IPR Term	Analysis	Definition
FAD-bd_2-like_sf	SUPERFAMILY	FAD-binding, type 2-like superfamily
2Fe2S_fd_BS	ProSitePatterns	2Fe-2S ferredoxin, iron-sulphur binding site
Mopterin_DH_FAD-bd	Pfam	Molybdopterin dehydrogenase, FAD-binding
Ald_Oxase/Xan_DH_a/b_sf	SUPERFAMILY	Aldehyde oxidase/xanthine dehydrogenase, a/b hammerhead superfamily
2Fe-2S_ferredoxin-type	ProSiteProfiles	2Fe-2S ferredoxin-type iron-sulfur binding domain
CO_DH_flav_C	Pfam	CO dehydrogenase flavoprotein, C-terminal
Ald_Oxase/xanthine_DH	PIRSF	Aldehyde oxidase/xanthine dehydrogenase
2Fe-2S_ferredoxin-like_sf	SUPERFAMILY	2Fe-2S ferredoxin-like superfamily
AldOxase/xan_DH_Mopterin-bd_sf	SUPERFAMILY	Aldehyde oxidase/xanthine dehydrogenase, molybdopterin binding domain superfamily
CO_DH_flav_C	SMART	CO dehydrogenase flavoprotein, C-terminal
FAD-bd_2	ProSiteProfiles	FAD-binding, type 2
Ald_Oxase/Xan_DH_a/b	Pfam	Aldehyde oxidase/xanthine dehydrogenase, a/b hammerhead
2Fe-2S-bd	Pfam	[2Fe-2S]-binding
AldOxase/xan_DH_Mopterin-bd	Pfam	Aldehyde oxidase/xanthine dehydrogenase, molybdopterin binding
CO_DH_flav_C_dom_sf	SUPERFAMILY	CO dehydrogenase flavoprotein, C-terminal domain superfamily
2Fe-2S_ferredoxin-type	Pfam	2Fe-2S ferredoxin-type iron-sulfur binding domain
2Fe-2S-bd_dom_sf	SUPERFAMILY	[2Fe-2S]-binding domain superfamily
Ald_Oxase/Xan_DH_a/b	SMART	Aldehyde oxidase/xanthine dehydrogenase, a/b hammerhead
Xanthine_DH_ssu	TIGRFAM	Xanthine dehydrogenase, small subunit

GO Term	Annotation Origin	Type
catalytic activity	Orthology	molecular function
iron ion binding	Orthology	molecular function
extracellular region	Orthology	cellular component
extracellular space	Orthology	cellular component
cytoplasm	Orthology	cellular component
peroxisome	Orthology	cellular component
cytosol	Orthology	cellular component
negative regulation of gene expression	Orthology	biological process
identical protein binding	Orthology	molecular function
protein homodimerization activity	Orthology	molecular function
metal ion binding	Orthology	molecular function
flavin adenine dinucleotide binding	Orthology	molecular function
oxidation-reduction process	Orthology	biological process
extracellular exosome	Orthology	cellular component
protein phosphorylation	Orthology	biological process
endopeptidase activity	Orthology	molecular function
positive regulation of hydrolase activity	Orthology	biological process
positive regulation of apoptotic process	Orthology	biological process
cellular metabolic process	Orthology	biological process
nucleobase-containing compound metabolic process	Orthology	biological process
aromatic compound catabolic process	Orthology	biological process
endoplasmic reticulum	Orthology	cellular component
multicellular organism development	Orthology	biological process
cell differentiation	Orthology	biological process
heterocyclic compound binding	Orthology	molecular function
organic cyclic compound binding	Orthology	molecular function
coenzyme binding	Orthology	molecular function
nucleotide binding	Orthology	molecular function
cofactor binding	Orthology	molecular function
intracellular signal transduction	Orthology	biological process
negative regulation of signal transduction	Orthology	biological process
cellular response to stress	Orthology	biological process
positive regulation of signal transduction	Orthology	biological process

GO Term	SpeciesCe = Caenorhabditis elegans Dr = Danio rerio Dm = Drosophila melanogaster Gg = Gallus gallus Hs = Homo sapiens Mm = Mus musculus Sc = Saccharomyces cerevisiae	Type
negative regulation of protein phosphorylation	Hs	biological process
catalytic activity	Hs	molecular function
aldehyde oxidase activity	Hs	molecular function
xanthine dehydrogenase activity	Hs	molecular function
xanthine oxidase activity	Hs	molecular function
iron ion binding	Hs	molecular function
extracellular region	Hs	cellular component
extracellular space	Hs	cellular component
cytoplasm	Hs	cellular component
peroxisome	Hs	cellular component
cytosol	Hs	cellular component
activation of cysteine-type endopeptidase activity involved in apoptotic process	Hs	biological process
electron carrier activity	Hs	molecular function
xanthine catabolic process	Hs	biological process
negative regulation of gene expression	Hs	biological process
oxidoreductase activity	Hs	molecular function
sarcoplasmic reticulum	Hs	cellular component
oxidoreductase activity, acting on CH-OH group of donors	Hs	molecular function
oxidoreductase activity, acting on the aldehyde or oxo group of donors	Hs	molecular function
electron transport chain	Hs	biological process
regulation of epithelial cell differentiation	Hs	biological process
identical protein binding	Hs	molecular function
protein homodimerization activity	Hs	molecular function
molybdopterin cofactor binding	Hs	molecular function
metal ion binding	Hs	molecular function
flavin adenine dinucleotide binding	Hs	molecular function
NAD binding	Hs	molecular function
iron-sulfur cluster binding	Hs	molecular function
2 iron, 2 sulfur cluster binding	Hs	molecular function
negative regulation of protein kinase B signaling	Hs	biological process
oxidation-reduction process	Hs	biological process
extracellular exosome	Hs	cellular component
geranial:oxygen oxidoreductase activity	Hs	molecular function
heptaldehyde:oxygen oxidoreductase activity	Hs	molecular function
positive regulation of p38MAPK cascade	Hs	biological process
positive regulation of reactive oxygen species metabolic process	Hs	biological process

GO Term	SpeciesCe = Caenorhabditis elegans Dr = Danio rerio Dm = Drosophila melanogaster Gg = Gallus gallus Hs = Homo sapiens Mm = Mus musculus Sc = Saccharomyces cerevisiae	Type	Score	E-value
catalytic activity	Hs	molecular function	1340	0.0
aldehyde oxidase activity	Hs	molecular function	1139	0.0
xanthine dehydrogenase activity	Hs	molecular function	1340	0.0
xanthine oxidase activity	Hs	molecular function	1340	0.0
iron ion binding	Hs	molecular function	1340	0.0
extracellular region	Hs	cellular component	1340	0.0
extracellular space	Hs	cellular component	1340	0.0
cytoplasm	Hs	cellular component	1340	0.0
peroxisome	Hs	cellular component	1340	0.0
cytosol	Hs	cellular component	1340	0.0
electron carrier activity	Hs	molecular function	1340	0.0
oxidoreductase activity	Hs	molecular function	1340	0.0
sarcoplasmic reticulum	Hs	cellular component	1340	0.0
oxidoreductase activity, acting on CH-OH group of donors	Hs	molecular function	1340	0.0
oxidoreductase activity, acting on the aldehyde or oxo group of donors	Hs	molecular function	1340	0.0
identical protein binding	Hs	molecular function	1139	0.0
protein homodimerization activity	Hs	molecular function	1340	0.0
molybdopterin cofactor binding	Hs	molecular function	1340	0.0
metal ion binding	Hs	molecular function	1340	0.0
flavin adenine dinucleotide binding	Hs	molecular function	1340	0.0
NAD binding	Hs	molecular function	1139	0.0
iron-sulfur cluster binding	Hs	molecular function	1340	0.0
2 iron, 2 sulfur cluster binding	Hs	molecular function	1340	0.0
extracellular exosome	Hs	cellular component	1139	0.0
geranial:oxygen oxidoreductase activity	Hs	molecular function	1139	0.0
heptaldehyde:oxygen oxidoreductase activity	Hs	molecular function	1139	0.0

GO Term	Analysis	Type	e-value
xanthine dehydrogenase activity	TIGRFAM	molecular function	6.5E-152
xanthine oxidase activity	TIGRFAM	molecular function	6.5E-152
iron ion binding	PIRSF	molecular function	0.0
electron carrier activity	SUPERFAMILY	molecular function	6.51E-20
oxidoreductase activity	PIRSF	molecular function	0.0
oxidoreductase activity, acting on CH-OH group of donors	SUPERFAMILY	molecular function	3.87E-53
metal ion binding	Pfam	molecular function	3.8E-29
flavin adenine dinucleotide binding	TIGRFAM	molecular function	6.5E-152
iron-sulfur cluster binding	SUPERFAMILY	molecular function	6.51E-20
2 iron, 2 sulfur cluster binding	ProSitePatterns	molecular function
oxidation-reduction process	PIRSF	biological process	0.0
FAD binding	ProSiteProfiles	molecular function	10.639