Gene Card
Best human hits
ARAF; KSR1; KSR2
Species
Unique Gene ID
Harore.g00006934
Gene Model ID
Harore.CG.MTP2014.S326.g06934
Location
S326:45359..58097
Transcript Models and Sequences
n/a
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The 'History' button on the left side permits you to see the changes you have made and eventually to go back.
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You can Press 'Ctrl' Key + Left Mouse Click on nodes to do a multiple selection.

IPR Term | Analysis | Definition |
---|---|---|
Ser/Thr_kinase_AS | ProSitePatterns | Serine/threonine-protein kinase, active site |
Kinase-like_dom_sf | SUPERFAMILY | Protein kinase-like domain superfamily |
Prot_kinase_dom | SMART | Protein kinase domain |
KSR_SAM-like_dom | Pfam | Kinase suppressor of RAS, SAM-like domain |
Prot_kinase_dom | ProSiteProfiles | Protein kinase domain |
Ser-Thr/Tyr_kinase_cat_dom | Pfam | Serine-threonine/tyrosine-protein kinase, catalytic domain |
GO Term | Annotation Origin | Type |
---|---|---|
nucleotide binding | Orthology | molecular function |
protein kinase activity | Orthology | molecular function |
protein serine/threonine kinase activity | Orthology | molecular function |
signal transducer activity | Orthology | molecular function |
protein binding | Orthology | molecular function |
ATP binding | Orthology | molecular function |
intracellular | Orthology | cellular component |
cytoplasm | Orthology | cellular component |
mitochondrion | Blast | cellular component |
endoplasmic reticulum | Orthology | cellular component |
endoplasmic reticulum membrane | Orthology | cellular component |
cytosol | Orthology | cellular component |
plasma membrane | Orthology | cellular component |
protein phosphorylation | Orthology | biological process |
protein C-terminus binding | Orthology | molecular function |
membrane | Orthology | cellular component |
kinase activity | Orthology | molecular function |
phosphorylation | Orthology | biological process |
transferase activity | Orthology | molecular function |
macromolecular complex | Orthology | cellular component |
intracellular signal transduction | Orthology | biological process |
cell projection | Orthology | cellular component |
metal ion binding | Orthology | molecular function |
kinase binding | Orthology | molecular function |
positive regulation of signal transduction | Orthology | biological process |
small GTPase mediated signal transduction | Orthology | biological process |
protein kinase binding | Orthology | molecular function |
cell projection membrane | Orthology | cellular component |
cell leading edge | Orthology | cellular component |
positive regulation of catalytic activity | Blast | biological process |
GO Term | SpeciesCe = Caenorhabditis elegans Dr = Danio rerio Dm = Drosophila melanogaster Gg = Gallus gallus Hs = Homo sapiens Mm = Mus musculus Sc = Saccharomyces cerevisiae |
Type |
---|---|---|
MAPK cascade | Hs | biological process |
nucleotide binding | Hs | molecular function |
protein kinase activity | Hs | molecular function |
protein serine/threonine kinase activity | Hs | molecular function |
signal transducer activity | Hs | molecular function |
MAP-kinase scaffold activity | Hs | molecular function |
protein binding | Hs | molecular function |
ATP binding | Hs | molecular function |
intracellular | Hs | cellular component |
cytoplasm | Hs | cellular component |
endoplasmic reticulum | Hs | cellular component |
endoplasmic reticulum membrane | Hs | cellular component |
cytosol | Hs | cellular component |
plasma membrane | Hs | cellular component |
protein phosphorylation | Hs | biological process |
Ras protein signal transduction | Hs | biological process |
protein C-terminus binding | Hs | molecular function |
membrane | Hs | cellular component |
kinase activity | Hs | molecular function |
phosphorylation | Hs | biological process |
transferase activity | Hs | molecular function |
calcium-mediated signaling | Hs | biological process |
cAMP-mediated signaling | Hs | biological process |
mitogen-activated protein kinase kinase binding | Hs | molecular function |
ruffle membrane | Hs | cellular component |
macromolecular complex | Hs | cellular component |
intracellular signal transduction | Hs | biological process |
cell projection | Hs | cellular component |
positive regulation of MAPK cascade | Hs | biological process |
metal ion binding | Hs | molecular function |
chaperone binding | Hs | molecular function |
Hsp90 protein binding | Hs | molecular function |
14-3-3 protein binding | Hs | molecular function |
GO Term | SpeciesCe = Caenorhabditis elegans Dr = Danio rerio Dm = Drosophila melanogaster Gg = Gallus gallus Hs = Homo sapiens Mm = Mus musculus Sc = Saccharomyces cerevisiae |
Type | Score | E-value |
---|---|---|---|---|
nucleotide binding | Hs | molecular function | 320 | 1.24e-93 |
protein kinase activity | Hs | molecular function | 320 | 1.24e-93 |
protein serine/threonine kinase activity | Hs | molecular function | 320 | 1.24e-93 |
MAP kinase kinase kinase activity | Hs | molecular function | 172 | 7.72e-45 |
signal transducer activity | Hs | molecular function | 320 | 1.24e-93 |
signal transducer activity, downstream of receptor | Hs | molecular function | 172 | 7.72e-45 |
MAP-kinase scaffold activity | Hs | molecular function | 297 | 3.28e-86 |
protein binding | Hs | molecular function | 320 | 1.24e-93 |
ATP binding | Hs | molecular function | 320 | 1.24e-93 |
intracellular | Hs | cellular component | 320 | 1.24e-93 |
cytoplasm | Hs | cellular component | 320 | 1.24e-93 |
mitochondrion | Hs | cellular component | 172 | 7.72e-45 |
endoplasmic reticulum | Hs | cellular component | 297 | 3.28e-86 |
endoplasmic reticulum membrane | Hs | cellular component | 297 | 3.28e-86 |
cytosol | Hs | cellular component | 320 | 1.24e-93 |
plasma membrane | Hs | cellular component | 320 | 1.24e-93 |
protein C-terminus binding | Hs | molecular function | 297 | 3.28e-86 |
membrane | Hs | cellular component | 320 | 1.24e-93 |
kinase activity | Hs | molecular function | 320 | 1.24e-93 |
transferase activity | Hs | molecular function | 320 | 1.24e-93 |
mitogen-activated protein kinase kinase binding | Hs | molecular function | 297 | 3.28e-86 |
ruffle membrane | Hs | cellular component | 297 | 3.28e-86 |
macromolecular complex | Hs | cellular component | 297 | 3.28e-86 |
cell projection | Hs | cellular component | 297 | 3.28e-86 |
metal ion binding | Hs | molecular function | 320 | 1.24e-93 |
chaperone binding | Hs | molecular function | 297 | 3.28e-86 |
Hsp90 protein binding | Hs | molecular function | 297 | 3.28e-86 |
14-3-3 protein binding | Hs | molecular function | 297 | 3.28e-86 |
GO Term | Analysis | Type | e-value |
---|---|---|---|
protein kinase activity | Pfam | molecular function | 2.8E-49 |
ATP binding | SMART | molecular function | 9.6E-38 |
protein phosphorylation | Pfam | biological process | 2.8E-49 |