Gene Card
Best human hits
NEDD4; SMURF1; SMURF2
Species
Unique Gene ID
Phfumi.g00001955
Gene Model ID
Phfumi.CG.MTP2014.S406.g01955
Location
S406:391..6925
Transcript Models and Sequences
n/a
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The 'History' button on the left side permits you to see the changes you have made and eventually to go back.
You can Press 'Shift' Key + Left Mouse Click on the leaf's node to access to a gene card in a new window.
You can Press 'Ctrl' Key + Left Mouse Click on nodes to do a multiple selection.

IPR Term | Analysis | Definition |
---|---|---|
C2_domain_sf | Gene3D | C2 domain superfamily |
HECT_dom | Pfam | HECT domain |
HECT_dom | SMART | HECT domain |
HECT_dom | CDD | HECT domain |
HECT_dom | ProSiteProfiles | HECT domain |
Hect_E3_ubiquitin_ligase | SUPERFAMILY | HECT, E3 ligase catalytic domain |
C2_dom | Pfam | C2 domain |
GO Term | Annotation Origin | Type |
---|---|---|
negative regulation of transcription from RNA polymerase II promoter | Orthology | biological process |
protein polyubiquitination | Orthology | biological process |
ubiquitin-protein transferase activity | Orthology | molecular function |
protein binding | Orthology | molecular function |
nucleus | Orthology | cellular component |
nucleoplasm | Orthology | cellular component |
cytoplasm | Orthology | cellular component |
mitochondrion | Orthology | cellular component |
Golgi apparatus | Blast | cellular component |
cytosol | Orthology | cellular component |
plasma membrane | Orthology | cellular component |
membrane | Orthology | cellular component |
protein ubiquitination | Orthology | biological process |
nuclear speck | Orthology | cellular component |
transferase activity | Orthology | molecular function |
cell differentiation | Orthology | biological process |
axon | Orthology | cellular component |
identical protein binding | Orthology | molecular function |
neuronal cell body | Orthology | cellular component |
membrane raft | Orthology | cellular component |
negative regulation of transcription, DNA-templated | Orthology | biological process |
perinuclear region of cytoplasm | Blast | cellular component |
extracellular exosome | Orthology | cellular component |
positive regulation of canonical Wnt signaling pathway | Orthology | biological process |
intracellular part | Orthology | cellular component |
macromolecular complex | Orthology | cellular component |
receptor binding | Orthology | molecular function |
anion binding | Orthology | molecular function |
proteolysis | Orthology | biological process |
intracellular protein transport | Orthology | biological process |
cell surface receptor signaling pathway | Orthology | biological process |
cellular response to organic substance | Orthology | biological process |
anatomical structure development | Orthology | biological process |
peptidase activity, acting on L-amino acid peptides | Orthology | molecular function |
regulation of signal transduction | Orthology | biological process |
regulation of transcription from RNA polymerase II promoter | Orthology | biological process |
negative regulation of signal transduction | Orthology | biological process |
cellular protein localization | Orthology | biological process |
macromolecular complex binding | Orthology | molecular function |
cell-cell signaling | Orthology | biological process |
anatomical structure morphogenesis | Orthology | biological process |
animal organ development | Orthology | biological process |
protein localization to membrane | Orthology | biological process |
cell migration | Orthology | biological process |
multicellular organism development | Orthology | biological process |
neuron projection morphogenesis | Orthology | biological process |
intracellular organelle part | Blast | cellular component |
intracellular non-membrane-bounded organelle | Blast | cellular component |
cell periphery | Blast | cellular component |
cytoplasmic part | Blast | cellular component |
plasma membrane region | Blast | cellular component |
molecular function regulator | Blast | molecular function |
transmembrane transport | Blast | biological process |
sodium ion transport | Blast | biological process |
enzyme binding | Blast | molecular function |
GO Term | SpeciesCe = Caenorhabditis elegans Dr = Danio rerio Dm = Drosophila melanogaster Gg = Gallus gallus Hs = Homo sapiens Mm = Mus musculus Sc = Saccharomyces cerevisiae |
Type | Score | E-value |
---|---|---|---|---|
ubiquitin ligase complex | Hs | cellular component | 516 | 2.05e-177 |
chromatin | Hs | cellular component | 321 | 5.90e-98 |
ubiquitin-protein transferase activity | Hs | molecular function | 516 | 2.05e-177 |
transforming growth factor beta receptor binding | Hs | molecular function | 516 | 2.05e-177 |
protein binding | Hs | molecular function | 516 | 2.05e-177 |
phospholipid binding | Hs | molecular function | 512 | 7.78e-176 |
nucleus | Hs | cellular component | 516 | 2.05e-177 |
nucleoplasm | Hs | cellular component | 516 | 2.05e-177 |
cytoplasm | Hs | cellular component | 516 | 2.05e-177 |
mitochondrion | Hs | cellular component | 512 | 7.78e-176 |
Golgi apparatus | Hs | cellular component | 321 | 5.90e-98 |
cytosol | Hs | cellular component | 516 | 2.05e-177 |
plasma membrane | Hs | cellular component | 516 | 2.05e-177 |
cell cortex | Hs | cellular component | 321 | 5.90e-98 |
membrane | Hs | cellular component | 516 | 2.05e-177 |
apicolateral plasma membrane | Hs | cellular component | 321 | 5.90e-98 |
nuclear speck | Hs | cellular component | 516 | 2.05e-177 |
transferase activity | Hs | molecular function | 516 | 2.05e-177 |
sodium channel inhibitor activity | Hs | molecular function | 321 | 5.90e-98 |
protein domain specific binding | Hs | molecular function | 321 | 5.90e-98 |
axon | Hs | cellular component | 512 | 7.78e-176 |
beta-2 adrenergic receptor binding | Hs | molecular function | 321 | 5.90e-98 |
identical protein binding | Hs | molecular function | 516 | 2.05e-177 |
neuronal cell body | Hs | cellular component | 512 | 7.78e-176 |
ubiquitin binding | Hs | molecular function | 321 | 5.90e-98 |
membrane raft | Hs | cellular component | 516 | 2.05e-177 |
SMAD binding | Hs | molecular function | 516 | 2.05e-177 |
activin binding | Hs | molecular function | 512 | 7.78e-176 |
perinuclear region of cytoplasm | Hs | cellular component | 321 | 5.90e-98 |
phosphoserine residue binding | Hs | molecular function | 321 | 5.90e-98 |
phosphothreonine residue binding | Hs | molecular function | 321 | 5.90e-98 |
ubiquitin protein ligase activity | Hs | molecular function | 516 | 2.05e-177 |
extracellular exosome | Hs | cellular component | 512 | 7.78e-176 |
RNA polymerase binding | Hs | molecular function | 321 | 5.90e-98 |
proline-rich region binding | Hs | molecular function | 321 | 5.90e-98 |
I-SMAD binding | Hs | molecular function | 512 | 7.78e-176 |
R-SMAD binding | Hs | molecular function | 512 | 7.78e-176 |
GO Term | Analysis | Type | e-value |
---|---|---|---|
ubiquitin-protein transferase activity | CDD | molecular function | 9.9253E-124 |