IPR Term	Analysis	Definition
C2_dom	Pfam	C2 domain
C2_domain_sf	Gene3D	C2 domain superfamily
HECT_dom	SMART	HECT domain
HECT_dom	Pfam	HECT domain
HECT_dom	CDD	HECT domain
HECT_dom	ProSiteProfiles	HECT domain
Hect_E3_ubiquitin_ligase	SUPERFAMILY	HECT, E3 ligase catalytic domain

GO Term	Annotation Origin	Type
negative regulation of transcription from RNA polymerase II promoter	Orthology	biological process
protein polyubiquitination	Orthology	biological process
ubiquitin-protein transferase activity	Orthology	molecular function
protein binding	Orthology	molecular function
nucleus	Orthology	cellular component
nucleoplasm	Orthology	cellular component
cytoplasm	Orthology	cellular component
mitochondrion	Orthology	cellular component
Golgi apparatus	Blast	cellular component
cytosol	Orthology	cellular component
plasma membrane	Orthology	cellular component
membrane	Orthology	cellular component
protein ubiquitination	Orthology	biological process
nuclear speck	Orthology	cellular component
transferase activity	Orthology	molecular function
cell differentiation	Orthology	biological process
axon	Orthology	cellular component
identical protein binding	Orthology	molecular function
neuronal cell body	Orthology	cellular component
membrane raft	Orthology	cellular component
negative regulation of transcription, DNA-templated	Orthology	biological process
perinuclear region of cytoplasm	Blast	cellular component
extracellular exosome	Orthology	cellular component
positive regulation of canonical Wnt signaling pathway	Orthology	biological process
intracellular part	Orthology	cellular component
macromolecular complex	Orthology	cellular component
receptor binding	Orthology	molecular function
anion binding	Orthology	molecular function
proteolysis	Orthology	biological process
intracellular protein transport	Orthology	biological process
cell surface receptor signaling pathway	Orthology	biological process
cellular response to organic substance	Orthology	biological process
anatomical structure development	Orthology	biological process
peptidase activity, acting on L-amino acid peptides	Orthology	molecular function
regulation of signal transduction	Orthology	biological process
regulation of transcription from RNA polymerase II promoter	Orthology	biological process
negative regulation of signal transduction	Orthology	biological process
cellular protein localization	Orthology	biological process
macromolecular complex binding	Orthology	molecular function
cell-cell signaling	Orthology	biological process
anatomical structure morphogenesis	Orthology	biological process
animal organ development	Orthology	biological process
protein localization to membrane	Orthology	biological process
cell migration	Orthology	biological process
multicellular organism development	Orthology	biological process
neuron projection morphogenesis	Orthology	biological process
intracellular organelle part	Blast	cellular component
intracellular non-membrane-bounded organelle	Blast	cellular component
cell periphery	Blast	cellular component
cytoplasmic part	Blast	cellular component
plasma membrane region	Blast	cellular component
molecular function regulator	Blast	molecular function
transmembrane transport	Blast	biological process
sodium ion transport	Blast	biological process
enzyme binding	Blast	molecular function

GO Term	SpeciesCe = Caenorhabditis elegans Dr = Danio rerio Dm = Drosophila melanogaster Gg = Gallus gallus Hs = Homo sapiens Mm = Mus musculus Sc = Saccharomyces cerevisiae	Type
negative regulation of transcription from RNA polymerase II promoter	Hs	biological process
ubiquitin ligase complex	Hs	cellular component
protein polyubiquitination	Hs	biological process
ubiquitin-protein transferase activity	Hs	molecular function
transforming growth factor beta receptor binding	Hs	molecular function
protein binding	Hs	molecular function
phospholipid binding	Hs	molecular function
nucleus	Hs	cellular component
nucleoplasm	Hs	cellular component
cytoplasm	Hs	cellular component
mitochondrion	Hs	cellular component
cytosol	Hs	cellular component
plasma membrane	Hs	cellular component
ubiquitin-dependent protein catabolic process	Hs	biological process
protein export from nucleus	Hs	biological process
transforming growth factor beta receptor signaling pathway	Hs	biological process
ectoderm development	Hs	biological process
membrane	Hs	cellular component
protein ubiquitination	Hs	biological process
protein deubiquitination	Hs	biological process
nuclear speck	Hs	cellular component
transferase activity	Hs	molecular function
regulation of transforming growth factor beta receptor signaling pathway	Hs	biological process
cell differentiation	Hs	biological process
negative regulation of ossification	Hs	biological process
axon	Hs	cellular component
BMP signaling pathway	Hs	biological process
negative regulation of transforming growth factor beta receptor signaling pathway	Hs	biological process
negative regulation of BMP signaling pathway	Hs	biological process
ubiquitin-dependent SMAD protein catabolic process	Hs	biological process
receptor catabolic process	Hs	biological process
protein localization to cell surface	Hs	biological process
identical protein binding	Hs	molecular function
neuronal cell body	Hs	cellular component
proteasome-mediated ubiquitin-dependent protein catabolic process	Hs	biological process
membrane raft	Hs	cellular component
negative regulation of transcription, DNA-templated	Hs	biological process
SMAD binding	Hs	molecular function
activin binding	Hs	molecular function
Wnt signaling pathway, planar cell polarity pathway	Hs	biological process
ubiquitin protein ligase activity	Hs	molecular function
extracellular exosome	Hs	cellular component
I-SMAD binding	Hs	molecular function
R-SMAD binding	Hs	molecular function
protein localization to plasma membrane	Hs	biological process
positive regulation of canonical Wnt signaling pathway	Hs	biological process
positive regulation of trophoblast cell migration	Hs	biological process
positive regulation of dendrite extension	Hs	biological process
positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process	Hs	biological process

GO Term	SpeciesCe = Caenorhabditis elegans Dr = Danio rerio Dm = Drosophila melanogaster Gg = Gallus gallus Hs = Homo sapiens Mm = Mus musculus Sc = Saccharomyces cerevisiae	Type	Score	E-value
ubiquitin ligase complex	Hs	cellular component	516	2.05e-177
chromatin	Hs	cellular component	327	5.09e-100
ubiquitin-protein transferase activity	Hs	molecular function	518	3.75e-178
transforming growth factor beta receptor binding	Hs	molecular function	516	2.05e-177
protein binding	Hs	molecular function	518	3.75e-178
phospholipid binding	Hs	molecular function	518	3.75e-178
nucleus	Hs	cellular component	516	2.05e-177
nucleoplasm	Hs	cellular component	518	3.75e-178
cytoplasm	Hs	cellular component	518	3.75e-178
mitochondrion	Hs	cellular component	518	3.75e-178
Golgi apparatus	Hs	cellular component	327	5.09e-100
cytosol	Hs	cellular component	518	3.75e-178
plasma membrane	Hs	cellular component	518	3.75e-178
cell cortex	Hs	cellular component	327	5.09e-100
membrane	Hs	cellular component	518	3.75e-178
apicolateral plasma membrane	Hs	cellular component	327	5.09e-100
nuclear speck	Hs	cellular component	516	2.05e-177
transferase activity	Hs	molecular function	518	3.75e-178
sodium channel inhibitor activity	Hs	molecular function	327	5.09e-100
protein domain specific binding	Hs	molecular function	327	5.09e-100
axon	Hs	cellular component	518	3.75e-178
beta-2 adrenergic receptor binding	Hs	molecular function	327	5.09e-100
identical protein binding	Hs	molecular function	516	2.05e-177
neuronal cell body	Hs	cellular component	518	3.75e-178
ubiquitin binding	Hs	molecular function	327	5.09e-100
membrane raft	Hs	cellular component	516	2.05e-177
SMAD binding	Hs	molecular function	516	2.05e-177
activin binding	Hs	molecular function	518	3.75e-178
perinuclear region of cytoplasm	Hs	cellular component	327	5.09e-100
phosphoserine residue binding	Hs	molecular function	327	5.09e-100
phosphothreonine residue binding	Hs	molecular function	327	5.09e-100
ubiquitin protein ligase activity	Hs	molecular function	518	3.75e-178
extracellular exosome	Hs	cellular component	518	3.75e-178
RNA polymerase binding	Hs	molecular function	327	5.09e-100
proline-rich region binding	Hs	molecular function	327	5.09e-100
I-SMAD binding	Hs	molecular function	518	3.75e-178
R-SMAD binding	Hs	molecular function	518	3.75e-178

GO Term	Analysis	Type	e-value
ubiquitin-protein transferase activity	CDD	molecular function	4.16705E-125