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GENE CARD

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Gene Card

Best human hits

RASGRF1; RASGRF2; SOS2

Species

B.leachii

Unique Gene ID

Boleac.g00007762

Gene Model ID

Boleac.CG.SB_v3.S327.g07762

Location

S327:59966..69461

Transcript Models and Sequences

  Boleac.CG.SB_v3.S327.g07762.01.t

External Database Gene Card

External database links

No result

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WashU Genome Browser

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Genomicus Synteny Browser

Genomicus browser link

Regulatory Regions

Regulatory Regions

No result

n/a

Gene Phylogeny

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Gene Annotations

InterPro

11 results

IPR Term Analysis Definition
RASGEF_cat_dom Pfam Ras guanine-nucleotide exchange factors catalytic domain
Ras-like_Gua-exchang_fac_N Pfam Ras-like guanine nucleotide exchange factor, N-terminal
Ras_GEF_dom_sf SUPERFAMILY Ras guanine nucleotide exchange factor domain superfamily
RASGEF_cat_dom SMART Ras guanine-nucleotide exchange factors catalytic domain
Ras-like_Gua-exchang_fac_N CDD Ras-like guanine nucleotide exchange factor, N-terminal
Ras-like_Gua-exchang_fac_N ProSiteProfiles Ras-like guanine nucleotide exchange factor, N-terminal
Ras-like_Gua-exchang_fac_N SMART Ras-like guanine nucleotide exchange factor, N-terminal
RASGEF_cat_dom ProSiteProfiles Ras guanine-nucleotide exchange factors catalytic domain
RASGEF_cat_dom_sf Gene3D Ras guanine-nucleotide exchange factor catalytic domain superfamily
RASGEF_cat_dom CDD Ras guanine-nucleotide exchange factors catalytic domain
Ras_G-nucl-exch_fac_CS ProSitePatterns Ras guanine-nucleotide exchange factor, conserved site

GOSlim

No result

GO Term Annotation Origin Type

GO (Orthology)

34 results

GO Term SpeciesCe = Caenorhabditis elegans
Dr = Danio rerio
Dm = Drosophila melanogaster
Gg = Gallus gallus
Hs = Homo sapiens
Mm = Mus musculus
Sc = Saccharomyces cerevisiae		 Type
guanyl-nucleotide exchange factor activity Hs molecular function
protein binding Hs molecular function
intracellular Hs cellular component
cytoplasm Hs cellular component
cytosol Hs cellular component
signal transduction Hs biological process
small GTPase mediated signal transduction Hs biological process
positive regulation of GTPase activity Hs biological process
regulation of molecular function Hs biological process
activation of MAPKK activity Hs biological process
blood vessel development Hs biological process
endosome Hs cellular component
early endosome Hs cellular component
transmembrane receptor protein tyrosine kinase signaling pathway Hs biological process
nervous system development Hs biological process
positive regulation of neuron projection development Hs biological process
Rap guanyl-nucleotide exchange factor activity Hs molecular function
SH3 domain binding Hs molecular function
cytokine-mediated signaling pathway Hs biological process
phagocytic vesicle membrane Hs cellular component
Rap protein signal transduction Hs biological process
nerve growth factor signaling pathway Hs biological process
regulation of JNK cascade Hs biological process
negative regulation of Ras protein signal transduction Hs biological process
platelet-derived growth factor receptor signaling pathway Hs biological process
perinuclear region of cytoplasm Hs cellular component
negative regulation of protein kinase B signaling Hs biological process
establishment of endothelial barrier Hs biological process
negative regulation of ERK1 and ERK2 cascade Hs biological process
positive regulation of ERK1 and ERK2 cascade Hs biological process
negative regulation of canonical Wnt signaling pathway Hs biological process
cell-cell adhesion Hs biological process
regulation of cell junction assembly Hs biological process
negative regulation of neural precursor cell proliferation Hs biological process

GO (Blast)

17 results

GO Term SpeciesCe = Caenorhabditis elegans
Dr = Danio rerio
Dm = Drosophila melanogaster
Gg = Gallus gallus
Hs = Homo sapiens
Mm = Mus musculus
Sc = Saccharomyces cerevisiae		 Type Score E-value
DNA binding Hs molecular function 117 7.83e-27
guanyl-nucleotide exchange factor activity Hs molecular function 132 1.98e-31
Ras guanyl-nucleotide exchange factor activity Hs molecular function 132 1.98e-31
Rho guanyl-nucleotide exchange factor activity Hs molecular function 132 1.98e-31
protein binding Hs molecular function 132 1.98e-31
calmodulin binding Hs molecular function 124 7.76e-29
intracellular Hs cellular component 124 7.76e-29
cytoplasm Hs cellular component 124 7.76e-29
endoplasmic reticulum Hs cellular component 124 7.76e-29
endoplasmic reticulum membrane Hs cellular component 124 7.76e-29
cytosol Hs cellular component 132 1.98e-31
plasma membrane Hs cellular component 132 1.98e-31
membrane Hs cellular component 124 7.76e-29
growth cone Hs cellular component 132 1.98e-31
glutamate receptor binding Hs molecular function 132 1.98e-31
neuron projection Hs cellular component 132 1.98e-31
protein heterodimerization activity Hs molecular function 117 7.83e-27

GO (InterProScan)

2 results

GO Term Analysis Type e-value
guanyl-nucleotide exchange factor activity SMART molecular function 1.8E-81
small GTPase mediated signal transduction SMART biological process 1.8E-81

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