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Gene Card

Best human hits

FGFR1; FGFR2; FGFR3

Species

C. robusta formely Ciona int. type A

Unique Gene ID

Cirobu.g00014992

Gene Model ID

KH2012:KH.S742.2

Location

KhS742:7983..25989

Transcript Models and Sequences

  KH2012:KH.S742.2.v1.B.SL1-1
KH2012:KH.S742.2.v2.B.SL2-1

External Database Gene Card

External database links

No result

Collections

Gateway full ORF

3 results

cien98762

Plate: VES85_K18

cien190405

Plate: VES99_L18

cien200974

Plate: VES101_G13

Gene collection 1 (N. Satoh)

1 result

citb040h06

Plate: R1CiGC32j14

WashU Genome Browser

Click here to view results in the tunicate WashU Browser

Genomicus Synteny Browser

Genomicus browser link

Regulatory Regions

Regulatory Regions

No result

n/a

Gene Phylogeny

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Gene Annotations

InterPro

13 results

IPR Term Analysis Definition
Ig-like_fold Gene3D Immunoglobulin-like fold
Ig-like_dom ProSiteProfiles Immunoglobulin-like domain
Prot_kinase_dom ProSiteProfiles Protein kinase domain
Ser-Thr/Tyr_kinase_cat_dom PRINTS Serine-threonine/tyrosine-protein kinase, catalytic domain
Ser-Thr/Tyr_kinase_cat_dom Pfam Serine-threonine/tyrosine-protein kinase, catalytic domain
Tyr_kinase_cat_dom SMART Tyrosine-protein kinase, catalytic domain
Tyr_kinase_AS ProSitePatterns Tyrosine-protein kinase, active site
Ig_I-set Pfam Immunoglobulin I-set
Ig-like_dom_sf SUPERFAMILY Immunoglobulin-like domain superfamily
Ig_sub SMART Immunoglobulin subtype
FGF_rcpt_fam PIRSF Fibroblast growth factor receptor family
Kinase-like_dom_sf SUPERFAMILY Protein kinase-like domain superfamily
Ig_sub2 SMART Immunoglobulin subtype 2

GOSlim

98 results

GO Term Annotation Origin Type
negative regulation of transcription from RNA polymerase II promoter Orthology biological process
nucleotide binding Orthology molecular function
angiogenesis Orthology biological process
protein kinase activity Orthology molecular function
protein binding Orthology molecular function
ATP binding Orthology molecular function
extracellular region Orthology cellular component
nucleus Orthology cellular component
nucleoplasm Orthology cellular component
nucleolus Orthology cellular component
cytoplasm Orthology cellular component
endoplasmic reticulum Orthology cellular component
Golgi apparatus Orthology cellular component
cytosol Orthology cellular component
plasma membrane Orthology cellular component
integral component of plasma membrane Orthology cellular component
focal adhesion Orthology cellular component
transcription, DNA-templated Orthology biological process
regulation of transcription, DNA-templated Orthology biological process
protein phosphorylation Orthology biological process
apoptotic process Orthology biological process
cell-cell signaling Orthology biological process
axonogenesis Orthology biological process
brain development Orthology biological process
sensory perception of sound Orthology biological process
positive regulation of cell proliferation Orthology biological process
cell surface Orthology cellular component
regulation of gene expression Orthology biological process
negative regulation of gene expression Orthology biological process
membrane Orthology cellular component
integral component of membrane Orthology cellular component
kinase activity Orthology molecular function
phosphorylation Orthology biological process
cell migration Orthology biological process
transferase activity Orthology molecular function
positive regulation of Wnt signaling pathway Orthology biological process
cytoplasmic vesicle Orthology cellular component
response to lipopolysaccharide Orthology biological process
wound healing Orthology biological process
regulation of cell proliferation Orthology biological process
identical protein binding Orthology molecular function
protein homodimerization activity Orthology molecular function
intracellular membrane-bounded organelle Orthology cellular component
positive regulation of transcription from RNA polymerase II promoter Orthology biological process
protein autophosphorylation Orthology biological process
blood vessel morphogenesis Orthology biological process
generation of neurons Orthology biological process
positive regulation of canonical Wnt signaling pathway Orthology biological process
endosome Orthology cellular component
positive regulation of gene expression Orthology biological process
positive regulation of catalytic activity Orthology biological process
intracellular signal transduction Orthology biological process
system development Orthology biological process
animal organ development Orthology biological process
anatomical structure formation involved in morphogenesis Orthology biological process
cell differentiation Orthology biological process
anatomical structure morphogenesis Orthology biological process
transmembrane signaling receptor activity Orthology molecular function
cell surface receptor signaling pathway Orthology biological process
cellular response to organic substance Orthology biological process
enzyme binding Orthology molecular function
molecular function regulator Orthology molecular function
cell periphery Orthology cellular component
cytoplasmic part Orthology cellular component
anion binding Orthology molecular function
carbohydrate derivative binding Orthology molecular function
regulation of signal transduction Orthology biological process
multicellular organism development Orthology biological process
positive regulation of hydrolase activity Orthology biological process
neuron projection development Orthology biological process
positive regulation of signal transduction Orthology biological process
phosphotransferase activity, alcohol group as acceptor Orthology molecular function
cellular biosynthetic process Orthology biological process
endomembrane system Orthology cellular component
anatomical structure development Orthology biological process
extracellular region part Orthology cellular component
developmental process Orthology biological process
cell proliferation Orthology biological process
phosphate-containing compound metabolic process Orthology biological process
macromolecular complex Orthology cellular component
protein serine/threonine kinase activity Orthology molecular function
response to organic substance Orthology biological process
cell development Orthology biological process
neuron differentiation Orthology biological process
cell cycle Orthology biological process
organic substance metabolic process Orthology biological process
reproductive process Orthology biological process
nervous system development Orthology biological process
negative regulation of cell proliferation Orthology biological process
cell division Orthology biological process
heart development Orthology biological process
synapse Orthology cellular component
neuron development Orthology biological process
regulation of cellular metabolic process Orthology biological process
response to lipid Orthology biological process
receptor binding Orthology molecular function
cell junction Orthology cellular component
proteolysis Orthology biological process

GO (Orthology)

141 results

GO Term SpeciesCe = Caenorhabditis elegans
Dr = Danio rerio
Dm = Drosophila melanogaster
Gg = Gallus gallus
Hs = Homo sapiens
Mm = Mus musculus
Sc = Saccharomyces cerevisiae		 Type
negative regulation of transcription from RNA polymerase II promoter Hs biological process
MAPK cascade Hs biological process
nucleotide binding Hs molecular function
skeletal system development Hs biological process
angiogenesis Hs biological process
ureteric bud development Hs biological process
organ induction Hs biological process
neuron migration Hs biological process
epithelial to mesenchymal transition Hs biological process
endochondral ossification Hs biological process
chondrocyte differentiation Hs biological process
protein kinase activity Hs molecular function
protein tyrosine kinase activity Hs molecular function
transmembrane receptor protein tyrosine kinase activity Hs molecular function
fibroblast growth factor-activated receptor activity Hs molecular function
Ras guanyl-nucleotide exchange factor activity Hs molecular function
protein binding Hs molecular function
ATP binding Hs molecular function
extracellular region Hs cellular component
nucleus Hs cellular component
nucleoplasm Hs cellular component
nucleolus Hs cellular component
cytoplasm Hs cellular component
endoplasmic reticulum Hs cellular component
Golgi apparatus Hs cellular component
cytosol Hs cellular component
plasma membrane Hs cellular component
integral component of plasma membrane Hs cellular component
focal adhesion Hs cellular component
cell cortex Hs cellular component
transcription, DNA-templated Hs biological process
regulation of transcription, DNA-templated Hs biological process
protein phosphorylation Hs biological process
apoptotic process Hs biological process
cell-cell signaling Hs biological process
axonogenesis Hs biological process
brain development Hs biological process
salivary gland morphogenesis Hs biological process
sensory perception of sound Hs biological process
heparin binding Hs molecular function
positive regulation of cell proliferation Hs biological process
fibroblast growth factor receptor signaling pathway Hs biological process
regulation of smoothened signaling pathway Hs biological process
post-embryonic development Hs biological process
embryonic pattern specification Hs biological process
animal organ morphogenesis Hs biological process
cell surface Hs cellular component
regulation of gene expression Hs biological process
negative regulation of gene expression Hs biological process
positive regulation of phospholipase C activity Hs biological process
positive regulation of neuron projection development Hs biological process
positive regulation of phosphatidylinositol 3-kinase signaling Hs biological process
membrane Hs cellular component
integral component of membrane Hs cellular component
kinase activity Hs molecular function
1-phosphatidylinositol-3-kinase activity Hs molecular function
phosphorylation Hs biological process
morphogenesis of embryonic epithelium Hs biological process
cell migration Hs biological process
transferase activity Hs molecular function
fibroblast growth factor binding Hs molecular function
peptidyl-tyrosine phosphorylation Hs biological process
transport vesicle Hs cellular component
positive regulation of Wnt signaling pathway Hs biological process
bone mineralization Hs biological process
lung development Hs biological process
embryonic limb morphogenesis Hs biological process
epithelial cell differentiation Hs biological process
midbrain development Hs biological process
otic vesicle formation Hs biological process
extracellular matrix Hs cellular component
cytoplasmic vesicle Hs cellular component
response to lipopolysaccharide Hs biological process
regulation of osteoblast proliferation Hs biological process
multicellular organism growth Hs biological process
organ growth Hs biological process
chondrocyte proliferation Hs biological process
phosphatidylinositol-3-phosphate biosynthetic process Hs biological process
regulation of multicellular organism growth Hs biological process
regulation of fibroblast growth factor receptor signaling pathway Hs biological process
wound healing Hs biological process
regulation of cell proliferation Hs biological process
inner ear morphogenesis Hs biological process
odontogenesis Hs biological process
positive regulation of tyrosine phosphorylation of STAT protein Hs biological process
identical protein binding Hs molecular function
protein homodimerization activity Hs molecular function
chordate embryonic development Hs biological process
intracellular membrane-bounded organelle Hs cellular component
receptor complex Hs cellular component
positive regulation of MAP kinase activity Hs biological process
positive regulation of MAPK cascade Hs biological process
ear development Hs biological process
cell fate commitment Hs biological process
response to ethanol Hs biological process
regulation of cell differentiation Hs biological process
positive regulation of neuron differentiation Hs biological process
regulation of osteoblast differentiation Hs biological process
positive regulation of cell cycle Hs biological process
positive regulation of transcription from RNA polymerase II promoter Hs biological process
protein autophosphorylation Hs biological process
phosphatidylinositol phosphorylation Hs biological process
phosphatidylinositol-4,5-bisphosphate 3-kinase activity Hs molecular function
phosphatidylinositol-mediated signaling Hs biological process
mesodermal cell differentiation Hs biological process
paraxial mesoderm development Hs biological process
blood vessel morphogenesis Hs biological process
embryonic digestive tract morphogenesis Hs biological process
embryonic organ morphogenesis Hs biological process
digestive tract development Hs biological process
embryonic organ development Hs biological process
reproductive structure development Hs biological process
generation of neurons Hs biological process
embryonic cranial skeleton morphogenesis Hs biological process
skeletal system morphogenesis Hs biological process
epidermis morphogenesis Hs biological process
branching morphogenesis of a nerve Hs biological process
positive regulation of epithelial cell proliferation Hs biological process
negative regulation of epithelial cell proliferation Hs biological process
positive regulation of cell division Hs biological process
positive regulation of protein kinase B signaling Hs biological process
ventricular cardiac muscle tissue morphogenesis Hs biological process
excitatory synapse Hs cellular component
auditory receptor cell development Hs biological process
limb bud formation Hs biological process
bone development Hs biological process
bone morphogenesis Hs biological process
regulation of ERK1 and ERK2 cascade Hs biological process
positive regulation of ERK1 and ERK2 cascade Hs biological process
cellular response to retinoic acid Hs biological process
cellular response to transforming growth factor beta stimulus Hs biological process
positive regulation of canonical Wnt signaling pathway Hs biological process
receptor-receptor interaction Hs molecular function
endosome Hs cellular component
cell-cell junction Hs cellular component
positive regulation of gene expression Hs biological process
regulation of lipid metabolic process Hs biological process
glucose homeostasis Hs biological process
positive regulation of catalytic activity Hs biological process
positive regulation of proteolysis Hs biological process
phosphate ion homeostasis Hs biological process

GO (Blast)

38 results

GO Term SpeciesCe = Caenorhabditis elegans
Dr = Danio rerio
Dm = Drosophila melanogaster
Gg = Gallus gallus
Hs = Homo sapiens
Mm = Mus musculus
Sc = Saccharomyces cerevisiae		 Type Score E-value
nucleotide binding Hs molecular function 603 0.0
protein kinase activity Hs molecular function 603 0.0
protein tyrosine kinase activity Hs molecular function 603 0.0
transmembrane receptor protein tyrosine kinase activity Hs molecular function 603 0.0
fibroblast growth factor-activated receptor activity Hs molecular function 603 0.0
Ras guanyl-nucleotide exchange factor activity Hs molecular function 603 0.0
protein binding Hs molecular function 603 0.0
ATP binding Hs molecular function 603 0.0
extracellular region Hs cellular component 603 0.0
nucleus Hs cellular component 603 0.0
nucleoplasm Hs cellular component 572 0.0
nucleolus Hs cellular component 603 0.0
cytoplasm Hs cellular component 603 0.0
endoplasmic reticulum Hs cellular component 543 0.0
Golgi apparatus Hs cellular component 572 0.0
cytosol Hs cellular component 603 0.0
plasma membrane Hs cellular component 603 0.0
integral component of plasma membrane Hs cellular component 603 0.0
focal adhesion Hs cellular component 543 0.0
cell cortex Hs cellular component 572 0.0
heparin binding Hs molecular function 603 0.0
cell surface Hs cellular component 572 0.0
membrane Hs cellular component 603 0.0
integral component of membrane Hs cellular component 603 0.0
kinase activity Hs molecular function 603 0.0
1-phosphatidylinositol-3-kinase activity Hs molecular function 603 0.0
transferase activity Hs molecular function 603 0.0
fibroblast growth factor binding Hs molecular function 603 0.0
transport vesicle Hs cellular component 543 0.0
extracellular matrix Hs cellular component 572 0.0
cytoplasmic vesicle Hs cellular component 603 0.0
identical protein binding Hs molecular function 603 0.0
protein homodimerization activity Hs molecular function 603 0.0
intracellular membrane-bounded organelle Hs cellular component 572 0.0
receptor complex Hs cellular component 603 0.0
phosphatidylinositol-4,5-bisphosphate 3-kinase activity Hs molecular function 603 0.0
excitatory synapse Hs cellular component 572 0.0
receptor-receptor interaction Hs molecular function 603 0.0

GO (InterProScan)

8 results

GO Term Analysis Type e-value
protein kinase activity Pfam molecular function 3.7E-92
protein tyrosine kinase activity SMART molecular function 2.3E-129
fibroblast growth factor-activated receptor activity PIRSF molecular function 0.0
ATP binding PIRSF molecular function 0.0
protein phosphorylation PIRSF biological process 0.0
positive regulation of cell proliferation PIRSF biological process 0.0
fibroblast growth factor receptor signaling pathway PIRSF biological process 0.0
integral component of membrane PIRSF cellular component 0.0

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