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GENE CARD

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Gene Card

Best human hits

LRP1; LRP4; LRP6

Species

H.roretzi

Unique Gene ID

Harore.g00015339

Gene Model ID

Harore.CG.MTP2014.S12.g15339

Location

S12:390765..405820

Transcript Models and Sequences

  Harore.CG.MTP2014.S12.g15339.01.t

External Database Gene Card

External database links

No result

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WashU Genome Browser

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Genomicus Synteny Browser

Genomicus browser link

Regulatory Regions

Regulatory Regions

No result

n/a

Gene Phylogeny

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Gene Annotations

InterPro

20 results

IPR Term Analysis Definition
LDrepeatLR_classA_rpt CDD Low-density lipoprotein (LDL) receptor class A repeat
LRP4 PANTHER Low-density lipoprotein receptor-related protein 4
LDLR_classB_rpt ProSiteProfiles LDLR class B repeat
EGF-like_dom SMART EGF-like domain
6-blade_b-propeller_TolB-like Gene3D Six-bladed beta-propeller, TolB-like
LDrepeatLR_classA_rpt ProSiteProfiles Low-density lipoprotein (LDL) receptor class A repeat
Growth_fac_rcpt_cys_sf SUPERFAMILY Growth factor receptor cysteine-rich domain superfamily
LDLR_class-A_CS ProSitePatterns Low-density lipoprotein (LDL) receptor class A, conserved site
LDrepeatLR_classA_rpt Pfam Low-density lipoprotein (LDL) receptor class A repeat
LDrepeatLR_classA_rpt SMART Low-density lipoprotein (LDL) receptor class A repeat
LDL_receptor-like_sf SUPERFAMILY LDL receptor-like superfamily
EGF-like_CS ProSitePatterns EGF-like, conserved site
EGF-like_Ca-bd_dom Pfam EGF-like calcium-binding domain
LDLR_classB_rpt SMART LDLR class B repeat
EGF-type_Asp/Asn_hydroxyl_site ProSitePatterns EGF-type aspartate/asparagine hydroxylation site
EGF-like_dom ProSiteProfiles EGF-like domain
LDLR_classB_rpt Pfam LDLR class B repeat
EGF-like_Ca-bd_dom SMART EGF-like calcium-binding domain
EGF_Ca-bd_CS ProSitePatterns EGF-like calcium-binding, conserved site
LDrepeatLR_classA_rpt PRINTS Low-density lipoprotein (LDL) receptor class A repeat

GOSlim

73 results

GO Term Annotation Origin Type
RNA binding Blast molecular function
receptor binding Orthology molecular function
calcium ion binding Orthology molecular function
protein binding Orthology molecular function
extracellular region Blast cellular component
nucleus Blast cellular component
cytoplasm Blast cellular component
lysosomal membrane Blast cellular component
endosome Blast cellular component
early endosome Blast cellular component
endoplasmic reticulum Blast cellular component
Golgi apparatus Blast cellular component
plasma membrane Orthology cellular component
integral component of plasma membrane Blast cellular component
focal adhesion Blast cellular component
multicellular organism development Orthology biological process
protein localization Orthology biological process
cell surface Orthology cellular component
membrane Orthology cellular component
integral component of membrane Orthology cellular component
basolateral plasma membrane Blast cellular component
cell differentiation Orthology biological process
negative regulation of Wnt signaling pathway Orthology biological process
cytoplasmic vesicle Blast cellular component
identical protein binding Blast molecular function
protein homodimerization activity Orthology molecular function
neuronal cell body Orthology cellular component
macromolecular complex binding Blast molecular function
membrane raft Orthology cellular component
synapse Orthology cellular component
metal ion binding Blast molecular function
animal organ development Orthology biological process
anatomical structure development Orthology biological process
regulation of canonical Wnt signaling pathway Orthology biological process
negative regulation of canonical Wnt signaling pathway Orthology biological process
synaptic membrane Orthology cellular component
regulation of cellular metabolic process Orthology biological process
protein phosphorylation Orthology biological process
membrane organization Orthology biological process
organelle organization Orthology biological process
organelle Orthology cellular component
postsynapse Orthology cellular component
neuron part Orthology cellular component
cell surface receptor signaling pathway Orthology biological process
cell-cell signaling Orthology biological process
plasma membrane region Orthology cellular component
macromolecular complex Orthology cellular component
anatomical structure morphogenesis Orthology biological process
regulation of transcription from RNA polymerase II promoter Orthology biological process
cellular response to organic substance Orthology biological process
protein kinase binding Orthology molecular function
transmembrane signaling receptor activity Orthology molecular function
protein localization to membrane Orthology biological process
cell morphogenesis involved in neuron differentiation Orthology biological process
neuron projection morphogenesis Orthology biological process
axonogenesis Orthology biological process
cellular component organization Orthology biological process
nervous system development Orthology biological process
protein oligomerization Orthology biological process
enzyme binding Blast molecular function
membrane part Blast cellular component
endomembrane system Blast cellular component
kinase activity Blast molecular function
enzyme regulator activity Blast molecular function
transmembrane transport Blast biological process
intracellular organelle part Blast cellular component
whole membrane Blast cellular component
bounding membrane of organelle Blast cellular component
protein transport Blast biological process
anion binding Blast molecular function
carbohydrate derivative binding Blast molecular function
signaling receptor activity Blast molecular function
plasma membrane part Blast cellular component

GO (Orthology)

49 results

GO Term SpeciesCe = Caenorhabditis elegans
Dr = Danio rerio
Dm = Drosophila melanogaster
Gg = Gallus gallus
Hs = Homo sapiens
Mm = Mus musculus
Sc = Saccharomyces cerevisiae		 Type
kidney development Hs biological process
regulation of protein phosphorylation Hs biological process
calcium ion binding Hs molecular function
protein binding Hs molecular function
plasma membrane Hs cellular component
endocytosis Hs biological process
multicellular organism development Hs biological process
protein localization Hs biological process
dorsal/ventral pattern formation Hs biological process
proximal/distal pattern formation Hs biological process
cell surface Hs cellular component
postsynaptic density Hs cellular component
membrane Hs cellular component
integral component of membrane Hs cellular component
Wnt signaling pathway Hs biological process
flotillin complex Hs cellular component
Wnt-protein binding Hs molecular function
cell differentiation Hs biological process
negative regulation of Wnt signaling pathway Hs biological process
negative regulation of ossification Hs biological process
embryonic limb morphogenesis Hs biological process
dendrite Hs cellular component
BMP signaling pathway Hs biological process
receptor tyrosine kinase binding Hs molecular function
neuromuscular junction Hs cellular component
apolipoprotein binding Hs molecular function
protein homodimerization activity Hs molecular function
Wnt-activated receptor activity Hs molecular function
neuronal cell body Hs cellular component
receptor clustering Hs biological process
receptor complex Hs cellular component
Wnt signaling pathway involved in dorsal/ventral axis specification Hs biological process
animal organ development Hs biological process
dendrite morphogenesis Hs biological process
anatomical structure development Hs biological process
positive regulation of peptidyl-tyrosine phosphorylation Hs biological process
negative regulation of axonogenesis Hs biological process
synapse organization Hs biological process
synaptic growth at neuromuscular junction Hs biological process
protein heterotetramerization Hs biological process
limb development Hs biological process
regulation of canonical Wnt signaling pathway Hs biological process
skeletal muscle acetylcholine-gated channel clustering Hs biological process
negative regulation of canonical Wnt signaling pathway Hs biological process
synaptic membrane Hs cellular component
postsynaptic membrane assembly Hs biological process
presynaptic membrane assembly Hs biological process
scaffold protein binding Hs molecular function
positive regulation of skeletal muscle acetylcholine-gated channel clustering Hs biological process

GO (Blast)

61 results

GO Term SpeciesCe = Caenorhabditis elegans
Dr = Danio rerio
Dm = Drosophila melanogaster
Gg = Gallus gallus
Hs = Homo sapiens
Mm = Mus musculus
Sc = Saccharomyces cerevisiae		 Type Score E-value
protease binding Hs molecular function 874 0.0
RNA binding Hs molecular function 874 0.0
receptor activity Hs molecular function 874 0.0
low-density lipoprotein receptor activity Hs molecular function 874 0.0
scavenger receptor activity Hs molecular function 874 0.0
receptor binding Hs molecular function 874 0.0
frizzled binding Hs molecular function 874 0.0
calcium ion binding Hs molecular function 1707 0.0
protein binding Hs molecular function 1707 0.0
extracellular region Hs cellular component 874 0.0
nucleus Hs cellular component 874 0.0
cytoplasm Hs cellular component 874 0.0
lysosomal membrane Hs cellular component 874 0.0
endosome Hs cellular component 874 0.0
early endosome Hs cellular component 874 0.0
endoplasmic reticulum Hs cellular component 874 0.0
Golgi apparatus Hs cellular component 874 0.0
plasma membrane Hs cellular component 1707 0.0
integral component of plasma membrane Hs cellular component 874 0.0
caveola Hs cellular component 874 0.0
clathrin-coated pit Hs cellular component 874 0.0
focal adhesion Hs cellular component 874 0.0
cell surface Hs cellular component 1707 0.0
postsynaptic density Hs cellular component 1707 0.0
membrane Hs cellular component 1707 0.0
integral component of membrane Hs cellular component 1707 0.0
basolateral plasma membrane Hs cellular component 874 0.0
flotillin complex Hs cellular component 1707 0.0
alpha-2 macroglobulin receptor activity Hs molecular function 874 0.0
Wnt-protein binding Hs molecular function 1707 0.0
kinase inhibitor activity Hs molecular function 874 0.0
toxin transporter activity Hs molecular function 874 0.0
clathrin-coated vesicle Hs cellular component 874 0.0
apolipoprotein receptor activity Hs molecular function 874 0.0
dendrite Hs cellular component 1707 0.0
endocytic vesicle membrane Hs cellular component 874 0.0
receptor tyrosine kinase binding Hs molecular function 1707 0.0
cytoplasmic vesicle Hs cellular component 874 0.0
neuromuscular junction Hs cellular component 1707 0.0
early endosome membrane Hs cellular component 874 0.0
clathrin heavy chain binding Hs molecular function 874 0.0
apolipoprotein binding Hs molecular function 1707 0.0
identical protein binding Hs molecular function 874 0.0
protein homodimerization activity Hs molecular function 1707 0.0
Wnt-activated receptor activity Hs molecular function 1707 0.0
lipoprotein transporter activity Hs molecular function 874 0.0
neuronal cell body Hs cellular component 1707 0.0
receptor complex Hs cellular component 1707 0.0
heparan sulfate proteoglycan binding Hs molecular function 874 0.0
macromolecular complex binding Hs molecular function 874 0.0
membrane raft Hs cellular component 874 0.0
synapse Hs cellular component 874 0.0
metal ion binding Hs molecular function 874 0.0
lipoprotein particle receptor binding Hs molecular function 874 0.0
coreceptor activity involved in Wnt signaling pathway Hs molecular function 874 0.0
synaptic membrane Hs cellular component 1707 0.0
scaffold protein binding Hs molecular function 1707 0.0
plasma membrane protein complex Hs cellular component 874 0.0
coreceptor activity involved in canonical Wnt signaling pathway Hs molecular function 874 0.0
Wnt-Frizzled-LRP5/6 complex Hs cellular component 874 0.0
Wnt signalosome Hs cellular component 874 0.0

GO (InterProScan)

5 results

GO Term Analysis Type e-value
calcium ion binding SMART molecular function 1.4E-8
protein binding PRINTS molecular function 5.0E-45
BMP signaling pathway PANTHER biological process 0.0
animal organ development PANTHER biological process 0.0
regulation of canonical Wnt signaling pathway PANTHER biological process 0.0

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