Gene Card
Best human hits
MAP2K1; MAP2K2; MAP2K5
Species
Unique Gene ID
Cisavi.g00000029
Gene Model ID
Cisavi.CG.ENS81.R0.1216963-1218983
Location
R0:1216962..1218983
Transcript Models and Sequences
n/a
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The 'History' button on the left side permits you to see the changes you have made and eventually to go back.
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You can Press 'Ctrl' Key + Left Mouse Click on nodes to do a multiple selection.

IPR Term | Analysis | Definition |
---|---|---|
Protein_kinase_ATP_BS | ProSitePatterns | Protein kinase, ATP binding site |
Prot_kinase_dom | SMART | Protein kinase domain |
Kinase-like_dom_sf | SUPERFAMILY | Protein kinase-like domain superfamily |
Prot_kinase_dom | ProSiteProfiles | Protein kinase domain |
Prot_kinase_dom | Pfam | Protein kinase domain |
Ser/Thr_kinase_AS | ProSitePatterns | Serine/threonine-protein kinase, active site |
GO Term | Annotation Origin | Type |
---|
GO Term | SpeciesCe = Caenorhabditis elegans Dr = Danio rerio Dm = Drosophila melanogaster Gg = Gallus gallus Hs = Homo sapiens Mm = Mus musculus Sc = Saccharomyces cerevisiae |
Type |
---|---|---|
MAPK cascade | Hs | biological process |
nucleotide binding | Hs | molecular function |
activation of MAPK activity | Hs | biological process |
regulation of protein phosphorylation | Hs | biological process |
protein kinase activity | Hs | molecular function |
protein serine/threonine kinase activity | Hs | molecular function |
MAP kinase kinase activity | Hs | molecular function |
protein serine/threonine/tyrosine kinase activity | Hs | molecular function |
protein tyrosine kinase activity | Hs | molecular function |
signal transducer, downstream of receptor, with protein tyrosine phosphatase activity | Hs | molecular function |
protein binding | Hs | molecular function |
ATP binding | Hs | molecular function |
extracellular region | Hs | cellular component |
nucleus | Hs | cellular component |
cytoplasm | Hs | cellular component |
mitochondrion | Hs | cellular component |
early endosome | Hs | cellular component |
late endosome | Hs | cellular component |
peroxisomal membrane | Hs | cellular component |
endoplasmic reticulum | Hs | cellular component |
Golgi apparatus | Hs | cellular component |
microtubule organizing center | Hs | cellular component |
cytosol | Hs | cellular component |
cytoskeleton | Hs | cellular component |
microtubule | Hs | cellular component |
plasma membrane | Hs | cellular component |
cell-cell junction | Hs | cellular component |
focal adhesion | Hs | cellular component |
protein phosphorylation | Hs | biological process |
chemotaxis | Hs | biological process |
cell cycle arrest | Hs | biological process |
signal transduction | Hs | biological process |
regulation of mitotic cell cycle | Hs | biological process |
heart development | Hs | biological process |
protein C-terminus binding | Hs | molecular function |
negative regulation of cell proliferation | Hs | biological process |
cytoplasmic side of plasma membrane | Hs | cellular component |
positive regulation of gene expression | Hs | biological process |
negative regulation of gene expression | Hs | biological process |
membrane | Hs | cellular component |
kinase activity | Hs | molecular function |
phosphorylation | Hs | biological process |
transferase activity | Hs | molecular function |
peptidyl-threonine phosphorylation | Hs | biological process |
peptidyl-tyrosine phosphorylation | Hs | biological process |
PDZ domain binding | Hs | molecular function |
neuron differentiation | Hs | biological process |
keratinocyte differentiation | Hs | biological process |
thyroid gland development | Hs | biological process |
regulation of apoptotic process | Hs | biological process |
protein serine/threonine kinase activator activity | Hs | molecular function |
positive regulation of cell differentiation | Hs | biological process |
positive regulation of transcription, DNA-templated | Hs | biological process |
metal ion binding | Hs | molecular function |
protein N-terminus binding | Hs | molecular function |
perinuclear region of cytoplasm | Hs | cellular component |
thymus development | Hs | biological process |
regulation of axon regeneration | Hs | biological process |
cell motility | Hs | biological process |
positive regulation of axonogenesis | Hs | biological process |
face development | Hs | biological process |
extracellular exosome | Hs | cellular component |
positive regulation of ERK1 and ERK2 cascade | Hs | biological process |
positive regulation of protein serine/threonine kinase activity | Hs | biological process |
cellular senescence | Hs | biological process |
scaffold protein binding | Hs | molecular function |
GO Term | SpeciesCe = Caenorhabditis elegans Dr = Danio rerio Dm = Drosophila melanogaster Gg = Gallus gallus Hs = Homo sapiens Mm = Mus musculus Sc = Saccharomyces cerevisiae |
Type | Score | E-value |
---|---|---|---|---|
nucleotide binding | Hs | molecular function | 457 | 1.19e-161 |
protein kinase activity | Hs | molecular function | 457 | 1.19e-161 |
protein serine/threonine kinase activity | Hs | molecular function | 457 | 1.19e-161 |
MAP kinase kinase activity | Hs | molecular function | 457 | 1.19e-161 |
protein serine/threonine/tyrosine kinase activity | Hs | molecular function | 457 | 1.19e-161 |
protein tyrosine kinase activity | Hs | molecular function | 457 | 1.19e-161 |
signal transducer, downstream of receptor, with protein tyrosine phosphatase activity | Hs | molecular function | 457 | 1.19e-161 |
protein binding | Hs | molecular function | 457 | 1.19e-161 |
ATP binding | Hs | molecular function | 457 | 1.19e-161 |
extracellular region | Hs | cellular component | 445 | 1.53e-156 |
nucleus | Hs | cellular component | 457 | 1.19e-161 |
cytoplasm | Hs | cellular component | 457 | 1.19e-161 |
mitochondrion | Hs | cellular component | 457 | 1.19e-161 |
early endosome | Hs | cellular component | 457 | 1.19e-161 |
late endosome | Hs | cellular component | 457 | 1.19e-161 |
peroxisomal membrane | Hs | cellular component | 445 | 1.53e-156 |
endoplasmic reticulum | Hs | cellular component | 457 | 1.19e-161 |
Golgi apparatus | Hs | cellular component | 457 | 1.19e-161 |
microtubule organizing center | Hs | cellular component | 457 | 1.19e-161 |
spindle | Hs | cellular component | 253 | 1.83e-80 |
cytosol | Hs | cellular component | 457 | 1.19e-161 |
cytoskeleton | Hs | cellular component | 457 | 1.19e-161 |
microtubule | Hs | cellular component | 445 | 1.53e-156 |
plasma membrane | Hs | cellular component | 457 | 1.19e-161 |
cell-cell junction | Hs | cellular component | 445 | 1.53e-156 |
focal adhesion | Hs | cellular component | 457 | 1.19e-161 |
protein C-terminus binding | Hs | molecular function | 457 | 1.19e-161 |
cytoplasmic side of plasma membrane | Hs | cellular component | 445 | 1.53e-156 |
membrane | Hs | cellular component | 457 | 1.19e-161 |
kinase activity | Hs | molecular function | 457 | 1.19e-161 |
transferase activity | Hs | molecular function | 457 | 1.19e-161 |
PDZ domain binding | Hs | molecular function | 445 | 1.53e-156 |
protein serine/threonine kinase activator activity | Hs | molecular function | 457 | 1.19e-161 |
metal ion binding | Hs | molecular function | 445 | 1.53e-156 |
protein N-terminus binding | Hs | molecular function | 457 | 1.19e-161 |
perinuclear region of cytoplasm | Hs | cellular component | 445 | 1.53e-156 |
extracellular exosome | Hs | cellular component | 457 | 1.19e-161 |
scaffold protein binding | Hs | molecular function | 457 | 1.19e-161 |
GO Term | Analysis | Type | e-value |
---|---|---|---|
protein kinase activity | SMART | molecular function | 1.3E-71 |
ATP binding | SMART | molecular function | 1.3E-71 |
protein phosphorylation | SMART | biological process | 1.3E-71 |