IPR Term	Analysis	Definition
Hsp90_fam	Hamap	Heat shock protein Hsp90 family
Hsp90_fam	Pfam	Heat shock protein Hsp90 family
HATPase_C	Pfam	Histidine kinase/HSP90-like ATPase
HATPase_C_sf	SUPERFAMILY	Histidine kinase/HSP90-like ATPase superfamily
Hsp90_fam	PIRSF	Heat shock protein Hsp90 family
Hsp90_N	PRINTS	Heat shock protein Hsp90, N-terminal
HSP90_C	Gene3D	HSP90, C-terminal domain
HATPase_C	CDD	Histidine kinase/HSP90-like ATPase
HATPase_C	SMART	Histidine kinase/HSP90-like ATPase
Ribosomal_S5_D2-typ_fold	SUPERFAMILY	Ribosomal protein S5 domain 2-type fold
Hsp90_fam	PANTHER	Heat shock protein Hsp90 family
Heat_shock_protein_90_CS	ProSitePatterns	Heat shock protein Hsp90, conserved site
HATPase_C_sf	Gene3D	Histidine kinase/HSP90-like ATPase superfamily
HSP90_C	SUPERFAMILY	HSP90, C-terminal domain

GO Term	Annotation Origin	Type
G2/M transition of mitotic cell cycle	Orthology	biological process
nucleotide binding	Orthology	molecular function
RNA binding	Orthology	molecular function
calcium ion binding	Blast	molecular function
protein binding	Orthology	molecular function
ATP binding	Orthology	molecular function
GTP binding	Orthology	molecular function
extracellular region	Orthology	cellular component
intracellular	Orthology	cellular component
nucleus	Orthology	cellular component
nucleoplasm	Orthology	cellular component
cytoplasm	Orthology	cellular component
mitochondrion	Orthology	cellular component
lysosomal membrane	Orthology	cellular component
endoplasmic reticulum	Blast	cellular component
endoplasmic reticulum lumen	Blast	cellular component
endoplasmic reticulum membrane	Blast	cellular component
cytosol	Orthology	cellular component
plasma membrane	Orthology	cellular component
focal adhesion	Blast	cellular component
protein folding	Orthology	biological process
response to stress	Orthology	biological process
signal transduction	Orthology	biological process
cell surface	Orthology	cellular component
response to organic substance	Orthology	biological process
membrane	Orthology	cellular component
basolateral plasma membrane	Orthology	cellular component
apical plasma membrane	Orthology	cellular component
cytokine-mediated signaling pathway	Orthology	biological process
kinase binding	Orthology	molecular function
protein kinase binding	Orthology	molecular function
midbody	Blast	cellular component
brush border membrane	Orthology	cellular component
macromolecular complex	Orthology	cellular component
melanosome	Orthology	cellular component
identical protein binding	Orthology	molecular function
protein homodimerization activity	Orthology	molecular function
neuronal cell body	Orthology	cellular component
negative regulation of apoptotic process	Orthology	biological process
myelin sheath	Orthology	cellular component
protein dimerization activity	Orthology	molecular function
perinuclear region of cytoplasm	Orthology	cellular component
unfolded protein binding	Orthology	molecular function
extracellular exosome	Orthology	cellular component
protein phosphorylation	Orthology	biological process
anion binding	Orthology	molecular function
ribonucleotide binding	Orthology	molecular function
protein kinase activity	Orthology	molecular function
cellular metabolic process	Orthology	biological process
membrane organization	Orthology	biological process
organelle organization	Orthology	biological process
transferase activity, transferring phosphorus-containing groups	Orthology	molecular function
DNA metabolic process	Orthology	biological process
binding	Orthology	molecular function
nuclear part	Orthology	cellular component
intracellular part	Orthology	cellular component
nucleoside-triphosphatase activity	Orthology	molecular function
receptor binding	Orthology	molecular function
regulation of cellular metabolic process	Orthology	biological process
enzyme regulator activity	Orthology	molecular function
axonogenesis	Orthology	biological process
central nervous system development	Orthology	biological process
macromolecular complex binding	Orthology	molecular function
cellular process	Orthology	biological process
enzyme binding	Orthology	molecular function
oxidation-reduction process	Orthology	biological process
cell surface receptor signaling pathway	Orthology	biological process
positive regulation of signal transduction	Orthology	biological process
cellular response to organic substance	Orthology	biological process
protein ubiquitination	Orthology	biological process
proteolysis	Orthology	biological process
protein dephosphorylation	Orthology	biological process
positive regulation of hydrolase activity	Orthology	biological process
adenyl nucleotide binding	Orthology	molecular function
carbohydrate derivative binding	Orthology	molecular function
cell projection membrane	Orthology	cellular component
cell leading edge	Orthology	cellular component
intracellular organelle part	Orthology	cellular component
cytoplasmic vesicle	Orthology	cellular component
endomembrane system	Orthology	cellular component
intracellular organelle lumen	Orthology	cellular component
lysosome	Orthology	cellular component
vacuolar part	Orthology	cellular component
axon	Orthology	cellular component
cell projection part	Orthology	cellular component
establishment of protein localization to membrane	Orthology	biological process
protein targeting	Orthology	biological process
establishment of protein localization to organelle	Orthology	biological process
cell adhesion molecule binding	Orthology	molecular function
cell differentiation	Orthology	biological process
cellular component organization	Orthology	biological process
cytoskeletal protein binding	Orthology	molecular function
regulation of catalytic activity	Orthology	biological process
regulation of metabolic process	Orthology	biological process
intracellular signal transduction	Orthology	biological process
regulation of signal transduction	Orthology	biological process
innate immune response	Orthology	biological process
positive regulation of catalytic activity	Orthology	biological process
protein serine/threonine kinase activity	Orthology	molecular function
cell cycle	Orthology	biological process
molecular transducer activity	Orthology	molecular function
plasma membrane region	Orthology	cellular component
cellular protein localization	Orthology	biological process
extracellular region part	Blast	cellular component
endoplasmic reticulum part	Blast	cellular component

GO Term	SpeciesCe = Caenorhabditis elegans Dr = Danio rerio Dm = Drosophila melanogaster Gg = Gallus gallus Hs = Homo sapiens Mm = Mus musculus Sc = Saccharomyces cerevisiae	Type
G2/M transition of mitotic cell cycle	Hs	biological process
nucleotide binding	Hs	molecular function
positive regulation of protein phosphorylation	Hs	biological process
UTP binding	Hs	molecular function
CTP binding	Hs	molecular function
RNA binding	Hs	molecular function
double-stranded RNA binding	Hs	molecular function
protein tyrosine kinase activity	Hs	molecular function
protein binding	Hs	molecular function
ATP binding	Hs	molecular function
GTP binding	Hs	molecular function
extracellular region	Hs	cellular component
intracellular	Hs	cellular component
nucleus	Hs	cellular component
nucleoplasm	Hs	cellular component
cytoplasm	Hs	cellular component
mitochondrion	Hs	cellular component
lysosomal membrane	Hs	cellular component
cytosol	Hs	cellular component
plasma membrane	Hs	cellular component
protein folding	Hs	biological process
xenobiotic metabolic process	Hs	biological process
mitochondrial transport	Hs	biological process
receptor-mediated endocytosis	Hs	biological process
response to stress	Hs	biological process
response to unfolded protein	Hs	biological process
telomere maintenance via telomerase	Hs	biological process
signal transduction	Hs	biological process
drug binding	Hs	molecular function
COP9 signalosome	Hs	cellular component
response to heat	Hs	biological process
response to cold	Hs	biological process
response to salt stress	Hs	biological process
cell surface	Hs	cellular component
response to organic substance	Hs	biological process
regulation of G2/M transition of mitotic cell cycle	Hs	biological process
membrane	Hs	cellular component
inclusion body	Hs	cellular component
basolateral plasma membrane	Hs	cellular component
apical plasma membrane	Hs	cellular component
ATPase activity	Hs	molecular function
sulfonylurea receptor binding	Hs	molecular function
peptidyl-tyrosine phosphorylation	Hs	biological process
cytokine-mediated signaling pathway	Hs	biological process
protein kinase regulator activity	Hs	molecular function
kinase binding	Hs	molecular function
protein kinase binding	Hs	molecular function
central nervous system neuron axonogenesis	Hs	biological process
MHC class II protein complex binding	Hs	molecular function
establishment of cell polarity	Hs	biological process
nitric-oxide synthase regulator activity	Hs	molecular function
positive regulation of transforming growth factor beta receptor signaling pathway	Hs	biological process
TPR domain binding	Hs	molecular function
heat shock protein binding	Hs	molecular function
regulation of protein ubiquitination	Hs	biological process
brush border membrane	Hs	cellular component
positive regulation of protein binding	Hs	biological process
negative regulation of proteasomal ubiquitin-dependent protein catabolic process	Hs	biological process
positive regulation of phosphoprotein phosphatase activity	Hs	biological process
dATP binding	Hs	molecular function
ruffle membrane	Hs	cellular component
macromolecular complex	Hs	cellular component
positive regulation of peptidyl-serine phosphorylation	Hs	biological process
positive regulation of protein import into nucleus, translocation	Hs	biological process
aryl hydrocarbon receptor complex	Hs	cellular component
secretory granule lumen	Hs	cellular component
protein refolding	Hs	biological process
response to cocaine	Hs	biological process
peptide binding	Hs	molecular function
melanosome	Hs	cellular component
response to drug	Hs	biological process
identical protein binding	Hs	molecular function
protein homodimerization activity	Hs	molecular function
histone deacetylase binding	Hs	molecular function
ATP-dependent protein binding	Hs	molecular function
neuronal cell body	Hs	cellular component
negative regulation of apoptotic process	Hs	biological process
lysosomal lumen	Hs	cellular component
myelin sheath	Hs	cellular component
negative regulation of neuron apoptotic process	Hs	biological process
dendritic growth cone	Hs	cellular component
axonal growth cone	Hs	cellular component
ion channel binding	Hs	molecular function
protein import into mitochondrial outer membrane	Hs	biological process
cadherin binding	Hs	molecular function
positive regulation of nitric oxide biosynthetic process	Hs	biological process
positive regulation of cell differentiation	Hs	biological process
positive regulation of cell size	Hs	biological process
response to antibiotic	Hs	biological process
protein dimerization activity	Hs	molecular function
vascular endothelial growth factor receptor signaling pathway	Hs	biological process
tau protein binding	Hs	molecular function
perinuclear region of cytoplasm	Hs	cellular component
axon extension	Hs	biological process
protein stabilization	Hs	biological process
regulation of nitric-oxide synthase activity	Hs	biological process
GTPase binding	Hs	molecular function
unfolded protein binding	Hs	molecular function
chaperone-mediated protein complex assembly	Hs	biological process
positive regulation of protein kinase B signaling	Hs	biological process
regulation of interferon-gamma-mediated signaling pathway	Hs	biological process
regulation of type I interferon-mediated signaling pathway	Hs	biological process
extracellular exosome	Hs	cellular component
DNA polymerase binding	Hs	molecular function
negative regulation of cell cycle arrest	Hs	biological process
cellular response to organic cyclic compound	Hs	biological process
endocytic vesicle lumen	Hs	cellular component
positive regulation of protein serine/threonine kinase activity	Hs	biological process
scaffold protein binding	Hs	molecular function
supramolecular fiber organization	Hs	biological process
disordered domain specific binding	Hs	molecular function
negative regulation of transforming growth factor beta activation	Hs	biological process
positive regulation of cellular protein catabolic process	Hs	biological process
positive regulation of cyclin-dependent protein kinase activity	Hs	biological process
ficolin-1-rich granule lumen	Hs	cellular component
histone methyltransferase binding	Hs	molecular function
protein tyrosine kinase binding	Hs	molecular function
sperm head plasma membrane	Hs	cellular component
ooplasm	Hs	cellular component
positive regulation of protein localization to cell surface	Hs	biological process

GO Term	SpeciesCe = Caenorhabditis elegans Dr = Danio rerio Dm = Drosophila melanogaster Gg = Gallus gallus Hs = Homo sapiens Mm = Mus musculus Sc = Saccharomyces cerevisiae	Type	Score	E-value
nucleotide binding	Hs	molecular function	1088	0.0
UTP binding	Hs	molecular function	1061	0.0
CTP binding	Hs	molecular function	1061	0.0
RNA binding	Hs	molecular function	1088	0.0
double-stranded RNA binding	Hs	molecular function	1061	0.0
protein tyrosine kinase activity	Hs	molecular function	1088	0.0
calcium ion binding	Hs	molecular function	607	0.0
protein binding	Hs	molecular function	1088	0.0
ATP binding	Hs	molecular function	1088	0.0
GTP binding	Hs	molecular function	1061	0.0
extracellular region	Hs	cellular component	1088	0.0
intracellular	Hs	cellular component	1088	0.0
nucleus	Hs	cellular component	1088	0.0
nucleoplasm	Hs	cellular component	1088	0.0
cytoplasm	Hs	cellular component	1088	0.0
mitochondrion	Hs	cellular component	1061	0.0
lysosomal membrane	Hs	cellular component	1061	0.0
endoplasmic reticulum	Hs	cellular component	607	0.0
endoplasmic reticulum lumen	Hs	cellular component	607	0.0
endoplasmic reticulum membrane	Hs	cellular component	607	0.0
cytosol	Hs	cellular component	1088	0.0
plasma membrane	Hs	cellular component	1088	0.0
focal adhesion	Hs	cellular component	607	0.0
drug binding	Hs	molecular function	1061	0.0
COP9 signalosome	Hs	cellular component	1061	0.0
cell surface	Hs	cellular component	1061	0.0
membrane	Hs	cellular component	1088	0.0
inclusion body	Hs	cellular component	1061	0.0
basolateral plasma membrane	Hs	cellular component	1061	0.0
apical plasma membrane	Hs	cellular component	1061	0.0
ATPase activity	Hs	molecular function	1088	0.0
sulfonylurea receptor binding	Hs	molecular function	1061	0.0
protein kinase regulator activity	Hs	molecular function	1061	0.0
kinase binding	Hs	molecular function	1061	0.0
protein kinase binding	Hs	molecular function	1061	0.0
protein phosphatase binding	Hs	molecular function	607	0.0
MHC class II protein complex binding	Hs	molecular function	1088	0.0
nitric-oxide synthase regulator activity	Hs	molecular function	1088	0.0
midbody	Hs	cellular component	607	0.0
TPR domain binding	Hs	molecular function	1088	0.0
extracellular matrix	Hs	cellular component	607	0.0
heat shock protein binding	Hs	molecular function	1061	0.0
brush border membrane	Hs	cellular component	1061	0.0
dATP binding	Hs	molecular function	1061	0.0
ruffle membrane	Hs	cellular component	1088	0.0
macromolecular complex	Hs	cellular component	1088	0.0
endoplasmic reticulum chaperone complex	Hs	cellular component	607	0.0
aryl hydrocarbon receptor complex	Hs	cellular component	1061	0.0
secretory granule lumen	Hs	cellular component	1088	0.0
peptide binding	Hs	molecular function	1061	0.0
melanosome	Hs	cellular component	1088	0.0
identical protein binding	Hs	molecular function	1088	0.0
protein homodimerization activity	Hs	molecular function	1088	0.0
histone deacetylase binding	Hs	molecular function	1088	0.0
ATP-dependent protein binding	Hs	molecular function	1061	0.0
neuronal cell body	Hs	cellular component	1088	0.0
lysosomal lumen	Hs	cellular component	1088	0.0
myelin sheath	Hs	cellular component	1088	0.0
dendritic growth cone	Hs	cellular component	1088	0.0
axonal growth cone	Hs	cellular component	1088	0.0
ion channel binding	Hs	molecular function	1061	0.0
cadherin binding	Hs	molecular function	1061	0.0
protein dimerization activity	Hs	molecular function	1061	0.0
tau protein binding	Hs	molecular function	1088	0.0
perinuclear region of cytoplasm	Hs	cellular component	1088	0.0
low-density lipoprotein particle receptor binding	Hs	molecular function	607	0.0
GTPase binding	Hs	molecular function	1088	0.0
unfolded protein binding	Hs	molecular function	1088	0.0
extracellular exosome	Hs	cellular component	1088	0.0
DNA polymerase binding	Hs	molecular function	1088	0.0
endocytic vesicle lumen	Hs	cellular component	1088	0.0
scaffold protein binding	Hs	molecular function	1088	0.0
disordered domain specific binding	Hs	molecular function	1088	0.0
ficolin-1-rich granule lumen	Hs	cellular component	1088	0.0
histone methyltransferase binding	Hs	molecular function	1061	0.0
protein tyrosine kinase binding	Hs	molecular function	1088	0.0
sperm head plasma membrane	Hs	cellular component	1061	0.0
ooplasm	Hs	cellular component	1061	0.0

GO Term	Analysis	Type	e-value
ATP binding	PANTHER	molecular function	0.0
protein folding	PANTHER	biological process	0.0
response to stress	PANTHER	biological process	0.0
unfolded protein binding	PANTHER	molecular function	0.0