Gene Card
Best human hits
MLH1; PMS1; PMS2
Species
Unique Gene ID
Phfumi.g00000078
Gene Model ID
Phfumi.CG.MTP2014.S3.g00078
Location
S3:284986..292063
Transcript Models and Sequences
n/a
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The 'History' button on the left side permits you to see the changes you have made and eventually to go back.
You can Press 'Shift' Key + Left Mouse Click on the leaf's node to access to a gene card in a new window.
You can Press 'Ctrl' Key + Left Mouse Click on nodes to do a multiple selection.

IPR Term | Analysis | Definition |
---|---|---|
DNA_mismatch_repair_C | Pfam | DNA mismatch repair protein, C-terminal |
DNA_mismatch_repair_MLH1 | PANTHER | DNA mismatch repair protein Mlh1 |
Ribosomal_S5_D2-typ_fold_subgr | Gene3D | Ribosomal protein S5 domain 2-type fold, subgroup |
DNA_mismatch_repair_CS | ProSitePatterns | DNA mismatch repair, conserved site |
HATPase_C_sf | Gene3D | Histidine kinase/HSP90-like ATPase superfamily |
HATPase_C | CDD | Histidine kinase/HSP90-like ATPase |
Mlh1_C | Pfam | DNA mismatch repair protein Mlh1, C-terminal |
DNA_mismatch_repair_C | SMART | DNA mismatch repair protein, C-terminal |
Ribosomal_S5_D2-typ_fold | SUPERFAMILY | Ribosomal protein S5 domain 2-type fold |
HATPase_C_sf | SUPERFAMILY | Histidine kinase/HSP90-like ATPase superfamily |
GO Term | Annotation Origin | Type |
---|---|---|
nucleotide binding | Orthology | molecular function |
DNA binding | Orthology | molecular function |
chromatin binding | Orthology | molecular function |
protein binding | Orthology | molecular function |
ATP binding | Orthology | molecular function |
nucleus | Orthology | cellular component |
nucleoplasm | Orthology | cellular component |
cytosol | Blast | cellular component |
plasma membrane | Blast | cellular component |
DNA repair | Orthology | biological process |
cellular response to DNA damage stimulus | Orthology | biological process |
cell cycle | Orthology | biological process |
spermatogenesis | Orthology | biological process |
microtubule cytoskeleton | Blast | cellular component |
membrane | Orthology | cellular component |
hydrolase activity | Blast | molecular function |
nuclear-transcribed mRNA catabolic process | Orthology | biological process |
reproductive process | Orthology | biological process |
DNA metabolic process | Orthology | biological process |
intracellular non-membrane-bounded organelle | Orthology | cellular component |
nuclear lumen | Orthology | cellular component |
male gamete generation | Orthology | biological process |
intracellular signal transduction | Orthology | biological process |
apoptotic process | Orthology | biological process |
gamete generation | Orthology | biological process |
system development | Orthology | biological process |
immune system process | Orthology | biological process |
nucleoside-triphosphatase activity | Orthology | molecular function |
double-stranded DNA binding | Orthology | molecular function |
intracellular part | Orthology | cellular component |
macromolecular complex | Orthology | cellular component |
nuclear part | Orthology | cellular component |
macromolecular complex binding | Orthology | molecular function |
immune response | Orthology | biological process |
cell development | Orthology | biological process |
microtubule-based process | Orthology | biological process |
cytoplasmic part | Blast | cellular component |
GO Term | SpeciesCe = Caenorhabditis elegans Dr = Danio rerio Dm = Drosophila melanogaster Gg = Gallus gallus Hs = Homo sapiens Mm = Mus musculus Sc = Saccharomyces cerevisiae |
Type |
---|---|---|
nucleotide binding | Hs | molecular function |
nuclear-transcribed mRNA poly(A) tail shortening | Hs | biological process |
resolution of meiotic recombination intermediates | Hs | biological process |
condensed chromosome | Hs | cellular component |
condensed nuclear chromosome | Hs | cellular component |
synaptonemal complex | Hs | cellular component |
male germ cell nucleus | Hs | cellular component |
chromatin binding | Hs | molecular function |
single-stranded DNA binding | Hs | molecular function |
protein binding | Hs | molecular function |
ATP binding | Hs | molecular function |
nucleus | Hs | cellular component |
nucleoplasm | Hs | cellular component |
chromosome | Hs | cellular component |
chiasma | Hs | cellular component |
late recombination nodule | Hs | cellular component |
DNA repair | Hs | biological process |
mismatch repair | Hs | biological process |
double-strand break repair via nonhomologous end joining | Hs | biological process |
cellular response to DNA damage stimulus | Hs | biological process |
cell cycle | Hs | biological process |
male meiosis chromosome segregation | Hs | biological process |
synapsis | Hs | biological process |
reciprocal meiotic recombination | Hs | biological process |
male meiotic nuclear division | Hs | biological process |
spermatogenesis | Hs | biological process |
intrinsic apoptotic signaling pathway in response to DNA damage | Hs | biological process |
membrane | Hs | cellular component |
female meiosis chromosome segregation | Hs | biological process |
somatic hypermutation of immunoglobulin genes | Hs | biological process |
ATPase activity | Hs | molecular function |
mismatched DNA binding | Hs | molecular function |
guanine/thymine mispair binding | Hs | molecular function |
mismatch repair complex | Hs | cellular component |
MutLalpha complex | Hs | cellular component |
MutSalpha complex binding | Hs | molecular function |
meiotic metaphase I plate congression | Hs | biological process |
meiotic chromosome segregation | Hs | biological process |
meiotic telomere clustering | Hs | biological process |
homologous chromosome segregation | Hs | biological process |
isotype switching | Hs | biological process |
negative regulation of mitotic recombination | Hs | biological process |
oogenesis | Hs | biological process |
meiotic spindle midzone assembly | Hs | biological process |
meiotic cell cycle | Hs | biological process |
GO Term | SpeciesCe = Caenorhabditis elegans Dr = Danio rerio Dm = Drosophila melanogaster Gg = Gallus gallus Hs = Homo sapiens Mm = Mus musculus Sc = Saccharomyces cerevisiae |
Type | Score | E-value |
---|---|---|---|---|
nucleotide binding | Hs | molecular function | 627 | 0.0 |
condensed chromosome | Hs | cellular component | 627 | 0.0 |
condensed nuclear chromosome | Hs | cellular component | 627 | 0.0 |
synaptonemal complex | Hs | cellular component | 627 | 0.0 |
male germ cell nucleus | Hs | cellular component | 627 | 0.0 |
DNA binding | Hs | molecular function | 94.0 | 6.44e-20 |
chromatin binding | Hs | molecular function | 627 | 0.0 |
single-stranded DNA binding | Hs | molecular function | 627 | 0.0 |
nuclease activity | Hs | molecular function | 94.0 | 6.44e-20 |
endonuclease activity | Hs | molecular function | 94.0 | 6.44e-20 |
protein binding | Hs | molecular function | 627 | 0.0 |
ATP binding | Hs | molecular function | 627 | 0.0 |
nucleus | Hs | cellular component | 627 | 0.0 |
nucleoplasm | Hs | cellular component | 627 | 0.0 |
chromosome | Hs | cellular component | 627 | 0.0 |
chiasma | Hs | cellular component | 627 | 0.0 |
late recombination nodule | Hs | cellular component | 627 | 0.0 |
cytosol | Hs | cellular component | 94.0 | 6.44e-20 |
plasma membrane | Hs | cellular component | 94.0 | 6.44e-20 |
microtubule cytoskeleton | Hs | cellular component | 94.0 | 6.44e-20 |
membrane | Hs | cellular component | 627 | 0.0 |
hydrolase activity | Hs | molecular function | 94.0 | 6.44e-20 |
ATPase activity | Hs | molecular function | 627 | 0.0 |
mismatched DNA binding | Hs | molecular function | 627 | 0.0 |
guanine/thymine mispair binding | Hs | molecular function | 627 | 0.0 |
single base insertion or deletion binding | Hs | molecular function | 94.0 | 6.44e-20 |
mismatch repair complex | Hs | cellular component | 627 | 0.0 |
MutLalpha complex | Hs | cellular component | 627 | 0.0 |
MutSalpha complex binding | Hs | molecular function | 627 | 0.0 |
cytoplasmic ribonucleoprotein granule | Hs | cellular component | 94.0 | 6.44e-20 |
GO Term | Analysis | Type | e-value |
---|---|---|---|
ATP binding | Pfam | molecular function | 2.6E-9 |
mismatch repair | PANTHER | biological process | 4.3E-186 |
mismatched DNA binding | Pfam | molecular function | 2.6E-9 |
mismatch repair complex | PANTHER | cellular component | 4.3E-186 |