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GENE CARD

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Gene Card

Best human hits

PAK1; PAK2; PAK3

Species

C.savignyi

Unique Gene ID

Cisavi.g00005146

Gene Model ID

Cisavi.CG.ENS81.R25.1559765-1575402

Location

R25:1559764..1575402

Transcript Models and Sequences

  Cisavi.CG.ENS81.R25.1559765-1575402.15021.t
Cisavi.CG.ENS81.R25.1559765-1575402.15022.t
Cisavi.CG.ENS81.R25.1559765-1575402.15023.t
Cisavi.CG.ENS81.R25.1559765-1575402.15024.t

External Database Gene Card

External database links

No result

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WashU Genome Browser

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Genomicus Synteny Browser

Genomicus browser link

Regulatory Regions

Regulatory Regions

No result

n/a

Gene Phylogeny

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Gene Annotations

InterPro

12 results

IPR Term Analysis Definition
PAK_BD CDD p21 activated kinase binding domain
Prot_kinase_dom ProSiteProfiles Protein kinase domain
Prot_kinase_dom Pfam Protein kinase domain
Kinase-like_dom_sf SUPERFAMILY Protein kinase-like domain superfamily
Protein_kinase_ATP_BS ProSitePatterns Protein kinase, ATP binding site
CRIB_dom SMART CRIB domain
Ser/Thr_kinase_AS ProSitePatterns Serine/threonine-protein kinase, active site
CRIB_dom_sf Gene3D CRIB domain superfamily
CRIB_dom ProSiteProfiles CRIB domain
Prot_kinase_dom SMART Protein kinase domain
CRIB_dom Pfam CRIB domain
PAK2/3 PANTHER Serine/threonine-protein kinase PAK2/3

GOSlim

No result

GO Term Annotation Origin Type

GO (Orthology)

105 results

GO Term SpeciesCe = Caenorhabditis elegans
Dr = Danio rerio
Dm = Drosophila melanogaster
Gg = Gallus gallus
Hs = Homo sapiens
Mm = Mus musculus
Sc = Saccharomyces cerevisiae		 Type
MAPK cascade Hs biological process
nucleotide binding Hs molecular function
activation of MAPK activity Hs biological process
response to hypoxia Hs biological process
ruffle Hs cellular component
positive regulation of protein phosphorylation Hs biological process
catalytic activity Hs molecular function
protein kinase activity Hs molecular function
protein serine/threonine kinase activity Hs molecular function
MAP kinase kinase activity Hs molecular function
protein binding Hs molecular function
collagen binding Hs molecular function
ATP binding Hs molecular function
nucleus Hs cellular component
cytoplasm Hs cellular component
endosome Hs cellular component
cytosol Hs cellular component
plasma membrane Hs cellular component
cell-cell junction Hs cellular component
focal adhesion Hs cellular component
protein phosphorylation Hs biological process
negative regulation of protein kinase activity Hs biological process
exocytosis Hs biological process
apoptotic process Hs biological process
signal transduction Hs biological process
Rho protein signal transduction Hs biological process
multicellular organism development Hs biological process
regulation of mitotic cell cycle Hs biological process
axonogenesis Hs biological process
metabolic process Hs biological process
positive regulation of cell proliferation Hs biological process
response to organic substance Hs biological process
regulation of neuron projection development Hs biological process
intercalated disc Hs cellular component
membrane Hs cellular component
viral process Hs biological process
kinase activity Hs molecular function
phosphorylation Hs biological process
dendrite development Hs biological process
cell migration Hs biological process
transferase activity Hs molecular function
Rho GTPase binding Hs molecular function
SH3 domain binding Hs molecular function
peptidyl-serine phosphorylation Hs biological process
protein kinase binding Hs molecular function
cerebellum development Hs biological process
signal transduction by protein phosphorylation Hs biological process
establishment of cell polarity Hs biological process
Z disc Hs cellular component
lamellipodium Hs cellular component
actin cytoskeleton organization Hs biological process
cell junction Hs cellular component
protein tyrosine kinase activator activity Hs molecular function
positive regulation of cell migration Hs biological process
axon Hs cellular component
dendrite Hs cellular component
regulation of actin filament polymerization Hs biological process
stress-activated protein kinase signaling cascade Hs biological process
positive regulation of microtubule polymerization Hs biological process
small GTPase binding Hs molecular function
actin cytoskeleton reorganization Hs biological process
filamentous actin Hs cellular component
nuclear membrane Hs cellular component
activation of protein kinase activity Hs biological process
ruffle membrane Hs cellular component
cellular response to insulin stimulus Hs biological process
regulation of actin cytoskeleton organization Hs biological process
macromolecular complex Hs cellular component
positive regulation of peptidyl-serine phosphorylation Hs biological process
Fc-epsilon receptor signaling pathway Hs biological process
regulation of growth Hs biological process
wound healing Hs biological process
identical protein binding Hs molecular function
regulation of apoptotic process Hs biological process
cell projection Hs cellular component
negative regulation of apoptotic process Hs biological process
regulation of MAPK cascade Hs biological process
positive regulation of JUN kinase activity Hs biological process
positive regulation of neuron apoptotic process Hs biological process
cadherin binding Hs molecular function
positive regulation of axon extension Hs biological process
protein autophosphorylation Hs biological process
metal ion binding Hs molecular function
vascular endothelial growth factor receptor signaling pathway Hs biological process
hepatocyte growth factor receptor signaling pathway Hs biological process
ephrin receptor signaling pathway Hs biological process
Rac GTPase binding Hs molecular function
perinuclear region of cytoplasm Hs cellular component
branching morphogenesis of an epithelial tube Hs biological process
neuron projection morphogenesis Hs biological process
positive regulation of peptidyl-tyrosine phosphorylation Hs biological process
regulation of axonogenesis Hs biological process
synapse organization Hs biological process
T cell receptor signaling pathway Hs biological process
GTPase binding Hs molecular function
positive regulation of stress fiber assembly Hs biological process
dendritic spine development Hs biological process
dendritic spine morphogenesis Hs biological process
positive regulation of dendritic spine morphogenesis Hs biological process
positive regulation of protein tyrosine kinase activity Hs biological process
cellular response to organic cyclic compound Hs biological process
invadopodium Hs cellular component
positive regulation of protein targeting to membrane Hs biological process
positive regulation of extrinsic apoptotic signaling pathway Hs biological process
negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis Hs biological process

GO (Blast)

42 results

GO Term SpeciesCe = Caenorhabditis elegans
Dr = Danio rerio
Dm = Drosophila melanogaster
Gg = Gallus gallus
Hs = Homo sapiens
Mm = Mus musculus
Sc = Saccharomyces cerevisiae		 Type Score E-value
nucleotide binding Hs molecular function 673 0.0
ruffle Hs cellular component 641 0.0
catalytic activity Hs molecular function 673 0.0
protein kinase activity Hs molecular function 673 0.0
protein serine/threonine kinase activity Hs molecular function 673 0.0
MAP kinase kinase activity Hs molecular function 673 0.0
protein binding Hs molecular function 673 0.0
collagen binding Hs molecular function 641 0.0
ATP binding Hs molecular function 673 0.0
nucleus Hs cellular component 638 0.0
cytoplasm Hs cellular component 673 0.0
endosome Hs cellular component 673 0.0
cytosol Hs cellular component 673 0.0
plasma membrane Hs cellular component 673 0.0
cell-cell junction Hs cellular component 641 0.0
focal adhesion Hs cellular component 641 0.0
intercalated disc Hs cellular component 641 0.0
membrane Hs cellular component 641 0.0
kinase activity Hs molecular function 673 0.0
transferase activity Hs molecular function 673 0.0
Rho GTPase binding Hs molecular function 673 0.0
SH3 domain binding Hs molecular function 673 0.0
protein kinase binding Hs molecular function 641 0.0
Z disc Hs cellular component 641 0.0
lamellipodium Hs cellular component 641 0.0
cell junction Hs cellular component 641 0.0
protein tyrosine kinase activator activity Hs molecular function 638 0.0
axon Hs cellular component 641 0.0
dendrite Hs cellular component 641 0.0
small GTPase binding Hs molecular function 638 0.0
filamentous actin Hs cellular component 641 0.0
nuclear membrane Hs cellular component 641 0.0
ruffle membrane Hs cellular component 641 0.0
macromolecular complex Hs cellular component 641 0.0
identical protein binding Hs molecular function 638 0.0
cell projection Hs cellular component 641 0.0
cadherin binding Hs molecular function 638 0.0
metal ion binding Hs molecular function 673 0.0
Rac GTPase binding Hs molecular function 673 0.0
perinuclear region of cytoplasm Hs cellular component 638 0.0
GTPase binding Hs molecular function 673 0.0
invadopodium Hs cellular component 641 0.0

GO (InterProScan)

5 results

GO Term Analysis Type e-value
protein kinase activity SMART molecular function 5.4E-95
protein serine/threonine kinase activity PANTHER molecular function 5.8E-213
ATP binding SMART molecular function 5.4E-95
protein phosphorylation SMART biological process 5.4E-95
regulation of apoptotic process PANTHER biological process 5.8E-213

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