Aniseed - Gene card

Gene Card

Best human hits

TRAF2; TRAF3; TRAF5

Species

C. robusta formely Ciona int. type A

Unique Gene ID

Cirobu.g00014171

Gene Model ID

KH2012:KH.S2039.1

Location

KhS2039:1196..3393

Transcript Models and Sequences

KH2012:KH.S2039.1.v1.A.ND1-1

External Database Gene Card

External database links

1 result

Database	Gene ID
ENSEMBL	ENSCING00000002932

Collections

Gene collection 1 (N. Satoh)

1 result

ciad063i21

Plate: R1CiGC06o12

WashU Genome Browser

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Genomicus Synteny Browser

Regulatory Regions

No result

n/a

Gene Phylogeny

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Gene Annotations

InterPro

5 results

IPR Term	Analysis	Definition
TRAF-like	SUPERFAMILY	TRAF-like
MATH/TRAF_dom	SMART	MATH/TRAF domain
MATH/TRAF_dom	ProSiteProfiles	MATH/TRAF domain
TRAF1	PANTHER	TNF receptor-associated factor 1
TRAF-like	Gene3D	TRAF-like

GOSlim

62 results

GO Term	Annotation Origin	Type
immune system process	Orthology	biological process
ubiquitin-protein transferase activity	Orthology	molecular function
signal transducer activity	Orthology	molecular function
receptor binding	Orthology	molecular function
protein binding	Orthology	molecular function
intracellular	Orthology	cellular component
nucleoplasm	Orthology	cellular component
cytoplasm	Orthology	cellular component
mitochondrion	Orthology	cellular component
endosome	Orthology	cellular component
centrosome	Orthology	cellular component
cytosol	Orthology	cellular component
apoptotic process	Orthology	biological process
signal transduction	Orthology	biological process
zinc ion binding	Orthology	molecular function
protein ubiquitination	Orthology	biological process
transferase activity	Orthology	molecular function
enzyme binding	Orthology	molecular function
protein kinase binding	Orthology	molecular function
ubiquitin protein ligase binding	Orthology	molecular function
identical protein binding	Orthology	molecular function
regulation of apoptotic process	Orthology	biological process
innate immune response	Orthology	biological process
membrane raft	Orthology	cellular component
metal ion binding	Orthology	molecular function
intracellular part	Orthology	cellular component
macromolecular complex	Orthology	cellular component
cell periphery	Orthology	cellular component
cytoplasmic part	Orthology	cellular component
endopeptidase activity	Orthology	molecular function
positive regulation of hydrolase activity	Orthology	biological process
positive regulation of apoptotic process	Orthology	biological process
transcription factor activity, sequence-specific DNA binding	Orthology	molecular function
intracellular signal transduction	Orthology	biological process
positive regulation of catalytic activity	Orthology	biological process
enzyme regulator activity	Orthology	molecular function
protein kinase activity	Orthology	molecular function
positive regulation of signal transduction	Orthology	biological process
cell surface receptor signaling pathway	Orthology	biological process
binding	Orthology	molecular function
plasma membrane part	Orthology	cellular component
vesicle	Orthology	cellular component
organelle membrane	Orthology	cellular component
peptidase activity, acting on L-amino acid peptides	Orthology	molecular function
proteolysis	Orthology	biological process
protein metabolic process	Orthology	biological process
regulation of molecular function	Orthology	biological process
cytokine-mediated signaling pathway	Orthology	biological process
negative regulation of apoptotic process	Orthology	biological process
cellular response to stress	Orthology	biological process
integral component of plasma membrane	Orthology	cellular component
protein serine/threonine kinase activity	Orthology	molecular function
regulation of signal transduction	Orthology	biological process
regulation of cellular metabolic process	Orthology	biological process
protein phosphorylation	Orthology	biological process
defense response	Orthology	biological process
protein oligomerization	Orthology	biological process
protein homooligomerization	Orthology	biological process
protein polyubiquitination	Orthology	biological process
negative regulation of cell death	Orthology	biological process
negative regulation of signal transduction	Orthology	biological process
endoplasmic reticulum membrane	Orthology	cellular component

GO (Orthology)

70 results

GO Term	SpeciesCe = Caenorhabditis elegans Dr = Danio rerio Dm = Drosophila melanogaster Gg = Gallus gallus Hs = Homo sapiens Mm = Mus musculus Sc = Saccharomyces cerevisiae	Type
ubiquitin ligase complex	Hs	cellular component
regulation of cytokine production	Hs	biological process
toll-like receptor signaling pathway	Hs	biological process
immune system process	Hs	biological process
ubiquitin-protein transferase activity	Hs	molecular function
signal transducer activity	Hs	molecular function
receptor binding	Hs	molecular function
tumor necrosis factor receptor binding	Hs	molecular function
CD40 receptor binding	Hs	molecular function
protein binding	Hs	molecular function
intracellular	Hs	cellular component
nucleoplasm	Hs	cellular component
cytoplasm	Hs	cellular component
mitochondrion	Hs	cellular component
endosome	Hs	cellular component
centrosome	Hs	cellular component
cytosol	Hs	cellular component
cell cortex	Hs	cellular component
apoptotic process	Hs	biological process
activation of cysteine-type endopeptidase activity involved in apoptotic process	Hs	biological process
signal transduction	Hs	biological process
I-kappaB kinase/NF-kappaB signaling	Hs	biological process
activation of NF-kappaB-inducing kinase activity	Hs	biological process
Toll signaling pathway	Hs	biological process
zinc ion binding	Hs	molecular function
lipid binding	Hs	molecular function
cytoplasmic side of plasma membrane	Hs	cellular component
vesicle membrane	Hs	cellular component
protein ubiquitination	Hs	biological process
protein deubiquitination	Hs	biological process
transferase activity	Hs	molecular function
enzyme binding	Hs	molecular function
protein kinase binding	Hs	molecular function
protein phosphatase binding	Hs	molecular function
regulation of proteolysis	Hs	biological process
protein catabolic process	Hs	biological process
mitogen-activated protein kinase kinase kinase binding	Hs	molecular function
ubiquitin protein ligase binding	Hs	molecular function
thioesterase binding	Hs	molecular function
negative regulation of NF-kappaB transcription factor activity	Hs	biological process
negative regulation of type I interferon production	Hs	biological process
tumor necrosis factor-mediated signaling pathway	Hs	biological process
negative regulation of glial cell apoptotic process	Hs	biological process
response to endoplasmic reticulum stress	Hs	biological process
CD40 receptor complex	Hs	cellular component
TRIF-dependent toll-like receptor signaling pathway	Hs	biological process
identical protein binding	Hs	molecular function
regulation of apoptotic process	Hs	biological process
positive regulation of I-kappaB kinase/NF-kappaB signaling	Hs	biological process
positive regulation of JUN kinase activity	Hs	biological process
innate immune response	Hs	biological process
membrane raft	Hs	cellular component
regulation of JNK cascade	Hs	biological process
sphingolipid binding	Hs	molecular function
metal ion binding	Hs	molecular function
regulation of defense response to virus	Hs	biological process
positive regulation of sequence-specific DNA binding transcription factor activity	Hs	biological process
positive regulation of NF-kappaB transcription factor activity	Hs	biological process
protein heterooligomerization	Hs	biological process
protein autoubiquitination	Hs	biological process
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress	Hs	biological process
protein homotrimerization	Hs	biological process
protein K63-linked ubiquitination	Hs	biological process
TRAF2-GSTP1 complex	Hs	cellular component
negative regulation of neuron death	Hs	biological process
regulation of extrinsic apoptotic signaling pathway via death domain receptors	Hs	biological process
negative regulation of extrinsic apoptotic signaling pathway via death domain receptors	Hs	biological process
AIP1-IRE1 complex	Hs	cellular component
IRE1-TRAF2-ASK1 complex	Hs	cellular component
positive regulation of extrinsic apoptotic signaling pathway	Hs	biological process

GO (Blast)

34 results

GO Term	SpeciesCe = Caenorhabditis elegans Dr = Danio rerio Dm = Drosophila melanogaster Gg = Gallus gallus Hs = Homo sapiens Mm = Mus musculus Sc = Saccharomyces cerevisiae	Type	Score	E-value
ubiquitin ligase complex	Hs	cellular component	230	2.06e-72
ubiquitin-protein transferase activity	Hs	molecular function	295	1.61e-96
signal transducer activity	Hs	molecular function	295	1.61e-96
receptor binding	Hs	molecular function	230	2.06e-72
tumor necrosis factor receptor binding	Hs	molecular function	295	1.61e-96
CD40 receptor binding	Hs	molecular function	230	2.06e-72
protein binding	Hs	molecular function	295	1.61e-96
intracellular	Hs	cellular component	230	2.06e-72
nucleoplasm	Hs	cellular component	230	2.06e-72
cytoplasm	Hs	cellular component	295	1.61e-96
mitochondrion	Hs	cellular component	295	1.61e-96
endosome	Hs	cellular component	295	1.61e-96
centrosome	Hs	cellular component	229	2.90e-71
cytosol	Hs	cellular component	295	1.61e-96
cell cortex	Hs	cellular component	230	2.06e-72
zinc ion binding	Hs	molecular function	295	1.61e-96
lipid binding	Hs	molecular function	230	2.06e-72
cytoplasmic side of plasma membrane	Hs	cellular component	295	1.61e-96
vesicle membrane	Hs	cellular component	230	2.06e-72
transferase activity	Hs	molecular function	295	1.61e-96
enzyme binding	Hs	molecular function	230	2.06e-72
protein kinase binding	Hs	molecular function	295	1.61e-96
protein phosphatase binding	Hs	molecular function	295	1.61e-96
mitogen-activated protein kinase kinase kinase binding	Hs	molecular function	230	2.06e-72
ubiquitin protein ligase binding	Hs	molecular function	295	1.61e-96
thioesterase binding	Hs	molecular function	295	1.61e-96
CD40 receptor complex	Hs	cellular component	295	1.61e-96
identical protein binding	Hs	molecular function	230	2.06e-72
membrane raft	Hs	cellular component	230	2.06e-72
sphingolipid binding	Hs	molecular function	230	2.06e-72
metal ion binding	Hs	molecular function	295	1.61e-96
TRAF2-GSTP1 complex	Hs	cellular component	230	2.06e-72
AIP1-IRE1 complex	Hs	cellular component	230	2.06e-72
IRE1-TRAF2-ASK1 complex	Hs	cellular component	230	2.06e-72

GO (InterProScan)

3 results

GO Term	Analysis	Type	e-value
tumor necrosis factor receptor binding	PANTHER	molecular function	3.2E-106
protein binding	Gene3D	molecular function	6.9E-69
regulation of apoptotic process	PANTHER	biological process	3.2E-106