IPR Term	Analysis	Definition
Small_GTPase_Rho	ProSiteProfiles	Small GTPase superfamily, Rho type
Small_GTP-bd_dom	TIGRFAM	Small GTP-binding protein domain
P-loop_NTPase	SUPERFAMILY	P-loop containing nucleoside triphosphate hydrolase
Small_GTPase	Pfam	Small GTPase superfamily

GO Term	Annotation Origin	Type
Golgi membrane	Orthology	cellular component
nucleotide binding	Orthology	molecular function
GTPase activity	Orthology	molecular function
protein serine/threonine kinase activity	Orthology	molecular function
protein binding	Orthology	molecular function
GTP binding	Orthology	molecular function
intracellular	Orthology	cellular component
nuclear envelope	Orthology	cellular component
cytoplasm	Orthology	cellular component
endoplasmic reticulum membrane	Orthology	cellular component
cytosol	Orthology	cellular component
cytoskeleton	Orthology	cellular component
plasma membrane	Orthology	cellular component
focal adhesion	Orthology	cellular component
protein phosphorylation	Orthology	biological process
chemotaxis	Orthology	biological process
cell adhesion	Orthology	biological process
signal transduction	Orthology	biological process
G-protein coupled receptor signaling pathway	Orthology	biological process
small GTPase mediated signal transduction	Orthology	biological process
blood coagulation	Orthology	biological process
cell proliferation	Orthology	biological process
positive regulation of cell proliferation	Orthology	biological process
response to wounding	Orthology	biological process
anatomical structure morphogenesis	Orthology	biological process
endomembrane system	Orthology	cellular component
membrane	Orthology	cellular component
enzyme binding	Orthology	molecular function
protein kinase binding	Orthology	molecular function
lamellipodium	Orthology	cellular component
cell projection assembly	Orthology	biological process
neuron projection development	Orthology	biological process
cytoplasmic vesicle	Orthology	cellular component
intracellular signal transduction	Orthology	biological process
melanosome	Orthology	cellular component
cell projection	Orthology	cellular component
neuron projection	Orthology	cellular component
neuronal cell body	Orthology	cellular component
positive regulation of apoptotic process	Orthology	biological process
perinuclear region of cytoplasm	Orthology	cellular component
cell motility	Orthology	biological process
extracellular exosome	Orthology	cellular component
cell periphery	Orthology	cellular component
Golgi apparatus part	Orthology	cellular component
cytoskeletal part	Orthology	cellular component
defense response	Orthology	biological process
organelle organization	Orthology	biological process
cellular component organization	Orthology	biological process
regulation of cellular metabolic process	Orthology	biological process
protein kinase activity	Orthology	molecular function
enzyme regulator activity	Orthology	molecular function
cell morphogenesis	Orthology	biological process
cellular process	Orthology	biological process
cell migration	Orthology	biological process
cell projection part	Orthology	cellular component
axon	Orthology	cellular component
intracellular organelle part	Orthology	cellular component
whole membrane	Orthology	cellular component
bounding membrane of organelle	Orthology	cellular component
microtubule-based process	Orthology	biological process
cell projection organization	Orthology	biological process
macromolecular complex	Orthology	cellular component
cell projection membrane	Orthology	cellular component
cell leading edge	Orthology	cellular component
cell morphogenesis involved in differentiation	Orthology	biological process
positive regulation of signal transduction	Orthology	biological process
cytoplasmic part	Orthology	cellular component
intracellular non-membrane-bounded organelle	Orthology	cellular component
cell surface receptor signaling pathway	Orthology	biological process
immune response	Orthology	biological process
regulation of cell proliferation	Orthology	biological process
immune system process	Orthology	biological process
postsynapse	Orthology	cellular component
intracellular transport	Orthology	biological process
membrane organization	Orthology	biological process
lysosome	Orthology	cellular component
DNA replication	Orthology	biological process
regulation of catalytic activity	Orthology	biological process
nervous system process	Orthology	biological process
regulation of signal transduction	Orthology	biological process
chemical synaptic transmission	Orthology	biological process
endosome	Orthology	cellular component
cell-cell signaling	Orthology	biological process
animal organ development	Orthology	biological process

GO Term	SpeciesCe = Caenorhabditis elegans Dr = Danio rerio Dm = Drosophila melanogaster Gg = Gallus gallus Hs = Homo sapiens Mm = Mus musculus Sc = Saccharomyces cerevisiae	Type
Golgi membrane	Hs	cellular component
nucleotide binding	Hs	molecular function
positive regulation of protein phosphorylation	Hs	biological process
GTPase activity	Hs	molecular function
protein serine/threonine kinase activity	Hs	molecular function
protein binding	Hs	molecular function
GTP binding	Hs	molecular function
intracellular	Hs	cellular component
nuclear envelope	Hs	cellular component
cytoplasm	Hs	cellular component
endoplasmic reticulum membrane	Hs	cellular component
trans-Golgi network	Hs	cellular component
cytosol	Hs	cellular component
cytoskeleton	Hs	cellular component
actin filament	Hs	cellular component
plasma membrane	Hs	cellular component
focal adhesion	Hs	cellular component
protein phosphorylation	Hs	biological process
chemotaxis	Hs	biological process
inflammatory response	Hs	biological process
actin filament organization	Hs	biological process
cell adhesion	Hs	biological process
cell-matrix adhesion	Hs	biological process
signal transduction	Hs	biological process
G-protein coupled receptor signaling pathway	Hs	biological process
small GTPase mediated signal transduction	Hs	biological process
blood coagulation	Hs	biological process
cell proliferation	Hs	biological process
positive regulation of cell proliferation	Hs	biological process
regulation of cell size	Hs	biological process
response to wounding	Hs	biological process
anatomical structure morphogenesis	Hs	biological process
regulation of hydrogen peroxide metabolic process	Hs	biological process
regulation of lamellipodium assembly	Hs	biological process
positive regulation of lamellipodium assembly	Hs	biological process
positive regulation of cell-substrate adhesion	Hs	biological process
endomembrane system	Hs	cellular component
membrane	Hs	cellular component
Rac protein signal transduction	Hs	biological process
Rab GTPase binding	Hs	molecular function
protein kinase regulator activity	Hs	molecular function
enzyme binding	Hs	molecular function
protein kinase binding	Hs	molecular function
regulation of cell morphogenesis	Hs	biological process
lamellipodium	Hs	cellular component
cell projection assembly	Hs	biological process
lamellipodium assembly	Hs	biological process
actin cytoskeleton organization	Hs	biological process
actin filament polymerization	Hs	biological process
platelet activation	Hs	biological process
regulation of cell migration	Hs	biological process
growth cone	Hs	cellular component
secretory granule membrane	Hs	cellular component
phagocytic vesicle membrane	Hs	cellular component
positive regulation of microtubule polymerization	Hs	biological process
neuron projection development	Hs	biological process
cytoplasmic vesicle	Hs	cellular component
ruffle organization	Hs	biological process
filamentous actin	Hs	cellular component
thioesterase binding	Hs	molecular function
ruffle membrane	Hs	cellular component
positive regulation of cell adhesion mediated by integrin	Hs	biological process
substrate adhesion-dependent cell spreading	Hs	biological process
positive regulation of Rho protein signal transduction	Hs	biological process
intracellular signal transduction	Hs	biological process
cytoplasmic ribonucleoprotein granule	Hs	cellular component
Fc-epsilon receptor signaling pathway	Hs	biological process
regulation of T cell proliferation	Hs	biological process
melanosome	Hs	cellular component
histone deacetylase binding	Hs	molecular function
cell projection	Hs	cellular component
neuron projection	Hs	cellular component
neuronal cell body	Hs	cellular component
positive regulation of apoptotic process	Hs	biological process
dendritic spine	Hs	cellular component
regulation of mast cell degranulation	Hs	biological process
bone resorption	Hs	biological process
positive regulation of DNA replication	Hs	biological process
regulation of protein kinase activity	Hs	biological process
vascular endothelial growth factor receptor signaling pathway	Hs	biological process
hepatocyte growth factor receptor signaling pathway	Hs	biological process
ephrin receptor signaling pathway	Hs	biological process
negative regulation of receptor-mediated endocytosis	Hs	biological process
calcium-dependent protein binding	Hs	molecular function
perinuclear region of cytoplasm	Hs	cellular component
cell motility	Hs	biological process
homeostasis of number of cells within a tissue	Hs	biological process
neuromuscular process controlling balance	Hs	biological process
neuromuscular process	Hs	biological process
Rho GDP-dissociation inhibitor binding	Hs	molecular function
regulation of small GTPase mediated signal transduction	Hs	biological process
ATPase binding	Hs	molecular function
regulation of stress fiber assembly	Hs	biological process
positive regulation of stress fiber assembly	Hs	biological process
localization within membrane	Hs	biological process
positive regulation of focal adhesion assembly	Hs	biological process
synaptic transmission, GABAergic	Hs	biological process
recycling endosome membrane	Hs	cellular component
Wnt signaling pathway, planar cell polarity pathway	Hs	biological process
extracellular exosome	Hs	cellular component
cellular response to mechanical stimulus	Hs	biological process
semaphorin-plexin signaling pathway	Hs	biological process
cell periphery	Hs	cellular component
positive regulation of neutrophil chemotaxis	Hs	biological process
ruffle assembly	Hs	biological process
ficolin-1-rich granule membrane	Hs	cellular component
positive regulation of substrate adhesion-dependent cell spreading	Hs	biological process
regulation of neutrophil migration	Hs	biological process

GO Term	SpeciesCe = Caenorhabditis elegans Dr = Danio rerio Dm = Drosophila melanogaster Gg = Gallus gallus Hs = Homo sapiens Mm = Mus musculus Sc = Saccharomyces cerevisiae	Type	Score	E-value
Golgi membrane	Hs	cellular component	342	1.00e-121
nucleotide binding	Hs	molecular function	352	5.58e-126
GTPase activity	Hs	molecular function	352	5.58e-126
protein serine/threonine kinase activity	Hs	molecular function	342	1.00e-121
protein binding	Hs	molecular function	352	5.58e-126
GTP binding	Hs	molecular function	352	5.58e-126
intracellular	Hs	cellular component	352	5.58e-126
nuclear envelope	Hs	cellular component	352	5.58e-126
cytoplasm	Hs	cellular component	352	5.58e-126
endoplasmic reticulum membrane	Hs	cellular component	342	1.00e-121
trans-Golgi network	Hs	cellular component	342	1.00e-121
cytosol	Hs	cellular component	352	5.58e-126
cytoskeleton	Hs	cellular component	341	1.30e-121
actin filament	Hs	cellular component	352	5.58e-126
plasma membrane	Hs	cellular component	352	5.58e-126
focal adhesion	Hs	cellular component	352	5.58e-126
endomembrane system	Hs	cellular component	341	1.30e-121
membrane	Hs	cellular component	352	5.58e-126
Rab GTPase binding	Hs	molecular function	342	1.00e-121
protein kinase regulator activity	Hs	molecular function	352	5.58e-126
enzyme binding	Hs	molecular function	342	1.00e-121
protein kinase binding	Hs	molecular function	342	1.00e-121
lamellipodium	Hs	cellular component	352	5.58e-126
growth cone	Hs	cellular component	341	1.30e-121
secretory granule membrane	Hs	cellular component	342	1.00e-121
phagocytic vesicle membrane	Hs	cellular component	352	5.58e-126
cytoplasmic vesicle	Hs	cellular component	342	1.00e-121
filamentous actin	Hs	cellular component	341	1.30e-121
thioesterase binding	Hs	molecular function	342	1.00e-121
ruffle membrane	Hs	cellular component	342	1.00e-121
cytoplasmic ribonucleoprotein granule	Hs	cellular component	342	1.00e-121
melanosome	Hs	cellular component	342	1.00e-121
histone deacetylase binding	Hs	molecular function	342	1.00e-121
cell projection	Hs	cellular component	341	1.30e-121
neuron projection	Hs	cellular component	341	1.30e-121
neuronal cell body	Hs	cellular component	341	1.30e-121
dendritic spine	Hs	cellular component	342	1.00e-121
calcium-dependent protein binding	Hs	molecular function	341	1.30e-121
perinuclear region of cytoplasm	Hs	cellular component	341	1.30e-121
Rho GDP-dissociation inhibitor binding	Hs	molecular function	342	1.00e-121
ATPase binding	Hs	molecular function	342	1.00e-121
recycling endosome membrane	Hs	cellular component	342	1.00e-121
extracellular exosome	Hs	cellular component	352	5.58e-126
cell periphery	Hs	cellular component	341	1.30e-121
ficolin-1-rich granule membrane	Hs	cellular component	342	1.00e-121

GO Term	Analysis	Type	e-value
GTPase activity	Pfam	molecular function	1.2E-53
GTP binding	Pfam	molecular function	1.2E-53
intracellular	ProSiteProfiles	cellular component	28.822
small GTPase mediated signal transduction	ProSiteProfiles	biological process	28.822