IPR Term	Analysis	Definition
GCS	PANTHER	Glutamate-cysteine ligase catalytic subunit
Gln_synth/guanido_kin_cat_dom	SUPERFAMILY	Glutamine synthetase/guanido kinase, catalytic domain
GCS	Pfam	Glutamate-cysteine ligase catalytic subunit

GO Term	Annotation Origin	Type
nucleotide binding	Orthology	molecular function
magnesium ion binding	Orthology	molecular function
catalytic activity	Orthology	molecular function
ATP binding	Orthology	molecular function
cytosol	Orthology	cellular component
response to oxidative stress	Orthology	biological process
ligase activity	Orthology	molecular function
negative regulation of apoptotic process	Orthology	biological process
negative regulation of transcription, DNA-templated	Orthology	biological process
protein heterodimerization activity	Orthology	molecular function
coenzyme binding	Orthology	molecular function
cellular metabolic process	Orthology	biological process
peptide metabolic process	Orthology	biological process
developmental process	Orthology	biological process
organelle organization	Orthology	biological process
apoptotic process	Orthology	biological process
response to stress	Orthology	biological process
response to organic substance	Orthology	biological process
response to stimulus	Orthology	biological process
small molecule binding	Orthology	molecular function
anion binding	Orthology	molecular function
cytoplasmic part	Orthology	cellular component
macromolecular complex	Orthology	cellular component
protein ubiquitination	Orthology	biological process
proteolysis	Orthology	biological process
cellular response to organic substance	Orthology	biological process
adenyl ribonucleotide binding	Orthology	molecular function
cell	Orthology	cellular component
mitochondrion	Orthology	cellular component
cell surface receptor signaling pathway	Orthology	biological process
negative regulation of signal transduction	Orthology	biological process

GO Term	SpeciesCe = Caenorhabditis elegans Dr = Danio rerio Dm = Drosophila melanogaster Gg = Gallus gallus Hs = Homo sapiens Mm = Mus musculus Sc = Saccharomyces cerevisiae	Type
nucleotide binding	Hs	molecular function
magnesium ion binding	Hs	molecular function
catalytic activity	Hs	molecular function
glutamate-cysteine ligase activity	Hs	molecular function
ATP binding	Hs	molecular function
cytosol	Hs	cellular component
cysteine metabolic process	Hs	biological process
glutamate metabolic process	Hs	biological process
glutathione metabolic process	Hs	biological process
glutathione biosynthetic process	Hs	biological process
response to oxidative stress	Hs	biological process
aging	Hs	biological process
response to nutrient	Hs	biological process
apoptotic mitochondrial changes	Hs	biological process
response to heat	Hs	biological process
response to xenobiotic stimulus	Hs	biological process
response to hormone	Hs	biological process
response to activity	Hs	biological process
glutamate binding	Hs	molecular function
ligase activity	Hs	molecular function
glutamate-cysteine ligase complex	Hs	cellular component
negative regulation of protein ubiquitination	Hs	biological process
positive regulation of proteasomal ubiquitin-dependent protein catabolic process	Hs	biological process
cellular response to insulin stimulus	Hs	biological process
negative regulation of apoptotic process	Hs	biological process
negative regulation of neuron apoptotic process	Hs	biological process
ADP binding	Hs	molecular function
cell redox homeostasis	Hs	biological process
negative regulation of transcription, DNA-templated	Hs	biological process
response to arsenic-containing substance	Hs	biological process
response to cadmium ion	Hs	biological process
protein heterodimerization activity	Hs	molecular function
coenzyme binding	Hs	molecular function
regulation of blood vessel size	Hs	biological process
regulation of mitochondrial depolarization	Hs	biological process
cellular response to mechanical stimulus	Hs	biological process
cellular response to glucose stimulus	Hs	biological process
negative regulation of extrinsic apoptotic signaling pathway	Hs	biological process

GO Term	SpeciesCe = Caenorhabditis elegans Dr = Danio rerio Dm = Drosophila melanogaster Gg = Gallus gallus Hs = Homo sapiens Mm = Mus musculus Sc = Saccharomyces cerevisiae	Type	Score	E-value
nucleotide binding	Hs	molecular function	581	0.0
magnesium ion binding	Hs	molecular function	581	0.0
catalytic activity	Hs	molecular function	581	0.0
glutamate-cysteine ligase activity	Hs	molecular function	581	0.0
ATP binding	Hs	molecular function	581	0.0
cytosol	Hs	cellular component	581	0.0
glutamate binding	Hs	molecular function	581	0.0
ligase activity	Hs	molecular function	581	0.0
glutamate-cysteine ligase complex	Hs	cellular component	581	0.0
ADP binding	Hs	molecular function	581	0.0
protein heterodimerization activity	Hs	molecular function	581	0.0
coenzyme binding	Hs	molecular function	581	0.0

GO Term	Analysis	Type	e-value
catalytic activity	SUPERFAMILY	molecular function	5.59E-42
glutamate-cysteine ligase activity	PANTHER	molecular function	1.8E-205
glutathione biosynthetic process	PANTHER	biological process	1.8E-205