Gene Card
Best human hits
SIRT2; SIRT3
Unique Gene ID
Cirobu.g00014461
Gene Model ID
KH2012:KH.S406.22
Location
KhS406:21661..25307
Transcript Models and Sequences
KH2012:KH.S406.22.v1.A.nonSL10-1
KH2012:KH.S406.22.v1.A.nonSL4-1
KH2012:KH.S406.22.v1.A.nonSL5-1
KH2012:KH.S406.22.v1.A.nonSL6-1
KH2012:KH.S406.22.v1.A.nonSL8-1
KH2012:KH.S406.22.v1.A.nonSL9-1
KH2012:KH.S406.22.v1.A.SL7-1
KH2012:KH.S406.22.v1.R.ND1-1
KH2012:KH.S406.22.v2.A.SL2-1
KH2012:KH.S406.22.v3.A.SL3-1
External database links
2 results
| Database | Gene ID |
|---|---|
| ENSEMBL | ENSCING00000022806 |
| NCBI Reference Sequence | XM_002127382.4 |
Gene collection 1 (N. Satoh)
2 results
cibd013n15
Plate: R1CiGC37l13
cigd011c08
Plate: R1CiGC41o23
n/a
You can Right Mouse Click on internal nodes, leaves and outside the tree to see multiple options adapted to your selection.
The 'History' button on the left side permits you to see the changes you have made and eventually to go back.
You can Press 'Shift' Key + Left Mouse Click on the leaf's node to access to a gene card in a new window.
You can Press 'Ctrl' Key + Left Mouse Click on nodes to do a multiple selection.
Click here to see how you can interact with this tree
The 'History' button on the left side permits you to see the changes you have made and eventually to go back.
You can Press 'Shift' Key + Left Mouse Click on the leaf's node to access to a gene card in a new window.
You can Press 'Ctrl' Key + Left Mouse Click on nodes to do a multiple selection.
Click here to see the tree inference method
InterPro
4 results
| IPR Term | Analysis | Definition |
|---|---|---|
| Sirtuin_cat_small_dom_sf | Gene3D | Sirtuin, catalytic core small domain superfamily |
| Sirtuin | Pfam | Sirtuin family |
| DHS-like_NAD/FAD-binding_dom | SUPERFAMILY | DHS-like NAD/FAD-binding domain superfamily |
| Ssirtuin_cat_dom | ProSiteProfiles | Sirtuin family, catalytic core domain |
GOSlim
51 results
| GO Term | Annotation Origin | Type |
|---|---|---|
| chromatin binding | Blast | molecular function |
| protein binding | Orthology | molecular function |
| nucleus | Blast | cellular component |
| nucleolus | Blast | cellular component |
| cytoplasm | Blast | cellular component |
| mitochondrion | Orthology | cellular component |
| mitochondrial matrix | Orthology | cellular component |
| centrosome | Blast | cellular component |
| microtubule organizing center | Blast | cellular component |
| cytosol | Blast | cellular component |
| cytoskeleton | Blast | cellular component |
| microtubule | Blast | cellular component |
| plasma membrane | Blast | cellular component |
| transcription factor binding | Blast | molecular function |
| zinc ion binding | Orthology | molecular function |
| membrane | Blast | cellular component |
| hydrolase activity | Orthology | molecular function |
| enzyme binding | Orthology | molecular function |
| midbody | Blast | cellular component |
| macromolecular complex | Orthology | cellular component |
| cell projection | Blast | cellular component |
| myelin sheath | Blast | cellular component |
| sequence-specific DNA binding | Orthology | molecular function |
| metal ion binding | Orthology | molecular function |
| perinuclear region of cytoplasm | Blast | cellular component |
| transferase activity | Orthology | molecular function |
| cellular protein modification process | Orthology | biological process |
| organelle organization | Orthology | biological process |
| developmental process | Orthology | biological process |
| oxidation-reduction process | Orthology | biological process |
| cellular metabolic process | Orthology | biological process |
| protein transport | Orthology | biological process |
| cell-cell signaling | Orthology | biological process |
| intracellular signal transduction | Orthology | biological process |
| negative regulation of signal transduction | Orthology | biological process |
| protein phosphorylation | Orthology | biological process |
| anion binding | Orthology | molecular function |
| nucleotide binding | Orthology | molecular function |
| coenzyme binding | Orthology | molecular function |
| intracellular organelle part | Blast | cellular component |
| intracellular non-membrane-bounded organelle | Blast | cellular component |
| nucleoplasm part | Blast | cellular component |
| nuclear lumen | Blast | cellular component |
| cytoplasmic part | Blast | cellular component |
| cytoskeletal part | Blast | cellular component |
| microtubule cytoskeleton | Blast | cellular component |
| cell projection part | Blast | cellular component |
| axon | Blast | cellular component |
| cell junction | Blast | cellular component |
| neuronal cell body | Blast | cellular component |
| plasma membrane region | Blast | cellular component |
GO (Orthology)
22 results
| GO Term | SpeciesCe = Caenorhabditis elegans Dr = Danio rerio Dm = Drosophila melanogaster Gg = Gallus gallus Hs = Homo sapiens Mm = Mus musculus Sc = Saccharomyces cerevisiae |
Type |
|---|---|---|
| NAD+ ADP-ribosyltransferase activity | Hs | molecular function |
| protein binding | Hs | molecular function |
| mitochondrion | Hs | cellular component |
| mitochondrial matrix | Hs | cellular component |
| protein ADP-ribosylation | Hs | biological process |
| protein deacetylation | Hs | biological process |
| mitochondrion organization | Hs | biological process |
| aging | Hs | biological process |
| zinc ion binding | Hs | molecular function |
| aerobic respiration | Hs | biological process |
| histone deacetylation | Hs | biological process |
| hydrolase activity | Hs | molecular function |
| NAD-dependent histone deacetylase activity | Hs | molecular function |
| enzyme binding | Hs | molecular function |
| positive regulation of insulin secretion | Hs | biological process |
| macromolecular complex | Hs | cellular component |
| NAD-dependent protein deacetylase activity | Hs | molecular function |
| sequence-specific DNA binding | Hs | molecular function |
| metal ion binding | Hs | molecular function |
| negative regulation of ERK1 and ERK2 cascade | Hs | biological process |
| NAD+ binding | Hs | molecular function |
| negative regulation of reactive oxygen species metabolic process | Hs | biological process |
GO (Blast)
52 results
| GO Term | SpeciesCe = Caenorhabditis elegans Dr = Danio rerio Dm = Drosophila melanogaster Gg = Gallus gallus Hs = Homo sapiens Mm = Mus musculus Sc = Saccharomyces cerevisiae |
Type | Score | E-value |
|---|---|---|---|---|
| chromosome, telomeric region | Hs | cellular component | 266 | 7.61e-84 |
| chromatin binding | Hs | molecular function | 266 | 7.61e-84 |
| NAD+ ADP-ribosyltransferase activity | Hs | molecular function | 327 | 2.70e-107 |
| histone deacetylase activity | Hs | molecular function | 266 | 7.61e-84 |
| protein binding | Hs | molecular function | 327 | 2.70e-107 |
| nucleus | Hs | cellular component | 266 | 7.61e-84 |
| chromatin silencing complex | Hs | cellular component | 266 | 7.61e-84 |
| chromosome | Hs | cellular component | 266 | 7.61e-84 |
| nuclear heterochromatin | Hs | cellular component | 266 | 7.61e-84 |
| nucleolus | Hs | cellular component | 266 | 7.61e-84 |
| cytoplasm | Hs | cellular component | 266 | 7.61e-84 |
| mitochondrion | Hs | cellular component | 327 | 2.70e-107 |
| mitochondrial matrix | Hs | cellular component | 327 | 2.70e-107 |
| centrosome | Hs | cellular component | 266 | 7.61e-84 |
| centriole | Hs | cellular component | 266 | 7.61e-84 |
| microtubule organizing center | Hs | cellular component | 266 | 7.61e-84 |
| spindle | Hs | cellular component | 266 | 7.61e-84 |
| cytosol | Hs | cellular component | 266 | 7.61e-84 |
| cytoskeleton | Hs | cellular component | 266 | 7.61e-84 |
| microtubule | Hs | cellular component | 266 | 7.61e-84 |
| plasma membrane | Hs | cellular component | 266 | 7.61e-84 |
| transcription factor binding | Hs | molecular function | 266 | 7.61e-84 |
| zinc ion binding | Hs | molecular function | 327 | 2.70e-107 |
| membrane | Hs | cellular component | 266 | 7.61e-84 |
| hydrolase activity | Hs | molecular function | 327 | 2.70e-107 |
| NAD-dependent histone deacetylase activity | Hs | molecular function | 327 | 2.70e-107 |
| enzyme binding | Hs | molecular function | 327 | 2.70e-107 |
| growth cone | Hs | cellular component | 266 | 7.61e-84 |
| midbody | Hs | cellular component | 266 | 7.61e-84 |
| macromolecular complex | Hs | cellular component | 327 | 2.70e-107 |
| paranodal junction | Hs | cellular component | 266 | 7.61e-84 |
| paranode region of axon | Hs | cellular component | 266 | 7.61e-84 |
| protein deacetylase activity | Hs | molecular function | 266 | 7.61e-84 |
| NAD-dependent protein deacetylase activity | Hs | molecular function | 327 | 2.70e-107 |
| histone acetyltransferase binding | Hs | molecular function | 266 | 7.61e-84 |
| histone deacetylase binding | Hs | molecular function | 266 | 7.61e-84 |
| tubulin deacetylase activity | Hs | molecular function | 266 | 7.61e-84 |
| cell projection | Hs | cellular component | 266 | 7.61e-84 |
| ubiquitin binding | Hs | molecular function | 266 | 7.61e-84 |
| perikaryon | Hs | cellular component | 266 | 7.61e-84 |
| myelin sheath | Hs | cellular component | 266 | 7.61e-84 |
| lateral loop | Hs | cellular component | 266 | 7.61e-84 |
| Schmidt-Lanterman incisure | Hs | cellular component | 266 | 7.61e-84 |
| sequence-specific DNA binding | Hs | molecular function | 327 | 2.70e-107 |
| juxtaparanode region of axon | Hs | cellular component | 266 | 7.61e-84 |
| metal ion binding | Hs | molecular function | 327 | 2.70e-107 |
| NAD-dependent histone deacetylase activity (H4-K16 specific) | Hs | molecular function | 266 | 7.61e-84 |
| perinuclear region of cytoplasm | Hs | cellular component | 266 | 7.61e-84 |
| NAD+ binding | Hs | molecular function | 327 | 2.70e-107 |
| mitotic spindle | Hs | cellular component | 266 | 7.61e-84 |
| meiotic spindle | Hs | cellular component | 266 | 7.61e-84 |
| glial cell projection | Hs | cellular component | 266 | 7.61e-84 |
GO (InterProScan)
1 result
| GO Term | Analysis | Type | e-value |
|---|---|---|---|
| NAD+ binding | Pfam | molecular function | 1.1E-52 |
