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Gene Card

Best human hits

MLH1; PMS1; PMS2

Species

P.fumigata

Unique Gene ID

Phfumi.g00000078

Gene Model ID

Phfumi.CG.MTP2014.S3.g00078

Location

S3:284986..292063

Transcript Models and Sequences

  Phfumi.CG.MTP2014.S3.g00078.01.t

External Database Gene Card

External database links

No result

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Genomicus Synteny Browser

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Regulatory Regions

Regulatory Regions

No result

n/a

Gene Phylogeny

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Gene Annotations

InterPro

10 results

IPR Term Analysis Definition
DNA_mismatch_repair_C Pfam DNA mismatch repair protein, C-terminal
DNA_mismatch_repair_MLH1 PANTHER DNA mismatch repair protein Mlh1
Ribosomal_S5_D2-typ_fold_subgr Gene3D Ribosomal protein S5 domain 2-type fold, subgroup
DNA_mismatch_repair_CS ProSitePatterns DNA mismatch repair, conserved site
HATPase_C_sf Gene3D Histidine kinase/HSP90-like ATPase superfamily
HATPase_C CDD Histidine kinase/HSP90-like ATPase
Mlh1_C Pfam DNA mismatch repair protein Mlh1, C-terminal
DNA_mismatch_repair_C SMART DNA mismatch repair protein, C-terminal
Ribosomal_S5_D2-typ_fold SUPERFAMILY Ribosomal protein S5 domain 2-type fold
HATPase_C_sf SUPERFAMILY Histidine kinase/HSP90-like ATPase superfamily

GOSlim

37 results

GO Term Annotation Origin Type
nucleotide binding Orthology molecular function
DNA binding Orthology molecular function
chromatin binding Orthology molecular function
protein binding Orthology molecular function
ATP binding Orthology molecular function
nucleus Orthology cellular component
nucleoplasm Orthology cellular component
cytosol Blast cellular component
plasma membrane Blast cellular component
DNA repair Orthology biological process
cellular response to DNA damage stimulus Orthology biological process
cell cycle Orthology biological process
spermatogenesis Orthology biological process
microtubule cytoskeleton Blast cellular component
membrane Orthology cellular component
hydrolase activity Blast molecular function
nuclear-transcribed mRNA catabolic process Orthology biological process
reproductive process Orthology biological process
DNA metabolic process Orthology biological process
intracellular non-membrane-bounded organelle Orthology cellular component
nuclear lumen Orthology cellular component
male gamete generation Orthology biological process
intracellular signal transduction Orthology biological process
apoptotic process Orthology biological process
gamete generation Orthology biological process
system development Orthology biological process
immune system process Orthology biological process
nucleoside-triphosphatase activity Orthology molecular function
double-stranded DNA binding Orthology molecular function
intracellular part Orthology cellular component
macromolecular complex Orthology cellular component
nuclear part Orthology cellular component
macromolecular complex binding Orthology molecular function
immune response Orthology biological process
cell development Orthology biological process
microtubule-based process Orthology biological process
cytoplasmic part Blast cellular component

GO (Orthology)

45 results

GO Term SpeciesCe = Caenorhabditis elegans
Dr = Danio rerio
Dm = Drosophila melanogaster
Gg = Gallus gallus
Hs = Homo sapiens
Mm = Mus musculus
Sc = Saccharomyces cerevisiae
Type
nucleotide binding Hs molecular function
nuclear-transcribed mRNA poly(A) tail shortening Hs biological process
resolution of meiotic recombination intermediates Hs biological process
condensed chromosome Hs cellular component
condensed nuclear chromosome Hs cellular component
synaptonemal complex Hs cellular component
male germ cell nucleus Hs cellular component
chromatin binding Hs molecular function
single-stranded DNA binding Hs molecular function
protein binding Hs molecular function
ATP binding Hs molecular function
nucleus Hs cellular component
nucleoplasm Hs cellular component
chromosome Hs cellular component
chiasma Hs cellular component
late recombination nodule Hs cellular component
DNA repair Hs biological process
mismatch repair Hs biological process
double-strand break repair via nonhomologous end joining Hs biological process
cellular response to DNA damage stimulus Hs biological process
cell cycle Hs biological process
male meiosis chromosome segregation Hs biological process
synapsis Hs biological process
reciprocal meiotic recombination Hs biological process
male meiotic nuclear division Hs biological process
spermatogenesis Hs biological process
intrinsic apoptotic signaling pathway in response to DNA damage Hs biological process
membrane Hs cellular component
female meiosis chromosome segregation Hs biological process
somatic hypermutation of immunoglobulin genes Hs biological process
ATPase activity Hs molecular function
mismatched DNA binding Hs molecular function
guanine/thymine mispair binding Hs molecular function
mismatch repair complex Hs cellular component
MutLalpha complex Hs cellular component
MutSalpha complex binding Hs molecular function
meiotic metaphase I plate congression Hs biological process
meiotic chromosome segregation Hs biological process
meiotic telomere clustering Hs biological process
homologous chromosome segregation Hs biological process
isotype switching Hs biological process
negative regulation of mitotic recombination Hs biological process
oogenesis Hs biological process
meiotic spindle midzone assembly Hs biological process
meiotic cell cycle Hs biological process

GO (Blast)

30 results

GO Term SpeciesCe = Caenorhabditis elegans
Dr = Danio rerio
Dm = Drosophila melanogaster
Gg = Gallus gallus
Hs = Homo sapiens
Mm = Mus musculus
Sc = Saccharomyces cerevisiae
Type Score E-value
nucleotide binding Hs molecular function 627 0.0
condensed chromosome Hs cellular component 627 0.0
condensed nuclear chromosome Hs cellular component 627 0.0
synaptonemal complex Hs cellular component 627 0.0
male germ cell nucleus Hs cellular component 627 0.0
DNA binding Hs molecular function 94.0 6.44e-20
chromatin binding Hs molecular function 627 0.0
single-stranded DNA binding Hs molecular function 627 0.0
nuclease activity Hs molecular function 94.0 6.44e-20
endonuclease activity Hs molecular function 94.0 6.44e-20
protein binding Hs molecular function 627 0.0
ATP binding Hs molecular function 627 0.0
nucleus Hs cellular component 627 0.0
nucleoplasm Hs cellular component 627 0.0
chromosome Hs cellular component 627 0.0
chiasma Hs cellular component 627 0.0
late recombination nodule Hs cellular component 627 0.0
cytosol Hs cellular component 94.0 6.44e-20
plasma membrane Hs cellular component 94.0 6.44e-20
microtubule cytoskeleton Hs cellular component 94.0 6.44e-20
membrane Hs cellular component 627 0.0
hydrolase activity Hs molecular function 94.0 6.44e-20
ATPase activity Hs molecular function 627 0.0
mismatched DNA binding Hs molecular function 627 0.0
guanine/thymine mispair binding Hs molecular function 627 0.0
single base insertion or deletion binding Hs molecular function 94.0 6.44e-20
mismatch repair complex Hs cellular component 627 0.0
MutLalpha complex Hs cellular component 627 0.0
MutSalpha complex binding Hs molecular function 627 0.0
cytoplasmic ribonucleoprotein granule Hs cellular component 94.0 6.44e-20

GO (InterProScan)

4 results

GO Term Analysis Type e-value
ATP binding Pfam molecular function 2.6E-9
mismatch repair PANTHER biological process 4.3E-186
mismatched DNA binding Pfam molecular function 2.6E-9
mismatch repair complex PANTHER cellular component 4.3E-186





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