IPR Term	Analysis	Definition
His_deacetylse	PANTHER	Histone deacetylase superfamily
His_deacetylse_dom_sf	Gene3D	Histone deacetylase domain superfamily
His_deacetylse_1	PIRSF	Histone deacetylase
Ureohydrolase_dom_sf	SUPERFAMILY	Ureohydrolase domain superfamily
His_deacetylse	PRINTS	Histone deacetylase superfamily
His_deacetylse_1	PRINTS	Histone deacetylase
His_deacetylse_dom	Pfam	Histone deacetylase domain

GO Term	Annotation Origin	Type
negative regulation of transcription from RNA polymerase II promoter	Orthology	biological process
transcription regulatory region sequence-specific DNA binding	Orthology	molecular function
RNA polymerase II core promoter proximal region sequence-specific DNA binding	Orthology	molecular function
chromatin binding	Orthology	molecular function
transcription factor activity, sequence-specific DNA binding	Orthology	molecular function
transcription corepressor activity	Blast	molecular function
RNA binding	Orthology	molecular function
protein binding	Orthology	molecular function
nucleus	Orthology	cellular component
nucleoplasm	Orthology	cellular component
cytoplasm	Orthology	cellular component
Golgi apparatus	Blast	cellular component
cytosol	Orthology	cellular component
plasma membrane	Blast	cellular component
transcription, DNA-templated	Orthology	biological process
regulation of transcription, DNA-templated	Orthology	biological process
blood coagulation	Orthology	biological process
transcription factor binding	Orthology	molecular function
positive regulation of cell proliferation	Orthology	biological process
negative regulation of gene expression	Orthology	biological process
membrane	Orthology	cellular component
integral component of membrane	Orthology	cellular component
hydrolase activity	Orthology	molecular function
enzyme binding	Orthology	molecular function
response to lipopolysaccharide	Orthology	biological process
macromolecular complex	Orthology	cellular component
negative regulation of apoptotic process	Orthology	biological process
sequence-specific DNA binding	Orthology	molecular function
transcription regulatory region DNA binding	Orthology	molecular function
negative regulation of transcription, DNA-templated	Orthology	biological process
positive regulation of transcription, DNA-templated	Orthology	biological process
positive regulation of transcription from RNA polymerase II promoter	Orthology	biological process
metal ion binding	Orthology	molecular function
protein N-terminus binding	Orthology	molecular function
negative regulation of canonical Wnt signaling pathway	Orthology	biological process
nucleoplasm part	Orthology	cellular component
intracellular organelle part	Orthology	cellular component
intracellular non-membrane-bounded organelle	Orthology	cellular component
nuclear lumen	Orthology	cellular component
RNA polymerase II regulatory region sequence-specific DNA binding	Orthology	molecular function
response to organic substance	Orthology	biological process
organelle organization	Orthology	biological process
cellular protein modification process	Orthology	biological process
DNA metabolic process	Orthology	biological process
anatomical structure development	Orthology	biological process
cell differentiation	Orthology	biological process
animal organ development	Orthology	biological process
neuron projection development	Orthology	biological process
macromolecular complex binding	Orthology	molecular function
DNA binding	Orthology	molecular function
regulation of gene expression	Orthology	biological process
cellular response to stress	Orthology	biological process
cell surface receptor signaling pathway	Orthology	biological process
positive regulation of signal transduction	Orthology	biological process
protein phosphorylation	Orthology	biological process
regulation of molecular function	Orthology	biological process
regulation of RNA biosynthetic process	Orthology	biological process
proteolysis	Orthology	biological process
cell development	Orthology	biological process
generation of neurons	Orthology	biological process
central nervous system development	Orthology	biological process
response to stress	Orthology	biological process
response to oxidative stress	Orthology	biological process
response to lipid	Orthology	biological process
cellular response to organic substance	Orthology	biological process
microtubule	Blast	cellular component

GO Term	SpeciesCe = Caenorhabditis elegans Dr = Danio rerio Dm = Drosophila melanogaster Gg = Gallus gallus Hs = Homo sapiens Mm = Mus musculus Sc = Saccharomyces cerevisiae	Type
histone deacetylase complex	Hs	cellular component
negative regulation of transcription from RNA polymerase II promoter	Hs	biological process
chromatin	Hs	cellular component
nuclear chromatin	Hs	cellular component
transcription regulatory region sequence-specific DNA binding	Hs	molecular function
RNA polymerase II core promoter proximal region sequence-specific DNA binding	Hs	molecular function
RNA polymerase II distal enhancer sequence-specific DNA binding	Hs	molecular function
core promoter sequence-specific DNA binding	Hs	molecular function
core promoter binding	Hs	molecular function
RNA polymerase II transcription factor binding	Hs	molecular function
RNA polymerase II repressing transcription factor binding	Hs	molecular function
RNA polymerase II transcription corepressor activity	Hs	molecular function
response to amphetamine	Hs	biological process
p53 binding	Hs	molecular function
chromatin binding	Hs	molecular function
transcription factor activity, sequence-specific DNA binding	Hs	molecular function
RNA binding	Hs	molecular function
histone deacetylase activity	Hs	molecular function
protein binding	Hs	molecular function
nucleus	Hs	cellular component
nucleoplasm	Hs	cellular component
cytoplasm	Hs	cellular component
cytosol	Hs	cellular component
chromatin organization	Hs	biological process
chromatin remodeling	Hs	biological process
methylation-dependent chromatin silencing	Hs	biological process
transcription, DNA-templated	Hs	biological process
regulation of transcription, DNA-templated	Hs	biological process
protein deacetylation	Hs	biological process
blood coagulation	Hs	biological process
transcription factor binding	Hs	molecular function
positive regulation of cell proliferation	Hs	biological process
epidermal cell differentiation	Hs	biological process
negative regulation of gene expression	Hs	biological process
positive regulation of epithelial to mesenchymal transition	Hs	biological process
negative regulation of neuron projection development	Hs	biological process
membrane	Hs	cellular component
integral component of membrane	Hs	cellular component
viral process	Hs	biological process
dendrite development	Hs	biological process
histone deacetylation	Hs	biological process
Sin3 complex	Hs	cellular component
NuRD complex	Hs	cellular component
hydrolase activity	Hs	molecular function
deacetylase activity	Hs	molecular function
enzyme binding	Hs	molecular function
response to caffeine	Hs	biological process
heat shock protein binding	Hs	molecular function
nucleosomal DNA binding	Hs	molecular function
NAD-dependent histone deacetylase activity (H3-K14 specific)	Hs	molecular function
response to lipopolysaccharide	Hs	biological process
circadian regulation of gene expression	Hs	biological process
macromolecular complex	Hs	cellular component
protein deacetylase activity	Hs	molecular function
activating transcription factor binding	Hs	molecular function
cellular response to heat	Hs	biological process
response to nicotine	Hs	biological process
ESC/E(Z) complex	Hs	cellular component
response to cocaine	Hs	biological process
response to drug	Hs	biological process
positive regulation of tyrosine phosphorylation of STAT protein	Hs	biological process
histone deacetylase binding	Hs	molecular function
ATP-dependent chromatin remodeling	Hs	biological process
negative regulation of apoptotic process	Hs	biological process
negative regulation of DNA binding	Hs	biological process
negative regulation of sequence-specific DNA binding transcription factor activity	Hs	biological process
sequence-specific DNA binding	Hs	molecular function
negative regulation by host of viral transcription	Hs	biological process
transcription regulatory region DNA binding	Hs	molecular function
positive regulation of proteolysis	Hs	biological process
negative regulation of transcription, DNA-templated	Hs	biological process
positive regulation of transcription, DNA-templated	Hs	biological process
positive regulation of transcription from RNA polymerase II promoter	Hs	biological process
metal ion binding	Hs	molecular function
protein N-terminus binding	Hs	molecular function
behavioral response to ethanol	Hs	biological process
rhythmic process	Hs	biological process
positive regulation of oligodendrocyte differentiation	Hs	biological process
NF-kappaB binding	Hs	molecular function
response to hyperoxia	Hs	biological process
cellular response to hydrogen peroxide	Hs	biological process
repressing transcription factor binding	Hs	molecular function
histone H3 deacetylation	Hs	biological process
cellular response to retinoic acid	Hs	biological process
cellular response to transforming growth factor beta stimulus	Hs	biological process
negative regulation of canonical Wnt signaling pathway	Hs	biological process
cellular response to dopamine	Hs	biological process
promoter-specific chromatin binding	Hs	molecular function

GO Term	SpeciesCe = Caenorhabditis elegans Dr = Danio rerio Dm = Drosophila melanogaster Gg = Gallus gallus Hs = Homo sapiens Mm = Mus musculus Sc = Saccharomyces cerevisiae	Type	Score	E-value
histone deacetylase complex	Hs	cellular component	681	0.0
chromatin	Hs	cellular component	684	0.0
nuclear chromatin	Hs	cellular component	684	0.0
transcription regulatory region sequence-specific DNA binding	Hs	molecular function	681	0.0
RNA polymerase II core promoter proximal region sequence-specific DNA binding	Hs	molecular function	684	0.0
RNA polymerase II distal enhancer sequence-specific DNA binding	Hs	molecular function	684	0.0
core promoter sequence-specific DNA binding	Hs	molecular function	681	0.0
core promoter binding	Hs	molecular function	681	0.0
RNA polymerase II transcription factor binding	Hs	molecular function	681	0.0
RNA polymerase II repressing transcription factor binding	Hs	molecular function	684	0.0
RNA polymerase II transcription corepressor activity	Hs	molecular function	681	0.0
p53 binding	Hs	molecular function	681	0.0
chromatin binding	Hs	molecular function	684	0.0
transcription factor activity, sequence-specific DNA binding	Hs	molecular function	681	0.0
transcription corepressor activity	Hs	molecular function	483	3.54e-169
RNA binding	Hs	molecular function	684	0.0
histone deacetylase activity	Hs	molecular function	684	0.0
protein binding	Hs	molecular function	684	0.0
nucleus	Hs	cellular component	684	0.0
nucleoplasm	Hs	cellular component	684	0.0
cytoplasm	Hs	cellular component	684	0.0
Golgi apparatus	Hs	cellular component	483	3.54e-169
cytosol	Hs	cellular component	681	0.0
spindle microtubule	Hs	cellular component	483	3.54e-169
plasma membrane	Hs	cellular component	483	3.54e-169
transcription factor binding	Hs	molecular function	684	0.0
membrane	Hs	cellular component	684	0.0
integral component of membrane	Hs	cellular component	684	0.0
Sin3 complex	Hs	cellular component	684	0.0
NuRD complex	Hs	cellular component	684	0.0
hydrolase activity	Hs	molecular function	684	0.0
transcriptional repressor complex	Hs	cellular component	483	3.54e-169
deacetylase activity	Hs	molecular function	684	0.0
enzyme binding	Hs	molecular function	684	0.0
cyclin binding	Hs	molecular function	483	3.54e-169
heat shock protein binding	Hs	molecular function	684	0.0
nucleosomal DNA binding	Hs	molecular function	684	0.0
NAD-dependent histone deacetylase activity (H3-K14 specific)	Hs	molecular function	684	0.0
macromolecular complex	Hs	cellular component	684	0.0
protein deacetylase activity	Hs	molecular function	684	0.0
activating transcription factor binding	Hs	molecular function	681	0.0
ESC/E(Z) complex	Hs	cellular component	684	0.0
histone deacetylase binding	Hs	molecular function	684	0.0
sequence-specific DNA binding	Hs	molecular function	684	0.0
transcription regulatory region DNA binding	Hs	molecular function	681	0.0
metal ion binding	Hs	molecular function	681	0.0
protein N-terminus binding	Hs	molecular function	681	0.0
NF-kappaB binding	Hs	molecular function	684	0.0
repressing transcription factor binding	Hs	molecular function	681	0.0
promoter-specific chromatin binding	Hs	molecular function	684	0.0

GO Term	Analysis	Type	e-value
histone deacetylase activity	PIRSF	molecular function	1.1E-163
histone deacetylation	PIRSF	biological process	1.1E-163