 60.8 5.26e-09
lysine-acetylated histone binding Hs molecular function 54.3 5.54e-07
MLL1 complex Hs cellular component 54.3 5.54e-07
promoter-specific chromatin binding Hs molecular function 1405 0.0

GO (InterProScan)

7 results

GO Term Analysis Type e-value
DNA binding Pfam molecular function 1.6E-14
chromatin binding SMART molecular function 2.2E-15
DNA (cytosine-5-)-methyltransferase activity PIRSF molecular function 0.0
nucleus PIRSF cellular component 0.0
methyltransferase activity Pfam molecular function 1.4E-46
zinc ion binding Pfam molecular function 1.6E-14
C-5 methylation of cytosine PIRSF biological process 0.0

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