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GENE CARD

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Gene Card

Best human hits

PAH; TPH1; TPH2

Species

H.roretzi

Unique Gene ID

Harore.g00005233

Gene Model ID

Harore.CG.MTP2014.S335.g05233

Location

S335:4120..12115

External Database Gene Card

External database links

No result

Collections
WashU Genome Browser

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Genomicus Synteny Browser

Genomicus browser link

Regulatory Regions

Regulatory Regions

No result

n/a

Gene Phylogeny

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Gene Annotations

InterPro

10 results

IPR Term Analysis Definition
Aro-AA_hydroxylase_C_sf SUPERFAMILY Aromatic amino acid monoxygenase, C-terminal domain superfamily
Tyrosine_3-monooxygenase-like PIRSF Tyrosine 3-monooxygenase-like
ArAA_hydroxylase PANTHER Aromatic amino acid hydroxylase
ArAA_hydroxylase_Fe/CU_BS ProSitePatterns Aromatic amino acid hydroxylase, iron/copper binding site
Aromatic-AA_hydroxylase_C PRINTS Aromatic amino acid hydroxylase, C-terminal
Phe-4-hydroxylase_tetra TIGRFAM Phenylalanine-4-hydroxylase, tetrameric form
ACT_dom ProSiteProfiles ACT domain
ArAA_hydroxylase_sf Gene3D Aromatic amino acid hydroxylase superfamily
Aromatic-AA_hydroxylase_C ProSiteProfiles Aromatic amino acid hydroxylase, C-terminal
Aromatic-AA_hydroxylase_C Pfam Aromatic amino acid hydroxylase, C-terminal

GOSlim

15 results

GO Term Annotation Origin Type
catalytic activity Orthology molecular function
iron ion binding Orthology molecular function
cytoplasm Orthology cellular component
cytosol Orthology cellular component
metabolic process Orthology biological process
neuron projection Orthology cellular component
metal ion binding Orthology molecular function
oxidation-reduction process Orthology biological process
extracellular exosome Orthology cellular component
aromatic compound catabolic process Orthology biological process
cellular biosynthetic process Orthology biological process
cellular aromatic compound metabolic process Orthology biological process
response to stimulus Orthology biological process
cell differentiation Orthology biological process
response to lipid Orthology biological process

GO (Orthology)

29 results

GO Term SpeciesCe = Caenorhabditis elegans
Dr = Danio rerio
Dm = Drosophila melanogaster
Gg = Gallus gallus
Hs = Homo sapiens
Mm = Mus musculus
Sc = Saccharomyces cerevisiae
Type
catalytic activity Hs molecular function
monooxygenase activity Hs molecular function
phenylalanine 4-monooxygenase activity Hs molecular function
tryptophan 5-monooxygenase activity Hs molecular function
iron ion binding Hs molecular function
cytoplasm Hs cellular component
cytosol Hs cellular component
L-phenylalanine catabolic process Hs biological process
circadian rhythm Hs biological process
metabolic process Hs biological process
cellular amino acid biosynthetic process Hs biological process
aromatic amino acid family metabolic process Hs biological process
response to activity Hs biological process
oxidoreductase activity Hs molecular function
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen Hs molecular function
negative regulation of ossification Hs biological process
response to nutrient levels Hs biological process
neurotransmitter biosynthetic process Hs biological process
catecholamine biosynthetic process Hs biological process
serotonin biosynthetic process Hs biological process
neuron projection Hs cellular component
response to estrogen Hs biological process
positive regulation of fat cell differentiation Hs biological process
bone remodeling Hs biological process
metal ion binding Hs molecular function
response to glucocorticoid Hs biological process
response to calcium ion Hs biological process
oxidation-reduction process Hs biological process
extracellular exosome Hs cellular component

GO (Blast)

12 results

GO Term SpeciesCe = Caenorhabditis elegans
Dr = Danio rerio
Dm = Drosophila melanogaster
Gg = Gallus gallus
Hs = Homo sapiens
Mm = Mus musculus
Sc = Saccharomyces cerevisiae
Type Score E-value
catalytic activity Hs molecular function 550 0.0
monooxygenase activity Hs molecular function 550 0.0
phenylalanine 4-monooxygenase activity Hs molecular function 550 0.0
tryptophan 5-monooxygenase activity Hs molecular function 493 1.45e-172
iron ion binding Hs molecular function 550 0.0
cytoplasm Hs cellular component 493 1.45e-172
cytosol Hs cellular component 550 0.0
oxidoreductase activity Hs molecular function 550 0.0
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen Hs molecular function 550 0.0
neuron projection Hs cellular component 493 1.45e-172
metal ion binding Hs molecular function 550 0.0
extracellular exosome Hs cellular component 550 0.0

GO (InterProScan)

7 results

GO Term Analysis Type e-value
monooxygenase activity PANTHER molecular function 1.2E-195
phenylalanine 4-monooxygenase activity TIGRFAM molecular function 4.0E-214
iron ion binding PANTHER molecular function 1.2E-195
L-phenylalanine catabolic process TIGRFAM biological process 4.0E-214
aromatic amino acid family metabolic process PANTHER biological process 1.2E-195
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen PIRSF molecular function 4.1E-202
oxidation-reduction process TIGRFAM biological process 4.0E-214