Gene Card
Best human hits
SIRT2; SIRT3
Species
Unique Gene ID
Phmamm.g00004173
Gene Model ID
Phmamm.CG.MTP2014.S146.g04173
Location
S146:129522..137169
Transcript Models and Sequences
Phmamm.CG.MTP2014.S146.g04173.01.t
Phmamm.CG.MTP2014.S146.g04173.02.t
Phmamm.CG.MTP2014.S146.g04173.03.t
AHC0AAA8YL03
Plate: Plate_8_L03
AHC0AAA106YL15
Plate: Plate_106_L15
AHC0AAA106YL13
Plate: Plate_106_L13
n/a
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You can Press 'Ctrl' Key + Left Mouse Click on nodes to do a multiple selection.

IPR Term | Analysis | Definition |
---|---|---|
Ssirtuin_cat_dom | ProSiteProfiles | Sirtuin family, catalytic core domain |
Sirtuin | Pfam | Sirtuin family |
Sirtuin_cat_small_dom_sf | Gene3D | Sirtuin, catalytic core small domain superfamily |
DHS-like_NAD/FAD-binding_dom | SUPERFAMILY | DHS-like NAD/FAD-binding domain superfamily |
GO Term | Annotation Origin | Type |
---|---|---|
chromatin binding | Blast | molecular function |
protein binding | Orthology | molecular function |
nucleus | Blast | cellular component |
nucleolus | Blast | cellular component |
cytoplasm | Blast | cellular component |
mitochondrion | Orthology | cellular component |
mitochondrial matrix | Orthology | cellular component |
centrosome | Blast | cellular component |
microtubule organizing center | Blast | cellular component |
cytosol | Blast | cellular component |
cytoskeleton | Blast | cellular component |
microtubule | Blast | cellular component |
plasma membrane | Blast | cellular component |
transcription factor binding | Blast | molecular function |
zinc ion binding | Orthology | molecular function |
membrane | Blast | cellular component |
hydrolase activity | Orthology | molecular function |
enzyme binding | Orthology | molecular function |
midbody | Blast | cellular component |
macromolecular complex | Orthology | cellular component |
cell projection | Blast | cellular component |
myelin sheath | Blast | cellular component |
sequence-specific DNA binding | Orthology | molecular function |
metal ion binding | Orthology | molecular function |
perinuclear region of cytoplasm | Blast | cellular component |
transferase activity | Orthology | molecular function |
cellular protein modification process | Orthology | biological process |
organelle organization | Orthology | biological process |
developmental process | Orthology | biological process |
oxidation-reduction process | Orthology | biological process |
cellular metabolic process | Orthology | biological process |
protein transport | Orthology | biological process |
cell-cell signaling | Orthology | biological process |
intracellular signal transduction | Orthology | biological process |
negative regulation of signal transduction | Orthology | biological process |
protein phosphorylation | Orthology | biological process |
anion binding | Orthology | molecular function |
nucleotide binding | Orthology | molecular function |
coenzyme binding | Orthology | molecular function |
intracellular organelle part | Blast | cellular component |
intracellular non-membrane-bounded organelle | Blast | cellular component |
nucleoplasm part | Blast | cellular component |
nuclear lumen | Blast | cellular component |
cytoplasmic part | Blast | cellular component |
cytoskeletal part | Blast | cellular component |
microtubule cytoskeleton | Blast | cellular component |
cell projection part | Blast | cellular component |
axon | Blast | cellular component |
cell junction | Blast | cellular component |
neuronal cell body | Blast | cellular component |
plasma membrane region | Blast | cellular component |
GO Term | SpeciesCe = Caenorhabditis elegans Dr = Danio rerio Dm = Drosophila melanogaster Gg = Gallus gallus Hs = Homo sapiens Mm = Mus musculus Sc = Saccharomyces cerevisiae |
Type |
---|---|---|
NAD+ ADP-ribosyltransferase activity | Hs | molecular function |
protein binding | Hs | molecular function |
mitochondrion | Hs | cellular component |
mitochondrial matrix | Hs | cellular component |
protein ADP-ribosylation | Hs | biological process |
protein deacetylation | Hs | biological process |
mitochondrion organization | Hs | biological process |
aging | Hs | biological process |
zinc ion binding | Hs | molecular function |
aerobic respiration | Hs | biological process |
histone deacetylation | Hs | biological process |
hydrolase activity | Hs | molecular function |
NAD-dependent histone deacetylase activity | Hs | molecular function |
enzyme binding | Hs | molecular function |
positive regulation of insulin secretion | Hs | biological process |
macromolecular complex | Hs | cellular component |
NAD-dependent protein deacetylase activity | Hs | molecular function |
sequence-specific DNA binding | Hs | molecular function |
metal ion binding | Hs | molecular function |
negative regulation of ERK1 and ERK2 cascade | Hs | biological process |
NAD+ binding | Hs | molecular function |
negative regulation of reactive oxygen species metabolic process | Hs | biological process |
GO Term | SpeciesCe = Caenorhabditis elegans Dr = Danio rerio Dm = Drosophila melanogaster Gg = Gallus gallus Hs = Homo sapiens Mm = Mus musculus Sc = Saccharomyces cerevisiae |
Type | Score | E-value |
---|---|---|---|---|
chromosome, telomeric region | Hs | cellular component | 276 | 2.11e-87 |
chromatin binding | Hs | molecular function | 276 | 2.11e-87 |
NAD+ ADP-ribosyltransferase activity | Hs | molecular function | 343 | 5.91e-113 |
histone deacetylase activity | Hs | molecular function | 276 | 2.11e-87 |
protein binding | Hs | molecular function | 343 | 5.91e-113 |
nucleus | Hs | cellular component | 276 | 2.11e-87 |
chromatin silencing complex | Hs | cellular component | 276 | 2.11e-87 |
chromosome | Hs | cellular component | 276 | 2.11e-87 |
nuclear heterochromatin | Hs | cellular component | 276 | 2.11e-87 |
nucleolus | Hs | cellular component | 276 | 2.11e-87 |
cytoplasm | Hs | cellular component | 276 | 2.11e-87 |
mitochondrion | Hs | cellular component | 343 | 5.91e-113 |
mitochondrial matrix | Hs | cellular component | 343 | 5.91e-113 |
centrosome | Hs | cellular component | 276 | 2.11e-87 |
centriole | Hs | cellular component | 276 | 2.11e-87 |
microtubule organizing center | Hs | cellular component | 276 | 2.11e-87 |
spindle | Hs | cellular component | 276 | 2.11e-87 |
cytosol | Hs | cellular component | 276 | 2.11e-87 |
cytoskeleton | Hs | cellular component | 276 | 2.11e-87 |
microtubule | Hs | cellular component | 276 | 2.11e-87 |
plasma membrane | Hs | cellular component | 276 | 2.11e-87 |
transcription factor binding | Hs | molecular function | 276 | 2.11e-87 |
zinc ion binding | Hs | molecular function | 343 | 5.91e-113 |
membrane | Hs | cellular component | 276 | 2.11e-87 |
hydrolase activity | Hs | molecular function | 343 | 5.91e-113 |
NAD-dependent histone deacetylase activity | Hs | molecular function | 343 | 5.91e-113 |
enzyme binding | Hs | molecular function | 343 | 5.91e-113 |
growth cone | Hs | cellular component | 276 | 2.11e-87 |
midbody | Hs | cellular component | 276 | 2.11e-87 |
macromolecular complex | Hs | cellular component | 343 | 5.91e-113 |
paranodal junction | Hs | cellular component | 276 | 2.11e-87 |
paranode region of axon | Hs | cellular component | 276 | 2.11e-87 |
protein deacetylase activity | Hs | molecular function | 276 | 2.11e-87 |
NAD-dependent protein deacetylase activity | Hs | molecular function | 343 | 5.91e-113 |
histone acetyltransferase binding | Hs | molecular function | 276 | 2.11e-87 |
histone deacetylase binding | Hs | molecular function | 276 | 2.11e-87 |
tubulin deacetylase activity | Hs | molecular function | 276 | 2.11e-87 |
cell projection | Hs | cellular component | 276 | 2.11e-87 |
ubiquitin binding | Hs | molecular function | 276 | 2.11e-87 |
perikaryon | Hs | cellular component | 276 | 2.11e-87 |
myelin sheath | Hs | cellular component | 276 | 2.11e-87 |
lateral loop | Hs | cellular component | 276 | 2.11e-87 |
Schmidt-Lanterman incisure | Hs | cellular component | 276 | 2.11e-87 |
sequence-specific DNA binding | Hs | molecular function | 343 | 5.91e-113 |
juxtaparanode region of axon | Hs | cellular component | 276 | 2.11e-87 |
metal ion binding | Hs | molecular function | 343 | 5.91e-113 |
NAD-dependent histone deacetylase activity (H4-K16 specific) | Hs | molecular function | 276 | 2.11e-87 |
perinuclear region of cytoplasm | Hs | cellular component | 276 | 2.11e-87 |
NAD+ binding | Hs | molecular function | 343 | 5.91e-113 |
mitotic spindle | Hs | cellular component | 276 | 2.11e-87 |
meiotic spindle | Hs | cellular component | 276 | 2.11e-87 |
glial cell projection | Hs | cellular component | 276 | 2.11e-87 |
GO Term | Analysis | Type | e-value |
---|---|---|---|
NAD+ binding | Pfam | molecular function | 7.2E-55 |