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GENE CARD

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Gene Card

Best human hits

EXD3; EXOSC10; WRN

Species

C.savignyi

Unique Gene ID

Cisavi.g00010636

Gene Model ID

Cisavi.CG.ENS81.R76.2824759-2832229

Location

R76:2824758..2832229

Transcript Models and Sequences

  Cisavi.CG.ENS81.R76.2824759-2832229.15603.t

External Database Gene Card

External database links

No result

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WashU Genome Browser

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Genomicus Synteny Browser

Genomicus browser link

Regulatory Regions

Regulatory Regions

No result

n/a

Gene Phylogeny

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Gene Annotations

InterPro

8 results

IPR Term Analysis Definition
HRDC_dom Pfam HRDC domain
RNaseH-like_sf SUPERFAMILY Ribonuclease H-like superfamily
HRDC_dom ProSiteProfiles HRDC domain
3'-5'_exonuclease_dom SMART 3'-5' exonuclease domain
HRDC_dom SMART HRDC domain
3'-5'_exonuclease_dom Pfam 3'-5' exonuclease domain
Exosome-assoc_fac_Rrp6_N Pfam Exosome-associated factor Rrp6, N-terminal
HRDC-like_sf SUPERFAMILY HRDC-like superfamily

GOSlim

No result

GO Term Annotation Origin Type

GO (Orthology)

36 results

GO Term SpeciesCe = Caenorhabditis elegans
Dr = Danio rerio
Dm = Drosophila melanogaster
Gg = Gallus gallus
Hs = Homo sapiens
Mm = Mus musculus
Sc = Saccharomyces cerevisiae		 Type
nucleotide binding Hs molecular function
3'-5'-exoribonuclease activity Hs molecular function
nuclear exosome (RNase complex) Hs cellular component
exosome (RNase complex) Hs cellular component
nuclear-transcribed mRNA catabolic process, nonsense-mediated decay Hs biological process
maturation of 5.8S rRNA Hs biological process
nuclear-transcribed mRNA catabolic process Hs biological process
nucleic acid binding Hs molecular function
RNA binding Hs molecular function
catalytic activity Hs molecular function
nuclease activity Hs molecular function
exonuclease activity Hs molecular function
exoribonuclease activity Hs molecular function
protein binding Hs molecular function
intracellular Hs cellular component
nucleus Hs cellular component
nucleoplasm Hs cellular component
nucleolus Hs cellular component
cytoplasm Hs cellular component
cytosol Hs cellular component
nucleobase-containing compound metabolic process Hs biological process
rRNA processing Hs biological process
RNA processing Hs biological process
3'-5' exonuclease activity Hs molecular function
membrane Hs cellular component
hydrolase activity Hs molecular function
negative regulation of telomere maintenance via telomerase Hs biological process
transcriptionally active chromatin Hs cellular component
cellular metabolic process Hs biological process
telomerase RNA binding Hs molecular function
nuclear mRNA surveillance Hs biological process
CUT catabolic process Hs biological process
nuclear polyadenylation-dependent rRNA catabolic process Hs biological process
nuclear retention of unspliced pre-mRNA at the site of transcription Hs biological process
nucleic acid phosphodiester bond hydrolysis Hs biological process
RNA phosphodiester bond hydrolysis, exonucleolytic Hs biological process

GO (Blast)

53 results

GO Term SpeciesCe = Caenorhabditis elegans
Dr = Danio rerio
Dm = Drosophila melanogaster
Gg = Gallus gallus
Hs = Homo sapiens
Mm = Mus musculus
Sc = Saccharomyces cerevisiae		 Type Score E-value
nucleotide binding Hs molecular function 543 0.0
3'-5'-exoribonuclease activity Hs molecular function 543 0.0
nuclear exosome (RNase complex) Hs cellular component 543 0.0
exosome (RNase complex) Hs cellular component 543 0.0
magnesium ion binding Hs molecular function 40.0 0.005
four-way junction DNA binding Hs molecular function 40.0 0.005
Y-form DNA binding Hs molecular function 40.0 0.005
bubble DNA binding Hs molecular function 40.0 0.005
chromosome, telomeric region Hs cellular component 40.0 0.005
nucleic acid binding Hs molecular function 543 0.0
DNA binding Hs molecular function 40.0 0.005
DNA helicase activity Hs molecular function 40.0 0.005
chromatin binding Hs molecular function 40.0 0.005
RNA binding Hs molecular function 543 0.0
catalytic activity Hs molecular function 543 0.0
ATP-dependent DNA helicase activity Hs molecular function 40.0 0.005
helicase activity Hs molecular function 40.0 0.005
nuclease activity Hs molecular function 543 0.0
exonuclease activity Hs molecular function 543 0.0
exoribonuclease activity Hs molecular function 543 0.0
protein binding Hs molecular function 543 0.0
ATP binding Hs molecular function 40.0 0.005
intracellular Hs cellular component 543 0.0
nucleus Hs cellular component 543 0.0
nucleoplasm Hs cellular component 543 0.0
replication fork Hs cellular component 40.0 0.005
nucleolus Hs cellular component 543 0.0
cytoplasm Hs cellular component 543 0.0
centrosome Hs cellular component 40.0 0.005
cytosol Hs cellular component 543 0.0
ATP-dependent helicase activity Hs molecular function 40.0 0.005
3'-5' exonuclease activity Hs molecular function 543 0.0
four-way junction helicase activity Hs molecular function 40.0 0.005
membrane Hs cellular component 543 0.0
nuclear speck Hs cellular component 40.0 0.005
hydrolase activity Hs molecular function 543 0.0
ATPase activity Hs molecular function 40.0 0.005
manganese ion binding Hs molecular function 40.0 0.005
MutLalpha complex Hs cellular component 40.0 0.005
transcriptionally active chromatin Hs cellular component 543 0.0
protein homodimerization activity Hs molecular function 40.0 0.005
neuron projection Hs cellular component 40.0 0.005
3'-5' DNA helicase activity Hs molecular function 40.0 0.005
ATP-dependent 3'-5' DNA helicase activity Hs molecular function 40.0 0.005
macromolecular complex binding Hs molecular function 40.0 0.005
metal ion binding Hs molecular function 40.0 0.005
G-quadruplex DNA binding Hs molecular function 40.0 0.005
forked DNA-dependent helicase activity Hs molecular function 40.0 0.005
telomeric D-loop binding Hs molecular function 40.0 0.005
telomeric G-quadruplex DNA binding Hs molecular function 40.0 0.005
telomerase RNA binding Hs molecular function 543 0.0
3'-flap-structured DNA binding Hs molecular function 40.0 0.005
8-hydroxy-2'-deoxyguanosine DNA binding Hs molecular function 40.0 0.005

GO (InterProScan)

9 results

GO Term Analysis Type e-value
nucleotide binding SUPERFAMILY molecular function 1.62E-22
nuclear exosome (RNase complex) Pfam cellular component 1.2E-15
nucleic acid binding SMART molecular function 1.0E-47
catalytic activity SUPERFAMILY molecular function 1.62E-22
intracellular SMART cellular component 3.8E-14
nucleobase-containing compound metabolic process SMART biological process 1.0E-47
RNA processing Pfam biological process 1.2E-15
3'-5' exonuclease activity SMART molecular function 1.0E-47
cellular metabolic process SUPERFAMILY biological process 1.62E-22

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