Aniseed - Gene card

Gene Card

Best human hits

SMAD3; SMAD4; SMAD5

Species

H.aurantium

Unique Gene ID

Haaura.g00008289

Gene Model ID

Haaura.CG.MTP2014.S1412.g08289

Location

S1412:14106..16493

Transcript Models and Sequences

Haaura.CG.MTP2014.S1412.g08289.01.t

External Database Gene Card

External database links

No result

Collections

WashU Genome Browser

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Genomicus Synteny Browser

Regulatory Regions

No result

n/a

Gene Phylogeny

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Gene Annotations

InterPro

11 results

IPR Term	Analysis	Definition
SMAD_dom_Dwarfin-type	SMART	SMAD domain, Dwarfin-type
SMAD_dom_Dwarfin-type	Pfam	SMAD domain, Dwarfin-type
SMAD_FHA_dom_sf	SUPERFAMILY	SMAD/FHA domain superfamily
SMAD_MH1_sf	SUPERFAMILY	SMAD MH1 domain superfamily
SMAD_dom_Dwarfin-type	ProSiteProfiles	SMAD domain, Dwarfin-type
MAD_homology_MH1	ProSiteProfiles	MAD homology, MH1
SMAD-like_dom_sf	Gene3D	SMAD-like domain superfamily
SMAD_MH1_sf	Gene3D	SMAD MH1 domain superfamily
MAD_homology1_Dwarfin-type	SMART	MAD homology 1, Dwarfin-type
MAD_homology1_Dwarfin-type	Pfam	MAD homology 1, Dwarfin-type
Dwarfin	PANTHER	Dwarfin

GOSlim

No result

GO Term	Annotation Origin	Type

GO (Orthology)

87 results

GO Term	SpeciesCe = Caenorhabditis elegans Dr = Danio rerio Dm = Drosophila melanogaster Gg = Gallus gallus Hs = Homo sapiens Mm = Mus musculus Sc = Saccharomyces cerevisiae	Type
negative regulation of transcription from RNA polymerase II promoter	Hs	biological process
nuclear chromatin	Hs	cellular component
RNA polymerase II regulatory region sequence-specific DNA binding	Hs	molecular function
RNA polymerase II core promoter proximal region sequence-specific DNA binding	Hs	molecular function
RNA polymerase II transcription factor activity, sequence-specific DNA binding	Hs	molecular function
core promoter proximal region sequence-specific DNA binding	Hs	molecular function
transcription factor activity, transcription factor binding	Hs	molecular function
transcription factor activity, RNA polymerase II transcription factor binding	Hs	molecular function
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding	Hs	molecular function
RNA polymerase II transcription factor binding	Hs	molecular function
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding	Hs	molecular function
ovarian follicle development	Hs	biological process
branching involved in ureteric bud morphogenesis	Hs	biological process
response to hypoxia	Hs	biological process
gastrulation with mouth forming second	Hs	biological process
kidney development	Hs	biological process
atrioventricular valve formation	Hs	biological process
DNA binding	Hs	molecular function
chromatin binding	Hs	molecular function
transcription factor activity, sequence-specific DNA binding	Hs	molecular function
protein binding	Hs	molecular function
collagen binding	Hs	molecular function
intracellular	Hs	cellular component
nucleus	Hs	cellular component
nucleoplasm	Hs	cellular component
transcription factor complex	Hs	cellular component
cytoplasm	Hs	cellular component
centrosome	Hs	cellular component
cytosol	Hs	cellular component
transcription, DNA-templated	Hs	biological process
regulation of transcription, DNA-templated	Hs	biological process
regulation of transcription from RNA polymerase II promoter	Hs	biological process
cellular iron ion homeostasis	Hs	biological process
transforming growth factor beta receptor signaling pathway	Hs	biological process
spermatogenesis	Hs	biological process
single fertilization	Hs	biological process
gastrulation	Hs	biological process
axon guidance	Hs	biological process
endoderm development	Hs	biological process
mesoderm development	Hs	biological process
cell proliferation	Hs	biological process
negative regulation of cell proliferation	Hs	biological process
male gonad development	Hs	biological process
female gonad development	Hs	biological process
anterior/posterior pattern specification	Hs	biological process
positive regulation of epithelial to mesenchymal transition	Hs	biological process
positive regulation of pathway-restricted SMAD protein phosphorylation	Hs	biological process
neural crest cell differentiation	Hs	biological process
protein deubiquitination	Hs	biological process
regulation of transforming growth factor beta receptor signaling pathway	Hs	biological process
negative regulation of cell growth	Hs	biological process
BMP signaling pathway	Hs	biological process
positive regulation of transforming growth factor beta receptor signaling pathway	Hs	biological process
positive regulation of BMP signaling pathway	Hs	biological process
transforming growth factor beta receptor, common-partner cytoplasmic mediator activity	Hs	molecular function
activin responsive factor complex	Hs	cellular component
somite rostral/caudal axis specification	Hs	biological process
somatic stem cell population maintenance	Hs	biological process
intracellular signal transduction	Hs	biological process
atrioventricular canal development	Hs	biological process
regulation of cell proliferation	Hs	biological process
identical protein binding	Hs	molecular function
protein homodimerization activity	Hs	molecular function
sulfate binding	Hs	molecular function
sequence-specific DNA binding	Hs	molecular function
transcription regulatory region DNA binding	Hs	molecular function
negative regulation of transcription, DNA-templated	Hs	biological process
positive regulation of transcription, DNA-templated	Hs	biological process
positive regulation of transcription from RNA polymerase II promoter	Hs	biological process
metal ion binding	Hs	molecular function
protein heterodimerization activity	Hs	molecular function
developmental growth	Hs	biological process
neuron fate commitment	Hs	biological process
tissue morphogenesis	Hs	biological process
formation of anatomical boundary	Hs	biological process
positive regulation of histone H3-K4 methylation	Hs	biological process
palate development	Hs	biological process
uterus development	Hs	biological process
SMAD protein signal transduction	Hs	biological process
negative regulation of cell death	Hs	biological process
endocardial cell differentiation	Hs	biological process
protein homotrimerization	Hs	biological process
negative regulation of ERK1 and ERK2 cascade	Hs	biological process
I-SMAD binding	Hs	molecular function
R-SMAD binding	Hs	molecular function
SMAD protein complex	Hs	cellular component
RNA polymerase II transcription factor complex	Hs	cellular component

GO (Blast)

64 results

GO Term	SpeciesCe = Caenorhabditis elegans Dr = Danio rerio Dm = Drosophila melanogaster Gg = Gallus gallus Hs = Homo sapiens Mm = Mus musculus Sc = Saccharomyces cerevisiae	Type	Score	E-value
nuclear chromatin	Hs	cellular component	672	0.0
RNA polymerase II regulatory region sequence-specific DNA binding	Hs	molecular function	672	0.0
RNA polymerase II core promoter proximal region sequence-specific DNA binding	Hs	molecular function	672	0.0
RNA polymerase II transcription factor activity, sequence-specific DNA binding	Hs	molecular function	672	0.0
transcription factor activity, RNA polymerase II core promoter sequence-specific	Hs	molecular function	261	5.80e-82
core promoter proximal region sequence-specific DNA binding	Hs	molecular function	672	0.0
transcription factor activity, transcription factor binding	Hs	molecular function	672	0.0
transcription factor activity, RNA polymerase II transcription factor binding	Hs	molecular function	672	0.0
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding	Hs	molecular function	672	0.0
RNA polymerase II transcription factor binding	Hs	molecular function	672	0.0
RNA polymerase II activating transcription factor binding	Hs	molecular function	261	5.80e-82
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding	Hs	molecular function	672	0.0
DNA binding	Hs	molecular function	672	0.0
chromatin binding	Hs	molecular function	672	0.0
double-stranded DNA binding	Hs	molecular function	261	5.80e-82
transcription factor activity, sequence-specific DNA binding	Hs	molecular function	672	0.0
signal transducer activity, downstream of receptor	Hs	molecular function	253	1.07e-78
transforming growth factor beta receptor binding	Hs	molecular function	261	5.80e-82
protein binding	Hs	molecular function	672	0.0
collagen binding	Hs	molecular function	672	0.0
intracellular	Hs	cellular component	672	0.0
nucleus	Hs	cellular component	672	0.0
nuclear inner membrane	Hs	cellular component	261	5.80e-82
nucleoplasm	Hs	cellular component	672	0.0
transcription factor complex	Hs	cellular component	672	0.0
cytoplasm	Hs	cellular component	672	0.0
centrosome	Hs	cellular component	672	0.0
cytosol	Hs	cellular component	672	0.0
plasma membrane	Hs	cellular component	261	5.80e-82
beta-catenin binding	Hs	molecular function	261	5.80e-82
transcription factor binding	Hs	molecular function	261	5.80e-82
zinc ion binding	Hs	molecular function	261	5.80e-82
integral component of membrane	Hs	cellular component	253	1.07e-78
DEAD/H-box RNA helicase binding	Hs	molecular function	261	5.80e-82
enzyme binding	Hs	molecular function	261	5.80e-82
protein kinase binding	Hs	molecular function	261	5.80e-82
phosphatase binding	Hs	molecular function	261	5.80e-82
transforming growth factor beta receptor, common-partner cytoplasmic mediator activity	Hs	molecular function	672	0.0
transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity	Hs	molecular function	261	5.80e-82
chromatin DNA binding	Hs	molecular function	261	5.80e-82
ubiquitin protein ligase binding	Hs	molecular function	261	5.80e-82
mineralocorticoid receptor binding	Hs	molecular function	261	5.80e-82
activin responsive factor complex	Hs	cellular component	672	0.0
macromolecular complex	Hs	cellular component	253	1.07e-78
glucocorticoid receptor binding	Hs	molecular function	261	5.80e-82
enhancer binding	Hs	molecular function	261	5.80e-82
identical protein binding	Hs	molecular function	672	0.0
protein homodimerization activity	Hs	molecular function	672	0.0
ubiquitin binding	Hs	molecular function	261	5.80e-82
sulfate binding	Hs	molecular function	672	0.0
receptor complex	Hs	cellular component	261	5.80e-82
bHLH transcription factor binding	Hs	molecular function	261	5.80e-82
sequence-specific DNA binding	Hs	molecular function	672	0.0
transcription regulatory region DNA binding	Hs	molecular function	672	0.0
SMAD binding	Hs	molecular function	261	5.80e-82
metal ion binding	Hs	molecular function	672	0.0
protein heterodimerization activity	Hs	molecular function	672	0.0
co-SMAD binding	Hs	molecular function	261	5.80e-82
I-SMAD binding	Hs	molecular function	672	0.0
R-SMAD binding	Hs	molecular function	672	0.0
primary miRNA binding	Hs	molecular function	261	5.80e-82
SMAD protein complex	Hs	cellular component	672	0.0
SMAD2-SMAD3 protein complex	Hs	cellular component	261	5.80e-82
RNA polymerase II transcription factor complex	Hs	cellular component	672	0.0

GO (InterProScan)

5 results

GO Term	Analysis	Type	e-value
transcription factor activity, sequence-specific DNA binding	ProSiteProfiles	molecular function	35.466
protein binding	SUPERFAMILY	molecular function	6.46E-89
intracellular	PANTHER	cellular component	4.3E-251
regulation of transcription, DNA-templated	PANTHER	biological process	4.3E-251
transforming growth factor beta receptor signaling pathway	Gene3D	biological process	3.3E-62