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GENE CARD

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Gene Card

Best human hits

PSEN1; PSEN2

Species

H.roretzi

Unique Gene ID

Harore.g00005635

Gene Model ID

Harore.CG.MTP2014.S359.g05635

Location

S359:17478..23951

Transcript Models and Sequences

  Harore.CG.MTP2014.S359.g05635.01.t
Harore.CG.MTP2014.S359.g05635.02.t

External Database Gene Card

External database links

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Genomicus Synteny Browser

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Regulatory Regions

Regulatory Regions

No result

n/a

Gene Phylogeny

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Gene Annotations

InterPro

4 results

IPR Term Analysis Definition
Peptidase_A22A Pfam Peptidase A22A, presenilin
Peptidase_A22A PANTHER Peptidase A22A, presenilin
Peptidase_A22A PRINTS Peptidase A22A, presenilin
Preselin/SPP SMART Presenilin/signal peptide peptidase

GOSlim

122 results

GO Term Annotation Origin Type
negative regulation of transcription from RNA polymerase II promoter Orthology biological process
Golgi membrane Orthology cellular component
blood vessel development Orthology biological process
response to hypoxia Orthology biological process
endopeptidase activity Orthology molecular function
protein binding Orthology molecular function
intracellular Orthology cellular component
nucleus Orthology cellular component
cytoplasm Orthology cellular component
mitochondrion Orthology cellular component
mitochondrial inner membrane Orthology cellular component
lysosomal membrane Orthology cellular component
endoplasmic reticulum Orthology cellular component
endoplasmic reticulum membrane Orthology cellular component
Golgi apparatus Orthology cellular component
centrosome Orthology cellular component
plasma membrane Orthology cellular component
integral component of plasma membrane Orthology cellular component
proteolysis Orthology biological process
apoptotic process Orthology biological process
cellular response to DNA damage stimulus Orthology biological process
response to oxidative stress Orthology biological process
cell adhesion Orthology biological process
Notch signaling pathway Orthology biological process
brain development Orthology biological process
heart development Orthology biological process
peptidase activity Orthology molecular function
cell surface Orthology cellular component
protein transport Orthology biological process
membrane Orthology cellular component
integral component of membrane Orthology cellular component
hydrolase activity Orthology molecular function
neurogenesis Orthology biological process
cell junction Orthology cellular component
neuron differentiation Orthology biological process
axon Orthology cellular component
cytoplasmic vesicle Orthology cellular component
nuclear membrane Orthology cellular component
macromolecular complex Orthology cellular component
intracellular signal transduction Orthology biological process
locomotion Orthology biological process
neuron projection Orthology cellular component
neuronal cell body Orthology cellular component
positive regulation of apoptotic process Orthology biological process
negative regulation of apoptotic process Orthology biological process
positive regulation of catalytic activity Orthology biological process
membrane-bounded organelle Orthology cellular component
membrane raft Orthology cellular component
positive regulation of transcription, DNA-templated Orthology biological process
perinuclear region of cytoplasm Orthology cellular component
neuron development Orthology biological process
regulation of canonical Wnt signaling pathway Orthology biological process
ubiquitin-like protein transferase activity Orthology molecular function
ligase activity Orthology molecular function
peptidase activity, acting on L-amino acid peptides Orthology molecular function
protein serine/threonine kinase activity Orthology molecular function
positive regulation of signal transduction Orthology biological process
intracellular organelle part Orthology cellular component
intracellular non-membrane-bounded organelle Orthology cellular component
cell differentiation Orthology biological process
anatomical structure formation involved in morphogenesis Orthology biological process
multicellular organism development Orthology biological process
cell migration Orthology biological process
generation of neurons Orthology biological process
organelle organization Orthology biological process
membrane organization Orthology biological process
protein phosphorylation Orthology biological process
anatomical structure morphogenesis Orthology biological process
animal organ development Orthology biological process
immune system process Orthology biological process
cellular process Orthology biological process
immune response Orthology biological process
metal ion transport Orthology biological process
transmembrane transport Orthology biological process
organelle inner membrane Orthology cellular component
membrane part Orthology cellular component
whole membrane Orthology cellular component
nuclear outer membrane-endoplasmic reticulum membrane network Orthology cellular component
bounding membrane of organelle Orthology cellular component
cell periphery Orthology cellular component
cytoplasmic part Orthology cellular component
regulation of catalytic activity Orthology biological process
protein kinase activity Orthology molecular function
cellular protein modification process Orthology biological process
cell Orthology cellular component
cell surface receptor signaling pathway Orthology biological process
transmembrane signaling receptor activity Orthology molecular function
negative regulation of signal transduction Orthology biological process
regulation of cellular metabolic process Orthology biological process
regulation of signal transduction Orthology biological process
nervous system process Orthology biological process
organic substance transport Orthology biological process
ion transport Orthology biological process
cation transport Orthology biological process
synapse part Orthology cellular component
intracellular transport Orthology biological process
neuron part Orthology cellular component
chemical synaptic transmission Orthology biological process
intracellular part Orthology cellular component
gene expression Orthology biological process
organelle part Orthology cellular component
cell projection part Orthology cellular component
synapse Orthology cellular component
protein metabolic process Orthology biological process
peptide metabolic process Orthology biological process
plasma membrane region Orthology cellular component
cytoskeletal part Orthology cellular component
endomembrane system Orthology cellular component
phosphorylation Orthology biological process
regulation of molecular function Orthology biological process
cell adhesion molecule binding Orthology molecular function
cell development Orthology biological process
defense response Orthology biological process
central nervous system development Orthology biological process
regulation of signaling Orthology biological process
cell proliferation Orthology biological process
axonogenesis Orthology biological process
cellular component organization Orthology biological process
cell-cell signaling Orthology biological process
neuron projection development Orthology biological process
plasma membrane part Orthology cellular component
cell projection organization Orthology biological process

GO (Orthology)

145 results

GO Term SpeciesCe = Caenorhabditis elegans
Dr = Danio rerio
Dm = Drosophila melanogaster
Gg = Gallus gallus
Hs = Homo sapiens
Mm = Mus musculus
Sc = Saccharomyces cerevisiae		 Type
autophagosome assembly Hs biological process
negative regulation of transcription from RNA polymerase II promoter Hs biological process
Golgi membrane Hs cellular component
activation of MAPKK activity Hs biological process
kinetochore Hs cellular component
blood vessel development Hs biological process
response to hypoxia Hs biological process
cell fate specification Hs biological process
somitogenesis Hs biological process
neuron migration Hs biological process
positive regulation of receptor recycling Hs biological process
negative regulation of protein phosphorylation Hs biological process
positive regulation of protein phosphorylation Hs biological process
heart looping Hs biological process
hematopoietic progenitor cell differentiation Hs biological process
T cell activation involved in immune response Hs biological process
myeloid leukocyte differentiation Hs biological process
neural retina development Hs biological process
endopeptidase activity Hs molecular function
aspartic-type endopeptidase activity Hs molecular function
calcium channel activity Hs molecular function
protein binding Hs molecular function
intracellular Hs cellular component
nucleus Hs cellular component
nuclear inner membrane Hs cellular component
nuclear outer membrane Hs cellular component
cytoplasm Hs cellular component
mitochondrion Hs cellular component
mitochondrial inner membrane Hs cellular component
lysosomal membrane Hs cellular component
endoplasmic reticulum Hs cellular component
endoplasmic reticulum membrane Hs cellular component
smooth endoplasmic reticulum Hs cellular component
rough endoplasmic reticulum Hs cellular component
Golgi apparatus Hs cellular component
centrosome Hs cellular component
plasma membrane Hs cellular component
integral component of plasma membrane Hs cellular component
cell cortex Hs cellular component
negative regulation of protein kinase activity Hs biological process
protein glycosylation Hs biological process
proteolysis Hs biological process
membrane protein ectodomain proteolysis Hs biological process
calcium ion transport Hs biological process
mitochondrial transport Hs biological process
cellular calcium ion homeostasis Hs biological process
autophagy Hs biological process
apoptotic process Hs biological process
cellular response to DNA damage stimulus Hs biological process
response to oxidative stress Hs biological process
cell adhesion Hs biological process
negative regulation of epidermal growth factor-activated receptor activity Hs biological process
regulation of epidermal growth factor-activated receptor activity Hs biological process
Notch signaling pathway Hs biological process
Notch receptor processing Hs biological process
brain development Hs biological process
heart development Hs biological process
learning or memory Hs biological process
memory Hs biological process
beta-catenin binding Hs molecular function
peptidase activity Hs molecular function
post-embryonic development Hs biological process
cell surface Hs cellular component
protein transport Hs biological process
L-glutamate transport Hs biological process
choline transport Hs biological process
membrane Hs cellular component
integral component of membrane Hs cellular component
synaptic vesicle targeting Hs biological process
aggresome Hs cellular component
protein processing Hs biological process
hydrolase activity Hs molecular function
cerebral cortex development Hs biological process
neurogenesis Hs biological process
Z disc Hs cellular component
cell junction Hs cellular component
PDZ domain binding Hs molecular function
neuron differentiation Hs biological process
embryonic limb morphogenesis Hs biological process
axon Hs cellular component
dendrite Hs cellular component
growth cone Hs cellular component
forebrain development Hs biological process
membrane protein intracellular domain proteolysis Hs biological process
cytoplasmic vesicle Hs cellular component
neuromuscular junction Hs cellular component
nuclear membrane Hs cellular component
positive regulation of protein binding Hs biological process
positive regulation of proteasomal ubiquitin-dependent protein catabolic process Hs biological process
endoplasmic reticulum calcium ion homeostasis Hs biological process
macromolecular complex Hs cellular component
positive regulation of protein import into nucleus, translocation Hs biological process
amyloid-beta formation Hs biological process
ciliary rootlet Hs cellular component
segmentation Hs biological process
intracellular signal transduction Hs biological process
azurophil granule membrane Hs cellular component
locomotion Hs biological process
regulation of phosphorylation Hs biological process
positive regulation of phosphorylation Hs biological process
aspartic endopeptidase activity, intramembrane cleaving Hs molecular function
amyloid precursor protein metabolic process Hs biological process
amyloid precursor protein catabolic process Hs biological process
neuron projection Hs cellular component
myeloid dendritic cell differentiation Hs biological process
neuronal cell body Hs cellular component
positive regulation of apoptotic process Hs biological process
negative regulation of apoptotic process Hs biological process
positive regulation of catalytic activity Hs biological process
dendritic shaft Hs cellular component
membrane-bounded organelle Hs cellular component
regulation of protein binding Hs biological process
positive regulation of MAP kinase activity Hs biological process
negative regulation of neuron apoptotic process Hs biological process
skin morphogenesis Hs biological process
membrane raft Hs cellular component
cadherin binding Hs molecular function
positive regulation of protein kinase activity Hs biological process
positive regulation of transcription, DNA-templated Hs biological process
ephrin receptor signaling pathway Hs biological process
astrocyte activation Hs biological process
regulation of synaptic plasticity Hs biological process
perinuclear region of cytoplasm Hs cellular component
thymus development Hs biological process
neuron development Hs biological process
skeletal system morphogenesis Hs biological process
brain morphogenesis Hs biological process
amyloid-beta metabolic process Hs biological process
epithelial cell proliferation Hs biological process
negative regulation of axonogenesis Hs biological process
synapse organization Hs biological process
T cell receptor signaling pathway Hs biological process
neuron apoptotic process Hs biological process
protein maturation Hs biological process
regulation of synaptic transmission, glutamatergic Hs biological process
canonical Wnt signaling pathway Hs biological process
regulation of canonical Wnt signaling pathway Hs biological process
positive regulation of dendritic spine development Hs biological process
calcium ion transmembrane transport Hs biological process
gamma-secretase complex Hs cellular component
cell-cell adhesion Hs biological process
presynapse Hs cellular component
neuron projection maintenance Hs biological process
negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process Hs biological process
negative regulation of apoptotic signaling pathway Hs biological process

GO (Blast)

52 results

GO Term SpeciesCe = Caenorhabditis elegans
Dr = Danio rerio
Dm = Drosophila melanogaster
Gg = Gallus gallus
Hs = Homo sapiens
Mm = Mus musculus
Sc = Saccharomyces cerevisiae		 Type Score E-value
Golgi membrane Hs cellular component 444 9.24e-153
kinetochore Hs cellular component 444 9.24e-153
endopeptidase activity Hs molecular function 444 9.24e-153
aspartic-type endopeptidase activity Hs molecular function 444 9.24e-153
calcium channel activity Hs molecular function 436 7.49e-150
protein binding Hs molecular function 444 9.24e-153
intracellular Hs cellular component 444 9.24e-153
nucleus Hs cellular component 436 7.49e-150
nuclear inner membrane Hs cellular component 444 9.24e-153
nuclear outer membrane Hs cellular component 436 7.49e-150
cytoplasm Hs cellular component 436 7.49e-150
mitochondrion Hs cellular component 436 7.49e-150
mitochondrial inner membrane Hs cellular component 444 9.24e-153
lysosomal membrane Hs cellular component 444 9.24e-153
endoplasmic reticulum Hs cellular component 444 9.24e-153
endoplasmic reticulum membrane Hs cellular component 444 9.24e-153
smooth endoplasmic reticulum Hs cellular component 436 7.49e-150
rough endoplasmic reticulum Hs cellular component 436 7.49e-150
Golgi apparatus Hs cellular component 444 9.24e-153
centrosome Hs cellular component 444 9.24e-153
plasma membrane Hs cellular component 444 9.24e-153
integral component of plasma membrane Hs cellular component 444 9.24e-153
cell cortex Hs cellular component 444 9.24e-153
beta-catenin binding Hs molecular function 436 7.49e-150
peptidase activity Hs molecular function 444 9.24e-153
cell surface Hs cellular component 444 9.24e-153
membrane Hs cellular component 444 9.24e-153
integral component of membrane Hs cellular component 444 9.24e-153
aggresome Hs cellular component 436 7.49e-150
hydrolase activity Hs molecular function 444 9.24e-153
Z disc Hs cellular component 444 9.24e-153
cell junction Hs cellular component 436 7.49e-150
PDZ domain binding Hs molecular function 436 7.49e-150
axon Hs cellular component 444 9.24e-153
dendrite Hs cellular component 436 7.49e-150
growth cone Hs cellular component 444 9.24e-153
cytoplasmic vesicle Hs cellular component 436 7.49e-150
neuromuscular junction Hs cellular component 444 9.24e-153
nuclear membrane Hs cellular component 436 7.49e-150
macromolecular complex Hs cellular component 444 9.24e-153
ciliary rootlet Hs cellular component 444 9.24e-153
azurophil granule membrane Hs cellular component 436 7.49e-150
aspartic endopeptidase activity, intramembrane cleaving Hs molecular function 444 9.24e-153
neuron projection Hs cellular component 436 7.49e-150
neuronal cell body Hs cellular component 444 9.24e-153
dendritic shaft Hs cellular component 444 9.24e-153
membrane-bounded organelle Hs cellular component 436 7.49e-150
membrane raft Hs cellular component 444 9.24e-153
cadherin binding Hs molecular function 436 7.49e-150
perinuclear region of cytoplasm Hs cellular component 444 9.24e-153
gamma-secretase complex Hs cellular component 436 7.49e-150
presynapse Hs cellular component 436 7.49e-150

GO (InterProScan)

3 results

GO Term Analysis Type e-value
aspartic-type endopeptidase activity PANTHER molecular function 4.7E-193
integral component of membrane PANTHER cellular component 4.7E-193
protein processing PANTHER biological process 4.7E-193

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