IPR Term	Analysis	Definition
SMAD_dom_Dwarfin-type	SMART	SMAD domain, Dwarfin-type
SMAD_dom_Dwarfin-type	ProSiteProfiles	SMAD domain, Dwarfin-type
SMAD_dom_Dwarfin-type	Pfam	SMAD domain, Dwarfin-type
SMAD_FHA_dom_sf	SUPERFAMILY	SMAD/FHA domain superfamily
SMAD-like_dom_sf	Gene3D	SMAD-like domain superfamily
Dwarfin	PANTHER	Dwarfin
MAD_homology1_Dwarfin-type	Pfam	MAD homology 1, Dwarfin-type
SMAD_MH1_sf	SUPERFAMILY	SMAD MH1 domain superfamily
SMAD_MH1_sf	Gene3D	SMAD MH1 domain superfamily
MAD_homology1_Dwarfin-type	SMART	MAD homology 1, Dwarfin-type
MAD_homology_MH1	ProSiteProfiles	MAD homology, MH1

GO Term	Annotation Origin	Type
negative regulation of transcription from RNA polymerase II promoter	Orthology	biological process
RNA polymerase II regulatory region sequence-specific DNA binding	Orthology	molecular function
RNA polymerase II core promoter proximal region sequence-specific DNA binding	Orthology	molecular function
RNA polymerase II transcription factor activity, sequence-specific DNA binding	Orthology	molecular function
core promoter proximal region sequence-specific DNA binding	Orthology	molecular function
transcription factor activity, transcription factor binding	Orthology	molecular function
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding	Orthology	molecular function
response to hypoxia	Orthology	biological process
DNA binding	Orthology	molecular function
chromatin binding	Orthology	molecular function
double-stranded DNA binding	Blast	molecular function
transcription factor activity, sequence-specific DNA binding	Orthology	molecular function
protein binding	Orthology	molecular function
intracellular	Orthology	cellular component
nucleus	Orthology	cellular component
nucleoplasm	Orthology	cellular component
cytoplasm	Orthology	cellular component
centrosome	Orthology	cellular component
cytosol	Orthology	cellular component
plasma membrane	Blast	cellular component
transcription, DNA-templated	Orthology	biological process
regulation of transcription, DNA-templated	Orthology	biological process
regulation of transcription from RNA polymerase II promoter	Orthology	biological process
protein phosphorylation	Orthology	biological process
spermatogenesis	Orthology	biological process
axon guidance	Orthology	biological process
heart development	Orthology	biological process
transcription factor binding	Orthology	molecular function
zinc ion binding	Blast	molecular function
cell proliferation	Orthology	biological process
negative regulation of cell proliferation	Orthology	biological process
membrane	Blast	cellular component
integral component of membrane	Blast	cellular component
enzyme binding	Blast	molecular function
protein kinase binding	Blast	molecular function
ubiquitin protein ligase binding	Blast	molecular function
macromolecular complex	Orthology	cellular component
intracellular signal transduction	Orthology	biological process
regulation of cell proliferation	Orthology	biological process
identical protein binding	Orthology	molecular function
protein homodimerization activity	Orthology	molecular function
sequence-specific DNA binding	Orthology	molecular function
transcription regulatory region DNA binding	Orthology	molecular function
negative regulation of transcription, DNA-templated	Orthology	biological process
positive regulation of transcription, DNA-templated	Orthology	biological process
positive regulation of transcription from RNA polymerase II promoter	Orthology	biological process
metal ion binding	Orthology	molecular function
protein heterodimerization activity	Orthology	molecular function
negative regulation of cell death	Orthology	biological process
intracellular non-membrane-bounded organelle	Orthology	cellular component
nuclear lumen	Orthology	cellular component
reproductive process	Orthology	biological process
animal organ development	Orthology	biological process
anatomical structure morphogenesis	Orthology	biological process
anatomical structure formation involved in morphogenesis	Orthology	biological process
multicellular organism development	Orthology	biological process
macromolecular complex binding	Orthology	molecular function
intracellular part	Orthology	cellular component
cellular process	Orthology	biological process
cell	Orthology	cellular component
cell surface receptor signaling pathway	Orthology	biological process
cellular response to organic substance	Orthology	biological process
sexual reproduction	Orthology	biological process
anatomical structure development	Orthology	biological process
cell differentiation	Orthology	biological process
positive regulation of signal transduction	Orthology	biological process
peptidase activity, acting on L-amino acid peptides	Orthology	molecular function
regulation of signal transduction	Orthology	biological process
cellular component organization	Orthology	biological process
molecular transducer activity	Orthology	molecular function
nuclear part	Orthology	cellular component
developmental process	Orthology	biological process
anion binding	Orthology	molecular function
neuron differentiation	Orthology	biological process
organelle organization	Orthology	biological process
cellular protein modification process	Orthology	biological process
protein homooligomerization	Orthology	biological process
negative regulation of signal transduction	Orthology	biological process
receptor binding	Blast	molecular function
organelle inner membrane	Blast	cellular component
nuclear membrane	Blast	cellular component
RNA binding	Blast	molecular function

GO Term	SpeciesCe = Caenorhabditis elegans Dr = Danio rerio Dm = Drosophila melanogaster Gg = Gallus gallus Hs = Homo sapiens Mm = Mus musculus Sc = Saccharomyces cerevisiae	Type
negative regulation of transcription from RNA polymerase II promoter	Hs	biological process
nuclear chromatin	Hs	cellular component
RNA polymerase II regulatory region sequence-specific DNA binding	Hs	molecular function
RNA polymerase II core promoter proximal region sequence-specific DNA binding	Hs	molecular function
RNA polymerase II transcription factor activity, sequence-specific DNA binding	Hs	molecular function
core promoter proximal region sequence-specific DNA binding	Hs	molecular function
transcription factor activity, transcription factor binding	Hs	molecular function
transcription factor activity, RNA polymerase II transcription factor binding	Hs	molecular function
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding	Hs	molecular function
RNA polymerase II transcription factor binding	Hs	molecular function
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding	Hs	molecular function
ovarian follicle development	Hs	biological process
branching involved in ureteric bud morphogenesis	Hs	biological process
response to hypoxia	Hs	biological process
gastrulation with mouth forming second	Hs	biological process
kidney development	Hs	biological process
atrioventricular valve formation	Hs	biological process
DNA binding	Hs	molecular function
chromatin binding	Hs	molecular function
transcription factor activity, sequence-specific DNA binding	Hs	molecular function
protein binding	Hs	molecular function
collagen binding	Hs	molecular function
intracellular	Hs	cellular component
nucleus	Hs	cellular component
nucleoplasm	Hs	cellular component
transcription factor complex	Hs	cellular component
cytoplasm	Hs	cellular component
centrosome	Hs	cellular component
cytosol	Hs	cellular component
transcription, DNA-templated	Hs	biological process
regulation of transcription, DNA-templated	Hs	biological process
regulation of transcription from RNA polymerase II promoter	Hs	biological process
cellular iron ion homeostasis	Hs	biological process
transforming growth factor beta receptor signaling pathway	Hs	biological process
spermatogenesis	Hs	biological process
single fertilization	Hs	biological process
gastrulation	Hs	biological process
axon guidance	Hs	biological process
endoderm development	Hs	biological process
mesoderm development	Hs	biological process
cell proliferation	Hs	biological process
negative regulation of cell proliferation	Hs	biological process
male gonad development	Hs	biological process
female gonad development	Hs	biological process
anterior/posterior pattern specification	Hs	biological process
positive regulation of epithelial to mesenchymal transition	Hs	biological process
positive regulation of pathway-restricted SMAD protein phosphorylation	Hs	biological process
neural crest cell differentiation	Hs	biological process
protein deubiquitination	Hs	biological process
regulation of transforming growth factor beta receptor signaling pathway	Hs	biological process
negative regulation of cell growth	Hs	biological process
BMP signaling pathway	Hs	biological process
positive regulation of transforming growth factor beta receptor signaling pathway	Hs	biological process
positive regulation of BMP signaling pathway	Hs	biological process
transforming growth factor beta receptor, common-partner cytoplasmic mediator activity	Hs	molecular function
activin responsive factor complex	Hs	cellular component
somite rostral/caudal axis specification	Hs	biological process
somatic stem cell population maintenance	Hs	biological process
intracellular signal transduction	Hs	biological process
atrioventricular canal development	Hs	biological process
regulation of cell proliferation	Hs	biological process
identical protein binding	Hs	molecular function
protein homodimerization activity	Hs	molecular function
sulfate binding	Hs	molecular function
sequence-specific DNA binding	Hs	molecular function
transcription regulatory region DNA binding	Hs	molecular function
negative regulation of transcription, DNA-templated	Hs	biological process
positive regulation of transcription, DNA-templated	Hs	biological process
positive regulation of transcription from RNA polymerase II promoter	Hs	biological process
metal ion binding	Hs	molecular function
protein heterodimerization activity	Hs	molecular function
developmental growth	Hs	biological process
neuron fate commitment	Hs	biological process
tissue morphogenesis	Hs	biological process
formation of anatomical boundary	Hs	biological process
positive regulation of histone H3-K4 methylation	Hs	biological process
palate development	Hs	biological process
uterus development	Hs	biological process
SMAD protein signal transduction	Hs	biological process
negative regulation of cell death	Hs	biological process
endocardial cell differentiation	Hs	biological process
protein homotrimerization	Hs	biological process
negative regulation of ERK1 and ERK2 cascade	Hs	biological process
I-SMAD binding	Hs	molecular function
R-SMAD binding	Hs	molecular function
SMAD protein complex	Hs	cellular component
RNA polymerase II transcription factor complex	Hs	cellular component

GO Term	SpeciesCe = Caenorhabditis elegans Dr = Danio rerio Dm = Drosophila melanogaster Gg = Gallus gallus Hs = Homo sapiens Mm = Mus musculus Sc = Saccharomyces cerevisiae	Type	Score	E-value
nuclear chromatin	Hs	cellular component	484	4.35e-167
RNA polymerase II regulatory region sequence-specific DNA binding	Hs	molecular function	484	4.35e-167
RNA polymerase II core promoter proximal region sequence-specific DNA binding	Hs	molecular function	484	4.35e-167
RNA polymerase II transcription factor activity, sequence-specific DNA binding	Hs	molecular function	484	4.35e-167
transcription factor activity, RNA polymerase II core promoter sequence-specific	Hs	molecular function	197	1.10e-57
core promoter proximal region sequence-specific DNA binding	Hs	molecular function	484	4.35e-167
transcription factor activity, transcription factor binding	Hs	molecular function	484	4.35e-167
transcription factor activity, RNA polymerase II transcription factor binding	Hs	molecular function	484	4.35e-167
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding	Hs	molecular function	484	4.35e-167
RNA polymerase II transcription factor binding	Hs	molecular function	484	4.35e-167
RNA polymerase II activating transcription factor binding	Hs	molecular function	197	1.10e-57
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding	Hs	molecular function	484	4.35e-167
DNA binding	Hs	molecular function	484	4.35e-167
chromatin binding	Hs	molecular function	484	4.35e-167
double-stranded DNA binding	Hs	molecular function	197	1.10e-57
transcription factor activity, sequence-specific DNA binding	Hs	molecular function	484	4.35e-167
transforming growth factor beta receptor binding	Hs	molecular function	197	1.10e-57
protein binding	Hs	molecular function	484	4.35e-167
collagen binding	Hs	molecular function	484	4.35e-167
intracellular	Hs	cellular component	484	4.35e-167
nucleus	Hs	cellular component	484	4.35e-167
nuclear inner membrane	Hs	cellular component	197	1.10e-57
nucleoplasm	Hs	cellular component	484	4.35e-167
transcription factor complex	Hs	cellular component	484	4.35e-167
cytoplasm	Hs	cellular component	484	4.35e-167
centrosome	Hs	cellular component	484	4.35e-167
cytosol	Hs	cellular component	484	4.35e-167
plasma membrane	Hs	cellular component	197	1.10e-57
beta-catenin binding	Hs	molecular function	197	1.10e-57
transcription factor binding	Hs	molecular function	197	1.10e-57
zinc ion binding	Hs	molecular function	197	1.10e-57
membrane	Hs	cellular component	187	3.09e-53
integral component of membrane	Hs	cellular component	187	3.09e-53
DEAD/H-box RNA helicase binding	Hs	molecular function	197	1.10e-57
enzyme binding	Hs	molecular function	197	1.10e-57
protein kinase binding	Hs	molecular function	197	1.10e-57
phosphatase binding	Hs	molecular function	197	1.10e-57
transforming growth factor beta receptor, common-partner cytoplasmic mediator activity	Hs	molecular function	484	4.35e-167
transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity	Hs	molecular function	197	1.10e-57
chromatin DNA binding	Hs	molecular function	197	1.10e-57
ubiquitin protein ligase binding	Hs	molecular function	197	1.10e-57
mineralocorticoid receptor binding	Hs	molecular function	197	1.10e-57
activin responsive factor complex	Hs	cellular component	484	4.35e-167
macromolecular complex	Hs	cellular component	187	3.09e-53
activating transcription factor binding	Hs	molecular function	187	3.09e-53
type I transforming growth factor beta receptor binding	Hs	molecular function	187	3.09e-53
glucocorticoid receptor binding	Hs	molecular function	197	1.10e-57
enhancer binding	Hs	molecular function	197	1.10e-57
identical protein binding	Hs	molecular function	484	4.35e-167
protein homodimerization activity	Hs	molecular function	484	4.35e-167
ubiquitin binding	Hs	molecular function	197	1.10e-57
sulfate binding	Hs	molecular function	484	4.35e-167
receptor complex	Hs	cellular component	197	1.10e-57
bHLH transcription factor binding	Hs	molecular function	197	1.10e-57
sequence-specific DNA binding	Hs	molecular function	484	4.35e-167
transcription regulatory region DNA binding	Hs	molecular function	484	4.35e-167
SMAD binding	Hs	molecular function	197	1.10e-57
metal ion binding	Hs	molecular function	484	4.35e-167
protein heterodimerization activity	Hs	molecular function	484	4.35e-167
co-SMAD binding	Hs	molecular function	197	1.10e-57
I-SMAD binding	Hs	molecular function	484	4.35e-167
R-SMAD binding	Hs	molecular function	484	4.35e-167
primary miRNA binding	Hs	molecular function	197	1.10e-57
SMAD protein complex	Hs	cellular component	484	4.35e-167
SMAD2-SMAD3 protein complex	Hs	cellular component	197	1.10e-57
RNA polymerase II transcription factor complex	Hs	cellular component	484	4.35e-167
disordered domain specific binding	Hs	molecular function	187	3.09e-53

GO Term	Analysis	Type	e-value
transcription factor activity, sequence-specific DNA binding	ProSiteProfiles	molecular function	16.627
protein binding	SUPERFAMILY	molecular function	2.19E-90
intracellular	PANTHER	cellular component	4.9E-173
transcription factor complex	ProSiteProfiles	cellular component	16.627
regulation of transcription, DNA-templated	PANTHER	biological process	4.9E-173
transforming growth factor beta receptor signaling pathway	Gene3D	biological process	4.2E-20