Gene Card
Best human hits
DAB2IP; RASA1; RASAL2
Species
Unique Gene ID
Phmamm.g00007897
Gene Model ID
Phmamm.CG.MTP2014.S368.g07897
Location
S368:94377..112704
Transcript Models and Sequences
Phmamm.CG.MTP2014.S368.g07897.01.t
Phmamm.CG.MTP2014.S368.g07897.02.t
AHC0AAA33YE04
Plate: Plate_33_E04
AHC0AAA44YE17
Plate: Plate_44_E17
AHC0AAA44YK17
Plate: Plate_44_K17
AHC0AAA64YI20
Plate: Plate_64_I20
AHC0AAA69YA16
Plate: Plate_69_A16
AHC0AAA100YD10
Plate: Plate_100_D10
AHC0AAA103YH16
Plate: Plate_103_H16
AHC0AAA117YF06
Plate: Plate_117_F06
AHC0AAA167YE04
Plate: Plate_167_E04
AHC0AAA184YO04
Plate: Plate_184_O04
AHC0AAA211YL07
Plate: Plate_211_L07
AHC0AAA227YO14
Plate: Plate_227_O14
AHC0AAA246YF21
Plate: Plate_246_F21
n/a
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IPR Term | Analysis | Definition |
---|---|---|
RasGAP_CS | ProSitePatterns | Ras GTPase-activating protein, conserved site |
RasGAP_SH3 | CDD | RasGAP, SH3 domain |
SH2 | SMART | SH2 domain |
RasGAP_dom | ProSiteProfiles | Ras GTPase-activating domain |
SH2_dom_sf | SUPERFAMILY | SH2 domain superfamily |
PH_domain | Pfam | Pleckstrin homology domain |
p120-RasGAP | PANTHER | Ras GTPase-activating protein 1 |
SH3_domain | SMART | SH3 domain |
SH2 | Pfam | SH2 domain |
C2_dom | Pfam | C2 domain |
SH3_domain | Pfam | SH3 domain |
SH2 | PRINTS | SH2 domain |
PH_domain | SMART | Pleckstrin homology domain |
RasGAP_dom | SMART | Ras GTPase-activating domain |
SH2 | ProSiteProfiles | SH2 domain |
PH-like_dom_sf | Gene3D | PH-like domain superfamily |
SH2_dom_sf | Gene3D | SH2 domain superfamily |
C2_dom | SMART | C2 domain |
C2_domain_sf | Gene3D | C2 domain superfamily |
SH3-like_dom_sf | SUPERFAMILY | SH3-like domain superfamily |
PH_domain | ProSiteProfiles | Pleckstrin homology domain |
C2_dom | ProSiteProfiles | C2 domain |
Rho_GTPase_activation_prot | SUPERFAMILY | Rho GTPase activation protein |
RasGAP_dom | Pfam | Ras GTPase-activating domain |
SH3_domain | ProSiteProfiles | SH3 domain |
GO Term | Annotation Origin | Type |
---|---|---|
GTPase activity | Orthology | molecular function |
GTPase activator activity | Orthology | molecular function |
receptor binding | Orthology | molecular function |
protein binding | Orthology | molecular function |
cytoplasm | Orthology | cellular component |
cytosol | Orthology | cellular component |
plasma membrane | Orthology | cellular component |
signal transduction | Orthology | biological process |
membrane | Blast | cellular component |
kinase binding | Blast | molecular function |
protein kinase binding | Blast | molecular function |
axon | Blast | cellular component |
intracellular signal transduction | Orthology | biological process |
identical protein binding | Blast | molecular function |
protein homodimerization activity | Blast | molecular function |
cell projection | Orthology | cellular component |
neuronal cell body | Blast | cellular component |
negative regulation of apoptotic process | Orthology | biological process |
regulation of GTPase activity | Orthology | biological process |
positive regulation of GTPase activity | Orthology | biological process |
macromolecular complex binding | Blast | molecular function |
blood vessel morphogenesis | Orthology | biological process |
extracellular exosome | Blast | cellular component |
protein phosphorylation | Orthology | biological process |
membrane organization | Orthology | biological process |
cell division | Orthology | biological process |
cell differentiation | Orthology | biological process |
plasma membrane region | Orthology | cellular component |
cell leading edge | Orthology | cellular component |
cell adhesion | Orthology | biological process |
cell morphogenesis | Orthology | biological process |
molecular function regulator | Orthology | molecular function |
transmembrane transport | Orthology | biological process |
monovalent inorganic cation transport | Orthology | biological process |
metal ion transport | Orthology | biological process |
organelle organization | Orthology | biological process |
intrinsic component of plasma membrane | Orthology | cellular component |
small GTPase mediated signal transduction | Orthology | biological process |
negative regulation of signal transduction | Orthology | biological process |
cell surface receptor signaling pathway | Orthology | biological process |
enzyme binding | Orthology | molecular function |
cytoplasmic vesicle | Blast | cellular component |
anion binding | Blast | molecular function |
plasma membrane part | Blast | cellular component |
positive regulation of signal transduction | Blast | biological process |
cell adhesion molecule binding | Blast | molecular function |
macromolecular complex | Blast | cellular component |
GO Term | SpeciesCe = Caenorhabditis elegans Dr = Danio rerio Dm = Drosophila melanogaster Gg = Gallus gallus Hs = Homo sapiens Mm = Mus musculus Sc = Saccharomyces cerevisiae |
Type |
---|---|---|
MAPK cascade | Hs | biological process |
mitotic cytokinesis | Hs | biological process |
vasculogenesis | Hs | biological process |
ruffle | Hs | cellular component |
phosphotyrosine residue binding | Hs | molecular function |
GTPase activity | Hs | molecular function |
GTPase activator activity | Hs | molecular function |
receptor binding | Hs | molecular function |
protein binding | Hs | molecular function |
cytoplasm | Hs | cellular component |
cytosol | Hs | cellular component |
plasma membrane | Hs | cellular component |
negative regulation of cell adhesion | Hs | biological process |
signal transduction | Hs | biological process |
regulation of cell shape | Hs | biological process |
potassium channel inhibitor activity | Hs | molecular function |
regulation of actin filament polymerization | Hs | biological process |
intrinsic component of the cytoplasmic side of the plasma membrane | Hs | cellular component |
intracellular signal transduction | Hs | biological process |
negative regulation of apoptotic process | Hs | biological process |
regulation of GTPase activity | Hs | biological process |
negative regulation of neuron apoptotic process | Hs | biological process |
positive regulation of GTPase activity | Hs | biological process |
negative regulation of Ras protein signal transduction | Hs | biological process |
ephrin receptor signaling pathway | Hs | biological process |
blood vessel morphogenesis | Hs | biological process |
GTPase binding | Hs | molecular function |
GO Term | SpeciesCe = Caenorhabditis elegans Dr = Danio rerio Dm = Drosophila melanogaster Gg = Gallus gallus Hs = Homo sapiens Mm = Mus musculus Sc = Saccharomyces cerevisiae |
Type | Score | E-value |
---|---|---|---|---|
ruffle | Hs | cellular component | 837 | 0.0 |
phosphotyrosine residue binding | Hs | molecular function | 837 | 0.0 |
GTPase activity | Hs | molecular function | 837 | 0.0 |
GTPase activator activity | Hs | molecular function | 837 | 0.0 |
receptor binding | Hs | molecular function | 837 | 0.0 |
death receptor binding | Hs | molecular function | 193 | 2.44e-50 |
protein binding | Hs | molecular function | 837 | 0.0 |
cytoplasm | Hs | cellular component | 837 | 0.0 |
cytosol | Hs | cellular component | 837 | 0.0 |
plasma membrane | Hs | cellular component | 837 | 0.0 |
membrane | Hs | cellular component | 193 | 2.44e-50 |
SH3 domain binding | Hs | molecular function | 193 | 2.44e-50 |
potassium channel inhibitor activity | Hs | molecular function | 837 | 0.0 |
kinase binding | Hs | molecular function | 193 | 2.44e-50 |
protein kinase binding | Hs | molecular function | 193 | 2.44e-50 |
endocytic vesicle | Hs | cellular component | 193 | 2.44e-50 |
axon | Hs | cellular component | 193 | 2.44e-50 |
dendrite | Hs | cellular component | 193 | 2.44e-50 |
intrinsic component of the cytoplasmic side of the plasma membrane | Hs | cellular component | 837 | 0.0 |
mitogen-activated protein kinase kinase binding | Hs | molecular function | 193 | 2.44e-50 |
mitogen-activated protein kinase kinase kinase binding | Hs | molecular function | 193 | 2.44e-50 |
phosphatidylinositol-3-phosphate binding | Hs | molecular function | 193 | 2.44e-50 |
neuronal cell body membrane | Hs | cellular component | 193 | 2.44e-50 |
signaling adaptor activity | Hs | molecular function | 193 | 2.44e-50 |
phosphatidylinositol 3-kinase regulatory subunit binding | Hs | molecular function | 193 | 2.44e-50 |
identical protein binding | Hs | molecular function | 193 | 2.44e-50 |
protein homodimerization activity | Hs | molecular function | 193 | 2.44e-50 |
cell projection | Hs | cellular component | 193 | 2.44e-50 |
neuronal cell body | Hs | cellular component | 193 | 2.44e-50 |
vascular endothelial growth factor receptor 2 binding | Hs | molecular function | 193 | 2.44e-50 |
phosphatidylinositol 3-kinase binding | Hs | molecular function | 193 | 2.44e-50 |
cerebellar mossy fiber | Hs | cellular component | 193 | 2.44e-50 |
climbing fiber | Hs | cellular component | 193 | 2.44e-50 |
macromolecular complex binding | Hs | molecular function | 193 | 2.44e-50 |
cadherin binding | Hs | molecular function | 193 | 2.44e-50 |
GTPase binding | Hs | molecular function | 837 | 0.0 |
protein phosphatase 2A binding | Hs | molecular function | 193 | 2.44e-50 |
extracellular exosome | Hs | cellular component | 193 | 2.44e-50 |
phosphatidylinositol-4-phosphate binding | Hs | molecular function | 193 | 2.44e-50 |
14-3-3 protein binding | Hs | molecular function | 193 | 2.44e-50 |
parallel fiber | Hs | cellular component | 193 | 2.44e-50 |
AIP1-IRE1 complex | Hs | cellular component | 193 | 2.44e-50 |
GO Term | Analysis | Type | e-value |
---|---|---|---|
GTPase activator activity | PANTHER | molecular function | 0.0 |
protein binding | SUPERFAMILY | molecular function | 1.31E-9 |
signal transduction | SUPERFAMILY | biological process | 1.22E-72 |
regulation of GTPase activity | SMART | biological process | 4.1E-95 |
positive regulation of GTPase activity | PANTHER | biological process | 0.0 |
negative regulation of Ras protein signal transduction | PANTHER | biological process | 0.0 |