IPR Term	Analysis	Definition
F-box_dom	SMART	F-box domain
Beta-TrCP_D	Pfam	D domain of beta-TrCP
WD40_repeat	ProSiteProfiles	WD40 repeat
WD40_repeat_CS	ProSitePatterns	WD40 repeat, conserved site
WD40/YVTN_repeat-like_dom_sf	Gene3D	WD40/YVTN repeat-like-containing domain superfamily
WD40_repeat	SMART	WD40 repeat
WD40_repeat_dom_sf	SUPERFAMILY	WD40-repeat-containing domain superfamily
F-box_dom	ProSiteProfiles	F-box domain
WD40_repeat_dom	ProSiteProfiles	WD40-repeat-containing domain
G-protein_beta_WD-40_rep	PRINTS	G-protein beta WD-40 repeat
WD40_repeat	Pfam	WD40 repeat
Beta-TrCP_D	SMART	D domain of beta-TrCP
F-box-like_dom_sf	SUPERFAMILY	F-box-like domain superfamily
F-box_dom	Pfam	F-box domain

GO Term	Annotation Origin	Type
G2/M transition of mitotic cell cycle	Orthology	biological process
protein polyubiquitination	Orthology	biological process
ubiquitin-protein transferase activity	Orthology	molecular function
protein binding	Orthology	molecular function
nucleus	Orthology	cellular component
nucleoplasm	Orthology	cellular component
nucleolus	Blast	cellular component
cytoplasm	Orthology	cellular component
centrosome	Orthology	cellular component
cytosol	Orthology	cellular component
protein dephosphorylation	Orthology	biological process
cell cycle	Orthology	biological process
signal transduction	Orthology	biological process
protein ubiquitination	Orthology	biological process
ligase activity	Orthology	molecular function
ubiquitin protein ligase binding	Blast	molecular function
identical protein binding	Blast	molecular function
negative regulation of transcription, DNA-templated	Orthology	biological process
positive regulation of transcription, DNA-templated	Orthology	biological process
protein dimerization activity	Orthology	molecular function
regulation of canonical Wnt signaling pathway	Orthology	biological process
intracellular part	Orthology	cellular component
macromolecular complex	Orthology	cellular component
proteolysis	Orthology	biological process
cell surface receptor signaling pathway	Orthology	biological process
cell-cell signaling	Orthology	biological process
protein metabolic process	Orthology	biological process
transcription factor activity, sequence-specific DNA binding	Orthology	molecular function
intracellular signal transduction	Orthology	biological process
immune response	Orthology	biological process
regulation of signal transduction	Orthology	biological process
regulation of molecular function	Orthology	biological process
cellular protein modification process	Orthology	biological process
negative regulation of signal transduction	Orthology	biological process
cellular response to stress	Orthology	biological process
protein phosphorylation	Orthology	biological process
regulation of cellular metabolic process	Orthology	biological process
cytokine-mediated signaling pathway	Orthology	biological process
cellular response to organic substance	Orthology	biological process
enzyme regulator activity	Blast	molecular function

GO Term	SpeciesCe = Caenorhabditis elegans Dr = Danio rerio Dm = Drosophila melanogaster Gg = Gallus gallus Hs = Homo sapiens Mm = Mus musculus Sc = Saccharomyces cerevisiae	Type
G2/M transition of mitotic cell cycle	Hs	biological process
ubiquitin ligase complex	Hs	cellular component
protein polyubiquitination	Hs	biological process
ubiquitin-protein transferase activity	Hs	molecular function
protein binding	Hs	molecular function
nucleus	Hs	cellular component
nucleoplasm	Hs	cellular component
cytoplasm	Hs	cellular component
centrosome	Hs	cellular component
cytosol	Hs	cellular component
protein dephosphorylation	Hs	biological process
ubiquitin-dependent protein catabolic process	Hs	biological process
cell cycle	Hs	biological process
signal transduction	Hs	biological process
beta-catenin binding	Hs	molecular function
viral process	Hs	biological process
Wnt signaling pathway	Hs	biological process
protein ubiquitination	Hs	biological process
ligase activity	Hs	molecular function
SCF ubiquitin ligase complex	Hs	cellular component
protein catabolic process	Hs	biological process
SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	Hs	biological process
protein destabilization	Hs	biological process
NIK/NF-kappaB signaling	Hs	biological process
Fc-epsilon receptor signaling pathway	Hs	biological process
regulation of circadian rhythm	Hs	biological process
positive regulation of circadian rhythm	Hs	biological process
regulation of I-kappaB kinase/NF-kappaB signaling	Hs	biological process
proteasome-mediated ubiquitin-dependent protein catabolic process	Hs	biological process
negative regulation of sequence-specific DNA binding transcription factor activity	Hs	biological process
post-translational protein modification	Hs	biological process
protein phosphorylated amino acid binding	Hs	molecular function
positive regulation of proteolysis	Hs	biological process
negative regulation of smoothened signaling pathway	Hs	biological process
negative regulation of transcription, DNA-templated	Hs	biological process
positive regulation of transcription, DNA-templated	Hs	biological process
protein dimerization activity	Hs	molecular function
rhythmic process	Hs	biological process
T cell receptor signaling pathway	Hs	biological process
stress-activated MAPK cascade	Hs	biological process
regulation of cell cycle	Hs	biological process
regulation of canonical Wnt signaling pathway	Hs	biological process
regulation of proteasomal protein catabolic process	Hs	biological process
ubiquitin protein ligase activity	Hs	molecular function
interleukin-1-mediated signaling pathway	Hs	biological process
cellular response to organic cyclic compound	Hs	biological process

GO Term	SpeciesCe = Caenorhabditis elegans Dr = Danio rerio Dm = Drosophila melanogaster Gg = Gallus gallus Hs = Homo sapiens Mm = Mus musculus Sc = Saccharomyces cerevisiae	Type	Score	E-value
ubiquitin ligase complex	Hs	cellular component	803	0.0
ubiquitin-protein transferase activity	Hs	molecular function	818	0.0
protein binding	Hs	molecular function	818	0.0
nucleus	Hs	cellular component	818	0.0
nucleoplasm	Hs	cellular component	818	0.0
nucleolus	Hs	cellular component	225	8.91e-65
cytoplasm	Hs	cellular component	818	0.0
centrosome	Hs	cellular component	803	0.0
cytosol	Hs	cellular component	818	0.0
beta-catenin binding	Hs	molecular function	818	0.0
ligase activity	Hs	molecular function	818	0.0
SCF ubiquitin ligase complex	Hs	cellular component	818	0.0
cyclin binding	Hs	molecular function	225	8.91e-65
protein binding, bridging	Hs	molecular function	225	8.91e-65
ubiquitin protein ligase binding	Hs	molecular function	225	8.91e-65
identical protein binding	Hs	molecular function	225	8.91e-65
protein phosphorylated amino acid binding	Hs	molecular function	818	0.0
protein dimerization activity	Hs	molecular function	818	0.0
phosphothreonine residue binding	Hs	molecular function	225	8.91e-65
ubiquitin protein ligase activity	Hs	molecular function	818	0.0
ubiquitin-protein transferase activator activity	Hs	molecular function	225	8.91e-65
Parkin-FBXW7-Cul1 ubiquitin ligase complex	Hs	cellular component	225	8.91e-65

GO Term	Analysis	Type	e-value
protein binding	Gene3D	molecular function	1.1E-106
protein dimerization activity	SMART	molecular function	3.2E-25