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Gene Card

Best human hits

PSEN1; PSEN2

Species

B.leachii

Unique Gene ID

Boleac.g00013977

Gene Model ID

Boleac.CG.SB_v3.S767.g13977

Location

S767:28588..33658

Transcript Models and Sequences

  Boleac.CG.SB_v3.S767.g13977.01.t

External Database Gene Card

External database links

No result

Collections
WashU Genome Browser

Click here to view results in the tunicate WashU Browser

Genomicus Synteny Browser

Genomicus browser link

Regulatory Regions

Regulatory Regions

No result

n/a

Gene Phylogeny

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Gene Annotations

InterPro

4 results

IPR Term Analysis Definition
Preselin/SPP SMART Presenilin/signal peptide peptidase
Peptidase_A22A Pfam Peptidase A22A, presenilin
Peptidase_A22A PANTHER Peptidase A22A, presenilin
Peptidase_A22A PRINTS Peptidase A22A, presenilin

GOSlim

No result

GO Term Annotation Origin Type

GO (Orthology)

145 results

GO Term SpeciesCe = Caenorhabditis elegans
Dr = Danio rerio
Dm = Drosophila melanogaster
Gg = Gallus gallus
Hs = Homo sapiens
Mm = Mus musculus
Sc = Saccharomyces cerevisiae		 Type
autophagosome assembly Hs biological process
negative regulation of transcription from RNA polymerase II promoter Hs biological process
Golgi membrane Hs cellular component
activation of MAPKK activity Hs biological process
kinetochore Hs cellular component
blood vessel development Hs biological process
response to hypoxia Hs biological process
cell fate specification Hs biological process
somitogenesis Hs biological process
neuron migration Hs biological process
positive regulation of receptor recycling Hs biological process
negative regulation of protein phosphorylation Hs biological process
positive regulation of protein phosphorylation Hs biological process
heart looping Hs biological process
hematopoietic progenitor cell differentiation Hs biological process
T cell activation involved in immune response Hs biological process
myeloid leukocyte differentiation Hs biological process
neural retina development Hs biological process
endopeptidase activity Hs molecular function
aspartic-type endopeptidase activity Hs molecular function
calcium channel activity Hs molecular function
protein binding Hs molecular function
intracellular Hs cellular component
nucleus Hs cellular component
nuclear inner membrane Hs cellular component
nuclear outer membrane Hs cellular component
cytoplasm Hs cellular component
mitochondrion Hs cellular component
mitochondrial inner membrane Hs cellular component
lysosomal membrane Hs cellular component
endoplasmic reticulum Hs cellular component
endoplasmic reticulum membrane Hs cellular component
smooth endoplasmic reticulum Hs cellular component
rough endoplasmic reticulum Hs cellular component
Golgi apparatus Hs cellular component
centrosome Hs cellular component
plasma membrane Hs cellular component
integral component of plasma membrane Hs cellular component
cell cortex Hs cellular component
negative regulation of protein kinase activity Hs biological process
protein glycosylation Hs biological process
proteolysis Hs biological process
membrane protein ectodomain proteolysis Hs biological process
calcium ion transport Hs biological process
mitochondrial transport Hs biological process
cellular calcium ion homeostasis Hs biological process
autophagy Hs biological process
apoptotic process Hs biological process
cellular response to DNA damage stimulus Hs biological process
response to oxidative stress Hs biological process
cell adhesion Hs biological process
negative regulation of epidermal growth factor-activated receptor activity Hs biological process
regulation of epidermal growth factor-activated receptor activity Hs biological process
Notch signaling pathway Hs biological process
Notch receptor processing Hs biological process
brain development Hs biological process
heart development Hs biological process
learning or memory Hs biological process
memory Hs biological process
beta-catenin binding Hs molecular function
peptidase activity Hs molecular function
post-embryonic development Hs biological process
cell surface Hs cellular component
protein transport Hs biological process
L-glutamate transport Hs biological process
choline transport Hs biological process
membrane Hs cellular component
integral component of membrane Hs cellular component
synaptic vesicle targeting Hs biological process
aggresome Hs cellular component
protein processing Hs biological process
hydrolase activity Hs molecular function
cerebral cortex development Hs biological process
neurogenesis Hs biological process
Z disc Hs cellular component
cell junction Hs cellular component
PDZ domain binding Hs molecular function
neuron differentiation Hs biological process
embryonic limb morphogenesis Hs biological process
axon Hs cellular component
dendrite Hs cellular component
growth cone Hs cellular component
forebrain development Hs biological process
membrane protein intracellular domain proteolysis Hs biological process
cytoplasmic vesicle Hs cellular component
neuromuscular junction Hs cellular component
nuclear membrane Hs cellular component
positive regulation of protein binding Hs biological process
positive regulation of proteasomal ubiquitin-dependent protein catabolic process Hs biological process
endoplasmic reticulum calcium ion homeostasis Hs biological process
macromolecular complex Hs cellular component
positive regulation of protein import into nucleus, translocation Hs biological process
amyloid-beta formation Hs biological process
ciliary rootlet Hs cellular component
segmentation Hs biological process
intracellular signal transduction Hs biological process
azurophil granule membrane Hs cellular component
locomotion Hs biological process
regulation of phosphorylation Hs biological process
positive regulation of phosphorylation Hs biological process
aspartic endopeptidase activity, intramembrane cleaving Hs molecular function
amyloid precursor protein metabolic process Hs biological process
amyloid precursor protein catabolic process Hs biological process
neuron projection Hs cellular component
myeloid dendritic cell differentiation Hs biological process
neuronal cell body Hs cellular component
positive regulation of apoptotic process Hs biological process
negative regulation of apoptotic process Hs biological process
positive regulation of catalytic activity Hs biological process
dendritic shaft Hs cellular component
membrane-bounded organelle Hs cellular component
regulation of protein binding Hs biological process
positive regulation of MAP kinase activity Hs biological process
negative regulation of neuron apoptotic process Hs biological process
skin morphogenesis Hs biological process
membrane raft Hs cellular component
cadherin binding Hs molecular function
positive regulation of protein kinase activity Hs biological process
positive regulation of transcription, DNA-templated Hs biological process
ephrin receptor signaling pathway Hs biological process
astrocyte activation Hs biological process
regulation of synaptic plasticity Hs biological process
perinuclear region of cytoplasm Hs cellular component
thymus development Hs biological process
neuron development Hs biological process
skeletal system morphogenesis Hs biological process
brain morphogenesis Hs biological process
amyloid-beta metabolic process Hs biological process
epithelial cell proliferation Hs biological process
negative regulation of axonogenesis Hs biological process
synapse organization Hs biological process
T cell receptor signaling pathway Hs biological process
neuron apoptotic process Hs biological process
protein maturation Hs biological process
regulation of synaptic transmission, glutamatergic Hs biological process
canonical Wnt signaling pathway Hs biological process
regulation of canonical Wnt signaling pathway Hs biological process
positive regulation of dendritic spine development Hs biological process
calcium ion transmembrane transport Hs biological process
gamma-secretase complex Hs cellular component
cell-cell adhesion Hs biological process
presynapse Hs cellular component
neuron projection maintenance Hs biological process
negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process Hs biological process
negative regulation of apoptotic signaling pathway Hs biological process

GO (Blast)

52 results

GO Term SpeciesCe = Caenorhabditis elegans
Dr = Danio rerio
Dm = Drosophila melanogaster
Gg = Gallus gallus
Hs = Homo sapiens
Mm = Mus musculus
Sc = Saccharomyces cerevisiae		 Type Score E-value
Golgi membrane Hs cellular component 451 4.72e-156
kinetochore Hs cellular component 451 4.72e-156
endopeptidase activity Hs molecular function 451 4.72e-156
aspartic-type endopeptidase activity Hs molecular function 451 4.72e-156
calcium channel activity Hs molecular function 435 8.54e-150
protein binding Hs molecular function 451 4.72e-156
intracellular Hs cellular component 451 4.72e-156
nucleus Hs cellular component 435 8.54e-150
nuclear inner membrane Hs cellular component 451 4.72e-156
nuclear outer membrane Hs cellular component 435 8.54e-150
cytoplasm Hs cellular component 435 8.54e-150
mitochondrion Hs cellular component 435 8.54e-150
mitochondrial inner membrane Hs cellular component 451 4.72e-156
lysosomal membrane Hs cellular component 451 4.72e-156
endoplasmic reticulum Hs cellular component 451 4.72e-156
endoplasmic reticulum membrane Hs cellular component 451 4.72e-156
smooth endoplasmic reticulum Hs cellular component 435 8.54e-150
rough endoplasmic reticulum Hs cellular component 435 8.54e-150
Golgi apparatus Hs cellular component 451 4.72e-156
centrosome Hs cellular component 451 4.72e-156
plasma membrane Hs cellular component 451 4.72e-156
integral component of plasma membrane Hs cellular component 451 4.72e-156
cell cortex Hs cellular component 451 4.72e-156
beta-catenin binding Hs molecular function 435 8.54e-150
peptidase activity Hs molecular function 451 4.72e-156
cell surface Hs cellular component 451 4.72e-156
membrane Hs cellular component 451 4.72e-156
integral component of membrane Hs cellular component 451 4.72e-156
aggresome Hs cellular component 435 8.54e-150
hydrolase activity Hs molecular function 451 4.72e-156
Z disc Hs cellular component 451 4.72e-156
cell junction Hs cellular component 435 8.54e-150
PDZ domain binding Hs molecular function 435 8.54e-150
axon Hs cellular component 451 4.72e-156
dendrite Hs cellular component 435 8.54e-150
growth cone Hs cellular component 451 4.72e-156
cytoplasmic vesicle Hs cellular component 435 8.54e-150
neuromuscular junction Hs cellular component 451 4.72e-156
nuclear membrane Hs cellular component 435 8.54e-150
macromolecular complex Hs cellular component 451 4.72e-156
ciliary rootlet Hs cellular component 451 4.72e-156
azurophil granule membrane Hs cellular component 435 8.54e-150
aspartic endopeptidase activity, intramembrane cleaving Hs molecular function 451 4.72e-156
neuron projection Hs cellular component 435 8.54e-150
neuronal cell body Hs cellular component 451 4.72e-156
dendritic shaft Hs cellular component 451 4.72e-156
membrane-bounded organelle Hs cellular component 435 8.54e-150
membrane raft Hs cellular component 451 4.72e-156
cadherin binding Hs molecular function 435 8.54e-150
perinuclear region of cytoplasm Hs cellular component 451 4.72e-156
gamma-secretase complex Hs cellular component 435 8.54e-150
presynapse Hs cellular component 435 8.54e-150

GO (InterProScan)

3 results

GO Term Analysis Type e-value
aspartic-type endopeptidase activity PANTHER molecular function 5.7E-185
integral component of membrane PANTHER cellular component 5.7E-185
protein processing PANTHER biological process 5.7E-185

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