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Gene Card

Best human hits

NEDD4L; SMURF1; SMURF2

Species

H.roretzi

Unique Gene ID

Harore.g00006428

Gene Model ID

Harore.CG.MTP2014.S379.g06428

Location

S379:11700..45544

Transcript Models and Sequences

  Harore.CG.MTP2014.S379.g06428.01.t

External Database Gene Card

External database links

No result

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WashU Genome Browser

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Genomicus Synteny Browser

Genomicus browser link

Regulatory Regions

Regulatory Regions

No result

n/a

Gene Phylogeny

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Gene Annotations

InterPro

16 results

IPR Term Analysis Definition
WW_dom_sf SUPERFAMILY WW domain superfamily
C2_dom Pfam C2 domain
HECT_dom Pfam HECT domain
HECT_dom ProSiteProfiles HECT domain
HECT_dom CDD HECT domain
E3_ub_ligase_SMURF1 PIRSF E3 ubiquitin-protein ligase, SMURF1 type
C2_domain_sf Gene3D C2 domain superfamily
C2_dom ProSiteProfiles C2 domain
WW_dom ProSiteProfiles WW domain
WW_dom CDD WW domain
Hect_E3_ubiquitin_ligase SUPERFAMILY HECT, E3 ligase catalytic domain
WW_dom Pfam WW domain
WW_dom SMART WW domain
C2_dom SMART C2 domain
HECT_dom SMART HECT domain
WW_dom ProSitePatterns WW domain

GOSlim

52 results

GO Term Annotation Origin Type
negative regulation of transcription from RNA polymerase II promoter Orthology biological process
protein polyubiquitination Orthology biological process
ubiquitin-protein transferase activity Orthology molecular function
protein binding Orthology molecular function
intracellular Blast cellular component
nucleus Orthology cellular component
nucleoplasm Orthology cellular component
cytoplasm Orthology cellular component
mitochondrion Orthology cellular component
endosome Blast cellular component
Golgi apparatus Blast cellular component
cytosol Orthology cellular component
plasma membrane Orthology cellular component
sodium ion transport Blast biological process
membrane Orthology cellular component
protein ubiquitination Orthology biological process
nuclear speck Orthology cellular component
transferase activity Orthology molecular function
cell differentiation Orthology biological process
axon Orthology cellular component
identical protein binding Orthology molecular function
neuronal cell body Orthology cellular component
membrane raft Orthology cellular component
negative regulation of transcription, DNA-templated Orthology biological process
extracellular exosome Orthology cellular component
positive regulation of canonical Wnt signaling pathway Orthology biological process
intracellular part Orthology cellular component
macromolecular complex Orthology cellular component
receptor binding Orthology molecular function
anion binding Orthology molecular function
proteolysis Orthology biological process
intracellular protein transport Orthology biological process
cell surface receptor signaling pathway Orthology biological process
cellular response to organic substance Orthology biological process
anatomical structure development Orthology biological process
peptidase activity, acting on L-amino acid peptides Orthology molecular function
regulation of signal transduction Orthology biological process
regulation of transcription from RNA polymerase II promoter Orthology biological process
negative regulation of signal transduction Orthology biological process
cellular protein localization Orthology biological process
macromolecular complex binding Orthology molecular function
cell-cell signaling Orthology biological process
anatomical structure morphogenesis Orthology biological process
animal organ development Orthology biological process
protein localization to membrane Orthology biological process
cell migration Orthology biological process
multicellular organism development Orthology biological process
neuron projection morphogenesis Orthology biological process
metal ion transport Blast biological process
molecular function regulator Blast molecular function
transmembrane transport Blast biological process
monovalent inorganic cation transport Blast biological process

GO (Orthology)

49 results

GO Term SpeciesCe = Caenorhabditis elegans
Dr = Danio rerio
Dm = Drosophila melanogaster
Gg = Gallus gallus
Hs = Homo sapiens
Mm = Mus musculus
Sc = Saccharomyces cerevisiae		 Type
negative regulation of transcription from RNA polymerase II promoter Hs biological process
ubiquitin ligase complex Hs cellular component
protein polyubiquitination Hs biological process
ubiquitin-protein transferase activity Hs molecular function
transforming growth factor beta receptor binding Hs molecular function
protein binding Hs molecular function
phospholipid binding Hs molecular function
nucleus Hs cellular component
nucleoplasm Hs cellular component
cytoplasm Hs cellular component
mitochondrion Hs cellular component
cytosol Hs cellular component
plasma membrane Hs cellular component
ubiquitin-dependent protein catabolic process Hs biological process
protein export from nucleus Hs biological process
transforming growth factor beta receptor signaling pathway Hs biological process
ectoderm development Hs biological process
membrane Hs cellular component
protein ubiquitination Hs biological process
protein deubiquitination Hs biological process
nuclear speck Hs cellular component
transferase activity Hs molecular function
regulation of transforming growth factor beta receptor signaling pathway Hs biological process
cell differentiation Hs biological process
negative regulation of ossification Hs biological process
axon Hs cellular component
BMP signaling pathway Hs biological process
negative regulation of transforming growth factor beta receptor signaling pathway Hs biological process
negative regulation of BMP signaling pathway Hs biological process
ubiquitin-dependent SMAD protein catabolic process Hs biological process
receptor catabolic process Hs biological process
protein localization to cell surface Hs biological process
identical protein binding Hs molecular function
neuronal cell body Hs cellular component
proteasome-mediated ubiquitin-dependent protein catabolic process Hs biological process
membrane raft Hs cellular component
negative regulation of transcription, DNA-templated Hs biological process
SMAD binding Hs molecular function
activin binding Hs molecular function
Wnt signaling pathway, planar cell polarity pathway Hs biological process
ubiquitin protein ligase activity Hs molecular function
extracellular exosome Hs cellular component
I-SMAD binding Hs molecular function
R-SMAD binding Hs molecular function
protein localization to plasma membrane Hs biological process
positive regulation of canonical Wnt signaling pathway Hs biological process
positive regulation of trophoblast cell migration Hs biological process
positive regulation of dendrite extension Hs biological process
positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process Hs biological process

GO (Blast)

33 results

GO Term SpeciesCe = Caenorhabditis elegans
Dr = Danio rerio
Dm = Drosophila melanogaster
Gg = Gallus gallus
Hs = Homo sapiens
Mm = Mus musculus
Sc = Saccharomyces cerevisiae		 Type Score E-value
ubiquitin ligase complex Hs cellular component 994 0.0
ubiquitin-protein transferase activity Hs molecular function 994 0.0
transforming growth factor beta receptor binding Hs molecular function 994 0.0
protein binding Hs molecular function 994 0.0
phospholipid binding Hs molecular function 803 0.0
intracellular Hs cellular component 488 6.65e-160
nucleus Hs cellular component 994 0.0
nucleoplasm Hs cellular component 994 0.0
cytoplasm Hs cellular component 994 0.0
mitochondrion Hs cellular component 803 0.0
endosome Hs cellular component 488 6.65e-160
multivesicular body Hs cellular component 488 6.65e-160
Golgi apparatus Hs cellular component 488 6.65e-160
cytosol Hs cellular component 994 0.0
plasma membrane Hs cellular component 994 0.0
potassium channel regulator activity Hs molecular function 488 6.65e-160
membrane Hs cellular component 994 0.0
nuclear speck Hs cellular component 994 0.0
transferase activity Hs molecular function 994 0.0
sodium channel regulator activity Hs molecular function 488 6.65e-160
potassium channel inhibitor activity Hs molecular function 488 6.65e-160
sodium channel inhibitor activity Hs molecular function 488 6.65e-160
axon Hs cellular component 803 0.0
identical protein binding Hs molecular function 994 0.0
neuronal cell body Hs cellular component 803 0.0
ion channel binding Hs molecular function 488 6.65e-160
membrane raft Hs cellular component 994 0.0
SMAD binding Hs molecular function 994 0.0
activin binding Hs molecular function 803 0.0
ubiquitin protein ligase activity Hs molecular function 994 0.0
extracellular exosome Hs cellular component 803 0.0
I-SMAD binding Hs molecular function 803 0.0
R-SMAD binding Hs molecular function 803 0.0

GO (InterProScan)

4 results

GO Term Analysis Type e-value
ubiquitin-protein transferase activity CDD molecular function 9.89486E-166
protein binding SUPERFAMILY molecular function 2.5E-13
ubiquitin-dependent protein catabolic process PIRSF biological process 1.9E-204
ubiquitin protein ligase activity PIRSF molecular function 1.9E-204

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