IPR Term	Analysis	Definition
DHS-like_NAD/FAD-binding_dom	SUPERFAMILY	DHS-like NAD/FAD-binding domain superfamily
Sirtuin	Pfam	Sirtuin family
Ssirtuin_cat_dom	ProSiteProfiles	Sirtuin family, catalytic core domain
Znf_C2H2_type	ProSitePatterns	Zinc finger C2H2-type
Sirtuin_cat_small_dom_sf	Gene3D	Sirtuin, catalytic core small domain superfamily

GO Term	Annotation Origin	Type
negative regulation of transcription from RNA polymerase II promoter	Orthology	biological process
chromatin binding	Orthology	molecular function
transcription corepressor activity	Blast	molecular function
protein binding	Orthology	molecular function
nucleus	Orthology	cellular component
nucleoplasm	Blast	cellular component
nucleolus	Orthology	cellular component
cytoplasm	Orthology	cellular component
mitochondrion	Blast	cellular component
mitochondrial matrix	Blast	cellular component
transcription, DNA-templated	Orthology	biological process
regulation of transcription, DNA-templated	Orthology	biological process
zinc ion binding	Blast	molecular function
hydrolase activity	Orthology	molecular function
enzyme binding	Blast	molecular function
macromolecular complex	Orthology	cellular component
sequence-specific DNA binding	Blast	molecular function
metal ion binding	Orthology	molecular function
nucleic acid binding	InterProScan	molecular function
organelle organization	Orthology	biological process
anion binding	Orthology	molecular function
nucleotide binding	Orthology	molecular function
coenzyme binding	Orthology	molecular function
cellular protein modification process	Orthology	biological process
transferase activity	Blast	molecular function
intracellular non-membrane-bounded organelle	Blast	cellular component
nuclear lumen	Blast	cellular component

GO Term	SpeciesCe = Caenorhabditis elegans Dr = Danio rerio Dm = Drosophila melanogaster Gg = Gallus gallus Hs = Homo sapiens Mm = Mus musculus Sc = Saccharomyces cerevisiae	Type
negative regulation of transcription from RNA polymerase II promoter	Hs	biological process
chromatin binding	Hs	molecular function
protein binding	Hs	molecular function
nucleus	Hs	cellular component
nucleolus	Hs	cellular component
nucleolus organizer region	Hs	cellular component
cytoplasm	Hs	cellular component
chromatin organization	Hs	biological process
transcription, DNA-templated	Hs	biological process
regulation of transcription, DNA-templated	Hs	biological process
rRNA transcription	Hs	biological process
hydrolase activity	Hs	molecular function
metal ion binding	Hs	molecular function
NAD+ binding	Hs	molecular function
histone H3 deacetylation	Hs	biological process
NAD-dependent histone deacetylase activity (H3-K18 specific)	Hs	molecular function

GO Term	SpeciesCe = Caenorhabditis elegans Dr = Danio rerio Dm = Drosophila melanogaster Gg = Gallus gallus Hs = Homo sapiens Mm = Mus musculus Sc = Saccharomyces cerevisiae	Type	Score	E-value
chromatin binding	Hs	molecular function	262	1.04e-83
transcription corepressor activity	Hs	molecular function	165	4.35e-47
NAD+ ADP-ribosyltransferase activity	Hs	molecular function	165	4.35e-47
NAD(P)+-protein-arginine ADP-ribosyltransferase activity	Hs	molecular function	165	4.35e-47
protein binding	Hs	molecular function	262	1.04e-83
nucleus	Hs	cellular component	262	1.04e-83
nucleoplasm	Hs	cellular component	165	4.35e-47
nuclear telomeric heterochromatin	Hs	cellular component	165	4.35e-47
nucleolus	Hs	cellular component	262	1.04e-83
nucleolus organizer region	Hs	cellular component	262	1.04e-83
cytoplasm	Hs	cellular component	262	1.04e-83
mitochondrion	Hs	cellular component	65.1	1.85e-11
mitochondrial matrix	Hs	cellular component	65.1	1.85e-11
zinc ion binding	Hs	molecular function	165	4.35e-47
hydrolase activity	Hs	molecular function	262	1.04e-83
NAD-dependent histone deacetylase activity	Hs	molecular function	165	4.35e-47
enzyme binding	Hs	molecular function	65.1	1.85e-11
macromolecular complex	Hs	cellular component	65.1	1.85e-11
protein deacetylase activity	Hs	molecular function	165	4.35e-47
NAD-dependent protein deacetylase activity	Hs	molecular function	165	4.35e-47
sequence-specific DNA binding	Hs	molecular function	65.1	1.85e-11
metal ion binding	Hs	molecular function	262	1.04e-83
NAD-dependent histone deacetylase activity (H3-K9 specific)	Hs	molecular function	165	4.35e-47
NAD+ binding	Hs	molecular function	262	1.04e-83
NAD-dependent histone deacetylase activity (H3-K18 specific)	Hs	molecular function	262	1.04e-83

GO Term	Analysis	Type	e-value
NAD+ binding	Pfam	molecular function	3.3E-16
nucleic acid binding	ProSitePatterns	molecular function