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Gene Card

Best human hits

FGFR1; FGFR2; FGFR3

Species

C.savignyi

Unique Gene ID

Cisavi.g00007377

Gene Model ID

Cisavi.CG.ENS81.R41.1596721-1623423

Location

R41:1596720..1623423

Transcript Models and Sequences

  Cisavi.CG.ENS81.R41.1596721-1623423.13024.t
Cisavi.CG.ENS81.R41.1596721-1623423.13025.t
Cisavi.CG.ENS81.R41.1596721-1623423.13026.t

External Database Gene Card

External database links

No result

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WashU Genome Browser

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Genomicus Synteny Browser

Genomicus browser link

Regulatory Regions

Regulatory Regions

No result

n/a

Gene Phylogeny

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Gene Annotations

InterPro

13 results

IPR Term Analysis Definition
Ig_sub2 SMART Immunoglobulin subtype 2
Ig_I-set Pfam Immunoglobulin I-set
FGF_rcpt_fam PIRSF Fibroblast growth factor receptor family
Tyr_kinase_AS ProSitePatterns Tyrosine-protein kinase, active site
Ig-like_dom_sf SUPERFAMILY Immunoglobulin-like domain superfamily
Kinase-like_dom_sf SUPERFAMILY Protein kinase-like domain superfamily
Ser-Thr/Tyr_kinase_cat_dom PRINTS Serine-threonine/tyrosine-protein kinase, catalytic domain
Ig-like_fold Gene3D Immunoglobulin-like fold
Ser-Thr/Tyr_kinase_cat_dom Pfam Serine-threonine/tyrosine-protein kinase, catalytic domain
Prot_kinase_dom ProSiteProfiles Protein kinase domain
Tyr_kinase_cat_dom SMART Tyrosine-protein kinase, catalytic domain
Ig-like_dom ProSiteProfiles Immunoglobulin-like domain
Ig_sub SMART Immunoglobulin subtype

GOSlim

No result

GO Term Annotation Origin Type

GO (Orthology)

141 results

GO Term SpeciesCe = Caenorhabditis elegans
Dr = Danio rerio
Dm = Drosophila melanogaster
Gg = Gallus gallus
Hs = Homo sapiens
Mm = Mus musculus
Sc = Saccharomyces cerevisiae		 Type
negative regulation of transcription from RNA polymerase II promoter Hs biological process
MAPK cascade Hs biological process
nucleotide binding Hs molecular function
skeletal system development Hs biological process
angiogenesis Hs biological process
ureteric bud development Hs biological process
organ induction Hs biological process
neuron migration Hs biological process
epithelial to mesenchymal transition Hs biological process
endochondral ossification Hs biological process
chondrocyte differentiation Hs biological process
protein kinase activity Hs molecular function
protein tyrosine kinase activity Hs molecular function
transmembrane receptor protein tyrosine kinase activity Hs molecular function
fibroblast growth factor-activated receptor activity Hs molecular function
Ras guanyl-nucleotide exchange factor activity Hs molecular function
protein binding Hs molecular function
ATP binding Hs molecular function
extracellular region Hs cellular component
nucleus Hs cellular component
nucleoplasm Hs cellular component
nucleolus Hs cellular component
cytoplasm Hs cellular component
endoplasmic reticulum Hs cellular component
Golgi apparatus Hs cellular component
cytosol Hs cellular component
plasma membrane Hs cellular component
integral component of plasma membrane Hs cellular component
focal adhesion Hs cellular component
cell cortex Hs cellular component
transcription, DNA-templated Hs biological process
regulation of transcription, DNA-templated Hs biological process
protein phosphorylation Hs biological process
apoptotic process Hs biological process
cell-cell signaling Hs biological process
axonogenesis Hs biological process
brain development Hs biological process
salivary gland morphogenesis Hs biological process
sensory perception of sound Hs biological process
heparin binding Hs molecular function
positive regulation of cell proliferation Hs biological process
fibroblast growth factor receptor signaling pathway Hs biological process
regulation of smoothened signaling pathway Hs biological process
post-embryonic development Hs biological process
embryonic pattern specification Hs biological process
animal organ morphogenesis Hs biological process
cell surface Hs cellular component
regulation of gene expression Hs biological process
negative regulation of gene expression Hs biological process
positive regulation of phospholipase C activity Hs biological process
positive regulation of neuron projection development Hs biological process
positive regulation of phosphatidylinositol 3-kinase signaling Hs biological process
membrane Hs cellular component
integral component of membrane Hs cellular component
kinase activity Hs molecular function
1-phosphatidylinositol-3-kinase activity Hs molecular function
phosphorylation Hs biological process
morphogenesis of embryonic epithelium Hs biological process
cell migration Hs biological process
transferase activity Hs molecular function
fibroblast growth factor binding Hs molecular function
peptidyl-tyrosine phosphorylation Hs biological process
transport vesicle Hs cellular component
positive regulation of Wnt signaling pathway Hs biological process
bone mineralization Hs biological process
lung development Hs biological process
embryonic limb morphogenesis Hs biological process
epithelial cell differentiation Hs biological process
midbrain development Hs biological process
otic vesicle formation Hs biological process
extracellular matrix Hs cellular component
cytoplasmic vesicle Hs cellular component
response to lipopolysaccharide Hs biological process
regulation of osteoblast proliferation Hs biological process
multicellular organism growth Hs biological process
organ growth Hs biological process
chondrocyte proliferation Hs biological process
phosphatidylinositol-3-phosphate biosynthetic process Hs biological process
regulation of multicellular organism growth Hs biological process
regulation of fibroblast growth factor receptor signaling pathway Hs biological process
wound healing Hs biological process
regulation of cell proliferation Hs biological process
inner ear morphogenesis Hs biological process
odontogenesis Hs biological process
positive regulation of tyrosine phosphorylation of STAT protein Hs biological process
identical protein binding Hs molecular function
protein homodimerization activity Hs molecular function
chordate embryonic development Hs biological process
intracellular membrane-bounded organelle Hs cellular component
receptor complex Hs cellular component
positive regulation of MAP kinase activity Hs biological process
positive regulation of MAPK cascade Hs biological process
ear development Hs biological process
cell fate commitment Hs biological process
response to ethanol Hs biological process
regulation of cell differentiation Hs biological process
positive regulation of neuron differentiation Hs biological process
regulation of osteoblast differentiation Hs biological process
positive regulation of cell cycle Hs biological process
positive regulation of transcription from RNA polymerase II promoter Hs biological process
protein autophosphorylation Hs biological process
phosphatidylinositol phosphorylation Hs biological process
phosphatidylinositol-4,5-bisphosphate 3-kinase activity Hs molecular function
phosphatidylinositol-mediated signaling Hs biological process
mesodermal cell differentiation Hs biological process
paraxial mesoderm development Hs biological process
blood vessel morphogenesis Hs biological process
embryonic digestive tract morphogenesis Hs biological process
embryonic organ morphogenesis Hs biological process
digestive tract development Hs biological process
embryonic organ development Hs biological process
reproductive structure development Hs biological process
generation of neurons Hs biological process
embryonic cranial skeleton morphogenesis Hs biological process
skeletal system morphogenesis Hs biological process
epidermis morphogenesis Hs biological process
branching morphogenesis of a nerve Hs biological process
positive regulation of epithelial cell proliferation Hs biological process
negative regulation of epithelial cell proliferation Hs biological process
positive regulation of cell division Hs biological process
positive regulation of protein kinase B signaling Hs biological process
ventricular cardiac muscle tissue morphogenesis Hs biological process
excitatory synapse Hs cellular component
auditory receptor cell development Hs biological process
limb bud formation Hs biological process
bone development Hs biological process
bone morphogenesis Hs biological process
regulation of ERK1 and ERK2 cascade Hs biological process
positive regulation of ERK1 and ERK2 cascade Hs biological process
cellular response to retinoic acid Hs biological process
cellular response to transforming growth factor beta stimulus Hs biological process
positive regulation of canonical Wnt signaling pathway Hs biological process
receptor-receptor interaction Hs molecular function
endosome Hs cellular component
cell-cell junction Hs cellular component
positive regulation of gene expression Hs biological process
regulation of lipid metabolic process Hs biological process
glucose homeostasis Hs biological process
positive regulation of catalytic activity Hs biological process
positive regulation of proteolysis Hs biological process
phosphate ion homeostasis Hs biological process

GO (Blast)

38 results

GO Term SpeciesCe = Caenorhabditis elegans
Dr = Danio rerio
Dm = Drosophila melanogaster
Gg = Gallus gallus
Hs = Homo sapiens
Mm = Mus musculus
Sc = Saccharomyces cerevisiae		 Type Score E-value
nucleotide binding Hs molecular function 556 0.0
protein kinase activity Hs molecular function 556 0.0
protein tyrosine kinase activity Hs molecular function 556 0.0
transmembrane receptor protein tyrosine kinase activity Hs molecular function 556 0.0
fibroblast growth factor-activated receptor activity Hs molecular function 556 0.0
Ras guanyl-nucleotide exchange factor activity Hs molecular function 556 0.0
protein binding Hs molecular function 556 0.0
ATP binding Hs molecular function 556 0.0
extracellular region Hs cellular component 556 0.0
nucleus Hs cellular component 556 0.0
nucleoplasm Hs cellular component 534 1.13e-180
nucleolus Hs cellular component 556 0.0
cytoplasm Hs cellular component 556 0.0
endoplasmic reticulum Hs cellular component 506 6.89e-170
Golgi apparatus Hs cellular component 534 1.13e-180
cytosol Hs cellular component 556 0.0
plasma membrane Hs cellular component 556 0.0
integral component of plasma membrane Hs cellular component 556 0.0
focal adhesion Hs cellular component 506 6.89e-170
cell cortex Hs cellular component 534 1.13e-180
heparin binding Hs molecular function 556 0.0
cell surface Hs cellular component 534 1.13e-180
membrane Hs cellular component 556 0.0
integral component of membrane Hs cellular component 556 0.0
kinase activity Hs molecular function 556 0.0
1-phosphatidylinositol-3-kinase activity Hs molecular function 556 0.0
transferase activity Hs molecular function 556 0.0
fibroblast growth factor binding Hs molecular function 556 0.0
transport vesicle Hs cellular component 506 6.89e-170
extracellular matrix Hs cellular component 534 1.13e-180
cytoplasmic vesicle Hs cellular component 556 0.0
identical protein binding Hs molecular function 556 0.0
protein homodimerization activity Hs molecular function 556 0.0
intracellular membrane-bounded organelle Hs cellular component 534 1.13e-180
receptor complex Hs cellular component 556 0.0
phosphatidylinositol-4,5-bisphosphate 3-kinase activity Hs molecular function 556 0.0
excitatory synapse Hs cellular component 534 1.13e-180
receptor-receptor interaction Hs molecular function 556 0.0

GO (InterProScan)

8 results

GO Term Analysis Type e-value
protein kinase activity Pfam molecular function 3.5E-92
protein tyrosine kinase activity SMART molecular function 2.1E-124
fibroblast growth factor-activated receptor activity PIRSF molecular function 7.8E-288
ATP binding ProSiteProfiles molecular function 36.98
protein phosphorylation SMART biological process 2.1E-124
positive regulation of cell proliferation PIRSF biological process 7.8E-288
fibroblast growth factor receptor signaling pathway PIRSF biological process 7.8E-288
integral component of membrane PIRSF cellular component 7.8E-288

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