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GENE CARD

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Gene Card

Best human hits

MITF; TFE3; TFEB

Species

H.roretzi

Unique Gene ID

Harore.g00007680

Gene Model ID

Harore.CG.MTP2014.S131.g07680

Location

S131:156800..169395

Transcript Models and Sequences

  Harore.CG.MTP2014.S131.g07680.01.t

External Database Gene Card

External database links

No result

Collections
WashU Genome Browser

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Genomicus Synteny Browser

Genomicus browser link

Regulatory Regions

Regulatory Regions

No result

n/a

Gene Phylogeny

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Gene Annotations

InterPro

8 results

IPR Term Analysis Definition
TFEB PANTHER Transcription factor EB
bHLH_dom Pfam Myc-type, basic helix-loop-helix (bHLH) domain
MiT/TFE_N Pfam MiT/TFE transcription factors, N-terminal
HLH_DNA-bd_sf Gene3D Helix-loop-helix DNA-binding domain superfamily
bHLH_dom SMART Myc-type, basic helix-loop-helix (bHLH) domain
HLH_DNA-bd_sf SUPERFAMILY Helix-loop-helix DNA-binding domain superfamily
bHLH_dom CDD Myc-type, basic helix-loop-helix (bHLH) domain
bHLH_dom ProSiteProfiles Myc-type, basic helix-loop-helix (bHLH) domain

GOSlim

39 results

GO Term Annotation Origin Type
negative regulation of transcription from RNA polymerase II promoter Orthology biological process
RNA polymerase II core promoter proximal region sequence-specific DNA binding Orthology molecular function
RNA polymerase II transcription factor activity, sequence-specific DNA binding Orthology molecular function
immune system process Orthology biological process
DNA binding Orthology molecular function
chromatin binding Orthology molecular function
transcription factor activity, sequence-specific DNA binding Orthology molecular function
protein binding Orthology molecular function
nucleus Orthology cellular component
nucleoplasm Orthology cellular component
cytoplasm Orthology cellular component
cytosol Orthology cellular component
transcription, DNA-templated Orthology biological process
regulation of transcription, DNA-templated Orthology biological process
regulation of transcription from RNA polymerase II promoter Orthology biological process
transcription from RNA polymerase II promoter Orthology biological process
multicellular organism development Orthology biological process
regulation of gene expression Orthology biological process
positive regulation of gene expression Orthology biological process
cell differentiation Orthology biological process
macromolecular complex Orthology cellular component
regulation of cell proliferation Orthology biological process
negative regulation of apoptotic process Orthology biological process
transcription regulatory region DNA binding Orthology molecular function
positive regulation of transcription, DNA-templated Orthology biological process
positive regulation of transcription from RNA polymerase II promoter Orthology biological process
protein dimerization activity Orthology molecular function
regulation of RNA biosynthetic process Orthology biological process
transcription coactivator activity Orthology molecular function
transcription corepressor activity Orthology molecular function
negative regulation of nucleic acid-templated transcription Orthology biological process
immune response Orthology biological process
organelle organization Orthology biological process
cell surface receptor signaling pathway Orthology biological process
cell-cell signaling Orthology biological process
protein modification by small protein conjugation Orthology biological process
animal organ development Orthology biological process
cell adhesion Orthology biological process
cellular response to stress Orthology biological process

GO (Orthology)

51 results

GO Term SpeciesCe = Caenorhabditis elegans
Dr = Danio rerio
Dm = Drosophila melanogaster
Gg = Gallus gallus
Hs = Homo sapiens
Mm = Mus musculus
Sc = Saccharomyces cerevisiae		 Type
negative regulation of transcription from RNA polymerase II promoter Hs biological process
RNA polymerase II core promoter proximal region sequence-specific DNA binding Hs molecular function
RNA polymerase II transcription factor activity, sequence-specific DNA binding Hs molecular function
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding Hs molecular function
transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding Hs molecular function
adaptive immune response Hs biological process
immune system process Hs biological process
DNA binding Hs molecular function
chromatin binding Hs molecular function
transcription factor activity, sequence-specific DNA binding Hs molecular function
transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding Hs molecular function
protein binding Hs molecular function
nucleus Hs cellular component
nucleoplasm Hs cellular component
cytoplasm Hs cellular component
cytosol Hs cellular component
transcription, DNA-templated Hs biological process
regulation of transcription, DNA-templated Hs biological process
regulation of transcription from RNA polymerase II promoter Hs biological process
transcription from RNA polymerase II promoter Hs biological process
autophagy Hs biological process
humoral immune response Hs biological process
lysosome organization Hs biological process
multicellular organism development Hs biological process
regulation of gene expression Hs biological process
positive regulation of autophagy Hs biological process
positive regulation of gene expression Hs biological process
Wnt signaling pathway Hs biological process
protein sumoylation Hs biological process
cell differentiation Hs biological process
osteoclast differentiation Hs biological process
melanocyte differentiation Hs biological process
macromolecular complex Hs cellular component
regulation of cell proliferation Hs biological process
camera-type eye development Hs biological process
negative regulation of apoptotic process Hs biological process
pigmentation Hs biological process
transcription regulatory region DNA binding Hs molecular function
cell fate commitment Hs biological process
regulation of osteoclast differentiation Hs biological process
positive regulation of cell adhesion Hs biological process
positive regulation of transcription, DNA-templated Hs biological process
positive regulation of transcription from RNA polymerase II promoter Hs biological process
bone remodeling Hs biological process
protein dimerization activity Hs molecular function
E-box binding Hs molecular function
regulation of RNA biosynthetic process Hs biological process
transcription coactivator activity Hs molecular function
transcription corepressor activity Hs molecular function
cellular response to heat Hs biological process
negative regulation of nucleic acid-templated transcription Hs biological process

GO (Blast)

17 results

GO Term SpeciesCe = Caenorhabditis elegans
Dr = Danio rerio
Dm = Drosophila melanogaster
Gg = Gallus gallus
Hs = Homo sapiens
Mm = Mus musculus
Sc = Saccharomyces cerevisiae		 Type Score E-value
RNA polymerase II core promoter proximal region sequence-specific DNA binding Hs molecular function 211 9.85e-62
RNA polymerase II transcription factor activity, sequence-specific DNA binding Hs molecular function 211 9.85e-62
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding Hs molecular function 211 9.85e-62
transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding Hs molecular function 196 2.01e-56
DNA binding Hs molecular function 211 9.85e-62
chromatin binding Hs molecular function 196 2.01e-56
transcription factor activity, sequence-specific DNA binding Hs molecular function 211 9.85e-62
transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding Hs molecular function 196 2.01e-56
protein binding Hs molecular function 211 9.85e-62
nucleus Hs cellular component 211 9.85e-62
nucleoplasm Hs cellular component 211 9.85e-62
cytoplasm Hs cellular component 203 1.24e-58
cytosol Hs cellular component 211 9.85e-62
macromolecular complex Hs cellular component 196 2.01e-56
transcription regulatory region DNA binding Hs molecular function 211 9.85e-62
protein dimerization activity Hs molecular function 211 9.85e-62
E-box binding Hs molecular function 196 2.01e-56

GO (InterProScan)

3 results

GO Term Analysis Type e-value
humoral immune response PANTHER biological process 1.6E-81
positive regulation of transcription, DNA-templated PANTHER biological process 1.6E-81
protein dimerization activity PANTHER molecular function 1.6E-81

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