Gene Card
Best human hits
NAE1; SAE1; UBA1
Species
Unique Gene ID
Harore.g00012180
Gene Model ID
Harore.CG.MTP2014.S334.g12180
Location
S334:91087..98872
Transcript Models and Sequences
Harore.CG.MTP2014.S334.g12180.01.t
Harore.CG.MTP2014.S334.g12180.02.t
n/a
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The 'History' button on the left side permits you to see the changes you have made and eventually to go back.
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You can Press 'Ctrl' Key + Left Mouse Click on nodes to do a multiple selection.

IPR Term | Analysis | Definition |
---|---|---|
Ubiquitin-activating_enz | SUPERFAMILY | Ubiquitin-activating enzyme |
APP-BP1 | PANTHER | NEDD8-activating enzyme E1 regulatory subunit APP-BP1 |
ThiF_NAD_FAD-bd | Pfam | THIF-type NAD/FAD binding fold |
APP-BP1 | PIRSF | NEDD8-activating enzyme E1 regulatory subunit APP-BP1 |
GO Term | Annotation Origin | Type |
---|---|---|
nucleotide binding | Blast | molecular function |
RNA binding | Blast | molecular function |
protein binding | Orthology | molecular function |
ATP binding | Blast | molecular function |
nucleus | Blast | cellular component |
nucleoplasm | Blast | cellular component |
cytoplasm | Orthology | cellular component |
mitochondrion | Blast | cellular component |
lysosomal membrane | Blast | cellular component |
cytosol | Orthology | cellular component |
plasma membrane | Orthology | cellular component |
cellular protein modification process | Orthology | biological process |
apoptotic process | Orthology | biological process |
cell cycle | Orthology | biological process |
signal transduction | Orthology | biological process |
protein C-terminus binding | Blast | molecular function |
enzyme activator activity | Blast | molecular function |
membrane | Orthology | cellular component |
protein ubiquitination | Blast | biological process |
ligase activity | Orthology | molecular function |
ubiquitin protein ligase binding | Orthology | molecular function |
regulation of apoptotic process | Orthology | biological process |
protein heterodimerization activity | Orthology | molecular function |
extracellular exosome | Blast | cellular component |
G2/M transition of mitotic cell cycle | Orthology | biological process |
protein modification by small protein conjugation | Orthology | biological process |
intracellular organelle part | Blast | cellular component |
intracellular non-membrane-bounded organelle | Blast | cellular component |
whole membrane | Blast | cellular component |
endosome | Blast | cellular component |
bounding membrane of organelle | Blast | cellular component |
anchoring junction | Blast | cellular component |
endoplasmic reticulum membrane | Blast | cellular component |
nuclear part | Blast | cellular component |
macromolecular complex | Blast | cellular component |
enzyme binding | Blast | molecular function |
GO Term | SpeciesCe = Caenorhabditis elegans Dr = Danio rerio Dm = Drosophila melanogaster Gg = Gallus gallus Hs = Homo sapiens Mm = Mus musculus Sc = Saccharomyces cerevisiae |
Type |
---|---|---|
protein binding | Hs | molecular function |
cytoplasm | Hs | cellular component |
cytosol | Hs | cellular component |
plasma membrane | Hs | cellular component |
apoptotic process | Hs | biological process |
cell cycle | Hs | biological process |
signal transduction | Hs | biological process |
ubiquitin-like modifier activating enzyme activity | Hs | molecular function |
membrane | Hs | cellular component |
NEDD8 activating enzyme activity | Hs | molecular function |
ubiquitin protein ligase binding | Hs | molecular function |
mitotic DNA replication checkpoint | Hs | biological process |
regulation of apoptotic process | Hs | biological process |
regulation of neuron apoptotic process | Hs | biological process |
post-translational protein modification | Hs | biological process |
protein neddylation | Hs | biological process |
protein heterodimerization activity | Hs | molecular function |
neuron apoptotic process | Hs | biological process |
GO Term | SpeciesCe = Caenorhabditis elegans Dr = Danio rerio Dm = Drosophila melanogaster Gg = Gallus gallus Hs = Homo sapiens Mm = Mus musculus Sc = Saccharomyces cerevisiae |
Type | Score | E-value |
---|---|---|---|---|
nucleotide binding | Hs | molecular function | 63.5 | 2.06e-10 |
heterochromatin | Hs | cellular component | 63.5 | 2.06e-10 |
RNA binding | Hs | molecular function | 63.5 | 2.06e-10 |
ubiquitin activating enzyme activity | Hs | molecular function | 95.5 | 1.77e-21 |
protein binding | Hs | molecular function | 540 | 0.0 |
ATP binding | Hs | molecular function | 63.5 | 2.06e-10 |
nucleus | Hs | cellular component | 95.5 | 1.77e-21 |
nucleoplasm | Hs | cellular component | 95.5 | 1.77e-21 |
cytoplasm | Hs | cellular component | 540 | 0.0 |
mitochondrion | Hs | cellular component | 63.5 | 2.06e-10 |
lysosomal membrane | Hs | cellular component | 63.5 | 2.06e-10 |
cytosol | Hs | cellular component | 540 | 0.0 |
plasma membrane | Hs | cellular component | 540 | 0.0 |
protein C-terminus binding | Hs | molecular function | 95.5 | 1.77e-21 |
enzyme activator activity | Hs | molecular function | 95.5 | 1.77e-21 |
ubiquitin-like modifier activating enzyme activity | Hs | molecular function | 540 | 0.0 |
endosome membrane | Hs | cellular component | 63.5 | 2.06e-10 |
membrane | Hs | cellular component | 540 | 0.0 |
ligase activity | Hs | molecular function | 95.5 | 1.77e-21 |
acid-amino acid ligase activity | Hs | molecular function | 63.5 | 2.06e-10 |
NEDD8 activating enzyme activity | Hs | molecular function | 540 | 0.0 |
SUMO activating enzyme activity | Hs | molecular function | 95.5 | 1.77e-21 |
desmosome | Hs | cellular component | 63.5 | 2.06e-10 |
rough endoplasmic reticulum membrane | Hs | cellular component | 63.5 | 2.06e-10 |
SUMO activating enzyme complex | Hs | cellular component | 95.5 | 1.77e-21 |
ubiquitin protein ligase binding | Hs | molecular function | 540 | 0.0 |
ATP-dependent protein binding | Hs | molecular function | 95.5 | 1.77e-21 |
small protein activating enzyme binding | Hs | molecular function | 95.5 | 1.77e-21 |
protein heterodimerization activity | Hs | molecular function | 540 | 0.0 |
extracellular exosome | Hs | cellular component | 63.5 | 2.06e-10 |
GO Term | Analysis | Type | e-value |
---|---|---|---|
ubiquitin-like modifier activating enzyme activity | SUPERFAMILY | molecular function | 1.22E-120 |
NEDD8 activating enzyme activity | PIRSF | molecular function | 1.7E-169 |
protein neddylation | PIRSF | biological process | 1.7E-169 |